LOCUS       NM_145998               2870 bp    mRNA    linear   ROD 25-DEC-2022
DEFINITION  Mus musculus H6 homeobox 2 (Hmx2), transcript variant 1, mRNA.
ACCESSION   NM_145998
VERSION     NM_145998.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Kim DW, Washington PW, Wang ZQ, Lin SH, Sun C, Ismail BT, Wang H,
            Jiang L and Blackshaw S.
  TITLE     The cellular and molecular landscape of hypothalamic patterning and
            differentiation from embryonic to late postnatal development
  JOURNAL   Nat Commun 11 (1), 4360 (2020)
   PUBMED   32868762
  REMARK    Erratum:[Nat Commun. 2022 Jan 11;13(1):332. PMID: 35017490]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Lee B, Kim J, An T, Kim S, Patel EM, Raber J, Lee SK, Lee S and Lee
            JW.
  TITLE     Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and
            AgRP-neurons
  JOURNAL   Nat Commun 9 (1), 2026 (2018)
   PUBMED   29795232
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C,
            Hjerling-Leffler J, Sundstrom E, Pachnis V and Marklund U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Espinosa-Medina I, Saha O, Boismoreau F, Chettouh Z, Rossi F,
            Richardson WD and Brunet JF.
  TITLE     The sacral autonomic outflow is sympathetic
  JOURNAL   Science 354 (6314), 893-897 (2016)
   PUBMED   27856909
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Lee B, Lee S, Lee SK and Lee JW.
  TITLE     The LIM-homeobox transcription factor Isl1 plays crucial roles in
            the development of multiple arcuate nucleus neurons
  JOURNAL   Development 143 (20), 3763-3773 (2016)
   PUBMED   27578785
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Hadrys T, Braun T, Rinkwitz-Brandt S, Arnold HH and Bober E.
  TITLE     Nkx5-1 controls semicircular canal formation in the mouse inner ear
  JOURNAL   Development 125 (1), 33-39 (1998)
   PUBMED   9389661
REFERENCE   7  (bases 1 to 2870)
  AUTHORS   Rinkwitz-Brandt S, Arnold HH and Bober E.
  TITLE     Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes
            during mouse inner ear development
  JOURNAL   Hear Res 99 (1-2), 129-138 (1996)
   PUBMED   8970821
REFERENCE   8  (bases 1 to 2870)
  AUTHORS   Rinkwitz-Brandt S, Justus M, Oldenettel I, Arnold HH and Bober E.
  TITLE     Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeobox
            genes during brain and ear development
  JOURNAL   Mech Dev 52 (2-3), 371-381 (1995)
   PUBMED   8541222
REFERENCE   9  (bases 1 to 2870)
  AUTHORS   Stadler HS, Murray JC, Leysens NJ, Goodfellow PJ and Solursh M.
  TITLE     Phylogenetic conservation and physical mapping of members of the H6
            homeobox gene family
  JOURNAL   Mamm Genome 6 (6), 383-388 (1995)
   PUBMED   7647458
REFERENCE   10 (bases 1 to 2870)
  AUTHORS   Bober E, Baum C, Braun T and Arnold HH.
  TITLE     A novel NK-related mouse homeobox gene: expression in central and
            peripheral nervous structures during embryonic development
  JOURNAL   Dev Biol 162 (1), 288-303 (1994)
   PUBMED   7510254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138228.1 and AC159994.7.
            
            On Feb 8, 2019 this sequence version replaced NM_145998.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053014.1, AK138228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1438              AK138228.1         233-1670
            1439-2870           AC159994.7         106180-107611
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 74.34 cM"
     gene            1..2870
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="H6 homeobox 2"
                     /db_xref="GeneID:15372"
                     /db_xref="MGI:MGI:107159"
     exon            1..282
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..836
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="NK-related homeobox; homeobox protein Nkx-5.2; H6
                     homeo box 2"
                     /codon_start=1
                     /product="homeobox protein HMX2"
                     /protein_id="NP_666110.1"
                     /db_xref="CCDS:CCDS21918.1"
                     /db_xref="GeneID:15372"
                     /db_xref="MGI:MGI:107159"
                     /translation="

