LOCUS       NM_131637               1976 bp    mRNA    linear   VRT 05-AUG-2023
DEFINITION  Danio rerio claudin 7b (cldn7b), mRNA.
ACCESSION   NM_131637
VERSION     NM_131637.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Garcia-Concejo A and Larhammar D.
  TITLE     Protein kinase C family evolution in jawed vertebrates
  JOURNAL   Dev Biol 479, 77-90 (2021)
   PUBMED   34329618
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Zhang FL, Yang YL, Zhang Z, Yao YY, Xia R, Gao CC, Du DD, Hu J, Ran
            C, Liu Z and Zhou ZG.
  TITLE     Surface-Displayed Amuc_1100 From Akkermansia muciniphila on
            Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal
            Health in High-Fat-Fed Zebrafish
  JOURNAL   Front Nutr 8, 726108 (2021)
   PUBMED   34722607
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Phatak M, Kulkarni S, Miles LB, Anjum N, Dworkin S and Sonawane M.
  TITLE     Grhl3 promotes retention of epidermal cells under endocytic stress
            to maintain epidermal architecture in zebrafish
  JOURNAL   PLoS Genet 17 (9), e1009823 (2021)
   PUBMED   34570762
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Solis CJ, Hamilton MK, Caruffo M, Garcia-Lopez JP, Navarrete P,
            Guillemin K and Feijoo CG.
  TITLE     Intestinal Inflammation Induced by Soybean Meal Ingestion Increases
            Intestinal Permeability and Neutrophil Turnover Independently of
            Microbiota in Zebrafish
  JOURNAL   Front Immunol 11, 1330 (2020)
   PUBMED   32793187
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Jin M, Wang D, Xu W, Wang H and Cao Y.
  TITLE     Claudin-7b and Claudin-h are required for controlling cilia
            morphogenesis in the zebrafish kidney
  JOURNAL   Mech Dev 161, 103595 (2020)
   PUBMED   31887432
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Gallardo VE, Liang J, Behra M, Elkahloun A, Villablanca EJ, Russo
            V, Allende ML and Burgess SM.
  TITLE     Molecular dissection of the migrating posterior lateral line
            primordium during early development in zebrafish
  JOURNAL   BMC Dev Biol 10, 120 (2010)
   PUBMED   21144052
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Clelland ES and Kelly SP.
  TITLE     Tight junction proteins in zebrafish ovarian follicles: stage
            specific mRNA abundance and response to 17beta-estradiol, human
            chorionic gonadotropin, and maturation inducing hormone
  JOURNAL   Gen Comp Endocrinol 168 (3), 388-400 (2010)
   PUBMED   20553723
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Davey C, Tallafuss A and Washbourne P.
  TITLE     Differential expression of neuroligin genes in the nervous system
            of zebrafish
  JOURNAL   Dev Dyn 239 (2), 703-714 (2010)
   PUBMED   20063411
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Reischauer S, Levesque MP, Nusslein-Volhard C and Sonawane M.
  TITLE     Lgl2 executes its function as a tumor suppressor by regulating ErbB
            signaling in the zebrafish epidermis
  JOURNAL   PLoS Genet 5 (11), e1000720 (2009)
   PUBMED   19911055
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Loh YH, Christoffels A, Brenner S, Hunziker W and Venkatesh B.
  TITLE     Extensive expansion of the claudin gene family in the teleost fish,
            Fugu rubripes
  JOURNAL   Genome Res 14 (7), 1248-1257 (2004)
   PUBMED   15197168
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX005027.13.
            
            On Jul 27, 2023 this sequence version replaced NM_131637.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066408.1, GDQH01004522.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168448, SAMEA4476729
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               BX005027.13        51719-52121
            404-568             BX005027.13        54059-54223
            569-653             BX005027.13        54487-54571
            654-1976            BX005027.13        55957-57279
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1976
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="claudin 7b"
                     /db_xref="GeneID:60635"
                     /db_xref="ZFIN:ZDB-GENE-001103-5"
     exon            1..403
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    163..165
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="upstream in-frame stop codon"
     CDS             181..828
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="claudin-like protein ZF4A22; claudin-7"
                     /codon_start=1
                     /product="claudin-7-B"
                     /protein_id="NP_571712.1"
                     /db_xref="GeneID:60635"
                     /db_xref="ZFIN:ZDB-GENE-001103-5"
                     /translation="

