LOCUS       NM_001091502            3564 bp    mRNA    linear   VRT 24-JUN-2020
DEFINITION  Xenopus laevis NRDE-2, necessary for RNA interference, domain
            containing L homeolog (nrde2.L), mRNA.
ACCESSION   NM_001091502
VERSION     NM_001091502.1
KEYWORDS    RefSeq.
SOURCE      Xenopus laevis (African clawed frog)
  ORGANISM  Xenopus laevis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Xenopus.
REFERENCE   1  (bases 1 to 3564)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev. Dyn. 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070786.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070786.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00012418, SAMD00012419
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3564
                     /organism="Xenopus laevis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8355"
                     /chromosome="8L"
     gene            1..3564
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /note="NRDE-2, necessary for RNA interference, domain
                     containing L homeolog"
                     /db_xref="GeneID:432030"
                     /db_xref="Xenbase:XB-GENE-960405"
     exon            1..73
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     misc_feature    4..6
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /note="upstream in-frame stop codon"
     CDS             13..3417
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /codon_start=1
                     /product="NRDE-2, necessary for RNA interference, domain
                     containing L homeolog"
                     /protein_id="NP_001084971.1"
                     /db_xref="GeneID:432030"
                     /db_xref="Xenbase:XB-GENE-960405"
                     /translation="

MALFPAFADSSSSEKHPTRQELDWLSNKSFCTEDALSLHQRTLQSALSPQPASHSPSRSPLQPGLSEESGTDSRSTKKKKKKKKKKQKKKHKKKRDYEEDEEGNTSDSDSSPEIRESTATERVARQDTCVVLPGRGIWLDEAQSVTEETFRIDKKSDPANWEYKSLYRGDIARYKRKGNSCLGINPKKQQIIWQDTLSKKKQPQRKIERYFTKSTVQLLRAKADFVSCKESASRNAGDFIPVLDPDMDGVVSSSGPISWVNPLGVYDSSTALWLEGKGGPEYETIQPVPRDNNILAKVEDYNKRLRECPSDIQLWMEFVSFQDELVKQPSMYSTSKGELESHRTSVKLLLEKKLAILERSIESNPGSTELKLAKLKLCEEFWEAPALLKEWQKLIFLHPNDSQLWQKYLLFCQGQFSTFSVSKMNGVYGKCLSTLAAVQDGSMLSHNALPDTDRQMYDIFLQQCQFLRQAGHTEKAISLFQALTDFTFYKPDTVKHMTTKEQVDFFEPFWDSGEPRFGEKGAKGWSSWMRQQERGGWVTINNLVGDDEDEADEEFNIKDKTCPRYKIWLDIEYSREARHWLPWHPDPTKKQTEDDCEDPERQVLFDDIGPSMFKIDSPQLQFQLLQSFLHFVGVPCGAHLSLYCFYLFLDETSIFDHVSPYERLLTSFEIPLSGIGTVGHLDTISRSRQQIGHFKEGETFIQNIFQSALSLLQGEEKRKLSVWWLRYEISKVVWWLQAKNKKKLKSQGKRSKRLAKGLLKESSNRNSLALWKEYALLEWLLGNIDDARKVFDTAISLAGSKGLKDQELCSLCLLYSELEGKILDNPEQNAGSRAVHILTSLTESSPYIPYSSPEHAVSILKARKVYEHALQDCLMQEPHWGRVSLSGCFALFQYLTVSVDAAVAVLRQAADSQLIPETPYNIERNSDCPLQAITLMHTNLLRHHYKASVYPLRPLRETLMSALKLYPTNVSLWKSYIMTESKLHNASKVRRFIDSIRRVTSALEPCLFAIRAEEDRRKLVDSVQRAELGEVHSIFPETGLSNRIKALFEHALQSEYGSRCPLLWRQYLYFMVSIKERSKGLFYKAIQSCPWAKALYLDAVEYFPEQLQETIDLMTEKELRVRVPLEELDLLLED"

     misc_feature    457..744
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /note="MTR4-interacting domain (MID) found in nuclear
                     exosome regulator NRDE2 and similar proteins; Region:
                     NRDE2_MID; cd22200"
                     /db_xref="CDD:412062"
     misc_feature    order(457..483,490..495,505..510,514..516,520..564,
                     571..579,583..591,613..621,631..636,640..645,652..672,
                     694..705,715..744)
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /note="MTR4 binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:412062"
     misc_feature    913..1911
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /note="necessary for RNA interference; Region: NRDE-2;
                     pfam08424"
                     /db_xref="CDD:462472"
     exon            74..182
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            183..386
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            387..530
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            531..978
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            979..1384
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            1385..1518
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            1519..1642
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            1643..1818
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            1819..2205
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            2206..3086
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            3087..3225
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            3226..3291
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
     exon            3292..3542
                     /gene="nrde2.L"
                     /gene_synonym="c14orf102; nrde2"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      

