LOCUS       NM_205015               2493 bp    mRNA    linear   VRT 24-SEP-2023
DEFINITION  Gallus gallus T-cell leukemia homeobox 1 (TLX1), mRNA.
ACCESSION   NM_205015 XM_429269
VERSION     NM_205015.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Tang H, Finn RD and Thomas PD.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
            Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Logan C, Wingate RJ, McKay IJ and Lumsden A.
  TITLE     Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia
            and hindbrain of the chick embryo: markers of patterned
            connectivity
  JOURNAL   J Neurosci 18 (14), 5389-5402 (1998)
   PUBMED   9651221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000232.1 and AF071874.1.
            
            On Dec 10, 2021 this sequence version replaced NM_205015.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267649.125444.1, AF071874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992290, SAMEA3109051
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               JAENSK010000232.1  3063758-3064322     c
            566-1161            AF071874.1         118-713
            1162-2493           JAENSK010000232.1  3057400-3058731     c
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="6"
                     /map="6"
     gene            1..2493
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="T-cell leukemia homeobox 1"
                     /db_xref="CGNC:5922"
                     /db_xref="GeneID:395868"
     exon            1..917
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    311..313
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="upstream in-frame stop codon"
     CDS             449..1342
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="homeobox TLX-1; homeobox protein Hox-11"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 1"
                     /protein_id="NP_990346.1"
                     /db_xref="CGNC:5922"
                     /db_xref="GeneID:395868"
                     /translation="

MEHLGAHHLHQGQAEPISFGIDQILNTSEPGSCMVSHPRLQDSADYGLGCIVGSAYNTVTGGYGASGGGAGAYGGTSCSMGALPGSYNVNMAVSMNGNALSSAGGVIRVPAHRPVAGGVHQPLSAAVPPVNGMNSLTGLTFPWMESNRRYTKDRFTGHPYQNRTPPKKKKPRTSFTRLQICELEKRFHRQKYLASAERAALAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRILMQLQQEAFQKTINQPIQADPICVHNSSLFALQNLQPWSDDSTKITSVTTVASACE"

     misc_feature    905..970
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="propagated from UniProtKB/Swiss-Prot (O93366.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(953..967,971..973,1022..1024,1040..1042,1079..1081,
                     1085..1090,1097..1102,1106..1114,1118..1123)
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    959..1120
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(959..961,968..970,1088..1090,1097..1102,1109..1111)
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            918..1119
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..2493
                     /gene="TLX1"
                     /gene_synonym="HOX11; TLX-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aaacaggacggaggggctctcgcacacgcactctgccgcgctccgctccgcaccgcggggctccggctccacatcgccggtgggggcttcggctcctggtcctcgcgtgtcggtgcgtgggtgtctcgggcgcggcggtatcttgggtgggggtgtgaggcgctattgggatccgagggtctcggggtgtgggctgcgtctcccgcgtgcaccccggcgatgcgtggctctgagtgcggggctggcgtggagcggtcgcgcgtggctctgtcgcggtgtcccgaggcgcgcaggtgcggagcgatgggtctgagggcgtagtgcctgcccggctcctgcgttctgctgccgcgttttggggtctgcgcggctgtgccggggtccggcggaggggccccggggctcagcgcgcggctccgctgccggagcgaggacggacggcggaggcatggagcacctcggggctcaccacctgcaccaaggccaagccgagcccatcagcttcggcatcgaccagatcctcaacacgtcggagccgggaagctgcatggtgtcccacccgcgactgcaggactcggcggattacggcctgggttgcatcgtgggcagcgcctacaacacggtcaccggcggctacggggcgagcggcggcggggccggagcctacggcggcacctcgtgcagtatgggagccttgcccggctcctacaacgtgaacatggcggtgagcatgaacggcaacgctttgagctcggccgggggggtgatccgcgtcccggcccaccgccccgtagccggcggcgtgcaccagcccctctccgccgccgtgccgccggtgaacggcatgaacagtctgacggggctcaccttcccctggatggagagcaacaggcggtacacaaaggacaggttcacaggtcacccctaccagaaccgcacgccccccaagaagaagaagccgcgcacgtccttcacccgcctgcagatctgtgagctggagaagcgcttccaccggcagaagtacctggcctctgctgagcgtgcagccctggccaaggccctcaagatgacggacgcccaggtgaagacgtggttccagaaccggcgcaccaagtggaggaggcagacagcggaggagcgggaggccgagaggcagcaagcaaaccgcatcctcatgcagctgcagcaggaggccttccaaaaaaccatcaaccagcccatccaggccgaccccatctgcgtgcacaactcctctctcttcgccctgcagaacctccagccctggtctgacgactccaccaagatcaccagcgtcaccaccgtcgcctccgcctgcgaataagggctggcacctgcggtgtcccctttgtccccgggcacacgtgcatcccacgaagcatccctctatgaggaccgatggggaagggaaatttgccccccaaactctccctgcccgcaggcctgaggagcagcagcggctcgcctcccccccagcccttttgttcttccgaaagtctctggtgccggcctcaaacttcctgacacgctgccagacaaagctgagccctgacagacgtggccgcgggcgagtgcccagctgggggaacttcctctgggttctgcagggctggaggcaccccataggactatatgtatatataacgcgcgtctatcggtacgcgctttggactgattggaacaaaaggacgcggctccttgggaagcgtgtttgtgcagccaggcaccgcgccgggcccttggcgctggagacgtttggggacgcaacacatggagaaagccacccgtctcttggcctcccagcagcaatttgtgctggcggcagcaggcagcccttcggacctcacctagcggcgtctcctcccctttttcattaatttttttcctgcgaggggggaagcagcgaaggaactgacagcctcctgaggacggtaaatgtgatatctcaattgcacgaagagcccaaactgtccccggctgccacggcgccgatcagcccgagctttaataaccaggagagcccggcggcgctgggcaggggtgctgctgctccgttccatgggttatttccatatcatttgcaaagcgcggccccacgggttgctctacccgcgtcccttgatgaggcaggaggtttgcgagggtgaaaatggatttcacttccgactttgttgtttctttaattgttctgagggaatgagacacaattaagcacttcctatagcaaacgccgggaatatatagatattatatatacagtatatatttttcagttacttataatctaaaacagcactgccagtttaaacagctagtacaggcaagcgagcagaaaacctattttcagtgagatttttttaaggcttttttttttttaagttatgcacttataaggtgttttctgtgtattcattttataaagtgcttgtgtaatttatgtggaaacgagaaataaaagataaaaaaaaaaagaag

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