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2020-04-06 10:21:44, GGRNA.v2 : RefSeq release 99 (Mar, 2020)

LOCUS       NM_001177326            1228 bp    mRNA    linear   ROD 25-DEC-2019
DEFINITION  Rattus norvegicus homeobox C8 (Hoxc8), mRNA.
ACCESSION   NM_001177326
VERSION     NM_001177326.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1228)
  AUTHORS   Vermot J, Schuhbaur B, Le Mouellic H, McCaffery P, Garnier JM,
            Hentsch D, Brulet P, Niederreither K, Chambon P, Dolle P and Le
            Roux I.
  TITLE     Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine
            brachial spinal cord for the specification of Lim1+ motoneurons and
            the correct distribution of Islet1+ motoneurons
  JOURNAL   Development 132 (7), 1611-1621 (2005)
   PUBMED   15753214
REFERENCE   2  (bases 1 to 1228)
  AUTHORS   Bayarsaihan D, Bitchevaia N, Enkhmandakh B, Tussie-Luna MI, Leckman
            JF, Roy A and Ruddle F.
  TITLE     Expression of BEN, a member of TFII-I family of transcription
            factors, during mouse pre- and postimplantation development
  JOURNAL   Gene Expr. Patterns 3 (5), 579-589 (2003)
   PUBMED   12971990
REFERENCE   3  (bases 1 to 1228)
  AUTHORS   Nauta AJ, Daha MR, Tijsma O, van de Water B, Tedesco F and Roos A.
  TITLE     The membrane attack complex of complement induces caspase
            activation and apoptosis
  JOURNAL   Eur. J. Immunol. 32 (3), 783-792 (2002)
   PUBMED   11870622
REFERENCE   4  (bases 1 to 1228)
  AUTHORS   van den Akker E, Fromental-Ramain C, de Graaff W, Le Mouellic H,
            Brulet P, Chambon P and Deschamps J.
  TITLE     Axial skeletal patterning in mice lacking all paralogous group 8
            Hox genes
  JOURNAL   Development 128 (10), 1911-1921 (2001)
   PUBMED   11311170
REFERENCE   5  (bases 1 to 1228)
  AUTHORS   Schnabel CA and Abate-Shen C.
  TITLE     Repression by HoxA7 is mediated by the homeodomain and the
            modulatory action of its N-terminal-arm residues
  JOURNAL   Mol. Cell. Biol. 16 (6), 2678-2688 (1996)
   PUBMED   8649375
REFERENCE   6  (bases 1 to 1228)
  AUTHORS   Sakoyama Y, Mizuta I, Ogasawara N and Yoshikawa H.
  TITLE     Cloning of rat homeobox genes
  JOURNAL   Biochem. Genet. 32 (9-10), 351-360 (1994)
   PUBMED   7702549
REFERENCE   7  (bases 1 to 1228)
  AUTHORS   Pellerin I, Schnabel C, Catron KM and Abate C.
  TITLE     Hox proteins have different affinities for a consensus DNA site
            that correlate with the positions of their genes on the hox cluster
  JOURNAL   Mol. Cell. Biol. 14 (7), 4532-4545 (1994)
   PUBMED   7911971
REFERENCE   8  (bases 1 to 1228)
  AUTHORS   Chung SY, Dai PH, Lei J, Riviere M, Levan G, Szpirer J and Szpirer
            C.
  TITLE     Chromosomal assignment of seven rat homeobox genes to rat
            chromosomes 3, 4, 7, and 10
  JOURNAL   Mamm. Genome 4 (9), 537-540 (1993)
   PUBMED   7906969
REFERENCE   9  (bases 1 to 1228)
  AUTHORS   Falzon M and Chung SY.
  TITLE     The expression of rat homeobox-containing genes is developmentally
            regulated and tissue specific
  JOURNAL   Development 103 (3), 601-610 (1988)
   PUBMED   2907739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AABR07058935.1.
            On Oct 20, 2010 this sequence version replaced NM_001177326.1.
            
            Summary: mouse homolog is a homeobox transcription factor; involved
            in controling bone formation [RGD, Feb 2006].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2689597,
                              SAMEA2689601 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               AABR07058935.1     10061-10496
            437-1228            AABR07058935.1     11837-12628
FEATURES             Location/Qualifiers
     source          1..1228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1228
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /note="homeobox C8"
                     /db_xref="GeneID:24460"
                     /db_xref="RGD:2821"
     CDS             1..729
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /note="homeobox protein R4; Homeobox gene C8; homeo box
                     C8"
                     /codon_start=1
                     /product="homeobox protein Hox-C8"
                     /protein_id="NP_001170797.2"
                     /db_xref="GeneID:24460"
                     /db_xref="RGD:2821"
                     /translation="
MSSYFVNPLFSKYKGGESLEPAYYDCRFPQSVGRSHALVYGPGGSAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGAQQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARDEEKVEEEGNEEEEKEEEEKEENKD"
     misc_feature    order(448..462,466..468,517..519,535..537,574..576,
                     580..585,592..597,601..609,613..618)
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(454..456,463..465,583..585,592..597,604..606)
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    457..618
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:333795"
     exon            1..436
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /inference="alignment:Splign:2.0.8"
     exon            437..1228
                     /gene="Hoxc8"
                     /gene_synonym="Hox3r4"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
atgagctcctacttcgtcaaccccctgttctccaaatacaaaggcggcgagtccctggaaccggcctattacgactgccggttccctcagagcgtgggcagaagccatgcgctggtgtacgggcccggcggctcagcgcccggcttccagcacgcctcgcaccacgtccaagacttcttccaccacggcacctccggcatctccaactcgggctaccagcagaacccgtgctcgctgagctgccacggagacgcctccaaattctatggctacgaggcgctccccagacagtccctttatggggctcagcaagaggcgagcgtggtgcaatatcccgactgtaaatcctccgccaacactaacagtagcgaaggacaaggccacttaaatcagaactcgtctcccagcctcatgtttccatggatgagaccccacgctcctgggcggcgcagcggacgacaaacttacagccggtatcagaccttggaactagagaaggagtttctctttaatccttatttgaccagaaagcgccggattgaagtctctcacgccctgggactgacggaaagacaagtgaagatttggttccagaatcgaaggatgaagtggaaaaaggagaacaacaaggataaacttcctggggcccgagatgaggagaaggtggaagaagaagggaatgaggaagaggagaaggaggaggaggaaaaggaagaaaataaggactaagaaaaaagagaaaatcagccccccccacaactcccttgaagtttcgttttatggtagcagataaattgagaagtttacgactgtcatttgcttttatagagaatagaatgacactcacaactgtaactacctgtcagatagttgcagctctgcttttattacctttggccttcccccactctttatttgtctgggggttgggagggggaacctgagacacagggaaaagttctgttccactccatgcccagcacacactcacttgtccctacttccacttctgagcccttcccgataaagcctaaccctacacacacacacacacacacacacacacacacacacacacacaccacacacacttctctccacactctttacacgattctctggtatttattttaaaagggattcccctgaagatgtagaagatgattcctggctttgcttgtatgctgggaattagaatactggattgacttttttttttaaatgaaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]