LOCUS       XM_054555313           14597 bp    mRNA    linear   PRI 06-MAR-2024
DEFINITION  PREDICTED: Pongo abelii argonaute RISC catalytic component 3
            (AGO3), transcript variant X3, mRNA.
ACCESSION   XM_054555313
VERSION     XM_054555313.1
DBLINK      BioProject: PRJNA944618
KEYWORDS    RefSeq.
SOURCE      Pongo abelii (Sumatran orangutan)
  ORGANISM  Pongo abelii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pongo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_071985) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_028885655.2-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/27/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14597
                     /organism="Pongo abelii"
                     /mol_type="mRNA"
                     /isolate="AG06213"
                     /db_xref="taxon:9601"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="fibroblast"
     gene            1..14597
                     /gene="AGO3"
                     /note="argonaute RISC catalytic component 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 115 long SRA reads, 11 Proteins"
                     /db_xref="GeneID:100440265"
     CDS             95..2470
                     /gene="AGO3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X3"
                     /protein_id="XP_054411288.1"
                     /db_xref="GeneID:100440265"
                     /translation="

MVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    104..388
                     /gene="AGO3"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    416..568
                     /gene="AGO3"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    569..931
                     /gene="AGO3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(725..727,770..772,812..814,824..826,878..880,
                     899..901,905..907)
                     /gene="AGO3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1064..2341
                     /gene="AGO3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1475..1477,1487..1489,1523..1534,1541..1543,
                     1565..1567,1574..1576,1586..1588,1598..1600)
                     /gene="AGO3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1679..1681,1685..1687,1895..1897,2309..2311)
                     /gene="AGO3"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      14597
                     /gene="AGO3"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gtttgccagtgaagacacacagggattggaaagataggagaaccaggacaaagtagaagctatttcagagaaggcaagggaggtggttgactcaatggttcagcattttaaagtaactatatttggagaccgtagaccagtttatgatggaaaaagaagtctttacaccgccaatccacttcctgtggcaactacaggggtagatttagacgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcgatcaaatttgtctctcgggtgagttggcacctactgcatgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaaccctgtccatgccgttgatgtggtgctacgacatctgccctccatgaaatacacgcctgtggggcgttcatttttctccgctccagaaggatatgaccaccctctgggagggggcagggaagtgtggtttggattccatcagtctgttcggcctgccatgtggaaaatgatgcttaatattgatgtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgatattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtttgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaaggaggcctgccagtcatcaaacctttcctttacagttagaaaacggccaaactgtggagagaacagtagcgcagtatttcagagaaaagtatactcttcagctgaagtacccgcaccttccctgtctgcaagtcgggcaagagcagaaacacacctacctgcctctagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaggcgacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggctcatgtaactggacgcgtacttccagcacctatgctccagtatggaggacggaatcggacagtagcaacaccgagccacggagtatgggacatgcgagggaaacaattccacacaggagttgaaatcaaaatgtgggctatcgcttgttttgccacacagaggcagtgcagagaagaaatattgaagggtttcacagaccagctgcgtaagatttctaaggatgcagggatgcccatccagggccagccgtgcttctgcaaatatgcacagggggcagacagcgtagagcccatgttccggcatctcaagaacacatattctggcctacagctcattatcgtcatcctgccagggaagacaccagtgtatgcggaagtgaaacgtgtaggagacacacttttgggtatggctacacaatgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctctcaaacttgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagctgatgtcactcatccacctgctggtgatggaaagaagccttctattgctgctgttgtaggtagtatggatgcccacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgggaacttcttattcaattttataagtcaactcggttcaagcctactcgtatcatcttttatcgggatggtgtttcagaggggcagtttaggcaggtattatattatgaactactagcgattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagacattacacacccatatgagtttgatttttacctctgtagccatgctggaatacagggtaccagtcgtccttcacactatcatgttttatgggatgataactgcttcactgcagatgaacttcagctgctaacttaccagctctgccacacttacgtacgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtagcatttagagccagatatcatcttgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacaaagcaatgggcgagatccacaagctcttgccaaggctgtacaaattcaccaagataccttacgtacaatgtactttgcttaaatagtccaagtatattctctgagaggaagtactgaaagatgaattgacatacaacgtatgtttccagtggagtcaattgagtaaggacacctccagccatacagaaaccaacactgtgtgggggccaaggtctgatccttatgttaatacaaggaagattgtttacttcatcaaggaacacagcatcattatgcaatatgaaaccagccaactgctttttgtgcggtctcctataggaagtatcgcaattgttttgttttcatttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaagtaaagaaaaagtaaatgatggtttaaaaaatacacaccttcatgaataatcaaagtgatttttcaaaattatgtgtgcaaaaaattaatgtgcattcatatattcttgtaaaaggtgtctgtgtatttttaaaatatatacatccatacttcatatgcatatatatctagatctggattgataatagatatatatgtgtctgttatatattttagagttcattccattggggaactttctttcccttttattcaacccccactaccgcctttatttctctatttcccttgccttcatcacctacatttttttcctaatcctaccagtgacattcaaatgttgacgtatctggttcgtttgaatataaaatatggcaaactagatttctacttttattttgcataccctactcctgactcctatctcatacacaattctgagttctcaactcttgatattgctgtcttaagaaacaaaattttatatatatatgtatacatacatacacagacacataacacacacatatatatacataaaatgactttctgtgagagtgtgtctctcccctcctactcagaacatacatttaccatttgcgcaatttgtatataagcagtagcaacctgaactattctttttcttttttctttttctttttttttttatgagacagagtctcgctctgtcaccaggctggagtggagtggcgagatcttggctcactgcaacttccgcctctcgattttaaacaattctcctgcctcagcctcccgagtagctgggactacaggcatgtgccaccacacccagctaatttttgtatttttagtagagacggggtttcaccgtgttggccaggatggtctcgatctcttgaccttgtgatccacccgcctcaacctcccaaagtgctgggattacaggtgtgagccaccgcacccggcctactattctttttctttagtgagtttgttaaagctgctataaatataaaacctgtcagaagttgtaactctttctctctgataattgatgtgttttctgaagccttctgtttctatgagttatacatggaaattctttaaaggttttataaagggtaaatattttaaaagattagaactctgtagggttgagacctctgaaattgagtagagagagagaagggtttgttgagggatttttttgttttgttttttgatagtttacttgctgcctctcataccttaatgtgattttcatatattttttacatatatatgtatgtgtgtgtatataaacacatatgtatgtgtttggaagtatagcttccttttcttttatatttattagaatagtgctttaataattatagaattgtattggcagcatcttttatagaaatataatcatgtttattttaagaactgacaacttgtttttgctatcttttagtgcaataagcagttttaaaggaaagttgtgtctgtttgcatctttaccatggatagtaggaggaacaggcacctccacaatttaaaagggcaaagaatacagccttaatttcagaaggaaagttttgcaattttcagttttaaagcctatcttttaaaattcatcgtgataaaaggctggacacggtggctcatgcctgtaatcctagcactttgggaggccgagacaggtgtatcacctgagctcaggagtttgagactagcctggccaacgtggtgaaaccccatctctactaaaaatacaaaaattagctgggcgtggtagcaggcacctctaatcccagctactcgggaggctgaggcaggattgcttgaaaccaggaggcagaagttgcagtgagccaagattgcaccattgcactccagcctgggcaacaaaagcaaaactccgtctcaaaagaaaaaaaaatcataatgaaaatgaagtgaaattgcctcaatgagtccaacttgaatattagaaataaagttgaactttgatataagaaataatcatgaatagcttaacatatttaaattatttgcaaatagattatgtttattgaagaatcatattggctagatgcccattttcatttactaaaatgaatcaggaaaatgcaagatgatattttaaaacttttgctaatgtatcaccggtgtaactttccttttaaaattaaggtgatagtaacaaaggaagttaggactttgatcat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