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2020-03-31 05:01:13, GGRNA.v2 : RefSeq release 99 (Mar, 2020)

LOCUS       NM_001008514            1626 bp    mRNA    linear   ROD 03-FEB-2020
DEFINITION  Rattus norvegicus claudin 19 (Cldn19), mRNA.
ACCESSION   NM_001008514 XM_216519
VERSION     NM_001008514.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Ziemens A, Sonntag SR, Wulfmeyer VC, Edemir B, Bleich M and
            Himmerkus N.
  TITLE     Claudin 19 Is Regulated by Extracellular Osmolality in Rat Kidney
            Inner Medullary Collecting Duct Cells
  JOURNAL   Int J Mol Sci 20 (18), E4401 (2019)
   PUBMED   31500238
  REMARK    GeneRIF: Results suggest that claudin-19 is part of the collecting
            duct tight junction (TJ) complex. Its presence in the TJ is under
            the control of ambient interstitial tonicity. Under iso-osmotic
            conditions, it is responsible for a high electrical transepithelial
            resistance and contributes to the tonicity-induced changes in
            paracellular ion selectivity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA and
            Rizzolo LJ.
  TITLE     Claudin-3 and claudin-19 partially restore native phenotype to
            ARPE-19 cells via effects on tight junctions and gene expression
  JOURNAL   Exp. Eye Res. 151, 179-189 (2016)
   PUBMED   27593915
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Hu B, Arpag S, Zhang X, Mobius W, Werner H, Sosinsky G, Ellisman M,
            Zhang Y, Hamilton A, Chernoff J and Li J.
  TITLE     Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP
  JOURNAL   PLoS Genet. 12 (9), e1006290 (2016)
   PUBMED   27583434
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A,
            Tsukita S and Fujiyoshi Y.
  TITLE     Tight junctions. Structural insight into tight junction disassembly
            by Clostridium perfringens enterotoxin
  JOURNAL   Science 347 (6223), 775-778 (2015)
   PUBMED   25678664
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig
            IE.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim. Biophys. Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Lee NP, Tong MK, Leung PP, Chan VW, Leung S, Tam PC, Chan KW, Lee
            KF, Yeung WS and Luk JM.
  TITLE     Kidney claudin-19: localization in distal tubules and collecting
            ducts and dysregulation in polycystic renal disease
  JOURNAL   FEBS Lett. 580 (3), 923-931 (2006)
   PUBMED   16427635
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Miyamoto T, Morita K, Takemoto D, Takeuchi K, Kitano Y, Miyakawa T,
            Nakayama K, Okamura Y, Sasaki H, Miyachi Y, Furuse M and Tsukita S.
  TITLE     Tight junctions in Schwann cells of peripheral myelinated axons: a
            lesson from claudin-19-deficient mice
  JOURNAL   J. Cell Biol. 169 (3), 527-538 (2005)
   PUBMED   15883201
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079172.1.
            On Dec 16, 2004 this sequence version replaced XM_216519.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079172.1, EX488559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2689597, SAMN00632251
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1626
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="claudin 19"
                     /db_xref="GeneID:298487"
                     /db_xref="RGD:1305000"
     exon            1..307
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.0.8"
     misc_feature    22..24
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="upstream in-frame stop codon"
     CDS             85..720
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /codon_start=1
                     /product="claudin-19"
                     /protein_id="NP_001008514.1"
                     /db_xref="GeneID:298487"
                     /db_xref="RGD:1305000"
                     /translation="
MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKGRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAILGGSFLCCTCPEPERANSIPQPYRSGPSTAAREYV"
     misc_feature    94..630
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:304458"
     misc_feature    106..168
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     misc_feature    328..390
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     misc_feature    436..498
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     misc_feature    565..627
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     exon            308..472
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.0.8"
     exon            473..557
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.0.8"
     exon            558..1594
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.0.8"
ORIGIN      
ctgttcctcttaccatgaccatagcgctcctccagaccctggcccatctctgagtcctggaaccctcagactcctacctgggccatggccaactcaggcctccagctcctgggctacttcctagccttgggtggctgggtgggcatcatcgccagcaccgccctgccacagtggaagcagtcctcctatgcaggcgatgccatcatcactgccgtgggcctctacgaagggctgtggatgtcctgcgcctctcagagcaccgggcaggtgcaatgcaaactctacgattcactcctggccctggacggtcatatccagtcagcaagagccctgatggtggtggctgtgctcctgggctttgtggccatggtgctcagtgtcgtgggcatgaagtgtactcgggttggagacagtaaccccactgccaagggccgtgtggccatctccggaggtgctctcttcctcttggcgggtctctgtactttgactgctgtctcatggtacgctaccctggtgacccaggaattcttcaaccccagcactcctgtcaacgccaggtatgaatttggtccagctctgttcgtcggctgggcctctgctgggctggccatcctgggcggttcctttctctgctgcacatgcccagagcctgagagagccaacagcatcccgcagccctatcgctctggaccctcaacggctgcccgagagtacgtctgagtctgcctaccctgcccagccccattgcccagcagccccattgtccagaactcgtgccagactatatagtaccctgggcagggtagatggggtacggatcacttgaactcagtctggagctccaagcacctggtcctcagcataggctctgagtcccagactcagacagtcaaagagagatcagaggcaagaccccgcccacacgtgacccagtaaggaccaggcctgttctgtctacatcagaatgagtatcagaatttatacactagcttagctacaggctccttcgcttgccaacttatttgctgaaggacccatctgcctagtataggctgggccctgagggcttcccagcaacagaaggatctcagcgcacggtgctttgggtcagacagacttccatactccatccagttctcacagcaagcacatagaagaagtactctgggttaaggactgtctccacatcagacccaaggacactgaactttagagagacacggaggcgtggctctccaatctgtgagatcatgcctcagcctctggcagtcagttacccaacattgtttggatgcccatacaggtctcgagggcagactgtcactcccacccctaggaaggggccccaggcagggctgccatcagaatcctgctcctgggcctgaactctgcagcccccgtctctctcagccatcgctcaccccactaaccagctttctctcttttgacttgcagacccgttgttaagttgtccacctcggtcaagggccccctgggtgtgtaaaggccaggttcccagccaggccctgccccctaccatctctagactgtgtgtttgatatttctggaaagagaagcgaacattcagccccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]