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2024-04-26 05:47:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_072994 4543 bp RNA linear PRI 17-JUL-2013
DEFINITION Homo sapiens protein phosphatase 1, regulatory subunit 10
(PPP1R10), transcript variant 2, non-coding RNA.
ACCESSION NR_072994
VERSION NR_072994.1 GI:393715057
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4543)
AUTHORS Kavela,S., Shinde,S.R., Ratheesh,R., Viswakalyan,K., Bashyam,M.D.,
Gowrishankar,S., Vamsy,M., Pattnaik,S., Rao,S., Sastry,R.A.,
Srinivasulu,M., Chen,J. and Maddika,S.
TITLE PNUTS functions as a proto-oncogene by sequestering PTEN
JOURNAL Cancer Res. 73 (1), 205-214 (2013)
PUBMED 23117887
REMARK GeneRIF: our studies reveal PNUTS as a novel PTEN regulator and a
likely oncogene.
REFERENCE 2 (bases 1 to 4543)
AUTHORS Landsverk,H.B., Mora-Bermudez,F., Landsverk,O.J., Hasvold,G.,
Naderi,S., Bakke,O., Ellenberg,J., Collas,P., Syljuasen,R.G. and
Kuntziger,T.
TITLE The protein phosphatase 1 regulator PNUTS is a new component of the
DNA damage response
JOURNAL EMBO Rep. 11 (11), 868-875 (2010)
PUBMED 20890310
REMARK GeneRIF: PNUTS is identified as a new and integral component of the
DNA damage response involved in DNA repair.
REFERENCE 3 (bases 1 to 4543)
AUTHORS Lee,J.H., You,J., Dobrota,E. and Skalnik,D.G.
TITLE Identification and characterization of a novel human PP1
phosphatase complex
JOURNAL J. Biol. Chem. 285 (32), 24466-24476 (2010)
PUBMED 20516061
REMARK GeneRIF: mammalian Wdr82 functions in a variety of cellular
processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1)
has a role in the regulation of chromatin structure during the
transition from mitosis into interphase
REFERENCE 4 (bases 1 to 4543)
AUTHORS De Leon,G., Cavino,M., D'Angelo,M. and Krucher,N.A.
TITLE PNUTS knockdown potentiates the apoptotic effect of Roscovitine in
breast and colon cancer cells
JOURNAL Int. J. Oncol. 36 (5), 1269-1275 (2010)
PUBMED 20372802
REMARK GeneRIF: stimulation of PP1 activity via siRNA mediated knockdown
of its interacting protein PNUTS (Phosphatase Nuclear Targeting
Subunit) leads to Rb dephosphorylation and apoptosis in cancer
cells
REFERENCE 5 (bases 1 to 4543)
AUTHORS Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
Harley,J.B., Gaffney,P.M. and Criswell,L.A.
TITLE High-density SNP screening of the major histocompatibility complex
in systemic lupus erythematosus demonstrates strong evidence for
independent susceptibility regions
JOURNAL PLoS Genet. 5 (10), E1000696 (2009)
PUBMED 19851445
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 4543)
AUTHORS Kim,Y.M., Watanabe,T., Allen,P.B., Kim,Y.M., Lee,S.J.,
Greengard,P., Nairn,A.C. and Kwon,Y.G.
TITLE PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit.
Characterization of its PP1- and RNA-binding domains and regulation
by phosphorylation
JOURNAL J. Biol. Chem. 278 (16), 13819-13828 (2003)
PUBMED 12574161
REMARK GeneRIF: PNUTS has a role in protein kinase A-regulated targeting
of PP1 to specific RNA-associated complexes in the nucleus
REFERENCE 7 (bases 1 to 4543)
AUTHORS Totaro,A., Grifa,A., Carella,M., Rommens,J.M., Valentino,M.A.,
Roetto,A., Zelante,L. and Gasparini,P.