ggttgagaagcaatggcactgtttccagcctttgcagactctagttctagtgagaaacatccaacacgccaagagttggactggctgagcaacaagagcttctgcacagaagatgccctatcactacatcagcgcactttacagtctgcactctctcctcagcctgcatcccactcacccagcaggagtccgttacagccaggattgtcagaggaaagtggaacagattctcggtcaacaaagaagaagaaaaagaagaaaaaaaagaaacagaaaaaaaagcacaagaaaaagagggattatgaggaggatgaagaagggaatacaagtgactctgactcaagtcctgagataagggaatctacagccactgaaagggtagcaaggcaggacacttgtgttgtgctccctggccgtggtatatggctagatgaagcacagtctgtgacagaggagacatttcgaattgataagaaatctgaccctgccaactgggaatataagtcactgtaccgaggagacatagcacgctacaaacgtaaaggaaattcctgtcttggcattaacccaaagaagcagcaaattatttggcaggatacattatctaagaagaaacagcctcagaggaaaattgagcgctattttaccaagagcacagtgcagcttctcagagccaaagcagattttgtgtcttgtaaagaaagtgcaagtcggaatgcaggggactttattcccgtcttggatcctgatatggatggtgttgtttcctccagtggccccattagttgggtgaatcctttgggagtttatgattcttctacagctctgtggttggaaggaaaagggggcccagaatatgaaaccatacagccagtaccccgggacaacaatattttagcaaaggtggaggattataataagcggctcagagaatgtccgagcgatatccagctatggatggagtttgtctctttccaggatgagctggtgaagcagcctagcatgtattctactagcaaaggagagcttgaaagccatcggacatctgtgaagttgttactggaaaagaaactagccatactagagagatccattgagagtaatccgggcagcactgaattgaagcttgcaaagctaaaactgtgtgaggaattctgggaggcacctgctcttctgaaggaatggcagaaactgatcttcttgcacccaaatgactcgcagctgtggcagaaatacctactcttctgccaggggcagtttagcactttctctgtgtccaagatgaatggtgtttatggcaaatgcctaagcaccctggcagcagttcaggatggcagtatgctttcccacaatgctctgccagacacagatcgccaaatgtatgatattttcctgcaacagtgccagtttttacgccaggctggacacaccgagaaagcaatatctttgttccaggccctgacagacttcacattttataaaccggacactgttaagcacatgacaaccaaagagcaggttgacttttttgagcctttttgggacagtggggaacctcgttttggtgagaaaggagcaaagggatggagctcctggatgcgtcaacaggagagagggggctgggtcaccattaacaacttggtgggggatgatgaagatgaagcagatgaagagttcaacataaaagacaaaacctgccccagatacaagatttggttggacattgaatactcacgggaagccagacactggttgccatggcatccagacccaactaaaaagcagacagaggacgactgtgaggacccagaaaggcaggtgctctttgatgacattggtccatcaatgttcaagattgacagtcctcaactgcagttccaactgttacagtctttcctgcactttgtgggggtcccctgtggggcacacctttccttatactgcttttatctttttcttgacgagacctccatctttgatcatgtttctccatatgaaaggctgcttacttcatttgaaatccctctgtccggaatcggaacagttggtcatttagacacaataagcagaagcagacagcaaataggacactttaaagaaggtgaaaccttcatacaaaacatcttccagtcagctctgtcacttttacaaggagaagagaaaaggaagctctctgtctggtggcttcggtatgaaatttcgaaggttgtttggtggctgcaagcaaaaaacaagaaaaagttgaaatctcagggcaagaggagtaagcgattggcaaagggtctactaaaggaatcatctaacagaaacagtctggcactctggaaagaatatgccctactggaatggcttctgggcaatattgatgatgcccgaaaggtgtttgatacagccataagcttagcaggaagcaaagggttaaaggaccaggaattatgcagtctgtgcctgctgtattcagaactggaagggaagatactggacaatccagagcaaaatgcagggtcccgtgctgttcatatactaaccagccttacagaaagctccccttacatcccctatagtagccctgagcatgctgttagtattcttaaagcacgcaaggtatacgaacacgctttgcaggactgcctgatgcaagagccacactgggggcgtgtgagcttatctggctgctttgcactttttcagtatcttacggtgagtgttgatgctgctgttgcagtattaagacaggctgctgactcacagttgattcctgaaacaccgtacaatattgaacggaactccgactgccccttgcaagcaatcacattgatgcacacaaatctgctcaggcaccattataaggccagtgtctatcctctgaggccacttagagaaacactgatgtctgccttaaagctgtatcccacaaatgtttctttgtggaaatcctacatcatgacagaaagtaaattacacaatgccagcaaagtgagacggtttatagacagcatcaggagagtgacatcagctctggaaccatgtctgtttgccattagggccgaggaagacagaagaaaactggtagactctgtgcaacgggcagaactaggggaggttcactccattttccctgaaactggtttgtcaaatcgaatcaaggccctgtttgaacatgctcttcaaagtgaatatggttccagatgccctctactctggagacagtacttgtactttatggtatctatcaaggagagaagcaaaggcctgttctacaaagcaatacagagctgcccatgggcaaaggcactgtatctggatgctgtagaatatttcccagagcagctacaagagaccattgatctaatgactgaaaaggagttgagagtacgagttcccctagaggaattggatcttctgctggaagattaaacaatggaacgattgaaatgtttctgtttgggttacatctataatgcaacaaacgtgtacaatacattttatataatatgtatatttttaagaaaaaaaacaataaaatgtgtccacaccctccaaaaaaaaaaaaaaaaaaaaaaa

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