LOCUS       NM_001190393            2517 bp    mRNA    linear   VRT 02-APR-2025
DEFINITION  Xenopus laevis transient receptor potential cation channel,
            subfamily V, member 1 S homeolog (trpv1.S), mRNA.
ACCESSION   NM_001190393
VERSION     NM_001190393.1
KEYWORDS    RefSeq.
SOURCE      Xenopus laevis (African clawed frog)
  ORGANISM  Xenopus laevis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Xenopus.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Saito,S., Ohkita,M., Saito,C.T., Takahashi,K., Tominaga,M. and
            Ohta,T.
  TITLE     Evolution of Heat Sensors Drove Shifts in Thermosensation between
            Xenopus Species Adapted to Different Thermal Niches
  JOURNAL   J Biol Chem 291 (21), 11446-11459 (2016)
   PUBMED   27022021
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Rivera-Acevedo,R.E., Pless,S.A., Schwarz,S.K. and Ahern,C.A.
  TITLE     Extracellular quaternary ammonium blockade of transient receptor
            potential vanilloid subtype 1 channels expressed in Xenopus laevis
            oocytes
  JOURNAL   Mol Pharmacol 82 (6), 1129-1135 (2012)
   PUBMED   22956771
  REMARK    GeneRIF: Lidocaine inhibits TRPV1 channels expressed in Xenopus
            laevis oocytes.
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Bohlen,C.J., Priel,A., Zhou,S., King,D., Siemens,J. and Julius,D.
  TITLE     A bivalent tarantula toxin activates the capsaicin receptor, TRPV1,
            by targeting the outer pore domain
  JOURNAL   Cell 141 (5), 834-845 (2010)
   PUBMED   20510930
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from HM015002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM015002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04111061, SAMN04111065
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Xenopus laevis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8355"
                     /chromosome="2S"
                     /map="2S"
     gene            1..2517
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="transient receptor potential cation channel,
                     subfamily V, member 1 S homeolog"
                     /db_xref="GeneID:100462763"
                     /db_xref="Xenbase:XB-GENE-6492384"
     CDS             1..2517
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="transient receptor potential vanilloid 1a"
                     /codon_start=1
                     /product="transient receptor potential cation channel,
                     subfamily V, member 1 S homeolog"
                     /protein_id="NP_001177322.1"
                     /db_xref="GeneID:100462763"
                     /db_xref="Xenbase:XB-GENE-6492384"
                     /translation="

MKKMGSSTDIDETEETCASIETDESHSDDTNRSAQENRKKLKFCQAKYSIFSSPKPKGRRFGKTETDRDMAPMDSVYQIESKVISPAIKFHRNLERGKLCNQLVRQSTSLESTSSCKDRTFKLYDQRRIFDAAAYGDCEELDDLLVYLLRTHKRLTNEEFKEKETGKTCLLKAMLNLDKGMNHTILLFLEIAEKTDNLKEFINSAYRDNYYRGQTALHIAIERRNMDLVQLLLQHGADVHARADGEFFRKAKGKAGFYFGELPLSLAACTNQTAIVRYLLQNQHSPANIAARDSFGNTVLHALVDIADNTQENTAFVTKMYNEILVLGAQIKPSLKIEEIANKKGLTPLSLAAKTGKIGVFAYILRREIKNLECRHLSRKFTEWAYGPVHSSLYDLSGVDTYEKNSVLEIIAYSSETPNRHDMLLVEPLNKLLQDKWDHFVKRIFYFNFFAYIIYVIIFTIAAYYRPVDGSPPFPVQYGSYLRTSGELITVIGGIYFFFRAIQYFTQRRPSLKALLADSYCEFLFFSQSVFLLLSTVLYFCGRNEYVAFLVICLAMSWANVLYYTRGFQLMGIYSVMIEKLILSDMVRFLFVYLLFLFGFAAALVTLIEDGEGRTDVNNTCGRRCCKPEPASYNNLYYTCQELFKFAIGMGDLEFTDNYKYKPVFIFLLITYVILTYILLLNMLIALMGETVSKVAQESKSIWKLQRAITILDIEKSFLNSFRDTFRSGKSVLVGITPDGKEDYRWCFRVDEVNWNKWNSNLGIIKEDPGNCHGFKSTLSASFRPRGRRWRSLVPHIKEINLGNENETVPEEVPLQIQPALSVQTVKEEDQEVTSKAE"

