LOCUS       NM_001076123            3522 bp    mRNA    linear   MAM 03-APR-2024
DEFINITION  Bos taurus claudin 12 (CLDN12), mRNA.
ACCESSION   NM_001076123 XM_582151
VERSION     NM_001076123.2
KEYWORDS    RefSeq.
SOURCE      Bos taurus (domestic cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (bases 1 to 3522)
  AUTHORS   Zimin,A.V., Delcher,A.L., Florea,L., Kelley,D.R., Schatz,M.C.,
            Puiu,D., Hanrahan,F., Pertea,G., Van Tassell,C.P., Sonstegard,T.S.,
            Marcais,G., Roberts,M., Subramanian,P., Yorke,J.A. and
            Salzberg,S.L.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol 10 (4), R42 (2009)
   PUBMED   19393038
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            NKLS02000002.1.
            
            On Feb 8, 2024 this sequence version replaced NM_001076123.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC122589.1, SRR5571263.28235.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA6648753, SAMEA6648754
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                NKLS02000002.1     121402061-121402150
            91-178              NKLS02000002.1     121403604-121403691
            179-3522            NKLS02000002.1     121413050-121416393
FEATURES             Location/Qualifiers
     source          1..3522
                     /organism="Bos taurus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9913"
                     /chromosome="2"
                     /map="2"
                     /breed="Hereford"
     gene            1..3522
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="claudin 12"
                     /db_xref="BGD:BT12778"
                     /db_xref="GeneID:538709"
                     /db_xref="VGNC:VGNC:27404"
     exon            1..90
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /inference="alignment:Splign:2.1.0"
     exon            91..178
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    144..146
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="upstream in-frame stop codon"
     exon            179..3522
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..950
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /codon_start=1
                     /product="claudin-12"
                     /protein_id="NP_001069591.1"
                     /db_xref="BGD:BT12778"
                     /db_xref="GeneID:538709"
                     /db_xref="VGNC:VGNC:27404"
                     /translation="

MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGGNDCLMYDAAWYSSVDQLDLRVLQFALPLSILIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNRKFEPVFAFDYAVYVTVASAGGLFMTALLLFIWYCACKSLPSPFWQPLYSHPPGMHTYSQPYSARSRLSAIEIDIPVVSHTT"

     misc_feature    246..308
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0IIL2.1);
                     transmembrane region"
     misc_feature    477..539
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0IIL2.1);
                     transmembrane region"
     misc_feature    621..683
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0IIL2.1);
                     transmembrane region"
     misc_feature    738..800
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0IIL2.1);
                     transmembrane region"
     misc_feature    897..899
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56749; propagated from
                     UniProtKB/Swiss-Prot (Q0IIL2.1); phosphorylation site"
     misc_feature    906..908
                     /gene="CLDN12"
                     /gene_synonym="claudin-12"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P56749; propagated from
                     UniProtKB/Swiss-Prot (Q0IIL2.1); phosphorylation site"
ORIGIN      

