2024-12-03 08:12:13, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NR_030359 97 bp RNA linear PRI 30-APR-2024 DEFINITION Homo sapiens microRNA 630 (MIR630), microRNA. ACCESSION NR_030359 VERSION NR_030359.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 97) AUTHORS Cui,F., Sun,Z., Zhang,X. and Liu,C. TITLE CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract JOURNAL Curr Eye Res 49 (5), 487-495 (2024) PUBMED 38152055 REMARK GeneRIF: CircMAP3K4 Suppresses H2O2-Induced Human Lens Epithelial Cell Injury by miR-630/ERCC6 Axis in Age-Related Cataract. REFERENCE 2 (bases 1 to 97) AUTHORS You,G.R., Cheng,A.J., Shen,E.Y., Fan,K.H., Huang,Y.F., Huang,Y.C., Chang,K.P. and Chang,J.T. TITLE MiR-630 Promotes Radioresistance by Induction of Anti-Apoptotic Effect via Nrf2-GPX2 Molecular Axis in Head-Neck Cancer JOURNAL Cells 12 (24), 2853 (2023) PUBMED 38132173 REMARK GeneRIF: MiR-630 Promotes Radioresistance by Induction of Anti-Apoptotic Effect via Nrf2-GPX2 Molecular Axis in Head-Neck Cancer. Publication Status: Online-Only REFERENCE 3 (bases 1 to 97) AUTHORS Li,X., Jiang,X., Lu,J., Lin,Y., Jiang,L., Li,Y., Wan,F. and Wang,C. TITLE CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8 JOURNAL Biochem Genet 60 (6), 2611-2629 (2022) PUBMED 35676548 REMARK GeneRIF: CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8. REFERENCE 4 (bases 1 to 97) AUTHORS Gao,Q., Ren,Z., Jiao,S., Guo,J., Miao,X., Wang,J. and Liu,J. TITLE HIF-3alpha-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop JOURNAL J Immunol Res 2022, 5262963 (2022) PUBMED 36277475 REMARK GeneRIF: HIF-3alpha-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop. Publication Status: Online-Only REFERENCE 5 (bases 1 to 97) AUTHORS Chu,W.K., Hung,L.M., Hou,C.W. and Chen,J.K. TITLE MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells JOURNAL Int J Mol Sci 23 (1), 46 (2021) PUBMED 35008480 REMARK GeneRIF: MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells. Publication Status: Online-Only REFERENCE 6 (bases 1 to 97) AUTHORS Corcoran,C., Rani,S., Breslin,S., Gogarty,M., Ghobrial,I.M., Crown,J. and O'Driscoll,L. TITLE miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer JOURNAL Mol Cancer 13, 71 (2014) PUBMED 24655723 REMARK GeneRIF: our findings suggest miR-630 as a key regulator of cancer cell progression in HER2 over-expressing breast cancer, through targeting of IGF1R. Publication Status: Online-Only REFERENCE 7 (bases 1 to 97) AUTHORS Chu,D., Zhao,Z., Li,Y., Li,J., Zheng,J., Wang,W., Zhao,Q. and Ji,G. TITLE Increased microRNA-630 expression in gastric cancer is associated with poor overall survival JOURNAL PLoS One 9 (3), e90526 (2014) PUBMED 24621930 REMARK GeneRIF: over-expression of miR-630 and its association with tumor progression in human gastric cancer Publication Status: Online-Only REFERENCE 8 (bases 1 to 97) AUTHORS Farhana,L., Dawson,M.I., Murshed,F., Das,J.K., Rishi,A.K. and Fontana,J.A. TITLE Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R JOURNAL PLoS One 8 (5), e61015 (2013) PUBMED 23675407 REMARK GeneRIF: Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. Publication Status: Online-Only REFERENCE 9 (bases 1 to 97) AUTHORS Cummins,J.M., He,Y., Leary,R.J., Pagliarini,R., Diaz,L.A. Jr., Sjoblom,T., Barad,O., Bentwich,Z., Szafranska,A.E., Labourier,E., Raymond,C.K., Roberts,B.S., Juhl,H., Kinzler,K.W., Vogelstein,B. and Velculescu,V.E. TITLE The colorectal microRNAome JOURNAL Proc Natl Acad Sci U S A 103 (10), 3687-3692 (2006) PUBMED 16505370 REFERENCE 10 (bases 1 to 97) AUTHORS Griffiths-Jones,S., Grocock,R.J., van Dongen,S., Bateman,A. and Enright,A.J. TITLE miRBase: microRNA sequences, targets and gene nomenclature JOURNAL Nucleic Acids Res 34 (Database issue), D140-D144 (2006) PUBMED 16381832 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AC100827.2. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-97 AC100827.2 67632-67728 c FEATURES Location/Qualifiers source 1..97 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="15" /map="15q24.1" gene 1..97 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /note="microRNA 630" /db_xref="GeneID:693215" /db_xref="HGNC:HGNC:32886" /db_xref="miRBase:MI0003644" precursor_RNA 1..97 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /product="microRNA 630" /db_xref="GeneID:693215" /db_xref="HGNC:HGNC:32886" /db_xref="miRBase:MI0003644" exon 1..97 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /inference="alignment:Splign:2.1.0" variation 4..5 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="" /replace="tt" /db_xref="dbSNP:750725925" variation 7..9 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="aca" /db_xref="dbSNP:2064320865" variation 8..13 