LOCUS       XM_004850945            9403 bp    mRNA    linear   ROD 23-MAY-2017
DEFINITION  PREDICTED: Heterocephalus glaber argonaute 3, RISC catalytic
            component (Ago3), transcript variant X5, mRNA.
ACCESSION   XM_004850945
VERSION     XM_004850945.2
DBLINK      BioProject: PRJNA197330
KEYWORDS    RefSeq.
SOURCE      Heterocephalus glaber (naked mole-rat)
  ORGANISM  Heterocephalus glaber
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Hystricomorpha; Bathyergidae; Heterocephalus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_004624764.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 23, 2017 this sequence version replaced XM_004850945.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Heterocephalus glaber Annotation
                                           Release 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9403
                     /organism="Heterocephalus glaber"
                     /mol_type="mRNA"
                     /isolate="NMR 29"
                     /db_xref="taxon:10181"
                     /chromosome="Unknown"
                     /sex="female"
     gene            1..9403
                     /gene="Ago3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 3 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 1 sample with support for all annotated introns"
                     /db_xref="GeneID:101716266"
     CDS             204..2309
                     /gene="Ago3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X4"
                     /protein_id="XP_004851002.2"
                     /db_xref="GeneID:101716266"
                     /translation="

MYTGTVLSYLLFQNIISFVCRYICKINSWRKRPLATVWKIDRGEKTNLRSQLGGFSITSSVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    408..770
                     /gene="Ago3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(564..566,609..611,651..653,663..665,717..719,
                     738..740,744..746)
                     /gene="Ago3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    903..2180
                     /gene="Ago3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1314..1316,1326..1328,1362..1373,1380..1382,
                     1404..1406,1413..1415,1425..1427,1437..1439)
                     /gene="Ago3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1518..1520,1524..1526,1734..1736,2148..2150)
                     /gene="Ago3"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

tctgccttccatgaaatacacacctgtggggcgttcctttttctcagctccagaaggatatgaccaccctctgggagggggcagggaagtatggtttggattccatcaatctgttcgacctgccatgtggaaaatgatgcttaatatcgatgcatctgcctttgtgaaaatgagagaggacatgtttaaccaatcccttttagatgtatactggaactgttctcagttacctgctgtttcagaacatcatttcatttgtatgtagatatatatgtaagataaattcttggagaaagagacctctggcaacagtgtggaaaatagatagaggagaaaaaactaatctgagaagccagttaggaggcttttcaatcactagttcagtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcataatattgatgagcaaccaagacctctgactgactcgcatcgggtaaaattcaccaaagagataaaaggtctaaaagttgaagtgactcattgtggaacaatgagacgaaaataccgtgtttgtaatgtaacaagaaggcctgccagtcatcaaacctttcctttacagttagaaaatggccaaactgtggagagaacagtagcacagtatttcagagaaaagtatactcttcagctgaagtacccacaccttccctgtctgcaagtggggcaggagcagaaacatacctacctgccactagaagtctgtaatattgtggcagggcaacgatgtatcaaaaagctaacagacaatcagacttctactatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaatcagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggcacatgtaaccggacgtgtacttccagcacctatgctccagtatggaggacggaaccggacagtagcaacaccaagccatggagtatgggacatgcgtggaaaacagttccacacaggagttgaaatcaaaatgtgggccatagcttgttttgccacacagaggcagtgcagagaagaaatattaaagggtttcacagaccagctgcgtaagatttccaaggatgccgggatgccaatccagggccagccgtgtttctgcaaatatgcccagggggcagatagcgtagaacccatgttccggcatctcaagaatacatattctgggctacagctcattattgtcatcctgccagggaaaacgccagtatatgcagaggtaaaacgtgtaggagatacacttttgggtatggctacccagtgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctctcaaacttgtgcctaaagataaatgttaaacttggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatatttttgggagcagatgtcactcatcctcctgctggtgatggaaagaagccttctatcgctgctgttgtaggtagtatggatgctcacccaagcagatactgtgccacagtcagagttcagagacctcgacaagagatcatacaggacttggcctccatggtccgggaacttctcattcaattttataagtcaactcggttcaaacctactcgtatcatcttttatcgggacggtgtttcagagggacagttcagacaggtattatattatgaactgctagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtggttcagaagaggcatcacactcgattattttgtgctgatagaacagaaagggttggaagaagtggcaatataccagctggaacaacagttgatacggacattacgcacccatatgagtttgatttttacctttgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaactccaactgctcacttaccagctctgccacacttacgtacgctgtacacgatctgtttctatacctgcaccagcatattatgctcatcttgtggcattcagagccagataccatctcgtggacaaagaacatgacagtgctgaaggaagccacgtttcaggacagagcaatgggcgagatccacaagctcttgctaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaacaagtccaagtgtgttctctaagaggaagaactgaaagatgaatcaacatacaacgtatgtttccagtagtcagctgagcagacacgcctccagccatacagaagccaacactgtgtgggagcctggtccttaggttgacacaggaagattgtttacttcatcgagaaatgcagcaccattatgcaatatgaaaccagccagctgctttttgtgcggtctcctataggaagtatcgcagttgttttgttttctcttcttatagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaagtaaagcaaaagtaaatgatggtttaaaaaacacacgcctacacaaaaaatcaaaatgattgttcacaattatgtgtgcaaaaaattaatgtgcattcatatattcttgtaaaaggagtctgtatttttaaatatatacatgcatacttcatatgcacatatatctgaatctaaattgataatagatatatatgcatctatgtatatattttatggttcattccattgggaaattttctttctcttttttctctgctcactaccacctttatttctcttttcctcccctgccttcatcatctacattttatttctaatgctaccagtgacattcaaatattcatatatgtgactcatttgaatgtgaagcatggcaaactagatttctgtttttattttgcacaccttgcttttgtctgctatttcatacacaattctgagtcctcttggtactgcttttttatgtgttcctcctgctctgaacttatatttgccatttgtgcaatgtgtacataaacagtagcaacctaaactattctttttctttagtgagtctgttgaagctgctataaatataaaaccttgtcagaagttctaaccctttctgtctgatatatgatatgtattctaaatccttctgtttctataagttatacataaggtaaatattttaaaagattagaatgctgtagtgttgaggcctctgaaattgggcggggagagagaaaggcttatggggggattggtttttgctagtttacttgctgcctctcatactttaatgtgattttcatatatatatttttatatatatgtatgtgtgtatatataaacatatatgtatgtgttttgaaataaatagcttccttttcttttatatttattagaatagtgctttaataattatagaattgtattggcaacatattttatagaaatataatcatgtttattttaagaacttacaacttgtttttgctattttttagtgcaataagcagttttaaaggaaagtgtctgtttgacaccattacaacagatagtaggagaaataggcacctccactgttttaaaatggcaaagtaatacagccttaatttcagaaggaagtttcataattttcaacttaaaataatgcatgtcttttaaaaaccataatgaaaatgaagtaaaattgcttaggtgagtctgactttgaatattagaaatatttgctttaagaaatgacagtgaacagtttaagacttgtttttaaattatttaaaagtagataattattgaagaataatactgataggtgcccaatttcatttactaaaatgaatccagaaaatacaggattttatttttaaaaggtctttttgctgatttaccacaaatgaacttgcttttcaaactgaaggtgatagggacaaaggacattaggactttgaacattttaaatgagttcaatcgctgaaatgtgaggaaaactttttataaaacttttgttttatggatttcactttaggatattaaaaaatactataaagttgtcaatacctggctcatcagtaacattgggttcaggggaatttggtactttgtaattcatgaaaattgcattttggggattacttttggtttttctttggggggagatattttacactggttcagagtatagataccacaggttgtttccagtgggcattgttattagcctttcagaattccttctgtacctaaaaattaatggatttagatctttagtttctttgttacctataatatactattattgccaatttactgtattttgagcctaaaatctgagcccatgtcctccaacaggcatgacatcttttgtccctttgccagaaaacttaaaaagtactgtattttctctgtttattattttgaagtatctgaaatgcaatttacaacactgtttcaaagcactttacataagataatatttgtacaatatatacgttttttcttctagccttctcccatcactcactaaaaaaattcctttgaaacatattttgttttatttgttgggcggggggggttgttttgttttgttttttggtacagggacttattgcccagaatggtttcaaactcctgggctcaagcaatcctcccacctcagcctccccagtggctggtactatatagggacataccactgtagccagctatgtttgttttttttacattgaagtttcactgaacatggtcgggaacatgggcaagagaagaaagcagtatggcgtagatggtaaaatcttgattgatatctgcttgctcagtataaaaacaccttcggttgtctatcgtaactgcacaaattcatgtgggaaactttagggagcaactgtggatgccatgtacctagttactgttttacctgtttccagtcactcagtctcacacatataaagcccttaatttaaatctatttggacaggcattttaaaaaggaaaaataattttttctaaaatacaaactttacctggtgagtgatttcttttttgtaaagtgctcttacactattcagaattgctagtttatgattgattaacttggaagatagttctactttgcttgctgacaagttggtataccaaattctaattgtaagaaacctcttgcttagaattttaagataaaaggctagatggcaaatacttcctgaaatttgttctaattgtttttgtacttctgagcagaattcctgatctttattttttaaaaaaaggttggtgttgttattttgttttttatttaagcatcatgaaactcagagacctttctacacctacccttgctctccctaactgtatgatgaatactaaatttggtctccagttttctttaaaatatccatcccagggccgaagatttagctcagtcattccaccacctgccccgcaagtgcaaggacctgagtttgatccctggtacccccccaaaaaaaatccatcccagcaactggtaaaattgattttcatatgaagaagagttgagagagttgagagtttcacacaacatttacctagtatgtgtgaggccctgagtttcatccccagagctgtaaaaaaaaagagttgggagtttaatgtgtattcttcatggtaaatatgtctgtgtaaagtgctaatatatgtcattgtattacagtatcaagttactggcattgaggaccatacatttatagtaccatagctgctatatttatttaagtagaatttgataattactgcactaaacaataatgagatgaacaggattcaaggctagtgtttagaccctttttattgtttttctaaatcagagtgaagacatgaaatactaaagtgataaagggtaatatcattttggtttcaatttaatatcagaatatccttgttttagaaatgtaaatttcttacttttacaatttaagaaaggattcgttgggcctgggattaattcagcggtgccatgcctacctcgcaagtgcaacgtcctgagtttgatccccagtaccagaaaaaaagggggggggttccttggccttctcagtactggtgtttggcacattttcacagaaatacaaatgccctttctttcttttccccctttctttttaataattacccttaacaagtttcttagaaaaactagcctatgcaaacagtcctgtttataatctattaatttacttctcttcctagaagaaattctagaaagattctggtaggaatttcctgggtgttttggaagaccatcagtataaattcaacagggacagccagccttctaaagaccaggactagttttccaagctaggttctctgtgacccacctcagcctaagattaacttgtgtcttctctaatggatcttagggagacagactcaatagacttagagttatggcaagacttaagatatgtctagggggaaaaaaaaaaaaaagatgtgtctagggaaacaaaagctaagctgccattcagtagaaagagctggcaaatgatctctgtcagaggagagggtgagcactcagccaggattaggtcagaagtccagaattagagactgttgtccaaaaaacatgataactcttttcagaggtttgcatcactttgccaaaggaatggtttttagaaaatttacctgaacatggatagactgttttgtagtcttcctacttcaaaattgatggtaatgttttgccaagttaaatggacaactctgcataactttcattcagtatcattaaaccttagttaaatgtttccttaactcatcctcttagattttctcctgttggagagaaagactacccttaacagtttcttgctacttaaattacgtttcatgtgttcatcaagctgtaaaaagatatcagtcagtccagtatctttattttggtttttttacccatttgaaataaaagtcttttttgaaaatctgtggatgttttaaaacttcagtaatagtagtttggagactgatatcacataaggccttcctgagtagcagtataaccctgatgtagggaatgttttcctgtttcccttgcatttgatcatataaagaaagcattttcgtgagtctagaggtcaaaaaataacccaagaataaatatgtaagaatcagtacagaaatcagaaagaattttctccaaaaacattttacatttctgcttatactaagaacattcttcaatgacagtgacagaaaggatgccatgagtgattaaaagaaagccaaagctgagtcctggagtcgagaggggaaatatttatgtgtgtatgtatatgtataaacatacatatataatagatataactatatgtctacgtttcatataaaaaggaaaatattgttacttttttcctactttaaaaatggtacatttaatcttataatttttatgtctgcataatttttttaatgatcaaggcttgtgctaatagccacagctagtttaaatttgttttactttacccatcaaaaatagtgctctagggccagggatttagctcagtggtgccgccacctgccttgcaagtgcaaggtctcgagttcgatccctggtaccaaaaaaaaaaaatagtgctctagatttttacattgttgactaaatatcaagaatcttttgggccggggatttagctcagtggttccggtgcctgccttgcaagcacaaggtcacaagttcaatccccggtaccccccccaaaaaaagaatcttttgttcttaaagtatgaaagttaaagattttaatttgaattaaagataaaaaatttaatatggagggttgagatgaaaaaccctgtcaagtaacaaagcatcgatccagccattgggttcccatcctttttaaaactgatgtctgaagtaaccaaaatctgatctcatattctatgttagggtttcagtaaagcaaagatttttttcaggatagactctgaattaaatttttaaaacatttttaaaagcaaggtggttcttagaaagtgccttttcagaagatggtgctgtagattttttatttttcaaatagcatgaggctaaaaattttaaagataaattattttagaatttcaagagtatgacagtttcatataatgttatttgttggcttgaatctggtcaagggaaccaatgaaagcttttatgtagtaaagaacccaggtaaacgctcaccacatttattttgtaaatttgaaaacaattttttttctgttctggggattgaacccaaggccttgtttatactagacaggcaatctaccactgagctatattcccagccctgaaaacaaaaatttttgacagttaaacctttttattctctgctgagttcaagataatctataaagtagtgtataaaggccatagtctacttaactttttaacaagataattgctagtagtagcagatatcccaagggaaagtaccttgccaggaattgttttttgttgttgttgctttgttttgttttttaagcacagattgccccaggcctaaacttttctaattagtctttagtaaccaagagttctaataaaaggagaactaaatcttcattgagttacaagagaacacaaataattatatcttttatttttagggcaattttctctttttagacattaaagaatgttttaaatgataatttctttttctgtggtgagagaaccatgaaaaatgacaacaatacatttaaaagggcatcagctaattaaaaatagaatataggaccaagatatattatgtaaaggtacaaattcccaataatgaatgtcagcatattgtgtacctaaaatgtaccaataaaatgaatgaaaagaaatagaatataggactggggatatgcctcagtggtagagttcatgcttagcatgttcaaggcccagattcattccatggcactgagagagaatatgcaatttttgcctttggagaagataaacaaaagaaaaaaaatagaaccattcatgcttagtagaaacacagttacctaccagaaagcaatttcccctgtaataggtagcagtaaacatcagtaaatgatcacttaaccagttcttgcttttgtgagtttggtgagcattactccagaaaataaatagactaaagcaaaaacaccacacctcagtaaccttgtatgctgcattatgtaatggtagtaaaactatagtgattgtttggtgtgtactgtgtctatttgcaaataaacatgcacattaaattttttcatttttataatgtcttgatagcaa

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