2024-12-03 07:48:01, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NR_182209 4953 bp RNA linear PRI 08-NOV-2022 DEFINITION Homo sapiens polyhomeotic homolog 1 (PHC1), transcript variant 19, non-coding RNA. ACCESSION NR_182209 VERSION NR_182209.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4953) AUTHORS Chen L, Tong Q, Chen X, Jiang P, Yu H, Zhao Q, Sun L, Liu C, Gu B, Zheng Y, Fei L, Jiang X, Li W, Volpe G, Abdul MM, Guo G, Zhang J, Qian P, Sun Q, Neculai D, Esteban MA, Li C, Wen F and Ji J. TITLE PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus JOURNAL Nat Commun 12 (1), 2829 (2021) PUBMED 33990559 REMARK GeneRIF: PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus. Publication Status: Online-Only REFERENCE 2 (bases 1 to 4953) AUTHORS Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood MA. TITLE A reference map of the human binary protein interactome JOURNAL Nature 580 (7803), 402-408 (2020) PUBMED 32296183 REFERENCE 3 (bases 1 to 4953) AUTHORS Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP and Harper JW. TITLE Architecture of the human interactome defines protein communities and disease networks JOURNAL Nature 545 (7655), 505-509 (2017) PUBMED 28514442 REFERENCE 4 (bases 1 to 4953) AUTHORS Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M and Beisel C. TITLE A High-Density Map for Navigating the Human Polycomb Complexome JOURNAL Cell Rep 17 (2), 583-595 (2016) PUBMED 27705803 REFERENCE 5 (bases 1 to 4953) AUTHORS Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K, Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson PKE, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Doring A, Elliott P, Epstein SE, Ingi Eyjolfsson G, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G, Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YI, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and Abecasis GR. CONSRTM Global Lipids Genetics Consortium TITLE Discovery and refinement of loci associated with lipid levels JOURNAL Nat Genet 45 (11), 1274-1283 (2013) PUBMED 24097068 REFERENCE 6 (bases 1 to 4953) AUTHORS Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P and Kingston RE. TITLE The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans JOURNAL Mol Cell Biol 22 (17), 6070-6078 (2002) PUBMED 12167701 REFERENCE 7 (bases 1 to 4953) AUTHORS Ohta H, Tokimasa S, Zou Z, Funaki S, Kurahashi H, Takahashi Y, Kimura M, Matsuoka R, Horie M, Hara J, Shimada K and Takihara Y. TITLE Structure and chromosomal localization of the RAE28/HPH1 gene, a human homologue of the polyhomeotic gene JOURNAL DNA Seq 11 (1-2), 61-73 (2000) PUBMED 10902910 REFERENCE 8 (bases 1 to 4953) AUTHORS Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R and Otte AP. TITLE RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor JOURNAL Mol Cell Biol 17 (7), 4105-4113 (1997) PUBMED 9199346 REFERENCE 9 (bases 1 to 4953) AUTHORS Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R and Otte AP. TITLE Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic JOURNAL Mol Cell Biol 17 (4), 2326-2335 (1997) PUBMED 9121482 REFERENCE 10 (bases 1 to 4953) AUTHORS Verloes,A., Drunat,S., Gressens,P. and Passemard,S. TITLE Primary Autosomal Recessive Microcephalies and Seckel Syndrome Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY JOURNAL (in) Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW and Amemiya A (Eds.); GENEREVIEWS((R)); (1993) PUBMED 20301772 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006581.16. Summary: This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR18074967.44404.1, SRR14038196.2538327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2155974 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-108 AC006581.16 62800-62907 109-270 AC006581.16 66587-66748 271-381 AC006581.16 