2024-10-23 02:05:56, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NR_030486 82 bp RNA linear ROD 05-AUG-2023 DEFINITION Mus musculus microRNA 705 (Mir705), microRNA. ACCESSION NR_030486 VERSION NR_030486.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 82) AUTHORS Liao L, Su X, Yang X, Hu C, Li B, Lv Y, Shuai Y, Jing H, Deng Z and Jin Y. TITLE TNF-alpha Inhibits FoxO1 by Upregulating miR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis JOURNAL Stem Cells 34 (4), 1054-1067 (2016) PUBMED 26700816 REMARK GeneRIF: Inhibition of NF-kappaB pathway or knockdown of miR-705 largely prevented the decline of FoxO1-mediated antioxidant defense caused by TNF-alpha and ameliorated the oxidative damage in osteoporotic bone marrow-derived mesenchymal stem cells REFERENCE 2 (bases 1 to 82) AUTHORS Liao L, Yang X, Su X, Hu C, Zhu X, Yang N, Chen X, Shi S, Shi S and Jin Y. TITLE Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow JOURNAL Cell Death Dis 4 (4), e600 (2013) PUBMED 23598412 REMARK GeneRIF: The miR-705 is acted as inhibitors of MSCs osteoblast differentiation and promoters of adipocyte differentiation, by targeting on the 3'untranslated region (3'UTR) of HOXA10 and RUNX2 mRNA. Publication Status: Online-Only REFERENCE 3 (bases 1 to 82) AUTHORS Prosser HM, Koike-Yusa H, Cooper JD, Law FC and Bradley A. TITLE A resource of vectors and ES cells for targeted deletion of microRNAs in mice JOURNAL Nat Biotechnol 29 (9), 840-845 (2011) PUBMED 21822254 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 82) AUTHORS Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H and Yoshikawa T. TITLE The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity JOURNAL Am J Physiol Endocrinol Metab 298 (4), E799-E806 (2010) PUBMED 20086200 REFERENCE 5 (bases 1 to 82) AUTHORS van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA and Olson EN. TITLE Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis JOURNAL Proc Natl Acad Sci U S A 105 (35), 13027-13032 (2008) PUBMED 18723672 REFERENCE 6 (bases 1 to 82) AUTHORS Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M and Kato I. TITLE The expression profile of microRNAs in mouse embryos JOURNAL Nucleic Acids Res 34 (6), 1765-1771 (2006) PUBMED 16582102 REMARK Publication Status: Online-Only REFERENCE 7 (bases 1 to 82) AUTHORS Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AC153605.2. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. ##Evidence-Data-START## Transcript is intronless :: AK078938.1, CX221927.1 [ECO:0000345] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-82 AC153605.2 219682-219763 c FEATURES Location/Qualifiers source 1..82 /organism="Mus musculus" /mol_type="transcribed RNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="6" /map="6 37.35 cM" gene 1..82 /gene="Mir705" /gene_synonym="Mirn705; mmu-mir-705" /note="microRNA 705" /db_xref="GeneID:735267" /db_xref="MGI:MGI:3629673" /db_xref="miRBase:MI0004689" precursor_RNA 1..82 /gene="Mir705" /gene_synonym="Mirn705; mmu-mir-705" /product="microRNA 705" /db_xref="GeneID:735267" /db_xref="MGI:MGI:3629673" /db_xref="miRBase:MI0004689" exon 1..82 /gene="Mir705" /gene_synonym="Mirn705; mmu-mir-705" /inference="alignment:Splign:2.1.0" ncRNA 14..33 /ncRNA_class="miRNA" /gene="Mir705" /gene_synonym="Mirn705; mmu-mir-705" /product="mmu-miR-705" /db_xref="miRBase:MIMAT0003495" /db_xref="GeneID:735267" /db_xref="MGI:MGI:3629673" /db_xref="miRBase:MI0004689" ORIGIN
atgtcccagtagtggtgggaggtggggtgggcacagagggaatgacttctttctcctgcagtcctccctacctccctaacat
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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