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="cat" /replace="catcat" /db_xref="dbSNP:1310846413" variation 8 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:1404480992" variation 9 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="c" /db_xref="dbSNP:775762051" variation 10 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="t" /db_xref="dbSNP:1402253095" variation 11 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:2064320935" variation 12 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:1444076655" variation 13 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:2064320964" variation 14 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:2140443122" variation 16 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:1308114046" variation 17 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:749669360" variation 18 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:1246367207" variation 19 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:2064321022" variation 27 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:2064321038" variation 31 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="t" /db_xref="dbSNP:769105916" variation 33..36 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="ttt" /replace="tttt" /db_xref="dbSNP:1341482597" variation 33 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="t" /db_xref="dbSNP:1356253254" variation 34 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:1053789818" variation 40 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:2064321101" variation 41 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:1311959732" variation 45..46 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="g" /replace="gg" /db_xref="dbSNP:758978114" variation 46 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:900622609" variation 47 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="g" /replace="t" /db_xref="dbSNP:1403734724" variation 48 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:774874333" variation 49 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="c" /db_xref="dbSNP:1461447148" variation 50..75 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="cag" /replace="cagaatgacctagtattctgtaccag" /db_xref="dbSNP:751079265" variation 50 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="cc" /db_xref="dbSNP:766744804" variation 52 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:765891587" variation 54 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="t" /db_xref="dbSNP:776063319" variation 59 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="g" /db_xref="dbSNP:996560227" ncRNA 61..82 /ncRNA_class="miRNA" /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /product="hsa-miR-630" /db_xref="miRBase:MIMAT0003299" /db_xref="GeneID:693215" /db_xref="HGNC:HGNC:32886" /db_xref="miRBase:MI0003644" variation 62 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:1172705615" variation 72..73 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="cc" /db_xref="dbSNP:1478064263" variation 72 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:759224089" variation 73 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:562760607" variation 77 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:2064321292" variation 80 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:752489103" variation 81 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:1011619093" variation 83 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:2064321336" variation 87 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:1368026265" variation 88 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="t" /db_xref="dbSNP:1030358336" variation 91 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:758299822" variation 92 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="c" /replace="g" /db_xref="dbSNP:533218961" variation 94..95 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="" /replace="cat" /db_xref="dbSNP:2064321414" variation 94 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:955437229" variation 95 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="t" /replace="tgtt" /db_xref="dbSNP:1472412360" variation 96..97 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="" /replace="g" /db_xref="dbSNP:2140443179" variation 96 /gene="MIR630" /gene_synonym="hsa-mir-630; MIRN630" /replace="a" /replace="g" /db_xref="dbSNP:113971639" ORIGIN
aacttaacatcatgctacctctttgtatcatattttgttattctggtcacagaatgacctagtattctgtaccagggaaggtagttcttaactatat
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@meso_cacase at
DBCLS
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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