LOCUS       XM_044237796            4123 bp    mRNA    linear   MAM 13-OCT-2021
DEFINITION  PREDICTED: Neovison vison argonaute RISC catalytic component 3
            (AGO3), transcript variant X5, mRNA.
ACCESSION   XM_044237796
VERSION     XM_044237796.1
DBLINK      BioProject: PRJNA769404
KEYWORDS    RefSeq.
SOURCE      Neogale vison (American mink)
  ORGANISM  Neogale vison
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Musteloidea; Mustelidae; Mustelinae; Neogale.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_058092.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Neovison vison Annotation Release
                                           100
            Annotation Version          :: 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4123
                     /organism="Neogale vison"
                     /mol_type="mRNA"
                     /isolate="M4711"
                     /db_xref="taxon:452646"
                     /chromosome="2"
                     /sex="female"
                     /tissue_type="tongue"
                     /dev_stage="mature"
     gene            1..4123
                     /gene="AGO3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 8 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 3 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:122899748"
     CDS             253..2319
                     /gene="AGO3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X4"
                     /protein_id="XP_044093731.1"
                     /db_xref="GeneID:122899748"
                     /translation="

MKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    265..417
                     /gene="AGO3"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    418..780
                     /gene="AGO3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(574..576,619..621,661..663,673..675,727..729,
                     748..750,754..756)
                     /gene="AGO3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    913..2190
                     /gene="AGO3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1324..1326,1336..1338,1372..1383,1390..1392,
                     1414..1416,1423..1425,1435..1437,1447..1449)
                     /gene="AGO3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1528..1530,1534..1536,1744..1746,2158..2160)
                     /gene="AGO3"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

tggaaaaagaagcctttacacagccaatccacttcctgtggcaactactgggatttagatgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcaattaaatttgtctctcgggtgagttggcacctactacatgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaatcctgtccatgccgttgatgtggtgctacgacatctgccctccatgaaatatacgcctgtggggcgttcctttttctcagctccagaaggatatgaccaccctctcggaggcggcagggaagtatggtttggattccatcaatctgtccgacctgccatgtggaaaatgatgcttaatattgatgtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcataatattgatgagcagccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaagaaggcctgccagtcatcaaacctttcctttacagttagaaaacggtcaaactgtggagagaacagtagcacagtatttcagagaaaagtatactcttcagctgaagtacccacaccttccttgtctgcaagtggggcaggaacagaaacatacctacctgccactagaagtctgtaatatcgtggcagggcaacgatgtatcaagaagttaacagacaatcagacttccacaatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggcccatgtaaccggacgtgtacttccagcacctatgctgcagtatggaggacggaatcggacagtagcaacaccaagccatggagtgtgggacatgcgggggaagcagtttcacacaggagttgagataaaaatgtgggctatagcttgttttgccacacagaggcagtgcagagaagaaatactgaagggtttcaccgaccagctgcgtaagatttctaaagatgcagggatgcccatccagggccagccttgcttctgcaaatatgcgcagggggcagacagcgtggagcccatgttccggcatctcaagaatacctactctgggctacagctcattatcgtcatcctgcccgggaagacgcccgtgtatgcggaagtgaaacgtgtaggagatacacttttgggtatggccacacagtgtgtccaagtcaagaatgtaataaaaacatcccctcaaactctctcaaacctgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagcagatgtcactcatccaccagctggtgatgggaagaagccttcgattgctgctgttgtaggtagtatggatgcccacccaagcagatactgtgccacagtaagagttcagcgaccccgacaggagatcatccaggacttagcctccatggttcgagaacttctcattcagttttataagtcaactcggttcaaacctactcgtatcatcttttatcgggatggtgtttcagagggacagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagatattacacacccatatgagtttgatttttacctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctactaacttaccagctctgccacacttacgtgcgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtggcattcagagccagatatcatctcgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacagagcaacgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaaaaagtccaagaatattctctgagaggaagaactgaaagaagcatcgacatacagcatatgtttctggtggagtcagttgagtggggatgcctccagccatacagcagccaacactgtgtggggaccagggtctgatttttatgttgatacaagaaagattgtttacttcatcaaggaacacagcaccattatgcaatatgaaaccagccaactgcttttttgtgcggtctccttaggaagtatcgccattgttttgttttcactttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaaaagtaaagaaaaagtaaatgacagttaaaaaaaacacacacctacgtgaataatctaagtgattgttcatgattatgtgtgcaaaaaaattaatgtgcattcgtgtattcttgtaaaaggtatctgtgtatattttaaatatatacatgtatacttcatgtgcatatatatctggatctacattgataatagatatatatgtgtctgtgcgtgtattttatagttcattccattggggaactttctttcccttttattatcttcccaccaccactttgatttttctctctacctcccttgccttcattaactacatttttttttcttaatgctaccaatgacattcagatgtttcatgtatctggttcatttggatataaagcatggaaaactagatttttatttttattttgcacaccctactcctgtctcttgtctcacgggcaattccaagtcctcaactcttgatattgctttctgaagaaacaaaattactatatatatataactatatatatatatatatatatatatacacacacacaatgtttctgtgagaatgcgtgtctgccccctcctgctctgaatttacatttgccatttgtgcagtgtgtacataagcagtagcaaccttaaactattctttttctttagtctgttaaagctgctataaatataaaaccttgtcagaagttgtaactcagaaatttctctctataagtgatatgtattctaaagccttctgtttctatgggttatacatgaaagtcccttataacttttataaagggcaaatattctaaatgattggaactctttagggttgaggcctctgaaattgggtggagagagagaaggggttattgagggtttttttattttattttattttatttttgctagtttacttgctgcctctcataccttaatgtgattttcatatatatatatttttatatatatgtgtgtatatataaacatatatgtatgtgttttgaagtacagcttccttttcttttatatttattagaatagtgctttaataattagagaattgtattggcaacgtcttttatagaaatgtaatcatgtttattttaagaactgacaacttgttttttgctgtcttttagtgcaataagcagttttaaaggaaagctgtgtctgtttgatatctttaccacggatagtgggagaaacaggcacctccataattttaaaagggcaaagtaatacagccttaatttcagaaggaaagttttgtaatttttcaagtttaaagcatgtcttttaaaaatcataatgaaaatcaagaaagttaaatttcctaatgagtctgaccgtgattattagagatagagttgagctttgttttaagaaatgacagtgaatgggtcacctagctggctcagtcactagagcatgtgactcctgatatgggggttgtaagttcaagccccacactgcg

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