LOCUS       XM_008517510            5229 bp    mRNA    linear   MAM 26-DEC-2024
DEFINITION  PREDICTED: Equus przewalskii argonaute RISC catalytic component 3
            (AGO3), transcript variant X6, mRNA.
ACCESSION   XM_008517510
VERSION     XM_008517510.2
DBLINK      BioProject: PRJNA1202102
KEYWORDS    RefSeq.
SOURCE      Equus przewalskii (Przewalski's horse)
  ORGANISM  Equus przewalskii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091832) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 26, 2024 this sequence version replaced XM_008517510.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_037783145.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5229
                     /organism="Equus przewalskii"
                     /mol_type="mRNA"
                     /isolate="Varuska"
                     /db_xref="taxon:9798"
                     /chromosome="2"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Minnesota"
                     /collection_date="2023-08-07"
     gene            1..5229
                     /gene="AGO3"
                     /note="argonaute RISC catalytic component 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 202 long SRA reads, 1 Protein"
                     /db_xref="GeneID:103549261"
     CDS             138..2018
                     /gene="AGO3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X3"
                     /protein_id="XP_008515732.1"
                     /db_xref="GeneID:103549261"
                     /translation="

MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    138..479
                     /gene="AGO3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(273..275,318..320,360..362,372..374,426..428,
                     447..449,453..455)
                     /gene="AGO3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    612..1889
                     /gene="AGO3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1023..1025,1035..1037,1071..1082,1089..1091,
                     1113..1115,1122..1124,1134..1136,1146..1148)
                     /gene="AGO3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1227..1229,1233..1235,1443..1445,1857..1859)
                     /gene="AGO3"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      5229
                     /gene="AGO3"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

