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Previous release (v1)
2025-04-20 15:24:18, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_013658 3224 bp mRNA linear ROD 05-JUN-2024
DEFINITION Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane
domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a),
transcript variant 1, mRNA.
ACCESSION NM_013658
VERSION NM_013658.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3224)
AUTHORS Bhat,G.P., Maurizio,A., Motta,A., Podini,P., Diprima,S.,
Malpighi,C., Brambilla,I., Martins,L., Badaloni,A., Boselli,D.,
Bianchi,F., Pellegatta,M., Genua,M., Ostuni,R., Del Carro,U.,
Taveggia,C., de Pretis,S., Quattrini,A. and Bonanomi,D.
TITLE Structured wound angiogenesis instructs mesenchymal barrier
compartments in the regenerating nerve
JOURNAL Neuron 112 (2), 209-229 (2024)
PUBMED 37972594
REFERENCE 2 (bases 1 to 3224)
AUTHORS Naito,Y., Koyama,S., Masuhiro,K., Hirai,T., Uenami,T., Inoue,T.,
Osa,A., Machiyama,H., Watanabe,G., Sax,N., Villa,J.,
Kinugasa-Katayama,Y., Nojima,S., Yaga,M., Hosono,Y., Okuzaki,D.,
Satoh,S., Tsuda,T., Nakanishi,Y., Suga,Y., Morita,T., Fukushima,K.,
Nishide,M., Shiroyama,T., Miyake,K., Iwahori,K., Hirata,H.,
Nagatomo,I., Yano,Y., Tamiya,M., Kumagai,T., Takemoto,N.,
Inohara,H., Yamasaki,S., Yamashita,K., Aoshi,T., Akbay,E.A.,
Hosen,N., Shintani,Y., Takamatsu,H., Mori,M., Takeda,Y. and
Kumanogoh,A.
TITLE Tumor-derived semaphorin 4A improves PD-1-blocking antibody
efficacy by enhancing CD8+ T cell cytotoxicity and proliferation
JOURNAL Sci Adv 9 (20), eade0718 (2023)
PUBMED 37205755
REFERENCE 3 (bases 1 to 3224)
AUTHORS Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
TITLE Motor neurons use push-pull signals to direct vascular remodeling
critical for their connectivity
JOURNAL Neuron 110 (24), 4090-4107 (2022)
PUBMED 36240771
REFERENCE 4 (bases 1 to 3224)
AUTHORS Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N.,
Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M.,
Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P.,
Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T.
TITLE A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin
expression and protects against peptic ulcers
JOURNAL Sci Transl Med 14 (654), eabf1922 (2022)
PUBMED 35857828
REFERENCE 5 (bases 1 to 3224)
AUTHORS Suga,Y., Nagatomo,I., Kinehara,Y., Koyama,S., Okuzaki,D., Osa,A.,
Naito,Y., Takamatsu,H., Nishide,M., Nojima,S., Ito,D., Tsuda,T.,
Nakatani,T., Nakanishi,Y., Futami,Y., Koba,T., Satoh,S., Hosono,Y.,
Miyake,K., Fukushima,K., Shiroyama,T., Iwahori,K., Hirata,H.,
Takeda,Y. and Kumanogoh,A.
TITLE IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts
Antitumor Immunity
JOURNAL J Immunol 207 (5), 1456-1467 (2021)
PUBMED 34380650
REFERENCE 6 (bases 1 to 3224)
AUTHORS Oster,S.F., Bodeker,M.O., He,F. and Sretavan,D.W.
TITLE Invariant Sema5A inhibition serves an ensheathing function during
optic nerve development
JOURNAL Development 130 (4), 775-784 (2003)
PUBMED 12506007
REFERENCE 7 (bases 1 to 3224)
AUTHORS Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
TITLE Noggin is required for correct guidance of dorsal root ganglion
axons
JOURNAL Dev Biol 251 (2), 283-293 (2002)
PUBMED 12435358
REFERENCE 8 (bases 1 to 3224)
AUTHORS Kumanogoh,A., Marukawa,S., Suzuki,K., Takegahara,N., Watanabe,C.,
Ch'ng,E., Ishida,I., Fujimura,H., Sakoda,S., Yoshida,K. and
Kikutani,H.
