LOCUS       XM_015438461           19970 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  PREDICTED: Macaca fascicularis argonaute RISC catalytic component 3
            (AGO3), transcript variant X11, mRNA.
ACCESSION   XM_015438461
VERSION     XM_015438461.3
DBLINK      BioProject: PRJNA1105996
KEYWORDS    RefSeq.
SOURCE      Macaca fascicularis (crab-eating macaque)
  ORGANISM  Macaca fascicularis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_088375) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jun 4, 2024 this sequence version replaced XM_015438461.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_037993035.1-RS_2024_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/24/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..19970
                     /organism="Macaca fascicularis"
                     /mol_type="mRNA"
                     /isolate="582-1"
                     /db_xref="taxon:9541"
                     /chromosome="1"
                     /sex="female"
                     /tissue_type="parthenogenetic embryonic stem cells"
     gene            1..19970
                     /gene="AGO3"
                     /note="argonaute RISC catalytic component 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 EST, 8 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 27 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:102144351"
     CDS             142..2022
                     /gene="AGO3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X5"
                     /protein_id="XP_015293947.1"
                     /db_xref="GeneID:102144351"
                     /translation="

MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    142..483
                     /gene="AGO3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(277..279,322..324,364..366,376..378,430..432,
                     451..453,457..459)
                     /gene="AGO3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    616..1893
                     /gene="AGO3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1027..1029,1039..1041,1075..1086,1093..1095,
                     1117..1119,1126..1128,1138..1140,1150..1152)
                     /gene="AGO3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1231..1233,1237..1239,1447..1449,1861..1863)
                     /gene="AGO3"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      19970
                     /gene="AGO3"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

tttcaatcactagttcaggtttcagtctacatgttacttccttgagaagcagtgtttgacacccttctccccccatccagccatcccccaagtctgatttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgatattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtttgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaaggaggcctgccagtcatcaaacctttcctttacagttagaaaatggccaaactgtggagagaacagtagcgcagtatttcagagaaaagtatactcttcagctgaagtacccgcaccttccctgcctgcaagtcgggcaggagcagaaacacacctacctgccgctagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacggatccatttgttcaggagtttcaatttaaagttcgggatgaaatggctcatgtaactggacgcgtacttccagcacctatgctccagtatggaggacggaatcggacagtagcaacaccaagccacggagtgtgggatatgcgagggaagcaattccacacaggagttgaaatcaaaatgtgggctatcgcttgttttgccacacagaggcagtgcagagaagaaatattgaagggtttcacagaccagctgcgtaagatttctaaggatgcagggatgcccatccagggccagccatgcttctgcaaatatgcacagggggcagacagcgtagagcccatgttccggcatctcaagaacacatattctggcctacagcttattatcgtcatcctgccagggaagacaccagtgtatgcggaagtgaaacgtgtaggagacacacttttgggtatggccacacaatgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctctcaaacttgtgcctaaagataaatgttaaactcggaggaatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagccgacgtcactcatccacctgctggtgatggaaagaagccttctattgctgctgttgtaggtagtatggatgcccacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgggaacttcttattcaattttataagtcaactcggttcaagcctactcgtatcatcttttatcgggatggtgtttcagaagggcagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacaccacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagatattacacacccatatgagtttgatttttacctctgtagccatgctggaatacagggtaccagtcgtccttcacactatcatgttttatgggatgataactgcttcactgcagatgaacttcagctgctaacttaccagctctgccatacttatgtacgctgtacacgatctgtttctatacctgcaccagcgtattacgctcacctggtagcatttagagccagatatcatcttgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacagagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaaatagtccaagtatattctctgagaggaagcactgaaagatgaattgacatacaacgtatgtttccagtggagtcaattgagtaaggacacctccagccatacagaaaccaacactgtgtgggggccaaggtctgatccttatgttaatacaaggaagattgtttacttcatcaaggaacacagcatcattatgcaatatgaaaccagccaactgctttttgtgcggtctcctgtaggaagtatcgcaattgttttgttttcatttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaagtatcgaaaaagtaaatgatggtttaaaaaatatacaccttcatgaataatcaaagtgatttttcaaaattatgtgcaaaaaattaatgtgcattcatatattcttgtaaaaggtgtctgtgtgtttttaaaatatatacatccatacttcatatgcatatatatctggatctggattgataatagatatatatgtgtctgtgtatatattttagaattcattccatttggggaacttcctttcccttttattctactagcactaccgcttttatttctctttttcccttgccttcatcacctacattttttccctaatcctaccagtgacattcaaacattcacctacctggttcctttgaatgtaaaatatggcaaactagatttctacttttattttgcataccctattcctgactcctatctcctacatgattctgagttctcaactcttgatattgctgtcttaagaatcaaacttttatatatatatagtatacatacatacacagacacatacacacatatatatacgtaaaataactttttgtgagagtgtgtctctcccctcccactctgaacatacatttgcgcaatttgtatataagcagtagcaacctgaactattctttttcttttcttttttttttttttttttttttttttgagacagagtcttgctctgtcaccaggctggagtgcagtggcaacatctcagctcgctgcaacttccgcctctcgggttcaagcgattctccggcctcagcctcccgagtagctgggactacaggcatgcgccaccacacccagctaatttttatatttttagtagagacggggtttcaccatgttggccaggatggtctcgatctcttgaccttgtgatccacccgcctcgacctcccaaagtgctgggattataggcgtgagccaccgcacctggcctgctattctttttctttagtgagtttgttaaagctgctataaatataaaacctgtcagaagttgtaactctttctctctgataagtgatgtgttttctgaaaccttctgtttctatgggttatacgcagaaattctttaaagcttttataaaggataaatattttaaaagattagaattctgtaggggttgagacctctgaaattgaatagagagagagaaggggttgttgagggacttttttgttctgttttttgatagtttacttgctgcctctcataccttaatgtgattttcatatattttatatatatatatgtatgtgtgtgtatataaacacatatgtatgtgtttggaagtatagcttccttttcttttatatttattagaatagtgctttaataattatagaattgtattggcagcatcttttataaaaatataatcatgtttattttaagaactgacaacttgtttttgctatcttttagtgcaataagcagttttaaaggaaagttgtgtctgtttgcatctttaccatggataggaggaggaacaggcacctccataatttaaaagggcaaagaatacagccttaatttcagaaggaaagttttgtaattttcagttttaaagcatatcttttaaaattcatcatgaaaaaaggctggacactgtggcttatgcctgtaatcctagcactttgggaggccgagacaggtgtatcacctgagctcaggagttcgagaccagcctggccaacatagtgaaaccccgtctctactaaaaatacaaaaattagctgggcatggtggtggacgtctgtaatcccagctactcgggaggctgaggcaggattgcttgaacccaggaggcggaagttgcagtgagccaagattgcaccattgccctccagcctgggcaacaaaagcaaaactctgtctcaaaagaaaaaaaaatcataatgaaaatgaagtgaaattgcctaaatgagtccaacttgaatattagaaataaagttgaacttttatataagaaataatcgtgaataggttaacatatttaaattatttgcaaatagattgtgtttattgaagaatcatattggctagttgcccattttcatttactaaaaagaatcaggaaaatgcaagatgatattttaaaacttttgctaatgtatcaccagtgtaactttccttttaaaattaaggtgatagtaacaaaggaagttaggactttgatcattttaaatccgttaaatcactgaaatgtgggaaattgttttacaaaacttttgttttattgattatactttaaggtattaaaaagtactataaagctatcaaaaccgagtttatcagtaacattggattcaggggagctttgcactttgtaactcatgaaaattgcattttgatttttttttttttcttgcactggttcagagtatagatactacagattgtttccagtgggcattgttgttagcctttcagaattccatctgcacgtgaaacctaatggatttagatctttagtttctctcttacctgtaatccactattattgccaattcactgtattttgagcctaaaatctgagcccatgtcctccgacaggcatgtaatcttttgtccctctgccagaaaactaagaaagtactgtattttgtatgtttattattttgaagtgtctga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