LOCUS       NM_001085757            1417 bp    mRNA    linear   VRT 19-DEC-2022
DEFINITION  Xenopus laevis H6 family homeobox 3 L homeolog (hmx3.L), mRNA.
ACCESSION   NM_001085757
VERSION     NM_001085757.1
KEYWORDS    RefSeq.
SOURCE      Xenopus laevis (African clawed frog)
  ORGANISM  Xenopus laevis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Xenopus.
REFERENCE   1  (bases 1 to 1417)
  AUTHORS   Bayramov AV, Martynova NY, Eroshkin FM, Ermakova GV and Zaraisky
            AG.
  TITLE     The homeodomain-containing transcription factor X-nkx-5.1 inhibits
            expression of the homeobox gene Xanf-1 during the Xenopus laevis
            forebrain development
  JOURNAL   Mech Dev 121 (12), 1425-1441 (2004)
   PUBMED   15511636
  REMARK    GeneRIF: a role of stage-specific inhibitor of Xanf-1 in the
            anterior neural plate during the Xenopus development
REFERENCE   2  (bases 1 to 1417)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF368235.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF368235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04111048, SAMN04111051
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1417
                     /organism="Xenopus laevis"
                     /mol_type="mRNA"
                     /db_xref="taxon:8355"
                     /chromosome="7L"
                     /map="7L"
     gene            1..1417
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="H6 family homeobox 3 L homeolog"
                     /db_xref="GeneID:373845"
                     /db_xref="Xenbase:XB-GENE-865014"
     misc_feature    212..214
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="upstream in-frame stop codon"
     CDS             233..1153
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="Nkx-5.1 homeodomain protein; X-nkx-5.1; homeobox
                     protein Nkx-5.1; homeobox protein H6 family member 3"
                     /codon_start=1
                     /product="homeobox protein HMX3"
                     /protein_id="NP_001079226.1"
                     /db_xref="GeneID:373845"
                     /db_xref="Xenbase:XB-GENE-865014"
                     /translation="

MPETGQESSNPPAKESPFSIKSLLTCEPSRAARPPKALFTPIKGALDGAAFAFSPLTDFTFPRLEIPTQRFALPAHYLERSPGWWYSYTLAHGGHTPRTEVPDKSLLLGPTSPVSGGERDSPDPIHPLKTELGAKESESKSPEEIILEESDPEEGKKDDSGEDWKKREDSPDKKPCRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSSSAESASSAANVPVSQPLLTFPHPVYYSHPVVTSVPLLRPV"

     misc_feature    515..775
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8JJ64.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(767..781,785..787,836..838,854..856,893..895,
                     899..904,911..916,920..928,932..937)
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    773..934
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="Homeobox domain; Region: Homeobox; pfam00046"
                     /db_xref="CDD:425441"
     misc_feature    order(773..775,782..784,902..904,911..916,923..925)
                     /gene="hmx3.L"
                     /gene_synonym="hmx3; nkx-5.1; nkx-5.1-A; nkx5-1; nkx5.1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
ORIGIN      

gcccagttgctatcagactccccagtctgcaggtagtcactgctcttccctggttgcctgttggcctgctgcttttgtctggccccacaaatgttggcttaggaatcctaggagcactcgcctggtttttctcctctttctctctccttccatcccaggattcttggggggatcccctgcaagggtctgacaccctccatctggttaatgctaagatctgccccgagctatcatgcccgagacaggacaggagagcagcaaccctccggccaaggagtcccccttctctatcaaaagccttctcacctgtgagcccagcagggcggcccgaccccccaaggctctcttcacccccattaaaggggccctggacggagcagcgtttgccttctccccgctgacagatttcaccttccctcggctagagatcccgactcaaaggttcgccctcccggctcattatttggagagatccccgggctggtggtattcttataccttggcacacggagggcacacgccgaggactgaagtgccagacaagagccttctgctgggccccacatctccagtgtctgggggcgagagggactcgcctgatccaatacatcccctcaaaacagagttgggggccaaggagagcgagtccaaaagcccggaggagattatcctggaggaaagtgatcctgaggaaggcaaaaaagacgacagcggggaggactggaagaaaagggaggacagcccggacaagaagccctgtaggaagaagaagacccggacagtgttctccaggagtcaggtcttccagctggagtccacctttgacatgaagagatacctgagcagctcagagagggcaggcttagcggcctccctgcacctcacagagacccaagtaaagatttggttccagaaccgcaggaacaagtggaaaaggcaactggccgcagaactggaggctgccaacttgagccacgcagccgcccagcgcatagtcagggtgcccatcttgtaccacgaaaactcatccagcgcagagagtgctagctctgcagccaacgtgcccgtcagccagcccctcctgacttttccccacccagtctattactcccaccccgtggtcacatcagtacctttgctcaggccagtgtgagatctgctattcctcctcattggcaccgggcacaagggtaagggggagccctccgtccaatccccaggacactcccgaagtgtttgtaagtactgaagactggcagaccccaggctacagggcgggggcagagtagatccaaaaaaaaaaaaggacacgaaataaaatgaataaaaatacagattttctgtttttgtaaaaataaaaacgcgcagattttgtgactctaaaaacattcaaaactggggtgacgttcgatttgcc

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