LOCUS       XM_066548500            3208 bp    mRNA    linear   VRT 17-JUL-2024
DEFINITION  PREDICTED: Molothrus aeneus argonaute RISC catalytic component 2
            (AGO2), mRNA.
ACCESSION   XM_066548500
VERSION     XM_066548500.1
DBLINK      BioProject: PRJNA1134154
KEYWORDS    RefSeq.
SOURCE      Molothrus aeneus (bronzed cowbird)
  ORGANISM  Molothrus aeneus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Australaves;
            Passeriformes; Passeroidea; Icteridae; Molothrus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_089646) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_037042795.1-RS_2024_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/12/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3208
                     /organism="Molothrus aeneus"
                     /mol_type="mRNA"
                     /isolate="106"
                     /db_xref="taxon:84833"
                     /chromosome="1"
                     /sex="female"
                     /tissue_type="brain"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Hidalgo County, Texas"
                     /collection_date="2016"
     gene            1..3208
                     /gene="AGO2"
                     /note="argonaute RISC catalytic component 2; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 37 Proteins"
                     /db_xref="GeneID:136555646"
     CDS             135..2726
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2"
                     /protein_id="XP_066404597.1"
                     /db_xref="GeneID:136555646"
                     /translation="

MYPGAPSAGPVLTPPPPLPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVAIKWMSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQENGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYTGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    420..644
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    672..824
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    825..1187
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(981..983,1026..1028,1068..1070,1080..1082,
                     1134..1136,1155..1157,1161..1163)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1320..2597
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1731..1733,1743..1745,1779..1790,1797..1799,
                     1821..1823,1830..1832,1842..1844,1854..1856)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1935..1937,1941..1943,2151..2153,2565..2567)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

tttccttccccctcccctttccttcctcctcctcctccccttcccccgacagcgtagccggggctcgggctcgctccctcccccgtgccctcccctggagccgccgccgcctccgccgccgcacacacggagacatgtacccgggagccccctccgccggacccgtgctcacacctcctcccccactgccaccaccaatacagggatatgcctttaaacctcctcctcgaccagattttggcacttctgggagaacaatcaaactgcaggccaacttctttgaaatggacattcctaaaatagatatctaccattatgaattggatataaagccagaaaaatgtcctagaagagttaacagagaaatagtggagcatatggttcagcactttaaaacccagatttttggggatcgcaaaccagtgtttgatggaagaaaaaacctttatacagctatgccacttcccattgggagagataaagtggagctggaggtcactctgccaggagaaggaaaggacagaatatttaaggtggccatcaagtggatgtcctgcgtgagcttgcaggctttgcacgatgctctctctggccggctgccgagcgtccccttcgagaccatccaggccctggatgtggtcatgaggcacttgccttccatgaggtatactcctgtggggagatctttctttacagcatcagaagggtgctcaaatcctttgggtggtggcagagaagtttggtttggcttccatcagtcagtcagaccttcattatggaaaatgatgctcaatattgatgtgtctgcaactgcattttacaaagcacagccagttattgagtttgtctgtgaagttctggacttcaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaataaaaggtctgaaggtggagataacgcactgtggacaaatgaaaaggaagtacagagtgtgcaatgtcaccagacgaccagcaagccaccaaacattcccacttcagcaggagaatggacaaacagttgaatgcactgtagctcagtattttaaggacaggcataaattagttttacgctaccctcaccttccatgtttacaagttggacaggagcagaaacacacataccttcctctagaggtgtgcaacatagtggcaggacaaagatgcatcaagaaactcactgacaatcaaacttccactatgattcgagccactgccagatcagccccggaccggcaggaagagatcagcaaattgatgcggagcgccagtttcaacacggacccttacgtgcgggagtttgggatcatggtcaaggatgaaatgacagatgtgactggcagagtccttcagcctccctccatcctctatggaggcaggaataaagcaattgctacaccagtgcaaggtgtctgggacatgaggaataaacaatttcacactggaattgaaataaaggtttgggcaattgcctgctttgctccccagcgccagtgcactgaagttcatcttaagtccttcacagagcagctgaggaagatttccagggatgctgggatgccaatccaggggcagccctgcttctgtaaatacgcccagggagccgatagcgtggagcccatgttcagacacctcaagaacacttacactgggctgcagctggtcgtggtcattttgccaggaaaaacaccagtctatgcggaggtgaagcgcgttggggacacagtgctgggaatggccactcagtgtgtgcagatgaaaaacgtccaaagaacaacaccacaaactctgtccaacctctgcttaaaaataaatgtcaaattaggaggtgtaaataacattctactgccacagggaagacccccagtattccaacagcctgtcatattccttggtgcagatgtaactcaccctccagctggggatgggaagaagccttccattgctgcagttgtaggaagcatggatgctcatcccaaccgttactgtgccacggtgcgggtgcagcagcaccgccaggaaatcatccaggacctggctgccatggtcagggagctgctgatccagttctacaaatcaaccaggttcaaaccaactcgaatcatcttctacagggatggtgtttctgaggggcagttccaacaggttctccaccacgagctgctggctatcagggaggcttgcattaaactggagaaggattatcagcctggcatcacatttatagtggtgcagaaaaggcaccacaccagactcttctgcacggataaaaacgaacgggtcggaaaaagtggaaacattccagctggtaccacagtggacacaaaaatcacccacccctcagagtttgacttctacctgtgcagtcatgctgggattcagggaacaagcagaccctctcactaccacgtgctgtgggatgacaatcgcttctcgtcggacgagctgcagatcctcacctaccagctgtgccacacctacgtgcgttgcacgcgctccgtctccatccctgcccccgcctactacgctcacctggtggccttcagagccaggtaccatctggtggataaggagcacgatagtgctgaaggaagccacacttctggccagagcaacggcagagaccaccaagcacttgctaaggcagtccaggtgcaccaggacacgctgcgcacgatgtactttgcttgacgtcttttaatgctcagcggctccggacaaggcagagttggattcacaccagaccagctgcacttagaccaacagatgccccagcccagggatggccagcaatgagtgatgcatctttattcctttctttcccatttgcaaggaagccttccatccagaatttcagacttgatcacaaactgcgttcttgtaccaaaccccactgttgtcggaaatgtggtttgccaaaaatctctgagctgcttggtataaaacagacccagattttataattaaatcaagagctgcaatctcagggcttagggaagaaaagcaaaaaaaccaaaccaacaacccaacccacaaaactcctcattcagtttgctgttcattgagttgcttttgataatttggaaagatctaattcttactaaggtttgatgagctaaaacgctgtgaatcagcttttagtacaaaggaaaggaaagcaaagcattttttga

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