LOCUS       XM_021387141           13718 bp    mRNA    linear   VRT 07-JUN-2017
DEFINITION  PREDICTED: Numida meleagris argonaute 2, RISC catalytic component
            (AGO2), transcript variant X5, mRNA.
ACCESSION   XM_021387141
VERSION     XM_021387141.1
DBLINK      BioProject: PRJNA383663
KEYWORDS    RefSeq.
SOURCE      Numida meleagris (helmeted guineafowl)
  ORGANISM  Numida meleagris
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Numididae; Numida.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_034410.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Numida meleagris Annotation Release
                                           100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13718
                     /organism="Numida meleagris"
                     /mol_type="mRNA"
                     /isolate="19003"
                     /db_xref="taxon:8996"
                     /chromosome="2"
                     /sex="male"
                     /tissue_type="Blood"
                     /breed="g44 Domestic line"
     gene            1..13718
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 24 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:110393816"
     CDS             208..2322
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X5"
                     /protein_id="XP_021242816.1"
                     /db_xref="GeneID:110393816"
                     /translation="

MEEKTFIQQCHFPLEEIKYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQENGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGMMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKTFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYTGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    268..420
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    421..783
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(577..579,622..624,664..666,676..678,730..732,
                     751..753,757..759)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    916..2193
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1327..1329,1339..1341,1375..1386,1393..1395,
                     1417..1419,1426..1428,1438..1440,1450..1452)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1531..1533,1537..1539,1747..1749,2161..2163)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

ctcctcgcccagattttgggacttcggggagaacaatcaaactgcaggccaacttctttgaaatggacattcctaaaatagatatctaccattatgagttggatataaagccagaaaaatgtcctagaagagttaacagagaaatagtggagcatatggttcagcactttaaaacacagatttttggggatcgcaagccagtgtttgatggaagaaaaaacctttatacagcaatgccacttcccattggaagagataaaatatactcctgtggggcgatctttttttacagcatcagaagggtgctcaaatccattaggcggtggcagagaggtttggtttggattccatcaatcagtcagaccttccttatggaaaatgatgttaaatattgatgtatcagcaactgcattttacaaagcacagccagttattgagtttgtatgtgaagttttggatttcaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaataaaaggtctaaaggtggaaataacacactgtggacaaatgaaaagaaagtacagagtgtgcaacgtcaccagacgaccagcaagtcaccaaacattcccacttcagcaggagaatggacaaacagttgaatgcactgtagctcagtattttaaggacaggcacaaattagttctacgctatcctcaccttccatgtttacaagttggacaggagcagaaacacacgtaccttcctcttgaggtgtgcaacatagtggcaggacaaagatgcataaaaaaactcactgacaatcaaacttccactatgattcgagcaactgccaggtcagcgcctgaccgtcaggaagagatcagcaaattgatgcggagtgcgagttttaacactgacccttatgttcgtgaatttgggatgatggtcaaggatgaaatgacagatgtgactggtagagtcctgcagcctccctcaatcctctatggaggcaggaataaagcaatcgctacaccagttcaaggagtttgggacatgaggaataaacagtttcacactggaattgaaataaaggtttgggccattgcatgctttgctccccagcgccaatgcactgaagtgcatcttaagactttcacggagcaattgaggaagatttccagagatgcaggaatgccaatccaagggcagccgtgcttctgtaaatatgcccagggagctgacagcgtggagcccatgttcaggcatctcaagaacacttacaccggactgcagctcgtggtagtaattttaccaggaaaaacaccagtctatgcggaggtgaagcgcgttggtgacacggtgctggggatggctacacagtgtgttcagatgaaaaatgtgcagagaacaacacctcagactctgtctaacctctgtttgaaaataaacgtcaagttaggaggtgtaaataatattttactgccacagggaagaccaccagtattccaacagcctgtcatattccttggtgcggacgtaactcatcctccagctggagatggaaaaaaaccctccattgctgccgttgtaggaagcatggatgctcatcccaatcgctactgtgccaccgttcgggtccagcagcaccgccaagaaatcatccaagatttggctgccatggtcagggagctgctgattcagttctacaaatcaaccagatttaaaccaactcgtatcattttctacagagatggagtttccgaggggcagtttcaacaggttctccatcatgaattgctggctatcagagaagcatgtattaaactagagaaggattaccagcctggaattacatttatagttgtgcagaaaaggcatcacaccagactcttctgtacagataaaaacgaacgggttggaaaaagtgggaacattccagctggtaccacagtggacacaaaaatcacccatccgtcagagtttgacttctacctgtgtagtcacgctggtattcagggaacaagcagaccttcgcattaccacgtcctctgggatgacaatcgtttctcttcagatgagctgcagattcttacctaccagctgtgtcatacgtacgtacgctgtactcgatctgtttccatccctgcaccagcatattacgcgcacctggttgccttcagagccaggtatcatctggtggataaagaacacgacagtgctgaaggcagccacacttcgggtcagagtaatggcagagatcaccaagcacttgctaaagcagttcaagttcaccaggacacgttgcgcactatgtactttgcttgacatgttttaatgtttagcgactcagttcagtaccgagttggattcacatgagaccagctgcacttagaccaacagttgcccaagctccagtgacagccagcaatgagtgatgcatcttcatttttttttttccctttttgcaagaaagccttccgtccgggatttcagacttggttacgaactgcattcttatacaaagccccacgattgttggaagtgtagtttgccaaaatctctaagctgcctgttataaaacagacccatattttataattaaatcaagagctgtgatctcagggcttaggggaaaaacaaaacacaaaactcttcattgtttgctattcatttaattgcttttaataatttggagagatctaattcatactaaagttaatgggctaaaatgctattactacaaaggaactacaaaggaaagcaaagcattttttgactatttatgaagccttgattttgttctagatgcatttccaaaatttttattgtcagaagagtgacaaaattctgtttttcaactgtcttacaaagatttttctctgcgtgtctaagggcaaatgtattttctgaagcttgttcttgaatgttttttattgtgctgcatttaaaaatgtttttcatagactaaagaagaattttaaaacagaatgaatgaacttgtacctaaacttttaataggtccagttgggttggcagaagaaaaggtgccatttttaagaaaagaaaaaaaacttaaagattgtttttaaatcatactgacagctaacttcagaatttgtcatacaggactgtgacacttactctccaaagtctctaaggaatacgggtctgtggtgatgaatacagtacaatcctctttcactgttatgtttgaattaatgtaaatgttatatgtgtttcgcagtattaatgtgataggctagatgctattatttatttttatttactaaggagtgctcattatacttctgttaacatatcaagaaagctttggatttagaaattaaaaccttaccgtgaggatgttactattccaatgcaaaaatatgcaattgactttgatgcgagagttcagagctgcatgcagtgggtgtttgtagcctgtcctttggagaaaggcttcttgaggcgtacacgcagcgtagcaggttttacctgcgcagccaaaggcgcacacgagaccaacgttctgcattcattcaagcacaagcaattgtattttatttgtgttgatgattggtgaagcaggagctctcagagagggaggtggttcgatgttggtcgcgtagacagaagtcagagaatctatacagtgaaggtaaatcttaggaaactgaagtttacttacgaagggaggtgaagccttcttcattatgcataagagtaaacgtgagagttttgccattctcttaagagaagcattaatgaactgataattactagacaaacacttctgttcttttgcacactgggttaataaaaaaacataataacgtatgaaaaccattgcactaatgatgatgccacaagcaggtgtagaagaagaaaggaaaaaagcccaggaaatgtgtttatgctgacttgtttttgtttgttttcataggataactttaaaatccgccctctcaacatgtatttaaagatgtcattctcttccattttgctttgtcttttcccttttctcttagcagatgctcagtcactgttgtgagtccatatacctctagctgagacgggcagggagctttaaccaagacagaggtctgtgccgtgcagcagggagcctggagctggctgcttgttcagtaagctaggaagtgcagtaagagtcctaggtacatcacttagtgccaattccatatgtcacctcgtggcagtgtgttggtgttgtttaggtgaaataacgatgtcaatcctattagcagatgaattgtgtttgtattactctgatttgttggttagcctgccaggtcagaccttcgtctcatgatgtgaatctagcttttgagtgatgctggtataacagaaagcaagctccacgttgcgttgtctgtcttccgtttcccagcagccaggttgtgcatacctcccttaaacgtactgctgacctgcaaaagcttttccacagttgacacgttgcacttctctgtgtttgcttaatgcgtttcagattttggattttgattgggcagagttttatatatgaatttatttttatatgaattactcttaacgaatacaagaaagatcaatcattttaaaactccgtttattttatttgctgcttgttacgcggagacctcttggatgtgaatttaatcctccttttccctctctgtgcagttctggcataactggctttgtacagatggacaggtagggtgaggaggacagacaatctgtcttgaccccaaatctcattttggaagcaggttgcggggctccctgcagcctctgttggatgcattctttgggctggcatagtagttgtggactcttcatctgagagtagccgtcgtctgtgggtcctcttggaatgaatggagatctctgtgtagttttccttccctgagtatgaagaatttgggatggttacgtgcatttcaggctagggacgttgctgccttttgcagttttttggtcctctattactgccaattcta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