LOCUS       NM_001003049            3299 bp    mRNA    linear   MAM 07-OCT-2024
DEFINITION  Canis lupus familiaris cone-rod homeobox (CRX), mRNA.
ACCESSION   NM_001003049
VERSION     NM_001003049.1
KEYWORDS    RefSeq.
SOURCE      Canis lupus familiaris (dog)
  ORGANISM  Canis lupus familiaris
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
            Canis.
REFERENCE   1  (bases 1 to 3299)
  AUTHORS   Akhmedov,N.B., Baldwin,V.J., Zangerl,B., Kijas,J.W., Hunter,L.,
            Minoofar,K.D., Mellersh,C., Ostrander,E.A., Acland,G.M.,
            Farber,D.B. and Aguirre,G.D.
  TITLE     Cloning and characterization of the canine photoreceptor specific
            cone-rod homeobox (CRX) gene and evaluation as a candidate for
            early onset photoreceptor diseases in the dog
  JOURNAL   Mol Vis 8, 79-84 (2002)
   PUBMED   11951083
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF454668.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF454668.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3299
                     /organism="Canis lupus familiaris"
                     /mol_type="mRNA"
                     /sub_species="familiaris"
                     /db_xref="taxon:9615"
                     /chromosome="1"
                     /map="1"
     gene            1..3299
                     /gene="CRX"
                     /note="cone-rod homeobox"
                     /db_xref="GeneID:403577"
                     /db_xref="VGNC:VGNC:39632"
     exon            1..67
                     /gene="CRX"
                     /inference="alignment:Splign:2.1.0"
     exon            68..202
                     /gene="CRX"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1002
                     /gene="CRX"
                     /note="photoreceptor-specific cone-rod homeobox protein;
                     crx gene for cone-rod homeobox protein"
                     /codon_start=1
                     /product="cone-rod homeobox protein"
                     /protein_id="NP_001003049.1"
                     /db_xref="GeneID:403577"
                     /db_xref="VGNC:VGNC:39632"
                     /translation="

MMAYMNPGPHYSVNALALSGPSVDLMHQAVSYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKEQPQPPGAQTKARPAKRKAGMSPRSSSDVCPDPLGISDSYSPPLLGPSGSPTTAVATVSIWSPASESPLPEAQRGGLVASGPPLTSTPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGTYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL"