68713-68823 382-462 AC006581.16 69942-70022 463-612 AC006581.16 70558-70707 613-768 AC006581.16 71590-71745 769-1261 AC006581.16 79392-79884 1262-2049 AC006581.16 81520-82307 2050-2197 AC006581.16 82822-82969 2198-2409 AC006581.16 83224-83435 2410-2524 AC006581.16 84081-84195 2525-2633 AC006581.16 85813-85921 2634-2784 AC006581.16 86133-86283 2785-3016 AC006581.16 86786-87017 3017-4729 AC006581.16 88262-89974 4730-4953 AC006581.16 90201-90424 FEATURES Location/Qualifiers source 1..4953 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="12" /map="12p13.31" gene 1..4953 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /note="polyhomeotic homolog 1" /db_xref="GeneID:1911" /db_xref="HGNC:HGNC:3182" /db_xref="MIM:602978" misc_RNA 1..4953 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /product="polyhomeotic homolog 1, transcript variant 19" /db_xref="GeneID:1911" /db_xref="HGNC:HGNC:3182" /db_xref="MIM:602978" exon 1..108 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 109..270 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" misc_feature 157..3171 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="COORDINATES: alignment:Blast2seq::RefSeq|NM_004426.3" /note="primary ORF has stop codon >50 nucleotides from the terminal splice site; nonsense-mediated decay (NMD) candidate" exon 271..381 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 382..462 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 463..612 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 613..768 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 769..1261 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 1262..2049 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 2050..2197 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 2198..2409 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 2410..2524 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 2525..2633 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 2634..2784 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 2785..3016 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 3017..4729 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" exon 4730..4953 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /inference="alignment:Splign:2.1.0" regulatory 4932..4937 /regulatory_class="polyA_signal_sequence" /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /note="hexamer: AAGAAA" polyA_site 4953 /gene="PHC1" /gene_synonym="EDR1; HPH1; MCPH11; RAE28" /note="major polyA site" ORIGIN
aaatgctatccaaaggaagttacattaggttgctgctttgaaaatgaagtcaactcctaatgggttagctgtttctgcagcattctttcccgccttcttggagttgaggtcttgagtcagacagagcaccagccttggggaccctggaccactatcatggagactgagagcgagcagaactccaattccaccaatgggagttctagctcagggggcagctctcggccccagatagctcaaatgtcactttatgaacgacaagcagtgcaggctctgcaagcactgcagcggcagcccaatgcagctcagtatttccaccagttcatgctccagcagcagctcagtaatgcccagctgcatagcctggctgccgtccagcaggccacaattgctgccagtcggcaggccagctccccaaacaccagcactacacagcagcagactaccaccacccaggcctcgatcaatctggccaccacatcggccgcccagctcatcagccgatcccagagtgtgagctctcccagtgctaccaccttgacccaatctgtgctactggggaacaccacctccccacccctcaaccagtctcaggcccagatgtatctacggccacagctgggaaacctattgcaggtaaaccgaaccctgggtcggaatgtgcctctagcctcccaactcatcctgatgcctaatggggcggtggctgcagtccagcaggaggtgccatctgctcagtctcctggagttcatgcagatgcagatcaggttcagaacttggcagtaaggaatcaacaggcctcagctcaaggacctcagatgcaaggctccactcagaaggccattcctccaggagcctcccctgtctctagcctctcccaggcctctagccaggccctagcggtggcacaggcttcctctggggccacaaaccagtccctcaaccttagtcaagctggtggaggcagtgggaatagcatcccagggtccatgggtccaggtggaggtgggcaggcacatggtggtttgggtcagttgccttcctcaggaatgggtggtgggagctgtcccagaaagggtacaggagtggtgcagcccttgcctgcagcccaaacagtgactgtgagccagggcagccagacagaggcagaaagtgcagcagccaagaaggcagaagcagatgggagtggccagcagaatgtgggcatgaacctgacacggacagccacacctgcgcccagccagacacttattagctcagccacctacacacagatccagccccattcactgattcagcaacagcaacagatccacctccagcagaaacaggtggtgatccagcagcagattgccatccaccaccagcagcagttccagcaccggcagtcccagctccttcacacagctacacacctccagttggcgcagcagcagcagcagcaacaacagcaacagcagcaacagcagcagccgcaagccaccaccctcactgcccctcagccaccacaggtcccacctactcagcaggtcccaccttcccagtcccagcagcaagcccaaaccctggtcgttcagcccatgcttcagtcttcacccttgtctcttccacctgatgcagcccctaagccaccaattcccatccaatccaaaccacctgtagcacctatcaagccgcctcagttaggggccgctaagatgtcagctgcccagcaaccaccaccccatatccctgtgcaagttgtaggcactcgacagccaggtacagcccaggcacaggctttggggttggcacagctggcagctgctgtacctacttcccgggggatgccaggtacagtgcagtctggtcaggcccatttggcctcctcgccaccttcatcccaggctcctggtgcactgcaggagtgccctcccacattggcccctgggatgacccttgctcctgtgcaggggacagcacatgtggtaaagggtggggctaccacctcctcacctgttgtagcccaggtccctgctgccttctatatgcagtctgtgcacttgccgggtaaaccccagacattggctgtcaaacgcaaggctgactctgaggaggagagagatgatgtctccacattgggttcaatgcttcctgccaaggcatctccagtagcagaaagcccaaaagtcatggacgagaagagcagtcttggagaaaaagctgaatcagtggctaatgtgaatgctaatactccaagcagtgaactagtagccttgacccccgccccttcagtaccgcctcctacactagccatggtgtctagacaaatgggtgactcaaaacccccacaggccatcgtgaagccccagattctcacccacatcattgaaggctttgttatccaggaaggagcagaacctttcccggtgggttgttctcagttactgaaggagtctgagaagccactacagactggccttccgacagggctgactgagaatcagtcaggtggccctttgggagtggacagcccatctgctgagttagataagaaggcgaatctcctgaagtgcgagtactgtgggaagtacgcccccgcagagcagtttcgtggctctaagaggttctgctccatgacttgcgctaagaggtacaatgtgagctgtagccatcagttccggctgaagaggaaaaaaatgaaagagtttcaagaagccaactatgctcgcgttcgcaggcgtggaccccgccgcagctcctctgacattgcccgtgccaagattcagggcaagtgccaccggggtcaagaagactctagccggggttcagataattccagttatgatgaagcactctctccaacatctcctgggcctttatcagtaagagctgggcatggagaacgtgacctggggaatcccaatacagctccacctacaccggaattacatggcatcaaccctgtgttcctgtccagtaatcccagccgttggagtgtagaggaggtgtacgagtttattgcttctctccaaggctgccaagagattgcagaggaatttcgctcacaggagattgatggacaggcccttttattacttaaagaagaacatcttatgagtgccatgaacatcaagctgggccctgccctcaagatctgcgccaagataaatgtcctcaaggagacctaaggtggccctcttgcacaaaccagcctaaggcagacactctccactgtccaggttataacctggtaccagcagactttgcagggaagaaagagttgttccaatcatgtaaccttctgtaggggattactgagacagggaagagaagtgcaagaattggttgctggtgctacatggcggcagctttgacattttctctgggttctactttattttttaaaatctttacagttctcaccatttcacgtaccttaatccaatctttataaaagaggcagtctagagaactaggactgctcagccttatcctggagtggagcatttagcccaggtcttaattctccaagaggaggaatacatagtatggtaaggcaaggaactgggtggaatgtcaggttgcctgcccaatgggagaggtagggtttttctagcttgtgtgacagaagtagcaaaatctggtcctcccccctcccagtgtagctgtggctcagagttttttctttttgttgtcacttactcccttgtgattgaattttttctcctgcatccatggcaggatccccagccagtatagagacttggttggcatcttctgctgcagggactaaaagtatttgactggggcacatgtggctgttgtcattctttctgcatcccactgttcccctccaatttatgttattttctaccctgtttttcagttccatctctgctctgtcctatagctttataaaaccagagtgtgtggggctgaggtcaggagtataagtacctgccttaggcactattccttatataacaaaaatattaaatatttttttcctcagtaaaaggatgaaaattggtttcagttgtcttactctattccagtctttgcccactttcacacaaatgacaaggccaatatgttttgtttgttttttaatcattaagagtttttgtacaaaaggtgatggttttttttcttcattttaaaacaccagggtgtgggggagggatgcaaacaaataacaaaaaagatgcttttgtaacattattttccctgtttagaaagaaaaaaatcactccaatagtattgaaaagtccaaagatgaaatagtttcattttcttttcctaaggcttataaaaggccccctgcctgttgattccatccctcttttgtgtccagtggagccatgttactcttcagtggcccaggggttcactattaaagaaagatcagtccaggtttctgggcacatggcctaaacaggaagatggaagcatcagaggattaaaaacctttccccacagaaatgtgggcaagaagacacttccctgagccagcagaagggacaggtgcagcagcattccacacccagcgcagaggacagcagagccctcgatgtcccacttctgcttccgttccctttctagaagattgaaaaaaaggtcaaaaccacatgcctgtggagaaagtgcgacatgtttagaaatactggtagggaaccaggagtaagaaaagctttaccagcttttactacaaatggatgaaagacatcaggatcccaccaccgcaagaggtgggagaagcaagtctagaacatctccaggctcagactaaacgagagtacttggactgcaaccaagtaatcactgcaaagtagttccaagcagcaagaaataccagattctcatggaggctactatagggtacagaataacaacatgaaagcaatcaaccctgtataaataatgtttcttggcattttttttttaattaaagaaatccagtgtctcaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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