LOCUS       NM_171826               2194 bp    mRNA    linear   ROD 28-APR-2025
DEFINITION  Mus musculus claudin domain containing 1 (Cldnd1), transcript
            variant 1, mRNA.
ACCESSION   NM_171826
VERSION     NM_171826.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Ohnishi,M., Ochiai,H., Matsuoka,K., Akagi,M., Nakayama,Y.,
            Shima,A., Uda,A., Matsuoka,H., Kamishikiryo,J., Michihara,A. and
            Inoue,A.
  TITLE     Claudin domain containing 1 contributing to endothelial cell
            adhesion decreases in presence of cerebellar hemorrhage
  JOURNAL   J Neurosci Res 95 (10), 2051-2058 (2017)
   PUBMED   28244141
  REMARK    GeneRIF: suggest that the transient decrease of CLDND1 after
            cerebellar hemorrhage is responsible for low-molecular-weight
            selective vascular hyperpermeability
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Mineta,K., Yamamoto,Y., Yamazaki,Y., Tanaka,H., Tada,Y., Saito,K.,
            Tamura,A., Igarashi,M., Endo,T., Takeuchi,K. and Tsukita,S.
  TITLE     Predicted expansion of the claudin multigene family
  JOURNAL   FEBS Lett 585 (4), 606-612 (2011)
   PUBMED   21276448
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122667.1, CA750661.1, BC055695.1 and AV368951.1.
            
            On Nov 14, 2011 this sequence version replaced NM_171826.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3304593.1, CA750661.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               BY122667.1         2-162
            162-948             CA750661.1         5-791
            949-2187            BC055695.1         706-1944
            2188-2194           AV368951.1         242-248
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 34.83 cM"
     gene            1..2194
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="claudin domain containing 1"
                     /db_xref="GeneID:224250"
                     /db_xref="MGI:MGI:2447860"
     exon            1..175
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            176..226
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            227..536
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1006
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     claudin domain-containing protein 1; claudin 25"
                     /codon_start=1
                     /product="claudin domain-containing protein 1 isoform 1"
                     /protein_id="NP_741968.1"
                     /db_xref="CCDS:CCDS28234.1"
                     /db_xref="GeneID:224250"
                     /db_xref="MGI:MGI:2447860"
                     /translation="

MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYRSPIQENSSDSNKIAWEDFLGDEADEKTYNDVLFRYNGSLGLWRRCITIPKNTHWYAPPERTESFDVVTKCMSFTLNEQFMEKYVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLCACICRSLYPTLATGILHLLAGLCTLGSVSCYVAGIELLHQKVELPKDVSGEFGWSFCLACVSAPLQFMAAALFIWAAHTNRKEYTLMKAYRVA"

     misc_feature    257..319
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQX5.1);
                     transmembrane region"
     misc_feature    293..946
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    368..370
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q9CQX5.1); glycosylation site"
     misc_feature    458..460
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9CQX5.1); glycosylation site"
     misc_feature    665..727
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQX5.1);
                     transmembrane region"
     misc_feature    767..829
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQX5.1);
                     transmembrane region"
     misc_feature    890..952
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CQX5.1);
                     transmembrane region"
     exon            537..647
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            648..785
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     exon            786..2194
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2167..2172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="Cldnd1"
                     /gene_synonym="1110019C08Rik; claudin-25; Cldn25"
                     /note="major polyA site"
ORIGIN      

aaggcccctcggcccagggccgctttggcccggcctggggtggaggtggaggcggaggcgcgggagttatggagggggcgggctctgcagggaagtacgtcagaggaggcgcggggagagtagggtgctgtggtcggagctggagggcgaagccggtggagtgagaggatgggcgtatgcaggtgatagactagagaacaagacttctgtctccgtagcatcttggagcagtctgaatgccagaatggataaccgttttgctactgcgtttgtgattgcttgtgtgcttagtctgatttccaccatctacatggcggcctccataggcacggacttctggtatgagtatcgaagtcccattcaagagaattcaagtgactcgaataaaatcgcctgggaagatttcctcggtgacgaggcggatgagaagacttacaacgatgttctgttccgatacaacggcagcttggggctgtggagacggtgcatcaccatacccaaaaacactcactggtatgcgccaccggaaaggacagagtcatttgatgtggttaccaaatgcatgagtttcacactaaacgagcagttcatggagaagtatgtggaccccggcaaccacaatagcggcatcgacctgcttcgcacctacctgtggcgctgccagttccttttacccttcgtcagcttgggcttgatgtgctttggggcgttgattggcctctgtgcctgtatctgccgcagcctgtatcccaccctcgccactggcattctccatctccttgcaggtctgtgcacactgggctccgtgagttgctatgttgccggcattgaactcttacatcagaaagtagagctgcccaaggatgtatctggagaatttggatggtccttctgcctggcctgcgtctcggctcccttacagttcatggcggccgctctcttcatctgggctgcccacaccaaccggaaagagtacaccttaatgaaggcttatcgtgtggcatgaagggaggctgcctgcttaatgattaatatttttcatacattttttttaactattgaggttttcccttgtcttcctctcagtcgtctttaatttttatttttgtggatatgccattgtattctaaaagccccttttatttatatacagtgccactaaataccatttaaaatgtgtgtggttttcactgagtgacttagtctttttttaccacactgatctaggttcagagttcagacagaaagaactgtagagatgtgacccaagtttgtaaaagaatattagcagtggcaaattgacccaaaacagggtctgctaacgtctgctcagtccagtagtgcagtaactatgaaactagaaatgaatttctgtatgatatctgttatcactgtcagacttcatctttactttcctgttgttgctagcagaaccagcgttcctcaagatgtgtgcacataaaattgggaaatgagctaacatgtgtccctaaactttggtacattactttatttgaggtgaaatatggcagctgtttatactgtgattgtctacaagaaaaaaaaaagtgaaaaatgatgtttacttgaaattgtgcttttaatttcacttcagtgaggaaagttgactaattgtactacactatacctgtttgttttttttttaaactgaaactcatcaggattttcagtgccaccaaaccattgtggatttttgctgctcccctcccccctcccccccacaccaggcttattaaagagtactttctttttaacagagtgagagaagagtcacagccaattcctcaacttctttgttctagctgagtactatatgggaggtcctaccaatatcgaccccccagaactgggggtactaccaccacaagatctaaagctgtagctgccacctactaacctccatttatgggtctttatttcttgtggtgaaatgatgtgcctttccttgcccaaatcccttcctggtgtgtatcaacattacttaatgtcttctaattcagtcatttttttataatatgtcttctgtaaacattgaacttaaaaatcttatttatttactccattattgtagcatttcacagattcaaaaaagtgtaactcagtaatttcttaccaaatcctaaatctgtcttttttaaaaaaataaataaaaaagagaatcatgtagagtgtc

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