LOCUS       NM_013601               2162 bp    mRNA    linear   ROD 14-NOV-2025
DEFINITION  Mus musculus msh homeobox 2 (Msx2), mRNA.
ACCESSION   NM_013601
VERSION     NM_013601.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2162)
  AUTHORS   Patel,R. and Mackem,S.
  TITLE     Dual Bmp-negative feedback loops modulate function of both AER and
            ZPA to buffer and constrain postaxial digit number
  JOURNAL   Proc Natl Acad Sci U S A 122 (39), e2427249122 (2025)
   PUBMED   40986357
REFERENCE   2  (bases 1 to 2162)
  AUTHORS   Adhikari,N., Wu,Z., Huang,Y., Lan,Y. and Jiang,R.
  TITLE     Twist1 Acts Upstream of the Dlx5-Hand2 Pathway to Pattern the
            Mammalian Jaw
  JOURNAL   J Dent Res 104 (3), 310-319 (2025)
   PUBMED   39707586
REFERENCE   3  (bases 1 to 2162)
  AUTHORS   Palacio,V., Pancho,A., Morabito,A., Malkmus,J., He,Z., Soussi,G.,
            Zeller,R., Treutlein,B. and Zuniga,A.
  TITLE     Single-cell profiling of penta- and tetradactyl mouse limb buds
            identifies mesenchymal progenitors controlling digit numbers and
            identities
  JOURNAL   Nat Commun 16 (1), 1226 (2025)
   PUBMED   39890843
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2162)
  AUTHORS   Gupta,I., Yeung,J., Rahimi-Balaei,M., Wu,S.R. and Goldowitz,D.
  TITLE     Msx genes delineate a novel molecular map of the developing
            cerebellar neuroepithelium
  JOURNAL   Front Mol Neurosci 17, 1356544 (2024)
   PUBMED   38742226
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2162)
  AUTHORS   Padmanabhan,A., de Soysa,T.Y., Pelonero,A., Sapp,V., Shah,P.P.,
            Wang,Q., Li,L., Lee,C.Y., Sadagopan,N., Nishino,T., Ye,L., Yang,R.,
            Karnay,A., Poleshko,A., Bolar,N., Linares-Saldana,R., Ranade,S.S.,
            Alexanian,M., Morton,S.U., Jain,M., Haldar,S.M., Srivastava,D. and
            Jain,R.
  TITLE     A genome-wide CRISPR screen identifies BRD4 as a regulator of
            cardiomyocyte differentiation
  JOURNAL   Nat Cardiovasc Res 3 (3), 317-331 (2024)
   PUBMED   39196112
REFERENCE   6  (bases 1 to 2162)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2162)
  AUTHORS   MacKenzie,A., Ferguson,M.W. and Sharpe,P.T.
  TITLE     Expression patterns of the homeobox gene, Hox-8, in the mouse
            embryo suggest a role in specifying tooth initiation and shape
  JOURNAL   Development 115 (2), 403-420 (1992)
   PUBMED   1358591
REFERENCE   8  (bases 1 to 2162)
  AUTHORS   Davidson,D.R., Crawley,A., Hill,R.E. and Tickle,C.
  TITLE     Position-dependent expression of two related homeobox genes in
            developing vertebrate limbs
  JOURNAL   Nature 352 (6334), 429-431 (1991)
   PUBMED   1677742
REFERENCE   9  (bases 1 to 2162)
  AUTHORS   Monaghan,A.P., Davidson,D.R., Sime,C., Graham,E., Baldock,R.,
            Bhattacharya,S.S. and Hill,R.E.
  TITLE     The Msh-like homeobox genes define domains in the developing
            vertebrate eye
  JOURNAL   Development 112 (4), 1053-1061 (1991)
   PUBMED   1682128
REFERENCE   10 (bases 1 to 2162)
  AUTHORS   Holland,P.W.
  TITLE     Cloning and evolutionary analysis of msh-like homeobox genes from
            mouse, zebrafish and ascidian
  JOURNAL   Gene 98 (2), 253-257 (1991)
   PUBMED   1673109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133846.1 and AV230604.1.
            