MGSKEDVGKGCPAAGGVSSFTIQSILGGGPSEAPREPAGWPARKRSLSVSSEEEEPEEGWKAPACFCPDPHGPKEPSPKHHTPIPFPCLGTPKGSGGAGPAASERTPFLSPSHPDFKEEKERLLPAGSPSPGPERPRDGGAERQTGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQVKTWFQNRRNKWKRQLSAELEAANMAHASAQTLVGMPLVFRDSSLLRVPVPRSLAFPAPLYYPSSNLSALPLYNLYNKLDY"

     misc_feature    15..476
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="propagated from UniProtKB/Swiss-Prot (P43687.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(462..476,480..482,531..533,549..551,588..590,
                     594..599,606..611,615..623,627..632)
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    468..629
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(468..470,477..479,597..599,606..611,618..620)
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            283..2870
                     /gene="Hmx2"
                     /gene_synonym="Nkx-5.2; Nkx5-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cttatgaacccaggatgggcagcaaggaagatgtggggaagggatgtccggcggccggtggcgtctccagcttcaccatccagtccatcctgggcgggggcccctccgaggcaccgcgggagcccgccgggtggccagccaggaaacgcagcctgtctgtgtcctcggaggaggaggagccggaggaaggttggaaggctccggcttgcttctgcccagatccgcacggccccaaggagccaagccctaagcaccatacccccatccctttcccttgcctgggtacccccaagggcagcggaggcgcagggcctgcggcctcggagcgcacgccattcctttctccttctcacccggactttaaggaagagaaggagaggcttttgccggcgggctcgccttctccgggcccggagcggccacgggacggcggtgcggagcgccaaaccggagcggccaagaagaagacgcgcaccgtcttctcccgcagccaagtgtaccagctcgagtctaccttcgacatgaaacgctacctgagcagctcggagcgcgcttgcctcgcctccagcctgcagctcaccgagacccaggttaagacttggttccagaatcgccgcaacaagtggaagcggcagctctcagccgagcttgaggcagccaacatggcacacgcgtcggcgcagactctcgtgggcatgccgctcgtgtttcgggacagttcgctgctgcgagtgccggtgccgcgctctctggccttcccggctccgctttattacccgagcagcaatctctcggccttaccgctctacaacctgtacaacaagcttgactactgacatgctcgcccgccggctcccgggacgcccctggtcgcctgcagctgcctgcatagcccggcgcggtcgggatccttcgcagagctccggagcagagcggcgcgtgtccagaaatattaagaaatacaccatgtgtattcgttatgtcttatttatggcctctttcctaccttttgttttgttttgttttattttgttttgttttgttttgagtatttatctgcattcctcacgccagagcacctgctttctacacaaaaccaaacaactcgcgtttgaaactattttggaaggggaggctctcgggtggtggtgggaagtggggttttgattaggtcggttttgaccagtagcaagaaaaaaaaaaaaacatcagaaaaaccaccaacagaaccaggcagtctttctcccatatatacacctgtatatagaaaatgtggtaggacacaagctcagccgagccgaaccaactagggctttggtcgttgaactaatcacttctctttattcccttcatcttgaggatgggtaggggcaaaacgaggagagtacagatctgtaaatatttttaaagagaaaaaaataaaacgttttaaacatggttgctaactttggagggatggattgtcccaggagacagcggcagaggagtttctggatttttttttttttttttgccagagcatgcaggattctgtctcctccctcagcccccaaggttctgctctcaccacgtgtgggtggggctgggctcagaggttaaaggtcgggatattggggctgcccaggcagcacgtgactggggctgcttacaggaacagcacagttcccacgacccaggtgtgcgggttggggtgcactcgagatggaatccagatccacagccccgcgcagcgaaagacaaagccaggagcctggctgctgacccggtcgcctctgggaatgagccaagcaaggaggtgaacatctccccgatactgggctgttttgggctagacgaaagctgggcacgccgcgaaaggccggagctcttggcgttcttggcgtcctcctgcgcggagtaaaacgtggggtgagagaaagcgtccgcttgggttccagagccacaggcgactggcttgcagccctcgcaggggtctcccgctggtgacacagttgcgagagttctgcgcagagcgggaagtgatgcctaagggtcagatttcgttggagggattcgtggagcagatgacacgggcgcttccctagtttctttttgtagttgttaaatttgcccgtgaatgacaaaaaggtcggatcactggctaacttgcagcagctgtttctgaattgagcactgaggattgcagtgcccggctgcctgcctccatgcagggttagggaggctctgcacccggagaactgcttcgtcaggatcatgcaaatcacagcactgtattttctctacgttttcatagcatccacctgttccttgttaaatgtcagaaatgggcctggagcttggaggaggcctcaggtagagttattaggtccagcccgcctcccctcagtggttgatcagggtgcaaagagctaggagtctgcagcgccaaggccctatctatttctttcttcagaagaaaacctggtgcctgagggaccggtctctttgagccaagggggcatcgaaatgacttgcattttgtagaaattcacagaatgtaaacgtttacatggcccatatcattccgtgaaatatgcctggcagaagagatttgctctgatattgcctatttttttcttaacacattatattttataaaacctgcaactcctcctaggtgacattagatggatgctacacaagaatgcaccgggcaatactaggttggtttgcttacatttgttttattttagctgtgttcacctcaataagtatttgttgaggtctcaacatgtgctaagaacctacactaaatttggggtggtccaaaggagaacacaaagaggcctatcagttctcttcttacttattaaatatgtgttttcaattgc

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