LOCUS       NM_001008514            1626 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus claudin 19 (Cldn19), mRNA.
ACCESSION   NM_001008514 XM_216519
VERSION     NM_001008514.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Ziemens,A., Sonntag,S.R., Wulfmeyer,V.C., Edemir,B., Bleich,M. and
            Himmerkus,N.
  TITLE     Claudin 19 Is Regulated by Extracellular Osmolality in Rat Kidney
            Inner Medullary Collecting Duct Cells
  JOURNAL   Int J Mol Sci 20 (18), 4401 (2019)
   PUBMED   31500238
  REMARK    GeneRIF: Results suggest that claudin-19 is part of the collecting
            duct tight junction (TJ) complex. Its presence in the TJ is under
            the control of ambient interstitial tonicity. Under iso-osmotic
            conditions, it is responsible for a high electrical transepithelial
            resistance and contributes to the tonicity-induced changes in
            paracellular ion selectivity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Monzon,C.M. and Garvin,J.L.
  TITLE     Claudin-19 mediates the effects of NO on the paracellular pathway
            in thick ascending limbs
  JOURNAL   Am J Physiol Renal Physiol 317 (2), F411-F418 (2019)
   PUBMED   31166708
  REMARK    GeneRIF: claudin-19 mediates the effects of the NO/cGMP signaling
            cascade on the paracellular pathway in the thick ascending limb of
            the loop of Henle.
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Peng,S., Wang,S.B., Singh,D., Zhao,P.Y., Davis,K., Chen,B.,
            Adelman,R.A. and Rizzolo,L.J.
  TITLE     Claudin-3 and claudin-19 partially restore native phenotype to
            ARPE-19 cells via effects on tight junctions and gene expression
  JOURNAL   Exp Eye Res 151, 179-189 (2016)
   PUBMED   27593915
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Hu,B., Arpag,S., Zhang,X., Mobius,W., Werner,H., Sosinsky,G.,
            Ellisman,M., Zhang,Y., Hamilton,A., Chernoff,J. and Li,J.
  TITLE     Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP
  JOURNAL   PLoS Genet 12 (9), e1006290 (2016)
   PUBMED   27583434
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Saitoh,Y., Suzuki,H., Tani,K., Nishikawa,K., Irie,K., Ogura,Y.,
            Tamura,A., Tsukita,S. and Fujiyoshi,Y.
  TITLE     Tight junctions. Structural insight into tight junction disassembly
            by Clostridium perfringens enterotoxin
  JOURNAL   Science 347 (6223), 775-778 (2015)
   PUBMED   25678664
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Lee,N.P., Tong,M.K., Leung,P.P., Chan,V.W., Leung,S., Tam,P.C.,
            Chan,K.W., Lee,K.F., Yeung,W.S. and Luk,J.M.
  TITLE     Kidney claudin-19: localization in distal tubules and collecting
            ducts and dysregulation in polycystic renal disease
  JOURNAL   FEBS Lett 580 (3), 923-931 (2006)
   PUBMED   16427635
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Miyamoto,T., Morita,K., Takemoto,D., Takeuchi,K., Kitano,Y.,
            Miyakawa,T., Nakayama,K., Okamura,Y., Sasaki,H., Miyachi,Y.,
            Furuse,M. and Tsukita,S.
  TITLE     Tight junctions in Schwann cells of peripheral myelinated axons: a
            lesson from claudin-19-deficient mice
  JOURNAL   J Cell Biol 169 (3), 527-538 (2005)
   PUBMED   15883201
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079172.1.
            
            On Dec 16, 2004 this sequence version replaced XM_216519.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079172.1, EX488559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1626
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="claudin 19"
                     /db_xref="GeneID:298487"
                     /db_xref="RGD:1305000"
     exon            1..307
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    22..24
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="upstream in-frame stop codon"
     CDS             85..720
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /codon_start=1
                     /product="claudin-19"
                     /protein_id="NP_001008514.1"
                     /db_xref="GeneID:298487"
                     /db_xref="RGD:1305000"
                     /translation="

MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKGRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAILGGSFLCCTCPEPERANSIPQPYRSGPSTAAREYV"

     misc_feature    94..630
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    106..168
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     misc_feature    328..390
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     misc_feature    436..498
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     misc_feature    565..627
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5QT56.1);
                     transmembrane region"
     exon            308..472
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.1.0"
     exon            473..557
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.1.0"
     exon            558..1594
                     /gene="Cldn19"
                     /gene_synonym="claudin-19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctgttcctcttaccatgaccatagcgctcctccagaccctggcccatctctgagtcctggaaccctcagactcctacctgggccatggccaactcaggcctccagctcctgggctacttcctagccttgggtggctgggtgggcatcatcgccagcaccgccctgccacagtggaagcagtcctcctatgcaggcgatgccatcatcactgccgtgggcctctacgaagggctgtggatgtcctgcgcctctcagagcaccgggcaggtgcaatgcaaactctacgattcactcctggccctggacggtcatatccagtcagcaagagccctgatggtggtggctgtgctcctgggctttgtggccatggtgctcagtgtcgtgggcatgaagtgtactcgggttggagacagtaaccccactgccaagggccgtgtggccatctccggaggtgctctcttcctcttggcgggtctctgtactttgactgctgtctcatggtacgctaccctggtgacccaggaattcttcaaccccagcactcctgtcaacgccaggtatgaatttggtccagctctgttcgtcggctgggcctctgctgggctggccatcctgggcggttcctttctctgctgcacatgcccagagcctgagagagccaacagcatcccgcagccctatcgctctggaccctcaacggctgcccgagagtacgtctgagtctgcctaccctgcccagccccattgcccagcagccccattgtccagaactcgtgccagactatatagtaccctgggcagggtagatggggtacggatcacttgaactcagtctggagctccaagcacctggtcctcagcataggctctgagtcccagactcagacagtcaaagagagatcagaggcaagaccccgcccacacgtgacccagtaaggaccaggcctgttctgtctacatcagaatgagtatcagaatttatacactagcttagctacaggctccttcgcttgccaacttatttgctgaaggacccatctgcctagtataggctgggccctgagggcttcccagcaacagaaggatctcagcgcacggtgctttgggtcagacagacttccatactccatccagttctcacagcaagcacatagaagaagtactctgggttaaggactgtctccacatcagacccaaggacactgaactttagagagacacggaggcgtggctctccaatctgtgagatcatgcctcagcctctggcagtcagttacccaacattgtttggatgcccatacaggtctcgagggcagactgtcactcccacccctaggaaggggccccaggcagggctgccatcagaatcctgctcctgggcctgaactctgcagcccccgtctctctcagccatcgctcaccccactaaccagctttctctcttttgacttgcagacccgttgttaagttgtccacctcggtcaagggccccctgggtgtgtaaaggccaggttcccagccaggccctgccccctaccatctctagactgtgtgtttgatatttctggaaagagaagcgaacattcagccccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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