     misc_feature    358..2298
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="Transient Receptor Potential channel, Vanilloid
                     subfamily (TRPV), type 1; Region: TRPV1; cd22196"
                     /db_xref="CDD:411980"
     misc_feature    496..624
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(634..636,640..642,652..657,664..672,676..681,
                     691..693,700..702,727..729,775..777,781..783,793..798,
                     805..813,817..822,832..834,841..843,877..879,883..885,
                     889..891,901..906,913..921)
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    634..729
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    775..879
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(1387..1392,1396..1398,1630..1635,1639..1644,
                     1651..1656,1660..1665,1672..1677,1684..1686,1720..1722,
                     1729..1734,1741..1746,1909..1911,1921..1923,1930..1935,
                     1942..1944,1948..1950,2041..2043,2053..2055,2062..2064,
                     2074..2079)
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="tetramer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411980"
     misc_feature    order(1630..1632,1909..1914,1972..1992)
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /note="toxin binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:411980"
     exon            1..314
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..484
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..637
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..778
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1077
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1254
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1413
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1503
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1574
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1740
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1807
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..2118
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2246
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2359
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2517
                     /gene="trpv1.S"
                     /gene_synonym="trpv1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgaagaaaatgggcagttccaccgatatcgatgaaaccgaagagacttgtgcttcgattgaaaccgacgaatcccacagtgatgacaccaatcgcagtgcacaggagaacaggaagaagctaaagttttgccaggccaagtattccatctttagctcccccaaaccaaaaggccgtcgctttgggaagacagagacggatcgggatatggctcctatggactctgtgtaccagatagaaagtaaagtcatatctccagccattaagtttcatcgcaatttggaaagaggaaaactatgcaatcagctggtgaggcaaagtacatctttggaatctaccagcagctgtaaggacagaacgtttaaactgtatgaccagagaaggatttttgatgcggctgcctatggggactgtgaagaacttgatgatctcctggtttatctgctgaggacacataaacggctcaccaatgaagagtttaaagagaaagagacggggaaaacctgcctgctgaaagccatgctgaatttagataaagggatgaaccacacaatcctattatttctggaaattgcagaaaagacggataatttaaaagaattcatcaattctgcttatagagacaactactacagaggtcagacagccctgcacattgccatcgaaagaaggaatatggatctggttcagcttttgttgcaacacggcgctgatgtccatgccagggcagatggggaattcttcagaaaagccaaaggaaaggctggtttctattttggggagctgcctctgtccctagcagcgtgcaccaatcagacagcgatagtccgatacctcctgcagaaccagcactctccagccaatattgctgccagagactcatttggaaacacagttcttcatgccctggtagacattgccgacaacactcaggagaacacggcatttgtgactaaaatgtacaatgagatcctggtgctgggtgctcagattaagccttcactgaagatagaggagattgcaaataaaaaaggactcacccctttgtccttagctgcaaaaactggcaagattggggtttttgcctatattctgaggagagagattaagaatttagagtgcagacatctctctcgaaaattcacagaatgggcatatgggccggtccattcctccctctatgatctgtcaggagtagacacctatgagaagaactctgtccttgaaatcattgcctacagcagtgagacgccgaatcgccatgacatgctattggtggagcctcttaacaaactgttacaagataaatgggaccactttgttaagcgcatattctactttaacttcttcgcgtacatcatatatgttatcatctttactatagctgcctactacagacctgtcgatggaagtcctccattcccagtacaatatggcagctatctccgcacctctggcgagttaatcacagtcattggaggaatctatttctttttcagagctatccagtactttacacagagacgaccgtccttgaaggctttgcttgctgacagctactgtgaatttctgttcttttcccagtctgtcttcctcctgttatccaccgtactatacttctgtggaaggaatgaatatgtagctttcttggtgatctgtttagcaatgagctgggccaatgtgctgtactacaccaggggcttccagctgatgggcatttattctgttatgattgagaagttaattctgagcgacatggtccggttcctgtttgtctaccttttgtttctttttgggtttgctgcagctctggtgaccctcattgaagatggagagggcagaacagacgtgaataatacatgcgggcggcgctgctgcaaacccgaacctgcctcctacaacaacctctactacacctgccaggaactctttaagtttgccattggaatgggagatctggaatttacagacaactacaaatacaagcccgtgttcatctttctgctcattacctatgttattttaacatacattctcctgcttaatatgttaatagccctgatgggggaaacagtaagcaaggttgctcaggaaagtaaaagtatctggaaactgcagagagcaattaccatactggacattgagaaaagctttctgaactccttcagagacacattcagatcaggaaaatcggtccttgtaggaattacacccgacggcaaggaggattacagatggtgctttagagtcgatgaagtgaactggaacaaatggaactcaaacttgggtataatcaaggaggaccctgggaactgtcatggatttaaaagcaccctcagtgcgtcattccgacctagagggagaaggtggaggtcgttggtccctcacataaaagaaataaatttgggaaatgaaaatgagacagttccggaggaagttccgttacagatacaacctgctttgtcagttcagacggtgaaagaagaagatcaggaggtgacatccaaggctgagtga

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