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2019-03-25 15:04:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_073112               2674 bp    RNA     linear   PRI 17-JUL-2013
DEFINITION  Homo sapiens serpin peptidase inhibitor, clade B (ovalbumin),
            member 1 (SERPINB1), transcript variant 3, non-coding RNA.
ACCESSION   NR_073112
VERSION     NR_073112.1  GI:401709979
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2674)
  AUTHORS   Wang,L., Li,Q., Wu,L., Liu,S., Zhang,Y., Yang,X., Zhu,P., Zhang,H.,
            Zhang,K., Lou,J., Liu,P., Tong,L., Sun,F. and Fan,Z.
  TITLE     Identification of SERPINB1 as a physiological inhibitor of human
            granzyme H
  JOURNAL   J. Immunol. 190 (3), 1319-1330 (2013)
   PUBMED   23269243
  REMARK    GeneRIF: Upon reactive center loop cleavage at Phe-343,SERPINB1
            covalently complexes with GzmH. SERPINB1 overexpression suppresses
            GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show
            possible conformational changes in GzmH for the suicide inhibition.
REFERENCE   2  (bases 1 to 2674)
  AUTHORS   Farley,K., Stolley,J.M., Zhao,P., Cooley,J. and Remold-O'Donnell,E.
  TITLE     A serpinB1 regulatory mechanism is essential for restricting
            neutrophil extracellular trap generation
  JOURNAL   J. Immunol. 189 (9), 4574-4581 (2012)
   PUBMED   23002442
  REMARK    GeneRIF: In the resting state during human neutrophil extracellar
            trap generation, SerpinB1 is exclusively in the cytoplasm,
            consistent with the current understanding of clade B serpins, and
            it may migrate and regulate events in the cell nucleus.
REFERENCE   3  (bases 1 to 2674)
  AUTHORS   Uchiyama,K., Naito,Y., Takagi,T., Mizushima,K., Hirai,Y.,
            Hayashi,N., Harusato,A., Inoue,K., Fukumoto,K., Yamada,S.,
            Handa,O., Ishikawa,T., Yagi,N., Kokura,S. and Yoshikawa,T.
  TITLE     Serpin B1 protects colonic epithelial cell via blockage of
            neutrophil elastase activity and its expression is enhanced in
            patients with ulcerative colitis
  JOURNAL   Am. J. Physiol. Gastrointest. Liver Physiol. 302 (10), G1163-G1170
            (2012)
   PUBMED   22421620
  REMARK    GeneRIF: These results suggest that serpin B1 may be a novel marker
            of active ulcerative colitis and may play an important role in the
            pathogenesis of inflammatory bowel disease.
REFERENCE   4  (bases 1 to 2674)
  AUTHORS   Chou,R.H., Wen,H.C., Liang,W.G., Lin,S.C., Yuan,H.W., Wu,C.W. and
            Chang,W.S.
  TITLE     Suppression of the invasion and migration of cancer cells by
            SERPINB family genes and their derived peptides
  JOURNAL   Oncol. Rep. 27 (1), 238-245 (2012)
   PUBMED   21993616
REFERENCE   5  (bases 1 to 2674)
  AUTHORS   Zeng,W., Silverman,G.A. and Remold-O'Donnell,E.
  TITLE     Structure and sequence of human M/NEI (monocyte/neutrophil elastase
            inhibitor), an Ov-serpin family gene
  JOURNAL   Gene 213 (1-2), 179-187 (1998)
   PUBMED   9630619
REFERENCE   6  (bases 1 to 2674)
  AUTHORS   Sun,J., Stephens,R., Mirza,G., Kanai,H., Ragoussis,J. and Bird,P.I.
  TITLE     A serpin gene cluster on human chromosome 6p25 contains PI6, PI9
            and ELANH2 which have a common structure almost identical to the
            18q21 ovalbumin serpin genes
  JOURNAL   Cytogenet. Cell Genet. 82 (3-4), 273-277 (1998)
   PUBMED   9858835
REFERENCE   7  (bases 1 to 2674)
  AUTHORS   Packard,B.Z., Lee,S.S., Remold-O'Donnell,E. and Komoriya,A.