            On Sep 14, 2006 this sequence version replaced NM_013601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133846.1, X59252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1478              AK133846.1         3-1480
            1479-2159           AK133846.1         1482-2162
            2160-2162           AV230604.1         160-162
FEATURES             Location/Qualifiers
     source          1..2162
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.84 cM"
     gene            1..2162
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="msh homeobox 2"
                     /db_xref="GeneID:17702"
                     /db_xref="MGI:MGI:97169"
     exon            1..449
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    20..22
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="upstream in-frame stop codon"
     CDS             71..874
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="homeobox protein Hox-8-1; homeo box, msh-like 2;
                     homeobox, msh-like 2"
                     /codon_start=1
                     /product="homeobox protein MSX-2"
                     /protein_id="NP_038629.2"
                     /db_xref="CCDS:CCDS26522.1"
                     /db_xref="GeneID:17702"
                     /db_xref="MGI:MGI:97169"
                     /translation="

MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPAVPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS"

     misc_feature    71..196
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03358.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    380..466
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03358.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    497..667
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            450..2162
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1130..1135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="hexamer: AATAAA"
     polyA_site      1157
                     /gene="Msx2"
                     /gene_synonym="Hox-8; Hox8; Hox8.1"
                     /note="major polyA site"
ORIGIN      

aaaagttggagtcttcgcttgagagttgccagcggagtcgcgcgccgacagctacgcggcgcagaaagtcatggcttctccgactaaaggcggtgacttgttttcgtcggatgaggagggccccgcggtactggccggcccgggtcccgggcctggaggagccgagggcagcgcagaggaacgcagggtcaaggtctccagcctgcccttcagcgtggaggcgctcatgtccgacaagaagccgcccaaggaatcgcccgcggtgccacccgactgcgcctcggctggcgctgtcctgcggccgctgctgctgccgggacacggcgtccgggacgctcacagtcccgggcctctcgtcaagcccttcgagaccgcctcggtcaagtcggaaaattccgaagacggagcaccgtggatacaggagcccggcagatactccccgccgcccagacatatgagccccaccacctgcaccctgaggaaacacaagaccaaccggaagccacgcacacccttcaccacatcccagcttctagccttggagcgcaagttccgccagaaacagtacctgtccatagcagagcgggccgagttctccagctctctgaaccttacagagacccaggtcaaaatctggttccagaaccgaagggctaaggcgaaaagactgcaagaggcggaactggaaaagctgaaaatggctgccaagcctatgctgccctcaggcttcagtctgcccttccctatcaactcacccctgcaagcagcatccatatacggcgcatcctaccccttccatagacctgtgctccccatcccgcctgttggactctatgccacgccggttggatatggcatgtaccatctatcctaaggaagaccagatggaccagactccaggatggatgtttgcataaaagcatccccctccctctccgagaaggtggtgccaactctgctcctgaatgcgagccttgcattgtcaccctaagcgacagggccacttgatacagagtgaatttgttatttaggtgagaggcactaagacctgttttgttttcataattttccaaatgccccctttcctctcacaaatattggctctgctagtttttatgtataaatatataataaaatataagactttttatatgccagatgtaaaaattcaagttattttaaaaggcaaaatttatatatacatttatccattttctttttttttctagatagcatcttcctaagatattgtgttaagtccatttgctacattttcttaaagggaaagagattaattgcagaatttgcaaggatggtggacttgcttatggaaaacatagcagaagtagacacattccatacaggatgtcacttcagacagattcttgcaagtgaagggggaggtgtaacgtgtttatttgcatttctgtgcacaagaaaaagaaatctcttgatgcacatttgatcctattttttttctctttttctccattccatattattaaatctttgttgttgttttaagatcgatgaaaagaggatgagaataactctgagagttactcagggtaaagtagaaaataggaaactccatgtcaggtccctggagtgagagggggttagaaggtgaaatattgtttgtaagaattgatttctatgaaatgctatctacatcagtcctcacacggtacagaggtgattggaagaggacatggtaaatctcttcttaaaaatgagtgtcttataactgtggcctatattttaaatattcttcaacagtccatagaatgaggaaggaaaacatgccttctctctctctctctctctctctctctctctctctctctctctctctagctctctctgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtactttgtgtgctaaacttcttagggaaatttatatactctaacgtgttgggcagatggagaagccatgtgcttgagttgctggagatggcgttgtcagtcagcacctgggtgtctcaccttcctgtccatctcttcccccagtatatttttatcccgttgaatgggtatcttgtataattttatatattttattgaagagttatttcttatctcttactctgaattaaattaaaatattttattgcagt

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