TITLE Class IV semaphorin Sema4A enhances T-cell activation and interacts
with Tim-2
JOURNAL Nature 419 (6907), 629-633 (2002)
PUBMED 12374982
REFERENCE 9 (bases 1 to 3224)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE The sensory innervation of the mouse spinal cord may be patterned
by differential expression of and differential responsiveness to
semaphorins
JOURNAL Mol Cell Neurosci 7 (5), 419-431 (1996)
PUBMED 8812066
REFERENCE 10 (bases 1 to 3224)
AUTHORS Puschel,A.W., Adams,R.H. and Betz,H.
TITLE Murine semaphorin D/collapsin is a member of a diverse gene family
and creates domains inhibitory for axonal extension
JOURNAL Neuron 14 (5), 941-948 (1995)
PUBMED 7748561
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BY201883.1, AK153164.1 and AK077976.1.
On Jul 22, 2009 this sequence version replaced NM_013658.2.
Transcript Variant: This variant (1) represents the longest
transcript. All four variants encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK154392.1, AK077976.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-9 BY201883.1 2-10
10-1808 AK153164.1 2-1800
1809-2096 AK077976.1 1790-2077
2097-2976 AK153164.1 2089-2968
2977-3224 AK077976.1 2958-3205
FEATURES Location/Qualifiers
source 1..3224
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="3"
/map="3 38.83 cM"
gene 1..3224
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="sema domain, immunoglobulin domain (Ig),
transmembrane domain (TM) and short cytoplasmic domain,
(semaphorin) 4A"
/db_xref="GeneID:20351"
/db_xref="MGI:MGI:107560"
exon 1..214
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
misc_feature 118..120
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="upstream in-frame stop codon"
exon 215..382
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
CDS 244..2526
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="semaphorin-4A; sema B; semaphorin-B"
/codon_start=1
/product="semaphorin-4A precursor"
/protein_id="NP_038686.3"
/db_xref="CCDS:CCDS17475.1"
/db_xref="GeneID:20351"
/db_xref="MGI:MGI:107560"
/translation="
MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKYHAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFMKDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQDSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKDHRTSASDVDADNNHLGAEVA"
sig_peptide 244..339
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 340..2523
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/product="Semaphorin-4A. /id=PRO_0000032323"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2)"
misc_feature 406..1728
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="The Sema domain, a protein interacting module, of
semaphorins and plexins; Region: Sema; cl15693"
/db_xref="CDD:472829"
misc_feature 601..603
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 646..648
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 1729..1863
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="domain found in Plexins, Semaphorins and Integrins;
Region: PSI; smart00423"
/db_xref="CDD:214655"
misc_feature 1729..1731
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 1951..2154
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Immunoglobulin domain; Region: Ig; cl11960"
/db_xref="CDD:472250"
misc_feature 1966..1980
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand B [structural motif]; Region: Ig strand
B"
/db_xref="CDD:409456"
misc_feature 2002..2016
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand C [structural motif]; Region: Ig strand
C"
/db_xref="CDD:409456"
misc_feature 2059..2073
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand E [structural motif]; Region: Ig strand
E"
/db_xref="CDD:409456"
misc_feature 2059..2061
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q62178.2); glycosylation site"
misc_feature 2101..2118
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="Ig strand F [structural motif]; Region: Ig strand
F"
/db_xref="CDD:409456"
misc_feature 2290..2352
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2);
transmembrane region"
misc_feature 2401..2523
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/note="propagated from UniProtKB/Swiss-Prot (Q62178.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 383..543