TITLE Cloning of a new gene (FB19) within HLA class I region
JOURNAL Biochem. Biophys. Res. Commun. 250 (3), 555-557 (1998)
PUBMED 9784381
REFERENCE 8 (bases 1 to 4543)
AUTHORS Allen,P.B., Kwon,Y.G., Nairn,A.C. and Greengard,P.
TITLE Isolation and characterization of PNUTS, a putative protein
phosphatase 1 nuclear targeting subunit
JOURNAL J. Biol. Chem. 273 (7), 4089-4095 (1998)
PUBMED 9461602
REFERENCE 9 (bases 1 to 4543)
AUTHORS Kreivi,J.P., Trinkle-Mulcahy,L., Lyon,C.E., Morrice,N.A., Cohen,P.
and Lamond,A.I.
TITLE Purification and characterisation of p99, a nuclear modulator of
protein phosphatase 1 activity
JOURNAL FEBS Lett. 420 (1), 57-62 (1997)
PUBMED 9450550
REFERENCE 10 (bases 1 to 4543)
AUTHORS Totaro,A., Rommens,J.M., Grifa,A., Lunardi,C., Carella,M.,
Huizenga,J.J., Roetto,A., Camaschella,C., De Sandre,G. and
Gasparini,P.
TITLE Hereditary hemochromatosis: generation of a transcription map
within a refined and extended map of the HLA class I region
JOURNAL Genomics 31 (3), 319-326 (1996)
PUBMED 8838313
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC150310.1, AK307406.1,
CD615451.1 and BU681199.1.
Summary: This gene encodes a protein phosphatase 1 binding protein.
The encoded protein plays a role in many cellular processes
including cell cycle progression, DNA repair and apoptosis by
regulating the activity of protein phosphatase 1. This gene lies
within the major histocompatibility complex class I region on
chromosome 6, and alternatively spliced transcript variants have
been observed for this gene. [provided by RefSeq, Jul 2012].
Transcript Variant: This variant (2) uses an alternate splice site,
compared to variant 1. This variant is represented as non-coding
because the use of the 5'-most expected translational start codon,
as used in variant 1, renders the transcript a candidate for
nonsense-mediated mRNA decay (NMD).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC150310.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-485 BC150310.1 1-485
486-513 AK307406.1 422-449
514-3885 BC150310.1 515-3886
3886-4137 CD615451.1 337-588
4138-4543 BU681199.1 1-406 c
FEATURES Location/Qualifiers
source 1..4543
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.3"
gene 1..4543
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/note="protein phosphatase 1, regulatory subunit 10"
/db_xref="GeneID:5514"
/db_xref="HGNC:9284"
/db_xref="MIM:603771"
misc_RNA 1..4543
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/product="protein phosphatase 1, regulatory subunit 10,
transcript variant 2"
/db_xref="GeneID:5514"
/db_xref="HGNC:9284"
/db_xref="MIM:603771"
exon 1..84
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 85..605
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
variation 500
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/replace="a"
/replace="t"
/db_xref="dbSNP:1052875"
exon 606..723
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
misc_feature 617..1723
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_002714.3"
/note="primary ORF has stop codon >50 nucleotides from the
terminal splice site; nonsense-mediated decay (NMD)
candidate"
exon 724..810
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 811..946
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 947..998
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 999..1076
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1077..1250
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1251..1356
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1357..1469
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1470..1570
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1571..1657
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1658..1816
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 1817..2063
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
variation 1851
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1264422"
exon 2064..2127
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 2128..2322
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 2323..2398
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 2399..2512
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
exon 2513..3268
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
variation 3179
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:1052945"
exon 3269..4527
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/inference="alignment:Splign:1.39.8"
variation 3483
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/replace="a"
/replace="g"
/db_xref="dbSNP:369182442"
variation 3806
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/replace="a"
/replace="g"
/db_xref="dbSNP:1264424"
variation 4443
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
/replace="c"
/replace="g"
/db_xref="dbSNP:1264425"
polyA_signal 4495..4500
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
polyA_site 4527
/gene="PPP1R10"
/gene_synonym="CAT53; FB19; p99; PNUTS; PP1R10; R111"
ORIGIN
agcacgtttgggcgcgttgggcggcgtccgggtataaaagactccacccgagcgggcggccgccattctggggttcgtttagaggtttgaattttctcggagaaagacaggccggccacgaggaaaacagaaacaagccgcagcaacatctaagcccttgaaaggatcctgagagaggggggaaagggaaaacagcagccaccagcccaaccacttgtgtcttctgccccttcccacctatcttgcccaccccaccagcccacgctgcttgggacttgaaatctgtggccgaaggaccgtcactacataacttcaaaaataatcaaccaccctcccttcccaaaccacccaaattcactcatccagcgtttacttttttgaatccactcagaacttttttctgcgacccccctccctaaatggagttgggtgggggggaaatgaatactgagttggcctttattttttaaaagactttttgatccaatgaggccccctaaataattgagttttgggtcctggttggttgttttattttttttcctccaaaattttaccccctcccccctgagcccgaggtgctgacgtcgcaaaaaaattggataaaaccaccatcatgggttcgggtcccatagaccccaaagaacttctcaagggcctggacagcttccttaaccgagatggggaagtcaaaagtgtggatgggatttccaagatcttcagtttgatgaaggaagcacgaaagatggtgagtcgatgcacttacttgaacattctcctgcagacccgttcaccagaaatattggtcaaatttattgacgttggcggctacaaacttcttaacaattggctgacgtattcaaagacaaccaacaacattcccctcctccagcaaattctactgaccctgcagcatctaccgctcactgtagaccatctcaagcagaacaacacagctaaactggtgaagcagctgagcaagtcaagtgaggatgaagagctccggaaattggcctcagtccttgtcagcgactggatggctgtcatccgctctcagagcagtacccagcctgctgagaaagataagaagaaacgtaaagatgaaggaaaaagtcgaactacccttcctgagcgacctttgacagaggtgaaggctgagacccgggctgaggaggccccagagaagaagagggagaagcccaagtctcttcgcaccacagcacccagtcatgccaagttccgttccactggactagagctggagacaccatccttggtgcctgtgaagaagaatgccagcacagtggtggtttctgacaagtacaaccttaaacccatccccctcaaacgtcagagcaacgtagctgctccaggagatgccactccccctgcagagaagaaatacaagccactcaacacaacacctaatgccaccaaagagatcaaagtgaagatcatcccgccacagcctatggagggcctgggctttctggatgctcttaattcagcccctgttccaggcatcaaaattaagaagaaaaaaaaagtactgtcacctacggctgccaagaaccagcaccaccttctgaggcaatggacgcagaccgtccaggcaccccggttccccctgttgaagtcccggagctcatggatacagcctctttggagccaggagctctggatgccaagccagtggagagtcctggagatcctaaccaactgacccggaaaggcaggaagaggaaaagtgtgacatggcctgaggaaggcaaactgagagaatatttctattttgaattggatgaaactgaacgagtaaatgtgaataagatcaaggactttggtgaggcggctaagcgagagatactgtcagaccgacatgcatttgagacagcgcggcgtctgagccatgataacatggaggagaaggtgccctgggtgtgcccccggcccctggttctgccctcacctcttgtcacccctggaagcaatagtcaggagcgatatatccaggctgagcgggagaagggaatccttcaggagctcttcctgaacaaggagagtcctcatgagcctgatcctgagccctacgagcccataccccctaaactcatccccctagatgaggagtgttccatggatgagactccgtatgttgagactctggaacctggggggtcaggtggctcacctgatggggcaggaggctccaagttgcctccagttctggccaatcttatgggaagcatgggtgctggaaagggcccccaaggccctggaggaggaggcattaatgtccaagagatcctcacctccatcatgggtagcccaaacagtcatccttcagaggaactactgaaacaaccagactattcggacaagatcaagcagatgctggtgccacatggactcctaggccctggcccaatagccaatggtttcccaccagggggtcctgggggccccaagggcatgcagcactttccccctggacctgggggacctatgccaggtccccatggaggccctggtgggccagtgggtccacgtcttctgggtcctccaccccctccccggggaggtgatcccttctgggatggcccgggcgaccctatgcggggtggcccaatgcgggggggtccaggaccaggtcctggaccataccatagaggccgaggtggccgaggaggaaacgaacctcctcctcctcctcctccattccgaggcgccagaggaggtcgctctggaggaggacccccaaatggacgagggggccctggtgggggcatggttggaggtggtgggcatcgtcctcacgaaggccctggtgggggcatgggcaacagcagtggacatcgtccccacgaaggccctggcggtggcatgggaagtgggcatcgcccccatgaaggccctggtggtagcatgggtgggggtggaggacatcgtccccacgaaggccctggcggtggcatcagtggtggcagtggccatcgtccccatgaaggccctggcggaggaatgggtgccggtggtggacatcgcccccacgaaggccctggcggaagcatgggtggaagtggtggacatcgtccccatgaaggccctggacacggggggccccatggccaccggcctcatgatgtccctggtcaccgaggccatgaccatcgagggccgccacctcatgagcaccgtggccatgatggtcctggccacgggggagggggccaccgagggcacgatggaggccacagccatggaggagacatgtcaaaccgccctgtctgccgacatttcatgatgaagggcaactgccgctatgagaacaactgtgccttctaccacccgggtgtcaatgggccccccctgccctagggaccatttgcctgccctgttcacacaacccctgtggactgcagcctcgctctttccaccctgttatggcttctgtgaggcccattttcccttttccccagctgatgaggagccggccccctcagttcccacttgcttgggttcctgggggttttctgatcactggtgcgcattgatgtacatattttcctccagtctggggaggagagagactggaaacgttcctggactgctgaagaggagacccagttggcttcactttttgagaagattcgccctgtaccccaaacccctttccagtattacccttaatgcttgagaacctaaagctggttatcctggcgaacacccctacccttctattgcgggtccccacatgcacacagaactctgacacaggatcagctgcacttaagaaatcatcccagctaagttcattattcctcatggggtggggagatgctgaaaggggtattgtatatcccactgcactgagagggctcaatcagctggatttgagttctggaacacacatcatccccacccctcccccagcgtgggctcaccattcttagtcctttctcaagtgggaccttcaactttctgtgaacacccagtctgcgtcctgggtctgctaggttcgatgatggcgaactcgtatctgcatccggtgcaagttttagctggcagaggtgagaccggtggtgctggtctgcctttgccaactatagccagtctggagacttgataaaatacttcagtgagaccagcttctcatcaacttgggcccggcgtgctgggcctgaaagtcacactacatgcactgcctttgggagtcagctcactccctgctcccacctggaaccttgccagcgtgaaggaggcttccaggtacttcaccctgtcaaccacctctgaatccccaccaggcgccttcctgggtggattcaacaagatgattttgccctttcccagttctctccttcactttggcatcagttgttttctatgaaaacagtggattggttgggttttgtgcagggtcttgggttagagccaaaatggatttgaggatgagtatttttttttttggttttgtatattttgtacattaataataaacagtggaaagagaagcagcttatttaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5514 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:5514 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:5514 -> Molecular function: GO:0004864 [protein phosphatase inhibitor activity] evidence: IEA
GeneID:5514 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:5514 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:5514 -> Biological process: GO:0006606 [protein import into nucleus] evidence: TAS
GeneID:5514 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:5514 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:5514 -> Cellular component: GO:0072357 [PTW/PP1 phosphatase complex] evidence: ISS
by
@meso_cacase at
DBCLS
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