aaagagacctctggcagcagtgtggagaatagatagaggagaaaaaactaatctgagaagccagttaggaggctttttcaatcactagttcagtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaagttcaccaaagagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaagaaggcctgccagtcatcaaacctttcctttacagttagaaaatggccaaactgtggagagaacagtagcacagtatttcagagaaaaatatactcttcagctgaagtacccgcaccttccctgtctgcaagtgggacaggagcagaaacatacctatctgccactagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacggacaatcagacttctactatgatcaaagcaacagcaagatctgcgccagatagacaagaggaaattagcagactggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaggttcgagatgaaatggcccatgtaactggacgagtacttccagcacctatgctccaatatggaggacggaatcggacagtagcaacgccaagccacggagtctgggacatgcgagggaaacagttccacacaggagttgaaatcaaaatgtgggctatagcttgttttgccacacagaggcagtgcagagaagaaatattgaagggttttacggaccagctgcgtaagatttctaaagatgcagggatgcccattcagggccagccttgcttctgcaaatatgcgcagggggcagacagcgtggagcccatgttccggcatctcaagaacacctactctgggctccagcttattatcgtcatcttgccggggaagacaccagtgtatgcggaggtgaaacgtgtaggagatacacttttgggtatggctacacagtgtgttcaagtcaagaatgtcataaaaacatcccctcagactctctcaaacctgtgcctaaagataaatgttaaactcggagggataaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagcagatgtcactcatccaccagctggtgatgggaagaagccttctattgctgctgttgtaggtagtatggatgcccacccaagcagatactgtgctacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgagaacttctcattcagttttataagtcaactcggttcaaacctactcgtatcatcttttatcgggatggtgtttcagagggacagtttaggcaggtattatattatgaactactagccattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctatattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaacgggtcggaagaagtggcaatatcccagctggaacaacagttgataccgatattacacatccgtatgagtttgacttttacctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctgctgacttaccagctctgccacacttatgtgcgctgtacacgatctgtttctatacctgcaccagcgtattacgctcacctggtggcatttagagccagatatcatctcgtggacaaagaacatgacagtgctgaaggaagccacgtttcaggacagagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaaaaagtccaagaatgttctctgagaggaagaaccgaaagatgaatcgacatacaacgtatgtttccagtggagtcagttgagtggtgatgcctccaaccatacagaaaccaacactgtttgggggccagggtctgatctttatgttgatgcaaggaagattgtttacttcatcaaggaacacagcaccattatgcaatatgaaaccagccaactgcttttttgtgcggtctcctgtaggaagtatcgcagttgttttgttttcactttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaagtaaagaaaaagaaaatgatggttttaaaaaaaaaacacacacctacatgaataatcaaagtgattgttcacaattatgtgtgcaaaaaaaataacgtgcattcatgtattcttgtaaaaggtatctatgtatattttaaatatatacatgcatacttcatatgcatatatatctggatctacattgataatagatatatatgtgtctatgtatatattttatagttcattccattggggaactttctttccctcttattcccccatcacgacttttctttctttctcgacctgccttgccttcaccacctacattttttttcctaatgctatcagtgacattcagatgttcctgtatctggttcctttgaatatgaagcatggcaaactagattttaatttttattttgcacaccctactcctgtctcttgtctcatacacaattctgaatcctcaactcttgatagtgctttcttaaaaaacagaattattttatatatatatatttgtttttgtgagagtgtgtgtctgccccctcctgctctgaacttacatttgccatttgtgcaatgtgtacataagcagtagcaacctaaactattctttttctttagtgagtttgttaaagctgctataaatataaaaccttgtcagaagttgtaactctttctctctataagtgatatgtattctaaagccttctgtttctatgggttatacatggaaatcccttaaagcttttataaagggtaaatattttaaatgattggaagtctgtagggttgtggcctctgaaattggatggaggggcgggggttgttgaggtttttaaaattttttgtttgctagtttacttgctgcctctcataccttaatgtgattttcatatatatatatttttatatatatgtgtgtgtatatataaacatatatgtatgtgttttaaagtatagcttccttttcttttatatttattagaatagtgctttaataattatagaaccatattggccacatcttttatagaaatataatcatgtttattttaagaactgacaacttctttttgctatcttttagtgcaataagcagttttaaaggaaagctgtgtctgacatctttaccacagaaagtgggagaaacaggcacctccataattttaaaagggcaaagtaatacagccttaatttcagaaggaaagttttgtaattttcaagtttaaagcatgtcttttaaaaatcataatgaaaatgaaggaagttaaatttcctaaatgagtctgaccttaaatattagaaataaagttgaattttgatttaagcaggacagtgaatagcttaagatttagaagatatttaaattctttgaaaatagatcatgtttattgaagaatcatactggttaggtgcccattttcatttactaaaatgaatcaggaaaattaaaatgatattttaaaaacatttttgctaacatcatcatcgtaactttccttttaaaattagggttatggtgacaaaggaagttaggactttgataattttaaatgagttaaatcactgaaatgtggaaaaaagttttgcaaaacttttgttttactgacttcacgttaagatattaaaaagtactataaagctgtcaagaccgagttcatcagtaacattggattcaggggagctttgcactttgtaactcatgaaaattgcattttaattttttggtttttgcactggttcagagtatagatgttaaagattgtttccagtgggcattgttcttaacctttcagtattccatctgcacatgaaaatgaatggattagctctttagtttctctcttacctataatccactcttattgccaatttactgtattttgagcctaaaatctgagcccatgtcctccaataggtatgaaatcttttgtcctctgccagaaaactaggaaagtactgtattttgtacgtttattatattgaagtgtctgaaatgcaatttacaacactgtttcaaagctctttacatgagataatatttgtacagtatatacattttttctcccaaccctgcccctaaaaaagattcctagtaagcatggttctggttggttggttgttttttaacattgaaatttcactgaatatagtcaggaacaacggcaagagaagaaagtagtatatcctagatggtagaaacttgattgctctgtgcttgctcagtatgagcaaaacatcttcctttaacggtgagagttgcagtttcatgtgggaaactttagggcccagggaagcactgtagataccctttccctatttactgttttacctaattttcagttacttagtttcacatgtgctatagtgaagccaatttggaaggaaatacagagggttttttaaatataaagctttacctttgaagtgaattcttttggggggtttctttcttagactttcaacagtgctagtttaaggttaagtttgaggtttcagcatacttgaaagagtatgtatagtgtatttctgttttgcttactaataaattggtatatcaaacctaattacaagaaatcttgtgcttagaattttaacatagaagtctaagtggcaaatactttttgaaatttgttttaattattactatacttctggtgtcgaattccgatcttttttattttttttaaaaaaaggttgttttgaatttaatggtcatgaaacacaatagtgacctttctgtgaagagttgggagttttaatgtatattctggatggcaaatgtgtctgtgtaaagtgcggatacatgttattatcttagagtatcaagttactggcattgaggaccatacatttataatactgtagctgctatatttat

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