  TITLE     A serpin from human tumor cells with direct lymphoid
            immunomodulatory activity: mitogenic stimulation of human
            tumor-infiltrating lymphocytes
  JOURNAL   Biochim. Biophys. Acta 1269 (1), 41-50 (1995)
   PUBMED   7578269
REFERENCE   8  (bases 1 to 2674)
  AUTHORS   Sugimori,T., Cooley,J., Hoidal,J.R. and Remold-O'Donnell,E.
  TITLE     Inhibitory properties of recombinant human monocyte/neutrophil
            elastase inhibitor
  JOURNAL   Am. J. Respir. Cell Mol. Biol. 13 (3), 314-322 (1995)
   PUBMED   7654387
REFERENCE   9  (bases 1 to 2674)
  AUTHORS   Evans,E., Cooley,J. and Remold-O'Donnell,E.
  TITLE     Characterization and chromosomal localization of ELANH2, the gene
            encoding human monocyte/neutrophil elastase inhibitor
  JOURNAL   Genomics 28 (2), 235-240 (1995)
   PUBMED   8530031
REFERENCE   10 (bases 1 to 2674)
  AUTHORS   Remold-O'Donnell,E., Chin,J. and Alberts,M.
  TITLE     Sequence and molecular characterization of human
            monocyte/neutrophil elastase inhibitor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (12), 5635-5639 (1992)
   PUBMED   1376927
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK309765.1, BU942473.1,
            BI521531.1, BC009015.1, BM785367.1, BM823453.1 and AW451326.1.
            
            Summary: The protein encoded by this gene is a member of the serpin
            family of proteinase inhibitors. Members of this family maintain
            homeostasis by neutralizing overexpressed proteinase activity
            through their function as suicide substrates. This protein inhibits
            the neutrophil-derived proteinases neutrophil elastase, cathepsin
            G, and proteinase-3 and thus protects tissues from damage at
            inflammatory sites. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in an internal exon compared to variant 1. This variant is
            represented as non-coding because the use of the 5'-most expected
            translational start codon, as used in variant 1, renders the
            transcript a candidate for nonsense-mediated mRNA decay (NMD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU942473.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AK309765.1         1-189
            190-743             BU942473.1         5-558
            744-996             BI521531.1         215-467
            997-1484            BC009015.1         799-1286
            1485-1843           BM785367.1         268-626
            1844-2485           BM823453.1         19-660
            2486-2674           AW451326.1         1-189               c
FEATURES             Location/Qualifiers
     source          1..2674
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25"
     gene            1..2674
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /note="serpin peptidase inhibitor, clade B (ovalbumin),
                     member 1"
                     /db_xref="GeneID:1992"
                     /db_xref="HGNC:3311"
                     /db_xref="MIM:130135"
     misc_RNA        1..2674
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /product="serpin peptidase inhibitor, clade B (ovalbumin),
                     member 1, transcript variant 3"
                     /db_xref="GeneID:1992"
                     /db_xref="HGNC:3311"
                     /db_xref="MIM:130135"
     exon            1..238
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     variation       145
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:386713"
     exon            239..414
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    247..828
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_030666.3"
                     /note="NR_073112.1, primary ORF has stop codon >50
                     nucleotides from the terminal splice site;
                     nonsense-mediated mRNA decay (NMD) candidate."
