LOCUS       NM_001081811            2295 bp    mRNA    linear   MAM 03-APR-2024
DEFINITION  Equus caballus follistatin (FST), mRNA.
ACCESSION   NM_001081811
VERSION     NM_001081811.2
KEYWORDS    RefSeq.
SOURCE      Equus caballus (horse)
  ORGANISM  Equus caballus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Hestand,M.S., Kalbfleisch,T.S., Coleman,S.J., Zeng,Z., Liu,J.,
            Orlando,L. and MacLeod,J.N.
  TITLE     Annotation of the Protein Coding Regions of the Equine Genome
  JOURNAL   PLoS One 10 (6), e0124375 (2015)
   PUBMED   26107351
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Sugawara,Y., Yamanouchi,K., Naito,K., Tachi,C., Tojo,H. and
            Sawasaki,T.
  TITLE     Molecular cloning of cDNA for equine follistatin and its gene
            expression in the reproductive tissues of the mare
  JOURNAL   J Vet Med Sci 61 (3), 201-207 (1999)
   PUBMED   10331189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB010829.1, DN510475.1 and PJAA01000022.1.
            
            On May 28, 2015 this sequence version replaced NM_001081811.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010829.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA2452530, SAMEA2452531
                                           [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-953               AB010829.1         1-953
            954-1250            DN510475.1         190-486
            1251-1583           AB010829.1         1252-1584
            1584-1584           PJAA01000022.1     19204871-19204871   c
            1585-2295           AB010829.1         1585-2295
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Equus caballus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9796"
                     /chromosome="21"
                     /map="21"
     gene            1..2295
                     /gene="FST"
                     /note="follistatin"
                     /db_xref="GeneID:100033825"
                     /db_xref="VGNC:VGNC:18145"
     exon            1..238
                     /gene="FST"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1188
                     /gene="FST"
                     /note="FS; activin-binding protein"
                     /codon_start=1
                     /product="follistatin precursor"
                     /protein_id="NP_001075280.1"
                     /db_xref="GeneID:100033825"
                     /db_xref="VGNC:VGNC:18145"
                     /translation="

MVRPRHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCDNVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGKCKKTCRDVNCPGSSTCVVDQTNNAYCVTCNRICPEPTSSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSEEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW"

     sig_peptide     154..240
                     /gene="FST"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O62650.1)"
     mat_peptide     241..1185
                     /gene="FST"
                     /product="Follistatin. /id=PRO_0000010102"
                     /note="propagated from UniProtKB/Swiss-Prot (O62650.1)"
     misc_feature    433..504
                     /gene="FST"
                     /note="Follistatin-N-terminal domain-like; Region: FOLN;
                     smart00274"
                     /db_xref="CDD:128570"
     misc_feature    502..645
                     /gene="FST"
                     /note="Kazal type serine protease inhibitors; Region:
                     KAZAL; smart00280"
                     /db_xref="CDD:197624"
     misc_feature    523..525
                     /gene="FST"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O62650.1); glycosylation site"
     misc_feature    652..723
                     /gene="FST"
                     /note="Follistatin-N-terminal domain-like; Region: FOLN;
                     smart00274"
                     /db_xref="CDD:128570"
     misc_feature    727..870
                     /gene="FST"
                     /note="Kazal type serine protease inhibitors; Region:
                     KAZAL; smart00280"
                     /db_xref="CDD:197624"
     misc_feature    961..1101
                     /gene="FST"
                     /note="Kazal type serine protease inhibitors; Region:
                     KAZAL; smart00280"
                     /db_xref="CDD:197624"
     misc_feature    1015..1017
                     /gene="FST"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O62650.1); glycosylation site"
     misc_feature    1093..1185
                     /gene="FST"
                     /note="propagated from UniProtKB/Swiss-Prot (O62650.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            239..430
                     /gene="FST"
                     /inference="alignment:Splign:2.1.0"
     exon            431..649
                     /gene="FST"
                     /inference="alignment:Splign:2.1.0"
     exon            650..874
                     /gene="FST"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1105
                     /gene="FST"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..2295
                     /gene="FST"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tcgcgcgggcggccggcggcgagcgcggggctgcgccgggatcgctgcgccctcagccgctcgcctctgcgacgcgcgccgctcgccagagccacccgccgccgcgcccgctccccgcgccgccgcgctcctcgccccgcgcctgcccccaggatggtccgtcccaggcaccagcccggcgggctttgcctcctgctgctgctgctctgccagttcatggaggaccgcagcgcccaggctgggaattgctggctccgccaagcgaagaacggccgctgccaggtcctgtacaagacagaactgagcaaggaggagtgctgcagcaccggccgcctgagcacctcgtggaccgaggaggacgtcaatgataacacgctcttcaagtggatgattttcaacgggggcgcccccaactgcatcccctgtaaagaaacgtgcgacaacgtggactgtggacccgggaaaaaatgccgaatgaacaagaagaataagccccgctgcgtctgtgccccagattgttccaatatcacctggaaaggcccagtctgtgggctggacgggaaaacctaccgcaacgaatgtgcgctcctcaaggccagatgtaaagagcagccagaactggaggtccagtaccagggcaaatgtaaaaagacctgccgggatgttaactgtccaggcagctccacgtgcgtggtggaccagacaaataatgcctactgtgtgacatgtaaccggatttgcccagagcccacctcctctgaacagtatctctgtgggaatgatggagtgacctactccagtgcctgtcacctgagaaaggctacctgcctgctgggcagatcgattggattagcctatgagggaaagtgtatcaaagcaaagtcctgtgaagatatccagtgcactggtggaaaaaaatgtttatgggatttcaaggttggcagaggccggtgttccctctgtgatgagctgtgccctgacagtaagtctgaggagcctgtctgtgccagtgacaatgccacttacgccagcgagtgtgccatgaaggaagctgcctgctcctcaggtgtgctgctggaagtaaagcattccggatcttgcaactccatttcggaagacaccgaggaagaggaggaagatgaagaccaggactacagctttcctatatcttccattctagagtggtaaaccctccgcccatgttcagtgttgatatagcctttgggcagaaaaaaaaaaaaaacaggaaagaaaagaaaaaatatattgtccatactgtaaataagtgtatgcttatttatttggggggaaaagtatacataaaggacctttgtcctaaagctgtctcccaggccaccttgttactcattggacccggagaggcggtcattgtgaggtctactggatgaggcccatagttgagaattgtagacatttatttatactgtgtcatgttttataatttatacataaaatgtctggttgactgtacaccttgtttttgaagaaatttattcgtgaaaggaagagcagttgttatttattgtgaggtctcttgcttgtaaagtaaaagcttttttttttccttgtaaaccatttaagtccattccttactattgactcactcatctgtctcccttcatttcactgttgttagactcttttccactttaacaaacttgcatgtcagtttctgtcatgtttatttattggattctctgctgcctgttctgtacatacatgatccctcgggttttgtttacaaggaatcttgactgaccaaaaggcattataactctgacttaaatagaaggtacagagaatacatcttgggggaaactcctatttcagttctcatgtcgtgacaaagacttctgtgagagagggggtgatagcaatgttagaattctagtaacgtaccttcaagatgttacagatccaaagagattgagtgatatgggtgtcgggagactgaagggagcagaatgctacactttcagcctttcattaggtgtttcctttaagctagtctgctgtaccttttaaatcagttctttttcaaccagtgtgtcactaaaagttatatcaaagctttatcagttcaagtttcttgcttttcataatacttttttctgatgcaattttatattttcaaacatggcaagttaaatataaattcatttaaatatatagttttgtacttttctaccatgtaaatgtgcaatgtatataaaagttataatgtgtatttgtaaataaatgatgagtgaaaaaataaaaaaattttaaaaagcc

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