gggaacgcacttcctgggacgccgagaggaagacgctccgagaggctcctcagtgtgggcgagtgaaaatgccctggatgtgagaaacaggtccaggccatcttgactgtgttcagatgtgcatacatttcttctaagttgattaaagttgttttggaactatcaagtacctcaaagatctgactggcagtactgcacacacctgcctgcctgccatgggctgtcgggatgtccacgcggccaccgtgctgtccttcctgtgtggaatcgcctccgtagcgggcctctttgcaggcacactgcttcccaactggaggaagttacgactgatcacgttcaacagaaacgagaagaacctgaccgtctacacaggcctgtgggtgaagtgcgcccgctatgacgggggcaatgactgcctgatgtacgacgctgcctggtactcctctgtggaccagctggacctgcgggtcctccagtttgccctgccactcagcatcctgatcgcgatgggcgccctgctgctctgcctgatcggaatgtgtaacacggccttcaggtcctccgtgcccaacatcaagctggctaagtgcctggtcaatagtgcgggctgccatctggtggccgggctgctgtttttcctggcgggtactgtgagcctctccccgtccatctgggtcatcttttacaacatccacctgaacaggaagttcgagccagtctttgcgtttgactatgctgtgtacgtcactgtggctagtgctgggggcttgtttatgacggccctgctactatttatttggtactgtgcatgcaagtccttgccctctcctttctggcagccgctgtactcccaccctcccggtatgcacacgtactcacagccctattcagcccgttcccgcctctctgccattgaaatcgacattccagtagtttcccacaccacctaatggggaagtcgttgttcaagaaaccttctagcctcacatttccctcgtgaagaagccgttttggacctatatccattttcctcggttcctgatcagtcagtgaagccaaatctgtatgtcttggtaggatgaagtgctgctagtttttatgaaaagtacaatattttaaatgtgaatcattccttttatcttgcttcttgtgctcaaagcatttttaacctccatattgatatctgatcagttatttaggtagaaaggacctgtgtctcaattgaggtgatttagagccacatggtaaaaaatggttattaagaggagctgttatatgcgatccttagaaatatttcagaatgtcagaatgtgtatcgccctttttctataataccttaaattggtgggaaaaaatggacaatttcaaattaagatttttttttttcaggtaagggtaatagtttatcagtagccagtctaccagcttaggctgtaacttttcttacttctttctcggggctagttgtattgaatagagtttggtattttgaagatgactttcttttgtgagttcttatcttctacctcatgcctatgtttaaaaataaaatgtatcttaagtgatgtcagaataagcctaacgtttaaaatatctattagtatggataacgtttaacctaattataaaagttaatggttctataagttgtattattagagttaaactgtgccatgtgatgggttggtgcttcctttgaggcaaaaaaaaaacacctatttttttccagatatcatcaaccaggtggcactcaggcccacatgtaatctcttagtgaccaagagaaagaaagaggcccgagtggttagttcttcaaatagtggcaggggacaagcatctgctcttcggtgacagctgcagaggatcatcggggtgactgccttttgggtgatgggtggagtgaggcatggcctccccatgaccaggttccctcttgattcagttcccgccccatcaccgactatttctgtgagtgtatatctttgcccagcacgttactaggtgcagttgagaatacatggaaagtatgagatctcgtcccatctactaagaaattttacttcaagatagaagatcatacagttaatgacctcagtggcagctgatcttcactcagtcattgtgcctggagtacatttcacccaaagcatggctttctggcagccaggcttattgtaaataccagcaatatttggatccagaaactcagtttgttggatcctgtagagcacctaccttagtcttgatgctgtgataacagggtatcagattcatgagaactggatgggccacagtggtaaaaaacaaacaaaacaaaacccaccaattgttcccttttcacctctaaaaatatgatggcatatcaaagagggagaagtatttaaatctctcttctaatgagataatgcttagaggaaaccatgttaacaccgagatgaatgcttacagattcagggatattgggtctttacccttcggaatttgagctgcgtacttatttgatgtcatttgctccacatcagtgctgtgttcatgcggaatttgttctattacccgttacaaatctcacgtacaactagttgcatgattgacacgttattgtgcctcttttgcaaatctgagtatgcttctggaacttctgtgcataagcagtactttcgtttctaattccaaacactggtttatgtaaatagcaagtacatccagttgtataatttttaaatgccttcagttgaaagcatgcaaaactctggtttttaagcaatagcttctgatttccttcagttctttttactcttcttggatgtagctgagttttgatcactccaagacaacagcaggtaaaattttaagattaatattaattttccttttactaattaatttctgttcccattttcactcactttgtccagaagtgtcaagaattccaccattctttgtataagtaatgttaaaagcagaccaagccattaatattctagacagtttttagtccatgggaccaatatatataaatacatataaaatgttgaacttttactacaagcattttttggattcttttcataaactatagcctcaaattagtgtttattatggattcacatggcaatagaaacaggtgtttcccttattgtcattaatatttcagatttgctgtcagaaactattcttattcttcaaagccatcaaaggaatccatatatttataattttttaaataacttttgagcattcatcaggctatcattgtgatgggtgatatctttcttttgttgttgcaagtctcttcatgttaaaggccttttacagaagcttgggaaacagtttggaagaccttaaatgtagtctaatggaccggctttggtttatccaaccacgggaggaaaaaacgcctgagtttacttgtaaataagtatacactataatagataatatgtttgctgtaaactgcagtgtaaaacttcgataaaactgcactgtacttcttgatgtttattaaaagatgtatttttacaa

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