     exon            415..552
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     exon            553..670
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     exon            671..813
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     exon            814..977
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     exon            978..2658
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /inference="alignment:Splign:1.39.8"
     variation       1080
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11551131"
     variation       1271
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3200960"
     polyA_signal    1471..1476
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
     variation       1485
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:15286"
     polyA_site      1491
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
     variation       1828
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1060143"
     variation       1880
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1064761"
     variation       1908
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1060144"
     polyA_signal    1940..1945
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
     polyA_site      1967
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
     variation       2161
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2049812"
     variation       2341
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2049813"
     polyA_signal    2630..2635
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
     polyA_site      2658
                     /gene="SERPINB1"
                     /gene_synonym="EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2"
ORIGIN      


agaaagaagccgcgcccctgaggagggcgctgcccggaagccacgctcacttctgcttgcacttaggcgacctcgggagctcggactcctacgcagtcaccgggaagggccgccgccccgcccgcggctgctggcccgggtgacgcttccgcctgctataagagcagcggccctcggtgcctccttcctgacctcgcacccagctcggagcccggagcgtgcctcggcggcctgtcggttttcaccatggagcagctgagctcagcaaacacccgcttcgccttggacctgttcctggcgttgagtgagaacaatccggctggaaacatcttcatctctcccttcagcatttcatctgctatggccatggtttttctggggaccagaggtaacacggcagcacagctgtccaagactttccatttcaacacggttgaagaggttcattcaagattccagagtctgaatgctgatatcaacaaacgtggagcgtcttatattctgaaacttgctaatagattatatggagagaaaacttacaatttccttcctgagttcttggtttcgactcagaaaacatatggtgctgacctggccagtgtggattttcagcatgcctctgaagatgcaaggaagaccataaaccagtgggtcaaaggacagacagaaggaaaaattccggaactgttggcttcgggcatggttgataacatgaccaaacttgtgctagtaaatgccatctatttcaagggaaactggaaggataaattcatgaaagaagccacgacgaatgcaccattcagattgaataagacagaaaaactgtgaaaatgatgtatcagaagaaaaaatttgcatatggctacatcgaggaccttaagtgccgtgtgctggaactgccttaccaaggcgaggagctcagcatggtcatcctgctgccggatgacattgaggacgagtccacgggcctgaagaagattgaggaacagttgactttggaaaagttgcatgagtggactaaacctgagaatctcgatttcattgaagttaatgtcagcttgcccaggttcaaactggaagagagttacactctcaactccgacctcgcccgcctaggtgtgcaggatctctttaacagtagcaaggctgatctgtctggcatgtcaggagccagagatatttttatatcaaaaattgtccacaagtcatttgtggaagtgaatgaagagggaacagaggcggcagctgccacagcaggcatcgcaactttctgcatgttgatgcccgaagaaaatttcactgccgaccatccattccttttctttattcggcataattcctcaggtagcatcctattcttggggagattttcttccccttagaagaaagagactgtagcaatacaaaaatcaagcttagtgctttattacctgagtttttaatagagccaatatgtcttatatctttaccaataaaaccactgttcagaaacaagtctttcattttctttgtaagtttggctctgttggctgtttacacccatgaattttggcatgggtatctatttttcttttttacattgaaaaaaatccagtggttgcttttgaatgcatcaagtaaagaagaagaaaagaatacatccgatgcgtagattcttgaccatgtagtaatctataaaattgctatatcctcctgatagccatgggaaaacatgataagatggtcatttattttgcagttagaattttggaagccacaaaatagacagacaccctgactgttgaagggaggtttaaaaacagatattcaattgaaatgtaagagagcaccccaattgagagcccaggttacgaagacaagcttgcctcgcctgacttttctgtcccttgttctgcaggattagtattctgttacagacctctagtttttagactcttcaattaaagggccaatggttataacctgcattcccttttttgttcttctttatgtataatatatagttcatgtggcgctgcatgaaatcaagaagtgggtgtcttaggataaaagataccaagagtctacaaaaataaccatgtagtaagataaactgctgaacaaaggttttactgttagccaccttctcatgtgttttcttttctctttttctttttctttctttctttcttttttttttttttgagacagagtcttgctctgttacccaggctggagtgcagtggcacgatctcagctcaccgcaacctctgcctcctgggttcaagtgattctcttgcttcagcctcctgagtagctgggattataggcatgcaccactaggcctggctaatttttgtatttttagtagagatggggtttttccatgttggccaggctggtcccgaactcctgacctcaggtgatccgcgcacctcagcctcccaaagtgctgggattacaggcatgagctaccatgcctggccttctcatgtgttttctgattaaggctcttgacttccaaggctgtgtggggagatggggtgggggctcttggactgatataaaactttgtcaaatgtagttctttgaatggagcttgaaacgccgcatattcttgctcccacaaggatagtgggcatcatgaattaataaaacgtcctaggattctgcaagctaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:1992 -> Molecular function: GO:0004867 [serine-type endopeptidase inhibitor activity] evidence: IBA
            GeneID:1992 -> Molecular function: GO:0004867 [serine-type endopeptidase inhibitor activity] evidence: NAS
            GeneID:1992 -> Biological process: GO:0010951 [negative regulation of endopeptidase activity] evidence: IBA
            GeneID:1992 -> Biological process: GO:0030162 [regulation of proteolysis] evidence: IBA
            GeneID:1992 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
            GeneID:1992 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS

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