LOCUS       XM_006212692           11036 bp    mRNA    linear   MAM 22-NOV-2019
DEFINITION  PREDICTED: Vicugna pacos argonaute RISC component 4 (AGO4),
            transcript variant X1, mRNA.
ACCESSION   XM_006212692
VERSION     XM_006212692.3
DBLINK      BioProject: PRJNA221631
KEYWORDS    RefSeq.
SOURCE      Vicugna pacos (alpaca)
  ORGANISM  Vicugna pacos
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda;
            Camelidae; Vicugna.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_021964181.1) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Nov 22, 2019 this sequence version replaced XM_006212692.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Vicugna pacos Annotation Release 102
            Annotation Version          :: 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.2
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11036
                     /organism="Vicugna pacos"
                     /mol_type="mRNA"
                     /isolate="Carlotta (AHFN-0088)"
                     /db_xref="taxon:30538"
                     /chromosome="13"
                     /map="unlocalized"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..11036
                     /gene="AGO4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 7 mRNAs, 53 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 34 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:102542337"
     CDS             4703..7321
                     /gene="AGO4"
                     /codon_start=1
                     /product="protein argonaute-4 isoform X1"
                     /protein_id="XP_006212754.2"
                     /db_xref="GeneID:102542337"
                     /translation="

MLSFTTKEHIKCLSISSGPPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"

     misc_feature    4811..5200
                     /gene="AGO4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    5231..5383
                     /gene="AGO4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    5384..5746
                     /gene="AGO4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(5540..5542,5585..5587,5627..5629,5639..5641,
                     5693..5695,5714..5716,5720..5722)
                     /gene="AGO4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    5885..7192
                     /gene="AGO4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(6296..6298,6308..6310,6344..6355,6362..6364,
                     6386..6388,6395..6397,6407..6409,6419..6421)
                     /gene="AGO4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(6500..6502,6506..6508,6746..6748,7160..7162)
                     /gene="AGO4"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

cctgaagtcttggagaatatggccctatgcctctgttttttgtcagtctgtgcgacagacccagagtagtctggtaactcgccttagtgacaggcgagttaccagccagcgcgctccagcacaggctttaatgccccgagtgtcttctaattgggttatgggtagttgtgaggatcaaatgaaggagaaagtgctttagaaactgtaagtccccatcgttatgagtggcctctggttatctccctgactgcccaaatcgaaggaaccattccaggttgtaatagatgccctgaagattggaggctggtgcttctacctggaactccaacaagtttctgatgtcttggctaagcagggtagggtttaggggctgtgatagaattaacttattaaaccttatctacagtggacttagttgtagagcatttcatttttttaacgcatagaaaattcagactaccatttgagtttggaaaaactttgcagatttacttaacacttgtttacatagctgaatgattaaaccacaccttaatttgcctcttggagtatttcttaaaggccttcataatcaaatttcatatgcctttaaaaaataaattggttttgccccattaatattatttgataaacctcagtgtgagtgttacactgggttactgcagctatgtccccaggctaaaggcatgatcaggtttttaggaatgtaacagacttctgttcaaatccagtctagtaatttaatagttgtacaaccgtgggcaaattgcttgttcctttagactttcattccctcatttataaaatgagggtaataataattatgtgctgcaagtttgttgtgagaatgaaatgagataatctatgtgagaaaacttgtagagaataatgtgttatagatactcaacaaatatttcttccctctctcccctgttaataactcataattgaatcaactgttgcttttatgagctgataatgaaaggactatgtaagtgtgtatacaaactaaatttcatggaaaagatcaatctggtggtgttaggaacatcccggagactctttttatttttggtttgattttagcttttgcaggtttgagggcttatcagttcacctaggattgtggaaaattaattctcatttataagacactagtgagtaaaccaaaatgtcacatagatattttttgttgactgtaatattttcttgtctgctgtctagcaaactccttttttggtgtcacagtaccttggaaacccaattaataacaagaagctgcttgctgagcatggaatcagagcaaagggagttggtaatcttgtgggttatttcatccaggctgtttaagaatccagagaagctttcctgcttctttgttaaagctcatggatgcagtgccagtgccctccctctctggaacaatcactgaagcatgcttagtcttgctctgctctccctcgtccaatttcaatttctgacaacaataacttggaaatagatttaattagattaccatttattttgcttgcattaatgataacttttatttttatactgctttaccgtttggaaagtgccttcacagctgttagctcatttgatcctctgtgagataggcaaggcaggtattatccccatcttacagatgagaaaagaggttcagagagcttcagtgactttaccaaggtctcaaggctgagtgatgaaatgaggatgagtctcagtcctctgactcctagtctaatgccctcctcttctttttagctggcttcatctggtttatgttgggttatatttgttacctttttgaaagatgtagttctctgacttggtcaccaaattttggagatgctcccaatataaagacctttgagcactggctataacatttatgcaagtgcagtcataatagctaacagtgaccatgtgcttactattctgaggcactgtgctaagccttttgtatacaccatctcatgggatcctcacagtagccttaggagatagttgctgtttttaccacatctccattttagatgaggccactgaggcacagagaggctaagaaactggccctaggtcatgcagttagggagtggtaaaaccaggattgaaacccaggtggtttgcttccagagccttagtcactgtgcttgtttcttcataaatatttttgataattcaaataaaccagcttttggaaaagaatatagaatatagtttttagaatgtagttttctaaataaatcttctaaacttatgaaaagaaatgatcactcaccttctaacttttctctcttgccagggaaaagaaacacactatttacttttctctgcttcttaatctcttttctttcattttctctgcctctgtctctttgacataaaatacttcagagaggtatagatgccataggattgtgaagaatattggggggaaaaaagcactggactggaaattaggagacctagattctagtcatgatttaaaatcaaagttgtgtatccttgggcaagtcacttgatccagatttctgtttctaaatgtataccataaagttggatttgtgattcaatgattacttaagtgtatcttggaatatgcaggactgacttatctatatgatttaattgggttagttcagcatgcctgtccacctccgatactatttattacttaccttttactttgtttataaacaccttatcacaccagagtagatcttgtccaccagaagaggaactcaaccccaagctataataatatttttattatgaattgtgtccttttgctttaatgaaaaataattgtcaattcttttgttttagaaatgactaggcttctgtttggtttctgtctgaaactgctactcagattgttggtgctgttcagttcaacatttgttgaattcctacaatgtgctcgccattgaattaggtattgagaaggcaacaatgaactagaagtcaatttcttctaagagtttacagtctagtcgaggagataatagtttaacaagttgtttctacgtacttgtgcaagtgctcccttatacagagggtcttggaaacacagaggattcattgtccagtttgggagactgtgggaagtctttctgaggaggtcacacttgacgtgagttttggaggatgagtataatttaagggaagaatgaacaatgaatttaatacgtgaaaagattttcagtactttaagaattagtatgtggtgatctgtcaacacaaatttcattgaagtatttgctttgattttcctgtgatgttggaccagaacagcttcttgctttgaagttttctctccttagtgaattatctttgttcttggtgaaatacaattgcaacaagagaatgtgttgtaactttcctttgcaatcacagctcactttactccacacctattcatagcagaaaagatgtttattttttaggccagtgtccatttgacattatcatcaaaaaggagtaagattttctgtagacagatgtttaccagactgtgtttccctaaatccttatctactgaaaattgatagatgttgattttacaaacagagagagttagtgtgtgtgcgtgtgtgtgtgtgtgcatgcacgtgtgtctgtgttctggagaaaaataagttgggtaaatgatgagttaaacaggttatttattacatgacttattagagaatttaatatgataatatatattggaattttaagaagaggagagaataggcagtttctttagcttatgggatcctttctttttacagaatatcttgtgagccatcagtggaatgatttggaatgactgctctgtctagaccaaggtttctcagcctcagtgctgtttgatactttgggctgaatgcctctttgttgggggtggctgtcctgtgcattgttggatgtttagctgtatccctggcccctacccattacatgtcagtatcacctccccctgcaagttgtcacaaacaaaaaggtctccagaagcttgcaaatgtttactggggagcaaaaactcccccaggttgagaaccactggtctccactgtaagttccttgaaggcagagggggctctttttcctgagtccacagtacaggttagacatgtaataaatgagtaaatgtctgttgaagaaataaactggactttatgatcaagaaatatcagattgtccaaatttttaaaatatcaggttatagacaagaaagtctagcattattggtgttgtttcactacttaaattagcaattaaattgataaatatagctgctgtttaatctcctacagtctgtgcaaactataataaagtagattaatttgtggaggattaatggatcatctccagccttaacaggtgatggcccccagagtttagaaatggtactaagatggtactattaaaatgcacataattttataagcctagctatggatctactgatgctgataaaagattttgtacagtagactgcctctgagatacagtatacctcatcatactatatctaatgttgatgtcctccatattcaaaacaatagcaacatggcaaaatatttagaaatctagagaaccttaggtcaaaagacattccaaactctttatatcagattatgttcagtgaataataagatctcagtgattgtagctgttaccagcccatcatcatcatgatctgaagggaatgttatccttcacaaccaaagagcacatcaaatgtctttcaatctcttcagggcctccagccagcctgtttcagccacctcgtcgtcctggccttggaactgttggaaaaccaattcgactgttagccaatcattttcaggttcagattcctaaaatagatgtgtatcattatgatgtcgacattaaaccagaaaaacggcctcgtagagtcaacagggaggtagtggatacaatggtgcggcacttcaagatgcaaatatttggtgaccggcagcctggctatgatggcaaaagaaacatgtacacagcacatccactgccaattggacgggatagggttgatatggaagtgacccttccaggtgagggtaaagaccaaacctttaaagtgtctgttcagtgggtgtcagttgtgagccttcagttacttttagaagctttggccgggcacttgaatgaagtcccagatgactcagtacaagcacttgatgttatcacaagacaccttccctccatgaggtacactccggtggggcgctcctttttctcacctccagagggttactaccaccctctgggagggggcagggaggtttggtttggctttcatcagtctgtgagacctgccatgtggaatatgatgctcaatattgacgtatctgcaactgctttctatcgggctcagcctatcattgagttcatgtgtgaggttttagacattcagaacatcaatgaacagaccaaacctctaacagactcccagcgtgtcaagtttaccaaagaaatcagaggtcttaaagttgaagtaacccactgtggacagatgaaacgaaaatatcgagtttgtaatgtgactagacggccagccagtcatcaaacttttcccttacagctagaaaatggccaagctatggaatgtacagtagctcaatattttaagcaaaagtatagtctgcagctgaaatatccccatcttccctgtctccaagtgggacaagaacaaaagcatacatacttgccacttgaggtctgtaatatagtggcaggacagcgatgtataaagaagctcacagacaatcagacttctacgatgatcaaagccacagcaagatctgctcctgacagacaggaagaaatcagtagactggtgaagagtaacagcatggtgggtggacctgatccataccttaaagaatttggtattgttgtccacaatgaaatgacagagctcacaggcagggtacttccagcaccaatgctgcagtatggaggccggaataaaacggtagccacacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaattaaagtttgggcagttgcttgttttgcgcctcagaaacaatgtagggaagatttactaaagagtttcactgaccagctccgtaaaatttctaaggatgctggaatgcctatccagggtcagccatgtttttgcaagtacgcgcaaggtgcagacagcgtggagcctatgtttaagcacctgaaaatgacctatgtgggcctacagctaatagtggttatcttgcctgggaagacaccagtatatgcggaggtgaaacgtgttggagatactctcctgggtatggctacacagtgtgtccaggtaaaaaatgtagtgaagacctcacctcaaaccctttccaacctttgcctgaagataaatgcaaagcttggaggaattaacaacgtgctcgtacctcatcaaaggccctcggtgttccagcagcccgtcatcttcctgggagcagatgtcacgcaccccccagcaggggatgggaagaagccttccatcgcagcagtggttggcagtatggacggccatcccagccggtactgtgccaccgttcgggtgcagacctcccgccaggagatctctcaggagctcctctatagtcaggaggtaatccaggacctcactaacatggttcgagagctgctgatccagttctacaaatccacacgcttcaaacccactcggatcatctattaccgtggaggggtatccgagggacagatgaaacaggtagcttggccagaactaatagcaattcgaaaggcatgtattagcttggaagaagattaccggccaggaataacctatattgtggtgcagaaaagacatcacacacgactcttctgtgcagataaaacagaaagggtgggtaaaagtggcaatgtaccagcaggcactaccgtggatagcaccattacacatccatctgagtttgacttttacctctgtagtcatgcaggaattcagggaaccagccgtccttcacattaccaggtcttgtgggatgacaattgcttcactgcagatgagctccagctactaacttaccagctgtgtcacacctatgtgcggtgcacgcgctcagtctctattccagcccctgcctattatgcccggcttgtagcattcagggcaaggtatcatctggtggataaagatcatgacagtgcggaaggcagtcacgtgtcaggacagagcaatggccgagatcctcaggccttggctaaagctgtgcagatccaccatgatacccagcacacaatgtattttgcctgagagtctcagaaaaaaaactcaaccaatttgacaccccatgcagcctcaaaatatttcaaatgcctactgcctctagagagccaagttgacttcagatggtcttctaccagcaacacgaaatagttgcactgaatctatactttgcagtgctgtctgatgcatcaacaaaattgagccatttttttaaaagtaataggtactcatagattgtcttttctgatgcactggactgaatttttacctcatcatgtaaaggctgatcagcctgaactttctaaaggactttacaagaaaggtttctatggaatattttgctagctgtggtgttcaccgcatccctctagtcttacaagagaaggttatttctttttttctgtattcatcgagtggggtgtgtgcataaatgggagagaaaaaccaaacaatctacttcagttcagtgtaactatttaattgtgtgggtccatagagtttttaatggagatttctgactttgccactgtaaatgcctttaacgagcattaatttttgaaagttttacagagttttattagttttattactttatctttttatctctacagacttgtgttggtgcaagtacaggctgccaggcaattgcactaaatttggctgcagattcagacaggcagttatcttatttggttgacttttgtgaatgtgtaacacaaaccgatgtaatgcatgtcacggtgacagataacactgccatggtaaaagtactcatgtttcccccacttagaaaaaaaattagcttttagtatttttcaaagttttcaaaagtgcccattttatgctgctgtgtggtttgttagagctaaatgatttttaaacttttctcatagaaagttaactttggcaataaacattttttaaggtccctcctcttcctccccctgacaatgtagttttttagatgagatttcggtatgatttttatcagctatttcttatagatcataatctggcaatttctgaaaccgatcagaaaaaacatatatttccttctttttaaagaattatttttatctgttttatagtcacagttggtgtcctgtcacttcgttttaaaataagctagaaccaggatgcttccttattggataggcttttgtcaatcctcaaggtacattgagtgatgctgcaacttgcaaaaaatgtaccagcatttaaaacctttttccctgggaatcaaggttactcacacaactacttgcagtgcaaattttctgtttctctttcaacctgaaatatatttggtggagtttccttccttttattaaacaaaaactgcatagaaaaggttgatttttcttaatagattctggattcagttcacagggagatgggattcctttcttgtccaaacaaaaagagttgatctaaagcaagcatcagttaaaatgtaggggtaatgtattttgtatttagtgtagataacactttgtgaatggacaacagttacatagagtcttgatagttccagccagtgtttcccagcccaaattttagtgacttgtaattctttgtcttggaacatcaggagtgaaagctggagaggaggataaaaggcccagagccactctatatgactgaggaaggtgctgggggaagagatagatgctacatggtaaaacgattttgccacctctgtctgcaaactgctggtgggggaaacactggatctaacggtgaaggatgtttgcttgaactcattagctggtccaaatctcttaaactagccttctcaaaatcccagcaatataaagcactgtttctcttcagtcttttaaacaagcttgtaaatacattaaagtttacatttctatgtgctgttgatcagcagctccaccagtgtttgctgagactggtctctgagagttttataatgtatatcaagtcctaaagctcattaagataggagtgcagacatccttgttctctgcatagagtgggatgaaagcaagcgctgtaactgaggcacagcataggcaggagtgcagaagatggcaggtgttaatttcttaagattttccttttttgcaaatacctcacttggatactacaaatcaggacatgttggtgagggggctggctgctgctttttattcacacttgttcagggagagcacagaaaatacccttcagcttggccaccgtggacccaagaggaggaagaacagaagctttttttagaagaactggctggagtccaggatgtgaggaactcttggaggctggctggctggccagtgggcaccacacctgcacttgtgtgcctcggacttgcttgataataatgcacagaagaagcatcacttctcaccatctcctggcatgtattggagcagggagcgaggcagagtgccaggaagccctgacttgctttcctgcaattgggctatacgctcgaccttgaactatagtttatatgaaactcagtcagtcctagtacactgtgggcaaatcagtgtggcagaggaggaaaagccaggaggcctattttataggaaaacagtacctttaagggtgcaatgctgtcgttttggacaaacggaaagaaatatggaagaactagagttgttgggaaaaacttgctgaggggtgaatttttaagagggaatcactgcagaaacagagttgcagcaatactattgcaagcaagtctgaatgcatggttttaattcagcttgacaatttgaatactttaacctcttgggactgactgaatcattatgcatgtgtcaatcaatgggaggtgtgcattctctagaagtaggtttaggctgtttgttttttttaaatgcagtctgtttaggcactgtcatgtggtatgaaagatttaaatgtagcaatgctaaagagtaacaatttggggctaaggggcaggggacattaaaagagtggtgaagatccaaatgttgaatcaggtatgttttgttgttgttgttagctgtaacatgaactagctggcctaaaacagccagcagtctgggcaggcagaacacaatcattcttactgtaaattctatttgctgcttccaaaggtgatgatttacaagcagacatattctatatggtctgtattttaggatctggtgcccagcctatatcagagcttacctacctggctcagctacctactcttcctgtgggaaaaggtaatgcactgtttaacaaggctcaccctctctgctctgccctagctaccctttgtggatgtgctgtaagattttcttgctcaatagcaaggcagtagctctgctttcattttaagaaagtggaggctgagggcattgtatcaatactgcatcaactccaaggatttttccttgtaaaattaaagggaagatcttgttattgattaaccattttcttatcccttgctattgacatattcatactctttctatgtctagtggctgaaaaatgtttgcatttgttcatttgactgatggtgtcatttttgtttctatattgttaggcctgtaatgttttaatatgtattttattaaatttggactgaatgtctctagcaatacgaggtactttctaaactattgagggatgggtggtatccccctgttgagataagatgatggttgtttcaattttgcaattttttttggcctgcagggatattttgtgttcatgtgtccaaaaaagaataaattggcattcttgtgccaaacgt

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