     misc_feature    220..387
                     /gene="CRX"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    376..564
                     /gene="CRX"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8SQ03.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    592..849
                     /gene="CRX"
                     /note="Otx1 transcription factor; Region: TF_Otx;
                     pfam03529"
                     /db_xref="CDD:427350"
     misc_feature    808..873
                     /gene="CRX"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8SQ03.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            203..354
                     /gene="CRX"
                     /inference="alignment:Splign:2.1.0"
     exon            355..3289
                     /gene="CRX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccacctgaggactctgactccaaccaggtcctgggccaccaggagagcctgaccctgtttttggaaggcccgcagacctgggccacagtatccccaaagatcatgatggcgtatatgaacccggggccccactactcggtcaacgccttggccctcagcggtcccagcgtggatctgatgcaccaagctgtgtcctatccaagtgccccaagaaagcagcggcgggagcggaccaccttcacccggagccagctggaggagctagaggctctgttcgccaagactcaatacccggatgtgtatgctcgagaggaggtggctctgaagatcaacctacctgagtccagggttcaggtttggtttaagaaccgcagagctaaatgccggcagcagcgccagcagcagaaagagcagcctcagccccccggcgcacagaccaaggctcgtcctgccaagaggaaggcaggcatgtccccaagatcctcctccgacgtctgtccagaccccctaggcatctcagactcctacagcccccctctactcggcccctcaggctctcctaccacggccgtggccaccgtgtccatctggagtccagcctcagagtcccctttgcctgaggcccagcgcggagggctggtggcctcggggccacccctgacctccacaccctacgccatgacctacgcccctgcctctgctttctgctcctccccttcggcctacgggtctccgagctcctatttcagtggcctggatccctatctttcccccatggtgccccagttggggggcccagccctcagccccctttcaggcccctccgtgggaccctccctggcccagtcccccacttccctgtcaggccagagctatggcacctatagccccgtggacagcttggagtttaaggaccccacagggacctggaagttcacctacaaccccatggatcctctggactacaaagatcagagtgcctggaagtttcagatcttgtagaagatcctcttctgtatgtctctctgcatctcatctcaacccggcatccccaggaaagcagtggggctggccctccctccaaaagttgtggcctctctggcctcatgtgtggagtagcccaccacagtccacccccctctccccgggacagtctcctcactctccggggaagttcaatagatcttagtaaccctccacccagccccgcctcaccatggatgctggctgccattttaaccatgagccctggactccagaaactggtgctatgaatgtgctctgagatgaaattaaaccaaattcaagtagtcagtttaggggtcctggtcaggtcagaatcgagatgccctggaacagacaggtagggagactcaatgtcataccttccatttgggacacttccttagcatgtggctaggatccttctagaaaatccaaagatagttttaagaagccccaccatggcagcttaggtcagttgtacagttcaattaaaaaatccatttggcgattttacagatttcccaaatatcaagtttacatggtaggtttagggggctctttgatatatatttttttctttttagtttcttcttaaagacatttcgtcaggaatgcattcttttggactttgagagtggccatgtttggntttgttttaggattttctaaaggtggatttcaccccagcgctggaggaactgtggtagttgccactggggccaaccatggtagttggctccaacatagctgtgggtatatcaaaaaaaagaagaacaggaggtggcaggcttctcatttgtaaatatgcaagagacgaggttggcgggataagtggatttggaacaagccccacatttcaaaaatacagtccctctcttagattttgtttccattgcaggatgggaccagagagcgcagcctgatggagtggcaccatatttctttctgtgcgttgacccccagtgacagagacaagcactgagagacttttaagatggagtcaggcattttaacactcttggtagtttgatgctttggccttgcttgaattttttttttttttttttttttttttgtctttggccctgggaggcagtagccacgagcctttcactggtgggcttcacaaggtaaaaggaagtagggcaggaaggtggtggtgtgctggtatgtggtaaccattggctccctaaaagaagaggaaaaaccttgatttgtagtgattgccaatttctgtggtgtaaattatcccactatggctgatttcaaggcaccaagtctgtggtcatggcctcggagctggatgcatgccatctgtgctcatgggctggtaggaactggttccaggtcgccggtgtaggaagggatgtcaggaggcaggcacagtgtggagagaggctgggaggcctcagatggatttttctgggtccaggccagaagaggtccatatggactagaccccccaagaccctctgaaggggcacacggcggatcactggaatcctcaaggatggtttactcagcacaccacatgaccatgtctcatgggcctgagtcatactggcctctgggacattagacccaggagtgagtggctcagagtccagtgtgggacacaaaggataaacagaggaggacagtgcaggtgggggtggaagatagacgatccaagcagaatccgcagnngagggacagggaggaggtgacattgtgtaaaagttgggaccagatgcactgccattgattcattttgcagagactcccagagtctgtgctggaggnnggggtctcaggagtacataggaatttctctctgccccacggagctcccagagctctggttcacngnngagggtgtgtcttgtgaacacgaacaattcacaggcacgctgataagggggtccgggagagcatgaaggatggacgtcatgttctggaggagggtggaaggtgtagagcctggggggccacagtcacaggcccacaggctcagatgtcaggagacccctctcgctagggctggacagagcaagagggtgcatttgttcgggaggtcctggcttcctttcccggggccaacctcctgagctgtggggatgtcaaaggttctacttctttgagacaaaaagccaggacaagtgacaagagagagaaggaagcggccaggagcccccttcactctgtgttccctcccccactccttgagactccagtccccttccttccaggacaaccaccccccaccccaagcgaaaataattaaattgttgaatctcgctaaaaaaaaaaaaaaa

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