MAHKGLQLLGFTLSLLGLIGLIIGTIMPQWKMSAYVGDNIITAIAMYQGLWMSCAYQSTGQQQCKVYDSVLQLDSALQATRALMVVAILLTVAGLGVASMGMKCTNCGGDDKVKKSRIAMTGGIILSVGALCSIVACGWFTSQIIRDFYNPFTPVNTKYEFGAAIFIAWAGAFLDIMGGGMLASSCSKGQSSPNYPKSSRPVKSSRPPSSSKEYV"

     misc_feature    190..726
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; pfam00822"
                     /db_xref="CDD:395662"
     misc_feature    202..264
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    424..486
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    532..594
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    667..729
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     transmembrane region"
     misc_feature    736..825
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9YH92.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            404..568
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     exon            569..653
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
     exon            654..1976
                     /gene="cldn7b"
                     /gene_synonym="cb388; claudin7; cldn7; fd19f08;
                     wu:fd19f08"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgcggcttcggtgaacaggtgtttgagtcagggcttctccgatttttatttacattttaaacgtattttttttattattttgaccgattcataatcggaaggctgctgaaagcgagcgatatttggacactattaggttatttgctaagcaggtttagtttttaaactcattctgagaagatggcacataaaggactgcaactcctagggtttactctatcgttgctagggttgattgggctcattattggcacaatcatgccccagtggaagatgtctgcttacgttggagataatataatcacagctattgcgatgtaccagggcctttggatgtcgtgcgcttaccagagcaccggccaacagcaatgcaaggtgtatgactccgtcctacaactcgacagtgctctccaggcaactcgtgcccttatggttgtagcaattcttcttacagtagctggactgggtgtggccagcatgggcatgaagtgtactaactgtggtggtgatgacaaggtcaaaaagtcccgcattgccatgacaggcggtataatcctctctgttggagccctctgtagcattgttgcctgtggctggtttacaagtcaaattatcagggatttctacaaccccttcacacctgtcaatacaaagtatgaatttggtgcagctattttcatcgcctgggctggtgcatttctcgatataatgggtggaggcatgttggcctcttcttgctcaaagggtcagtcatctcctaattaccctaagtcctccagacccgtcaagtcctccagaccacccagcagcagcaaggaatatgtttgagccatttgttcacgacctggaaaggacatgatcaatcccagagtatgggtagaagtttgccctgtcagctgatatgagatctgtttaatttggtttgtatgtttgactatagatagaaaaaacagctcagaaaggtatttttggccaacttttacttgtgttctgatacagcagcccaccaaaaatggtcacttctttcttttggttagctccttgttccaccttccccacccccgattataaaatgtgagtttgcaaaggggcttcttccccagagtcttcctcatttcagattactgtcacctttagtgaacatgaaagagggagacctgctcagggaaaaatcattactcatactgctctgttacaccaaatctctgcttccagctgttaaacccttgcttgcatcattttaggaactgcgccagacactgaggtgcttatgaacaattaatacatgcattacatttttaaagctaagagtaacatgcaaataacctggttcactttgcagcattttccctgtctggtccccatgccagcagaaactcttttcatacttcattttatacaaattagcaccctttaagtaaagtttcactcgtaaattcaatgaatcattcttttcagtgtatgctgatgaagctggattaaaactttagatggaaaaatgaagattaatttggtttggatgaggcttaacatgaagcactaaaatcaaattgctctttcttatgcaacttgaaccttttgatttgctgttgtcctttgttttgagtgtacaccttggtttttgtgcccatttaggaaggtaacatgttttttgtttttatacactccattaattggtcacaaaaaagctgtgaatattggcttagttgaatcactgctggttccaactatttttatgttactgtaaaacttttttttatccataatatgaacatttaaaactggactatacttttttttttttattttgctttggtctgtgcttgaaccatttgatgtgggttgcactcaagtctacttaggatagagtcacgtgaatgtctgtgactagcttatgcaaatatttaactttttaaaatgtttttgacttcaagtttgcaattgaaaaattttatgtaaataaattttttaaacag

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