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 544..606
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 607..705
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 706..811
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 812..928
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 929..1053
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1054..1226
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1227..1377
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1378..1558
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1559..1677
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1678..1835
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1836..1933
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
exon 1934..3224
/gene="Sema4a"
/gene_synonym="Semab; SemB"
/inference="alignment:Splign:2.1.0"
ORIGIN
aagccagccaggatctgtcacaactcgaggtagaaattctggtttccctggcctgaaacccacactggctctggcaggatgggtgcctggagggccgcgcgcccgttccagccaggctgagcctgcttgccttgcctggacccccttctttgcctcggatggcaccctgattcagggtttgaacacaggacttctcagtgtggctggctcaaggaaccatctggtgaccatctcaggctgaccatggccctaccatccctgggccaggactcatggagtctcctgcgtgtttttttcttccaactcttcctgctgccatcactgccacctgcttctgggactggtggtcaggggcccatgcccagagtcaaataccatgctggagacgggcacagggccctcagcttcttccaacaaaaaggcctccgagactttgacacgctgctcctgagtgacgatggcaacactctctatgtgggggctcgagaggccgtcctggccttgaatatccagaacccaggaatcccaaggctaaagaacatgataccctggccagccagtgagagaaaaaagaccgaatgtgcctttaagaagaagagcaatgagacacagtgtttcaacttcattcgagtcctggtctcttacaatgctactcacctctatgcctgtgggacctttgccttcagccctgcctgtaccttcattgaactccaagattccctcctgttgcccatcttgatagacaaggtcatggacgggaagggccaaagcccctttgaccctgttcacaagcacacagctgtcttggtcgatgggatgctttattccggcaccatgaacaacttcctgggcagcgagcccatcctgatgcggacactgggatcccagcctgttctcaagactgacatcttcttacgctggctgcacgcggatgcctccttcgtggcagccattccatccacccaggtcgtctatttcttctttgaggagacagccagcgagtttgacttctttgaagagctgtatatatccagggtggctcaagtctgcaagaacgacgtgggcggtgaaaagctgctgcagaagaagtggaccaccttcctcaaagcccagttgctctgcgctcagccagggcagctgccattcaacatcatccgccacgcggtcctgctgcccgccgattctccctctgtttcccgcatctacgcagtctttacctcccagtggcaggttggcgggaccaggagctcagcagtctgtgccttctctctcacggacattgagcgagtctttaaagggaagtacaaggagctgaacaaggagacctcccgctggaccacttaccggggctcagaggtcagcccgaggccaggcagttgctccatgggcccctcctctgacaaagccttgaccttcatgaaggaccattttctgatggatgagcacgtggtaggaacacccctgctggtgaagtctggtgtggagtacacacggcttgctgtggagtcagctcggggccttgatgggagcagccatgtggtcatgtatctgggtacctccacggggtccctgcacaaggctgtggtgcctcaggacagcagtgcttatctcgtggaggagattcagctgagccctgactctgagcctgttcgaaacctgcagctggcccccgcccagggtgcagtgtttgcaggcttctctggaggcatctggagagttcccagggccaattgcagtgtctacgagagctgtgtggactgtgtgcttgccagggaccctcactgtgcctgggaccctgaatcaagactctgcagccttctgtctggctctaccaagccttggaagcaggacatggaacgcggcaacccggagtgggtatgcacccgtggccccatggccaggagcccccggcgtcagagcccccctcaactaattaaagaagtcctgacagtccccaactccatcctggagctgccctgcccccacctgtcagcactggcctcttaccactggagtcatggccgagccaaaatctcagaagcctctgctaccgtctacaatggctccctcttgctgctgccgcaggatggtgtcgggggcctctaccagtgtgtggcgactgagaacggctactcataccctgtggtctcctattgggtagacagccaggaccagcccctggcgctggaccctgagctggcgggcgttccccgtgagcgtgtgcaggtcccgctgaccagggtcggaggcggagcttccatggctgcccagcggtcctactggccccattttctcatcgttaccgtcctcctggccatcgtgctcctgggagtgctcactctcctcctcgcttccccactgggggcgctgcgggctcggggtaaggttcagggctgtgggatgctgccccccagggaaaaggctccactgagcagggaccagcacctccagccctccaaggaccacaggacctctgccagtgacgtagatgccgacaacaaccatctgggcgccgaagtggcttaaacagggacacagatccgcagctgagcagagcaagccactggccttgttggctatgccaggcacagtgccactctgaccagggtaggaggctctcctgctaacgtgtgtcacctacagcacccagtaggtcctcccctgtgggactctcttctgcaagcacattgggctgtctccatacctgtacttgtgctgtgacaggaagagccagacaggtttctttgattttgattgacccaagagccctcctgtaacaaacgtgctccaggagaccatgaaaggtgtggctgtctgggattctgtggtgacaaacctaagcatccgagcaagctggggctattcctgcaaactccatcctgaacgctgtcactctagaagcagctgctgctttgaacaccagcccaccctccttcccaagagtctctatggagttggccccttgtgtttcctttaccagtcatgccatactgtttgggaagtcatctctgaagtctaaccaccttccttcttgcttcagtttggacagattgttattattgtctctgccctggctagaatggggggcataatctgagccttgttcccttgtccagtgtggctgacccttgacctcttccttcctcctccctttgttttgggattcagaaaactgcttgtcacagacaatttattttttattaaaaaagatataagctttaaag
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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