2024-12-03 07:56:38, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NR_029477 72 bp RNA linear PRI 03-SEP-2023 DEFINITION Homo sapiens microRNA let-7a-2 (MIRLET7A2), microRNA. ACCESSION NR_029477 VERSION NR_029477.1 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 72) AUTHORS Dong Q, Qiu H, Piao C, Li Z and Cui X. TITLE LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network JOURNAL J Exp Clin Cancer Res 42 (1), 209 (2023) PUBMED 37596700 REMARK GeneRIF: LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let-7a/RREB1 positive feedback loop and a ceRNA network. Publication Status: Online-Only REFERENCE 2 (bases 1 to 72) AUTHORS Liu X, Chen Z, Li S, Jin L, Cui X, Cui C, Deng Y, Gao Q, Fan L, Niu Y, Wang W, Cui C, Zhong J, Cui Q, Geng B and Cai J. TITLE Pre-miRNA Hsa-Let-7a-2: a Novel Intracellular Partner of Angiotensin II Type 2 Receptor Negatively Regulating its Signals JOURNAL Int J Biol Sci 18 (8), 3237-3250 (2022) PUBMED 35637969 REMARK GeneRIF: Pre-miRNA Hsa-Let-7a-2: a Novel Intracellular Partner of Angiotensin II Type 2 Receptor Negatively Regulating its Signals. Publication Status: Online-Only REFERENCE 3 (bases 1 to 72) AUTHORS Serej ZA, Ebrahimi A, Kazemi T, Najafi S, Amini M, Nastarin P, Baghbani E and Baradaran B. TITLE NANOG gene suppression and replacement of let-7 modulate the stemness, invasion, and apoptosis in breast cancer JOURNAL Gene 801, 145844 (2021) PUBMED 34274471 REMARK GeneRIF: NANOG gene suppression and replacement of let-7 modulate the stemness, invasion, and apoptosis in breast cancer. REFERENCE 4 (bases 1 to 72) AUTHORS Xie X, Du D, Guan Y, Jin T, Chen J, Wang Q, Li D, Xie Y, Liu N and Xie P. TITLE Predictive Value of let-7a for Cancer Cell Repopulation between Chemotherapy and Long-Term Survival: A Prospective Study JOURNAL Ann Clin Lab Sci 51 (5), 638-645 (2021) PUBMED 34686505 REMARK GeneRIF: Predictive Value of let-7a for Cancer Cell Repopulation between Chemotherapy and Long-Term Survival: A Prospective Study. REFERENCE 5 (bases 1 to 72) AUTHORS Liu H and Jiang B. TITLE Let-7a-5p represses proliferation, migration, invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-b2-induced human lens epithelial cells JOURNAL J Biosci 45 (2020) PUBMED 32345785 REMARK GeneRIF: Let-7a-5p represses proliferation, migration, invasion and epithelial-mesenchymal transition by targeting Smad2 in TGF-b2-induced human lens epithelial cells. REFERENCE 6 (bases 1 to 72) AUTHORS Kasashima K, Nakamura Y and Kozu T. TITLE Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells JOURNAL Biochem Biophys Res Commun 322 (2), 403-410 (2004) PUBMED 15325244 REFERENCE 7 (bases 1 to 72) AUTHORS Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN and Kim KS. TITLE Human embryonic stem cells express a unique set of microRNAs JOURNAL Dev Biol 270 (2), 488-498 (2004) PUBMED 15183728 REFERENCE 8 (bases 1 to 72) AUTHORS Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP and James RJ. TITLE Reduced accumulation of specific microRNAs in colorectal neoplasia JOURNAL Mol Cancer Res 1 (12), 882-891 (2003) PUBMED 14573789 REFERENCE 9 (bases 1 to 72) AUTHORS Dostie J, Mourelatos Z, Yang M, Sharma A and Dreyfuss G. TITLE Numerous microRNPs in neuronal cells containing novel microRNAs JOURNAL RNA 9 (2), 180-186 (2003) PUBMED 12554860 REMARK Erratum:[RNA. 2003 May;9(5):631-2] REFERENCE 10 (bases 1 to 72) AUTHORS Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T. TITLE Identification of novel genes coding for small expressed RNAs JOURNAL Science 294 (5543), 853-858 (2001) PUBMED 11679670 COMMENT PROVISIONAL REFSEQ: This record is based on preliminary annotation provided by NCBI staff in collaboration with miRBase. The reference sequence was derived from AP001359.4. Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]. Sequence Note: This record represents a predicted microRNA stem-loop as defined by miRBase. Some sequence at the 5' and 3' ends may not be included in the intermediate precursor miRNA produced by Drosha cleavage. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: LM608150.1 [ECO:0000345] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 AP001359.4 114480-114551 c FEATURES Location/Qualifiers source 1..72 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="11" /map="11q24.1" gene 1..72 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /note="microRNA let-7a-2" /db_xref="GeneID:406882" /db_xref="HGNC:HGNC:31477" /db_xref="MIM:612142" /db_xref="miRBase:MI0000061" precursor_RNA 1..72 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /product="microRNA let-7a-2" /db_xref="GeneID:406882" /db_xref="HGNC:HGNC:31477" /db_xref="MIM:612142" /db_xref="miRBase:MI0000061" exon 1..72 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /inference="alignment:Splign:2.1.0" variation 1 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="g" /db_xref="dbSNP:1942706673" variation 2 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="g" /db_xref="dbSNP:1023002595" ncRNA 5..26 /ncRNA_class="miRNA" /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /product="hsa-let-7a-5p" /db_xref="miRBase:MIMAT0000062" /db_xref="GeneID:406882" /db_xref="HGNC:HGNC:31477" /db_xref="MIM:612142" /db_xref="miRBase:MI0000061" variation 10 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="g" /replace="t" /db_xref="dbSNP:1362975136" variation 19 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="g" /db_xref="dbSNP:1176612700" variation 21 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="g" /db_xref="dbSNP:760725471" variation 25 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="t" /db_xref="dbSNP:770465876" variation 27 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="t" /db_xref="dbSNP:370340749" polyA_site 28 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /note="major polyA site" variation 31..32 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="at" /replace="atat" /db_xref="dbSNP:1942705719" variation 32 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="t" /db_xref="dbSNP:1942705572" variation 35..36 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="" /replace="tatatatacagtt" /db_xref="dbSNP:778742532" variation 35 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="t" /db_xref="dbSNP:1942705433" variation 37 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="t" /db_xref="dbSNP:772905825" variation 38 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="g" /db_xref="dbSNP:1285776542" variation 41 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:1205331984" variation 42 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="g" /db_xref="dbSNP:769568675" variation 44 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="g" /db_xref="dbSNP:561124326" ncRNA 50..71 /ncRNA_class="miRNA" /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /product="hsa-let-7a-2-3p" /db_xref="miRBase:MIMAT0010195" /db_xref="GeneID:406882" /db_xref="HGNC:HGNC:31477" /db_xref="MIM:612142" /db_xref="miRBase:MI0000061" variation 50 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="a" /replace="c" /db_xref="dbSNP:2134641361" variation 59 /gene="MIRLET7A2" /gene_synonym="let-7a-2; LET7A2; MIRNLET7A2" /replace="c" /replace="g" /db_xref="dbSNP:781140476" ORIGIN
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@meso_cacase at
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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