LOCUS       XM_063643578           14650 bp    mRNA    linear   PRI 17-JUL-2024
DEFINITION  PREDICTED: Symphalangus syndactylus argonaute RISC catalytic
            component 2 (AGO2), transcript variant X6, mRNA.
ACCESSION   XM_063643578
VERSION     XM_063643578.1
DBLINK      BioProject: PRJNA946760
KEYWORDS    RefSeq.
SOURCE      Symphalangus syndactylus (siamang)
  ORGANISM  Symphalangus syndactylus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hylobatidae; Symphalangus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072429) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_028878055.3-RS_2024_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/16/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14650
                     /organism="Symphalangus syndactylus"
                     /mol_type="mRNA"
                     /isolate="Jambi"
                     /db_xref="taxon:9590"
                     /chromosome="7"
                     /sex="male"
                     /cell_line="Jambi"
                     /cell_type="lymphoblastoid"
                     /tissue_type="blood"
     gene            1..14650
                     /gene="AGO2"
                     /note="argonaute RISC catalytic component 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 236 long SRA reads, 14 Proteins"
                     /db_xref="GeneID:129486859"
     CDS             333..2774
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X3"
                     /protein_id="XP_063499648.1"
                     /db_xref="GeneID:129486859"
                     /translation="

MDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    468..692
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    720..872
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    873..1235
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1029..1031,1074..1076,1116..1118,1128..1130,
                     1182..1184,1203..1205,1209..1211)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1368..2645
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1779..1781,1791..1793,1827..1838,1845..1847,
                     1869..1871,1878..1880,1890..1892,1902..1904)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1983..1985,1989..1991,2199..2201,2613..2615)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      14650
                     /gene="AGO2"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

ctggctgctcggtgctgcagtctcccgcagctgcatctcctgggtgtagcccggcatgccctctgttctgagtgtctttcttgcagattggtggccggagctggagcggtagtttggatgcaggctgtccaagtttgggtttgttctgccgctgtccatccccgtccagggtgaggtggtcacctgccacacacgccggctctgtgccctgagcactcgcgcctcctgcgccgccgccaccccccatccaaggatatgccttcaagcctccacctagacccgactttgggacctccgggagaacaatcaaattacaggccaatttcttcgaaatggacatccccaaaattgacatctatcattatgaattggatatcaagccagagaagtgcccgaggagagttaacagggaaatcgtggaacacatggtccagcactttaaaacacagatctttggggatcggaagcccgtgtttgacggcaggaagaatctatacacagccatgccccttccgattgggagggacaaggtggagctggaggtcacgctgccaggagaaggcaaggatcgcatcttcaaggtgtccatcaagtgggtgtcctgtgtgagcttgcaggcgttacacgatgcactttcagggcggctgcccagcgtcccttttgagacgatccaggccctggacgtggtcatgaggcacttgccatccatgaggtacacccccgtgggccgctccttcttcaccgcatccgagggctgctccaaccctcttggcgggggccgagaagtgtggtttggcttccatcagtccgtccggccttctctctggaaaatgatgctgaatattgatgtgtcggcaacagcgttttacaaggcacagccagtaatcgagtttgtttgtgaagttttggattttaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaattaaaggtctaaaggtggagataacgcactgtgggcagatgaagaggaagtaccgcgtctgcaacgtgacccggcggcccgccagtcaccaaacattcccgctgcagcaggagagcgggcagacggtggagtgcacggtggcccagtacttcaaggacaggcacaagttggttctgcgctacccccacctcccatgtttacaagttggacaggagcagaaacacacctaccttcccctggaggtctgtaacatagtggcaggacaaagatgtattaaaaaattaacggacaatcagacctcaaccatgatcagagcgactgctaggtcggcgcccgatcgtcaagaagagattagcaaattgatgcgaagtgcaagtttcaacacagatccatacgtccgtgaatttggaatcatggtcaaagatgagatgacagacgtgactgggcgggtgctgcagccgccctccatcttgtacgggggcaggaataaagcgatcgcaactcctgtccagggcgtctgggacatgcggaacaagcagttccacacgggcattgagatcaaggtgtgggccatcgcgtgcttcgctccccagcgccagtgcacggaagtccatctgaagtctttcacagagcagctcagaaagatctcgagagacgccggcatgcccatccagggccagccgtgcttctgcaaatacgcccagggggcggacagcgtggagcccatgttccggcacctgaagaacacgtatgcgggcctgcagctggtggtggtcatcctgcccggcaagacacccgtgtacgctgaggtcaagcgcgtgggagacacagtgctggggatggccacgcagtgcgtgcagatgaagaacgtgcagaggaccacgccgcagaccctgtccaacctctgcctgaagatcaacgtcaagctgggaggcgtgaacaacatcctgctgcctcagggcaggccgccagtgttccagcagcccgtcatctttctgggagcggacgtcactcatccccccgccggggacgggaagaagccctccattgccgccgtggtgggcagcatggacgcccaccccaatcgctactgcgccaccgtgcgcgtgcagcagcaccggcaggagatcatacaagacctggccgccatggtccgcgagctcctcatccagttctacaagtccacgcgcttcaagcccacccgcatcatcttctaccgcgacggcgtctccgaagggcagttccagcaggttctccaccacgagttgctggccatccgtgaggcctgtatcaagctggaaaaagactaccagcccgggatcaccttcatcgtggtgcagaagaggcaccacacccggctcttctgcactgacaagaacgagcgggttgggaaaagtggaaacattccagcaggcacgactgtggacacgaaaatcacccaccccaccgagttcgacttctacctgtgtagtcacgctggcatccaggggacaagcaggccttcgcactatcacgtcctctgggacgacaatcgtttctcctctgatgagctgcagatcctaacctaccagctgtgtcacacttacgtgcgctgcacacgctccgtgtccatcccagcgccagcatactatgcccacctggtggccttccgggccaggtaccacctggtggataaggaacatgacagtgctgaaggaagccatacctctgggcagagtaacgggcgagaccaccaagcactggccaaggcggtccaggttcaccaagacactctgcgcaccatgtactttgcttgacatgttttagtgtttagcgattgtgtaccgagtgggattcacgagaccagctacactcagaccaacagatggccagcccttccgtgacagccagcatcgaacatgagacgtcattgattttattagattctccgttttccagaatgccttccgtcccagatttcaaacttggattttgaactgcagacctgtatgagaacccaatgtcataggaaatatggtttgctaaaatctataagctgcttattaaaatagagtcccgtgcatcctaaaaatttcctaaaaccagtctatgaactcagggctttaaaacatttttaatttatctggtcattcaatttacttgtttttaatacatgattctctatgaaattgatgggctcaaactagctgtgaatcttctgagagtgaaagcgacacaaaacacaagtgtggttttaaagccttgaacattctgatgttgtcactaaagttgatttccaggcgatgctcgtgtgcccctggcgtggctcacccaagttcctcgactgagggccggtggccatgcagaggcgtccgcaggtgccgtgttctgccagcaccgccctgagctaaggagcagtggagaaggtgggccccgtgtgtttacagcatttccaggtccagagaggttggcagacaagtgccattttaataaaaaatgtatttaaaaaaagaaaaaagacaatgtactgacagtctaatcatcagatttgtcctataggactgtgacatttattttccaaagtttttaaagaatacgggtctgtggtgataaatacagtacaatcctttttcactgtcgtctttaatgtaagagaaaaatatatatatctggtttgcagtattaatgtgatagatagatgctgttttttcattttattgactatggggtgcttctgtgatctgtttagcatatcgagagtgttctggagcctggagatgggaccgcctctcagttcttagtgcttacggatgggaatatgcaattgacttaatgtgacagcaacccgcttccccccgtggagactgtgcagcgtgtacccatgggaggggcggatgtgccctcggcgccgcgcgccaccctccctgccgcctcgtccccatgtgtcactcactcagctgatgaagcacaagtggaaattatttattcttgcattgctgggaaacattgatgtgtcgggactcactcctctccgtgtgcgcttttgtcagatgactttcatagatgtatgcactgagatttcgtagaaagctgtcagtggtggctctgctgggcgtgaggccgtcggtcacagcgaaggagcctgcccggccctgggaggccccaggatagcagggccagcagagggcatggaccattcttctggggtttgcatttgggccccagacgtgggtttgccaatctagaaactgttgcactaagagtgacaccacggacgattttgaaggctaacaacagacaactctgtgctgagtgggctttttgtctctgtacacagttttagtaagactcaaatccatgttccgtgtagaggtgtcaggaaggaggcgagcctcccctagtgctgctgtgcgctccataggtcccctcttcccgctgctgttccctccccggccctgcgcgacacttacctcggcactgtggtggagtggggtgccaaaggagctgcctcctgctgagcggcaccccctccacctttgtgctcagctgctttggaggcagcaggaggggcagcaagccgcaggtggggggtctccggatacctcgcctggatgttggcggcaatgacaaagggatgactattatttgtgaagatgtgtactcagagtggtgtgtgtgtgtgtgtgtgtgcacgcgtgtgtccctgtgtgtgtgtgagtgtcttattaatggcattagtctcttctggctgtatttttttttttttttttttatctttttaaatgacagaagctcccactctaagaaatggcagttccttttgttttattggcaagtggcactttctcctgttttcagaaggatacagacatgctcgtagcttaaattaacagatgcattcaagctaaggagggaatcttgtgactaataacttttcaaatctgaaattagattagtttccagccgtttatagaatcatctggaaccatgtgtctcaaaggtgtgtttcttccacctgcgtctgactgtctgggggatggtgg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