LOCUS       NM_065433               3537 bp    mRNA    linear   INV 22-NOV-2023
DEFINITION  Caenorhabditis elegans Heritable RNAi Deficient (hrde-1), mRNA.
ACCESSION   NM_065433
VERSION     NM_065433.8
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 3537)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (22-NOV-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 3537)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2023) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 3537)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003281).
            
            On Feb 2, 2021 this sequence version replaced NM_065433.7.
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="III"
     gene            1..3537
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /db_xref="GeneID:175535"
                     /db_xref="WormBase:WBGene00007624"
     CDS             7..3105
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /standard_name="C16C10.3"
                     /note="Product from WormBase gene class hrde;
                     Confirmed by transcript evidence"
                     /codon_start=1
                     /product="Heritable RNAi Deficient"
                     /protein_id="NP_497834.1"
                     /db_xref="EnsemblGenomes-Gn:WBGene00007624"
                     /db_xref="EnsemblGenomes-Tr:C16C10.3"
                     /db_xref="GeneID:175535"
                     /db_xref="WormBase:WBGene00007624"
                     /translation="

MADLLDKIMGSSSSNRIPKRDNRMNQDKDEPTSKRSAPMFSTPKSTTPIGRDSFATMDTMNVQMNMFPVDIKDMPHKIQRFQVDVIVCSSNGKQINANLGVLAAKGDVNSHNRRLAQYYIMRTVHDKLLVKFSGKSHHFLAYDCAATLYLPEGVYTGDDQEEVTLTIDDFPKEEWKFVSKLSRRKDDSYLVVLKPAGFVYTQGEVAQEEANRMELTRIIEIVTSQKLNNEDYLQFGNATFPRLSPPHSEPDAISEIRSGFAKVSRLSQNGGGKAFMTVDTKISPFYKDTSVIKFSSNKLSEMKGGGGGRGGYGRSDSRDSRGGYRGGRSDSRDFRGVYGNRGGNDRYRDESRGRRDMYDSRRDSGSSNGADYSPSDAAELEHAFGERGNTKRCIEEALKGLDVECTHLKGNLIRVSSIAENNAENTSFMMKDDKGEREVTVAEYFLLQYNIKLKYPRLPLVVSKRFKHESFFPMELLRIAPGQRIKVNKMSPTVQSAMTGRNASMPQHHVKLVQDILRDNLKLEQNKYMDAFGIKLMSTEPIQMTAKLLPPAQIKFKGQTYMPDMSRPAFRTQDKFVEPARIRKIGIVVFDNCIQMRQAEDFCDKLSNFCRDNGITVEKDSRDWSIRELNSSDSVAIQNLMKKWLDDRVDILVGIAREKKPDVHDILKYFEESIGLQTIQLCQQTVDKMMGGQGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVCSNNETLRKKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLTNSTQLGGFTYLQTQKEYKLQKLDEFFPKCVRSYKEHSKTLPTRIVIYRVGAGEGNFNRVKEEVEEMRRTFDKIQPGYRPHLVVIIAQRASHARVFPSCISGNRATDQNIPSGTCVENVLTSYGYDEFILSSQTPLIGTVRPCKYTILVNDAKWSKNELMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKRGRNNYKIHQRYVNLQAVENRIIKDHSELINEDMREELAAAIVDEMSVAMNGMTIPKRNFWA"

     misc_feature    1171..1446
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1243..1245,1288..1290,1327..1329,1339..1341,
                     1393..1395,1414..1416,1420..1422)
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1624..2928
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /note="PIWI domain. Domain found in proteins involved in
                     RNA silencing. RNA silencing refers to a group of related
                     gene-silencing mechanisms mediated by short RNA molecules,
                     including siRNAs, miRNAs, and heterochromatin-related
                     guide RNAs. The central component...; Region: Piwi-like;
                     cd02826"
                     /db_xref="CDD:239208"
     misc_feature    order(1996..1998,2008..2010,2035..2046,2059..2061,
                     2098..2100,2107..2109,2119..2121,2131..2133)
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:239208"
     misc_feature    order(2251..2253,2257..2259,2491..2493,2902..2904)
                     /gene="hrde-1"
                     /locus_tag="CELE_C16C10.3"
                     /note="active site"
                     /db_xref="CDD:239208"
ORIGIN      

