LOCUS       XM_021263314            6900 bp    mRNA    linear   ROD 23-MAY-2017
DEFINITION  PREDICTED: Heterocephalus glaber argonaute 1, RISC catalytic
            component (Ago1), transcript variant X3, mRNA.
ACCESSION   XM_021263314
VERSION     XM_021263314.1
DBLINK      BioProject: PRJNA197330
KEYWORDS    RefSeq.
SOURCE      Heterocephalus glaber (naked mole-rat)
  ORGANISM  Heterocephalus glaber
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Hystricomorpha; Bathyergidae; Heterocephalus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_004624764.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Heterocephalus glaber Annotation
                                           Release 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6900
                     /organism="Heterocephalus glaber"
                     /mol_type="mRNA"
                     /isolate="NMR 29"
                     /db_xref="taxon:10181"
                     /chromosome="Unknown"
                     /sex="female"
     gene            1..6900
                     /gene="Ago1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 3 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 11 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:101715713"
     CDS             194..2323
                     /gene="Ago1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X3"
                     /protein_id="XP_021118973.1"
                     /db_xref="GeneID:101715713"
                     /translation="

MPHRVGACARGTSSLPVPARYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    260..412
                     /gene="Ago1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    413..775
                     /gene="Ago1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(569..571,614..616,656..658,668..670,722..724,
                     743..745,749..751)
                     /gene="Ago1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    908..2194
                     /gene="Ago1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1328..1330,1340..1342,1376..1387,1394..1396,
                     1418..1420,1427..1429,1439..1441,1451..1453)
                     /gene="Ago1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1532..1534,1538..1540,1748..1750,2162..2164)
                     /gene="Ago1"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

gtgacaatccctggggaggggaaggatcgaatctttaaggtctctatcaagtggctagctattgtgagctggcgcatgctgcatgaggccctggtcagtggccagatccctgttcccctggagtctgtgcaagccctggatgtggccatgagacatctggcatccatgaggccagggctcctccgtgcccaggatgcctcacagggtgggggcctgtgcccgagggaccagttctctgcctgtccctgccaggtacacccctgtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcagccactgccttctacaaggcacagccagtgattgaattcatgtgtgaagtactggacatcaggaacatagatgagcagcccaagcctctcacagactcccagcgtgttcgctttaccaaggagatcaagggcctgaaggtggaagtgacccactgtggacagatgaagaggaaataccgcgtgtgtaatgttacccgccgccctgctagccatcagacgtttcccttacagctggagagtggacagactgtggagtgcacagtggcacaatatttcaaacagaaatataaccttcagctcaagtatccccaccttccctgcctgcaagttggccaggaacaaaagcatacctacctgcctctagaggtgtgtaatattgtagctgggcagcgctgcattaagaagctgactgacaaccagacttcaaccatgataaaggctacagctaggtcggctccagacagacaggaggagatcagtcgcctgatgaagaatgccagctacaacctagatccctacatccaagaatttggaatcaaagtgaaggatgacatgacggaggtgacagggcgagtgctgccggcgcccatcttgcagtacggcggccgggtgagcaggaaccgggccattgccacacccaaccaaggtgtctgggacatgcggggaaaacagttctacaatgggattgaaatcaaagtctgggccatcgcctgcttcgctccacaaaaacagtgtcgagaagaggtgctcaagaacttcacagaccagctgcgaaagatttccaaggatgcagggatgcccatccagggtcagccgtgtttctgcaaatatgcccagggagcagacagtgtggaacccatgtttcggcatctcaagaacacctactcagggctgcaactcattatcgtcatcctgccagggaagacgccagtatatgctgaagtgaaacgtgttggagatacacttttgggaatggcaacacagtgtgtgcaggtgaagaatgtggtgaagacctcgcctcagactctgtccaacctctgtctcaagatcaatgtcaaacttggtggcattaacaacatcctagtcccacaccagcgctctgctgtctttcaacagccagtgatattcctgggagcagatgttacacatcccccagcaggggatgggaaaaaaccttctatcacagcagtagtaggcagtatggatgcccaccccagccgatattgtgccactgtgcgagtgcagcgaccacggcaggagatcattgaagacttgtcctacatggtgcgtgagctactcatccagttctacaaatctacccgcttcaagcctacccgcatcatcttttatcgagatggggtccctgaaggccagctgccccagatcctccactatgagctgctggccattcgtgatgcctgcatcaaactggaaaaggactaccagcctgggatcacttatattgtggtgcagaaacgccatcacacccgccttttttgtgctgacaagaacgagcgaattgggaagagtggtaacatcccagctggaaccactgtggacaccaacatcacccacccttttgagtttgacttctatctgtgcagccacgcaggcattcagggcaccagccgaccatcccattattatgttctttgggatgacaaccgtttcacagcggatgagctccagatcttgacataccagctgtgccacacttatgtacgatgcacacgttccgtctctatcccagcaccagcctactatgcccgcctggtggctttccgggcacgataccacctggtggacaaggagcatgacagtggagaagggagccacatatcggggcagagcaatgggcgggacccccaggccctggccaaagctgtgcaggtccaccaggacactcttcgcaccatgtacttcgcttgaaggcagaacgctgttacctcactggatagaagaaagctttccaagccccaggagctgtgctgcccaaatccagaggaagcaaggaggagggaggtggggtaggcaggagtacaggaggccttgtttctttctatagcgggggtataaaggtggggaacagggtcagcaagacagaccaccagccagaaatctctgatgtcaacctcatgcccccacccttcaccccatcttgtcacatctggccctgactccactggaccaagaggggtagcgctgatgcccaccatatacacaggtgtctcatgtgactctcagtgctaaaactcacgcttgacagcttggtaaggttggctctgcagccctgcagacaaatgctggtaggtttgggtttgatattttagatgggaaagtgaggggcttgagaaactgggtgggatgagggaaggattttttaggagccttaatcagaaaaggtctagatttgtttaagaagaaaaatgaaaccagacccagatcaatattttaggatactagatgttttcatgggttcagaatccagtttgtaggaaaatttttaatgctaatggttttggttgctcctcccccagctcctcccaccccattccactctcccacattttctaccccttaaacttcctccctgacagacatccagccccgctagtaacacttaaggcactatggcacttagctctgaagtgacacgaccctgtcttccttccgcctgctggtgggtaaccagtgccttccctgtaatggtaatgctgcagaactgcaaccttttgtacctttctttgggggtaggggtgggggtgggagaggaggtaggtggggaagaaatatcccaaacccaatgagcctccagccagaatgccagctattttgcatttgaaggaattgacttccacattctttgagcttttaaaaagacccgcaacctcaagatggttaaaatccattgacatttgcactttcagacatgacaagtctctgagctgctgagatgactggcccctggcttttccacttttgcctcctttttaccctgtccccatgcctcccaccttatcgggtctggagttactttcatagcatttctcagttttggcggcttttttccccctgattctcaagtcttgtgtttcagttatttctcaaccagggtgtcttataacagaagatccttagatctaaaataagaaaaaaaaatcctaaatgttatttttataccataacttgagtctattgccaaaatctggaaatccctcccatgcctgatgagtttacatcctggaaacattgagccatctgaaggaactatgtacctgacttgttctctggcctggctaggaaaggggtgggtatgtccccaagttggggctcaggctctgttcttcctctgtgcagataatacctttttcttgctgcaggctccttcctctgcactgtcctgcactccttcctgcaagtgcaccttccctttccctggactggactgttctttgacctctgactcatcccatattctagcgtgtcctgtgggcaggctggggaattttgctgctcctggttgcttctgtttacacaaatgaaatttttcctggttcccactagggcatgtgagtgggtggcatgggttttgtttgtttttcttttttttccccttaagatatggtgtttggctgtcttgcaggatagagaaggaaggggcttctaacttgatacttgtgggccttgactcaagccccactccttccttgactgttcctccttactacttggtggggagtttcaacttcagtgtggaaattcctctttttgaggagcatgggcttgggtttgtcccactctggtaatgaagccatgatactttagacctagcccgagcctggaggccagctggaaggagtgtctgaatcctgccctgtggaggtacagctaccctttcctctccccagcagcccttgtaaagacccagatttgctatgcaaaacaatctatcccaggttttgttctggttggctatattggtcagcaatttcagaaagtagcacaaacattcattttggagaaagcaacaggactattgagtaattcctcctctgctttttttccctgctggtataacttgaggtgccccttgggcacaagcccagctgaagaatagaatggagggccctgggaggaggcagctcactggagagcctacattccttacacaagtgcctaaagagagtgatgccaacactccatctgccctgtccatcgccttcatatagtctacttcatgttccgttacccttcggggagggagctctctaggacaatgggctctgcatgttctcttcttgggtacattttggggctgggataaggatactattcctggagggtccagtcattcaccagcatttgcaaatgtccaaagggagcaggtggcagtcactactcccagcaacgagtttgtgttctctccttttctctctttgcctcactctctccagttggatttcaggctggggcttgaaaggcattttagttctttgacattatatgtgccattcagtcagtaaaagcaagagaagtagcttgggcaatgataagaaaactaacttcttgctctgatttacacaaaaaaagtctctaagacttgaaaattccccgaccatgttggctattcttgtttgaaaggtggtacatgcacattgaaaaatgttttaagatttggtttaagtggtgcttcttactgaactatgaggaggcactgggaggaccccagctttatccttttaggtctcttgttccctttgtcccactgtttctgcctgtcttttcctcttctctctttccctgccttacttttcctttattctgttcactgagcctgcttactggctggcctgcctccctgtctgcctacatgatgatgaattctctgcatggctgcagtgaaccaacttgccactgttagttgtcaaggtcaggcttaaccccttgaatgcagaagaccatgaacctgttctgcataccagtggtgttaaccctggggtatattgtagaaaagcttacgctagagcattgcagcaggctctgcccaactagcatgaaattgagagggcttctggcagtttctacacctatccattccttggagctggtttctctcattgctttttcttctgctgcttctttttctctccacctggggcttctttttactgagggtgttctagggttgagctacttcggtattcagggttagaggtttagaagatggatatagaggaagatgagtgaaaagaagagaagagagagtttggatagaagatgagaaagcagaagagtattctagttatccagcccagagtgacctattggttgaggtgctatgctgactctgaggataagcctggggctgttgttgctgagaacttaggcctttaataaggctgaagaaaaaggtacctaaaagtgtgaaacctccctaaaaagttccgctttcccacctgctacataggtcctctgtagcttctttgaccgagcaacaacatcttttggatagtttactttttctgtccagaattttgtaaatgaggccagtacacatgataggcagccaaggagatagttttcctagctggcccatgcaatatcttcaaggctagtaggacggtgttttttagaccaggcatcatatgtaaaaaaggatagaagttccttccctttcagggtagaaaagtcatctcaaactagccaaaaggcagttttagaaattacatcggggaaggttatttttatttatttactgtgcttaggccagtgcaggatactagctgggatgctttccttctcaaagtctgatcatggcaggaatatgcaggcactctttcttatttggccttctaagcagactggagaggagggattctcagttttctctttcccctatttactaggacttgccttctcccttagccaggagagaggctgggttggtgctctccccttactccactcctactgacttggaacctctggctgctgtttgggagcccaaaaaagggagtggaagtagtgggctcaaaacagaatgatgtgggaaatacagatgtccttctttaaaaaggaaataggaaactccaagaattgtgtaagtaaagacagtgtgtccaaatgcactgagttccctggtgcagtagcaataaggaaaaatgaaatgactttcctgtgcacacagtctgacctaatggtgtgtcatattgcacttagcagccatgtggtgggcatgtgtgatactctggttttcactttagtttctaaactttttatccctcttcaagtccagcatggatggggaaatatccctggagccccacagctgtgtacttgtttgcatttgtttccattcgtgtttttgtcctgctttgagctgtaccttgtccagtccattgtgaaattatcccagcagctgtaatgtacagttccttctgaagcaagcaacagcagcagcacaattctgtgttttataaagacaacagtggcttctatttctaaaa

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