tcaaacatggccgacttgctcgacaaaattatgggaagttcgtcttccaacaggattcccaaacgagacaaccgaatgaatcaggacaaggacgaaccgacgtcaaagagaagtgcaccaatgttctctactccgaagtcaacaacaccaattggacgggactctttcgcaacgatggacacgatgaatgttcagatgaacatgtttccagtggacatcaaggatatgccccacaagatccaacgctttcaagttgacgtcatcgtctgttccagcaacggaaaacagatcaatgccaaccttggagttttggcggccaagggagatgtcaattcccataaccgtcgcttggcacaatactacatcatgagaacagtacatgacaagcttctggtgaagttcagtggaaagagtcaccacttccttgcttacgactgcgctgcgactctctatcttccggagggagtctacactggtgacgatcaagaagaagtcacgttgacgatcgatgacttcccgaaggaagaatggaaattcgtgtcgaagttgtctcgcagaaaggacgattcttaccttgttgttctcaaacctgccggatttgtgtacacccaaggagaagttgcccaggaggaggctaatcgtatggagttgactcgtattatcgaaatcgtcacttcacaaaagctcaacaatgaggattacttacaatttggtaatgccacattcccacgtctttctccgccacactcggaacctgatgctatttcggagatccgctcaggttttgcgaaagtatctcgtctatcgcaaaacggaggtggcaaagctttcatgacggttgatacgaagatttctccattttacaaggatacatcagttatcaagttttcaagcaacaagttatccgaaatgaaaggtggaggcggtggaagaggcggatacggaagaagtgactcgcgagactctcgtggtggataccgtggcggccgttccgactcgagagactttcgtggtgtctatggaaaccgaggtggcaacgacaggtaccgagatgaaagcagaggacgtcgcgacatgtacgattcccgtcgagacagtggttcttcaaatggagcggactactctccgagtgatgctgctgagttggaacacgcttttggcgaaagaggaaacacgaagcgatgcattgaagaagcactcaaaggattggacgtggaatgcactcacttgaagggtaaccttattcgcgtatcctcgattgccgagaacaatgctgagaacacttcgttcatgatgaaggacgacaagggagaacgcgaggtcaccgtggcggaatatttcctgttgcagtacaacatcaagctgaaatatccgagacttcctctcgtcgtctcaaaaagattcaaacatgaatctttcttcccaatggagttgcttcgaattgctccaggccagcggatcaaggtcaacaagatgagcccgacagtacaatcggcgatgacaggaagaaatgcgtctatgccacagcatcatgtgaagttggttcaagatattctccgcgacaacttgaagcttgaacaaaataagtacatggatgctttcggaatcaaactgatgtcgactgagccaatccaaatgactgcgaagctcctcccaccagctcaaatcaagttcaagggccagacttacatgcctgacatgagccgtccagcgttccgcacacaggacaagtttgtcgaaccagcacggatcagaaaaattggtattgttgtctttgacaactgtatccaaatgagacaggccgaagatttctgcgacaagctgtccaatttctgtcgtgacaatggaatcacggtcgaaaaggactcgcgagattggtccatccgtgaattgaactccagtgattccgttgctatccaaaatctgatgaagaaatggctcgatgatagagtggacattcttgttggaatagcaagggagaagaagccggatgttcacgacatactcaaatactttgaggaatcgattggcctgcaaacaatccaattgtgtcaacagactgtcgataaaatgatgggaggtcaaggtggacgccaaacgattgacaacgtcatgagaaagttcaacctcaagtgtggtggaaccaacttcttcgtcgagatcccgaatgctgtgcgtggaaaagcagtgtgctcaaacaatgaaacattgagaaagaaacttctcgaacatgtacaattcatcggattcgagatttctcatggcgcatcacgcactttgttcgatcgcagtagatcacaaatggatggtgagccatcagttgttggagtctcgtattccctgaccaactcgacgcagctcggaggcttcacataccttcaaacccaaaaggagtacaaacttcaaaaacttgatgaattcttcccaaagtgtgtcagatcgtacaaggagcattcgaagacactcccaacaagaatcgtcatctatcgtgttggtgctggagaaggaaacttcaatcgtgttaaggaagaagtcgaagagatgcgacgaacatttgacaagattcagcccggataccgtccacatctcgtggtgatcatcgcacaaagagcttcacatgctcgcgtttttccatcatgtatcagtggcaacagagcgacggatcagaacatcccatctggaacatgtgtcgagaatgtcctgacatcctacggatacgacgagttcattttgtcttcacagacgccgcttattggtaccgttcgtccgtgcaagtacacgatccttgtcaatgatgccaaatggtctaaaaacgagctcatgcacttgacgtacttccgcgcattcggtcatcaagtgtcctaccagccaccatcggttccagatgttctttatgcggcagaaaatctggctaaacgaggacgcaacaattacaaaattcatcagcgttacgtgaatttgcaagcagttgagaaccgcatcatcaaagaccattcggaactcatcaacgaagacatgcgagaagaactggcggcagccattgttgatgagatgtccgttgcaatgaacggaatgaccattccgaagcgaaacttctgggcgtaatcccgagattctctcttttattgtcacgtattcaccccctttacatattaccaacattttttatccactaccctatacctactctctatacaagtacttaaattcccatgcttttgtttttctgaacattctttattacatttttccccataattgtatcgtattcccctttatgtttttataatttcaactaagaatccttttgtaatttaatctagagtagagtacattgacacatagtttgaatagtagatactcctgttttacctgcctttttttctgtgcgaatttcctccaactttcttattaggagttttcgaaggcgaaagaaacttccaattagaacgtttttggaaatttcgattttcaataatcttacttgctctaccccccgtccattatcatttattaagcaataaattattcgagaag

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