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2019-03-25 14:33:32, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_051988               3494 bp    RNA     linear   PRI 17-JUL-2013
DEFINITION  Homo sapiens F-box and WD repeat domain containing 10 (FBXW10),
            transcript variant 3, non-coding RNA.
ACCESSION   NR_051988
VERSION     NR_051988.1  GI:389885062
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3494)
  AUTHORS   Chaturvedi,P. and Parnaik,V.K.
  TITLE     Lamin A rod domain mutants target heterochromatin protein 1alpha
            and beta for proteasomal degradation by activation of F-box
            protein, FBXW10
  JOURNAL   PLoS ONE 5 (5), E10620 (2010)
   PUBMED   20498703
  REMARK    GeneRIF: Mislocalized lamins can induce ubiquitin-mediated
            proteasomal degradation of certain HP1 isoforms by activation of
            FBXW10, a member of the F-box family of proteins that is involved
            in E3 ubiquitin ligase activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3494)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev. 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB055860.1, AK310383.1, AC107982.6 and AL136822.1.
            
            Summary: Members of the F-box protein family, such as FBXW10, are
            characterized by an approximately 40-amino acid F-box motif. SCF
            complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM
            603134), and F-box proteins, act as protein-ubiquitin ligases.
            F-box proteins interact with SKP1 through the F box, and they
            interact with ubiquitination targets through other protein
            interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) uses alternate 5' and 3'
            terminal exons, compared to variant 1. This variant is represented
            as non-coding because use of the expected translational start
            codon, as used in variant 1, renders the transcript a candidate for
            nonsense-mediated mRNA decay (NMD).
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-300               DB055860.1         1-300
            301-1062            AK310383.1         242-1003
            1063-1190           AC107982.6         128467-128594       c
            1191-1583           AK310383.1         1130-1522
            1584-1584           AC107982.6         123912-123912       c
            1585-2961           AK310383.1         1524-2900
            2962-2962           AC107982.6         101180-101180       c
            2963-3220           AK310383.1         2902-3159
            3221-3494           AL136822.1         2958-3231
FEATURES             Location/Qualifiers
     source          1..3494
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3494
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /note="F-box and WD repeat domain containing 10"
                     /db_xref="GeneID:10517"
                     /db_xref="HGNC:1211"
                     /db_xref="MIM:611679"
     misc_RNA        1..3494
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /product="F-box and WD repeat domain containing 10,
                     transcript variant 3"
                     /db_xref="GeneID:10517"
                     /db_xref="HGNC:1211"
                     /db_xref="MIM:611679"
     exon            1..1383
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       3
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371194302"
     variation       25
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367810251"
     variation       138
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150230158"
     variation       183
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369742505"
     variation       198
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186119518"
     variation       214
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116483657"
     misc_feature    233..823
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001267585.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated mRNA decay (NMD)
                     candidate"
     variation       300
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:74502778"
     variation       312
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200553727"
     variation       326
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143662391"
     variation       338
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138647311"
     variation       397
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200806553"
     variation       441
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149323817"
     variation       464
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143573197"
     variation       477
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201935353"
     variation       500
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148027955"
     variation       536
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377476079"
     variation       575
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142528410"
     variation       640
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145973790"
     variation       746
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370104676"
     variation       786
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370158560"
     variation       853
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:114381083"
     variation       861
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149324181"
     variation       1063
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112087876"
     variation       1216
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191912090"
     variation       1365
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114067349"
     exon            1384..1548
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1388
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376114266"
     variation       1399
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370476175"
     variation       1500
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376241364"
     variation       1526
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370045217"
     variation       1537
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370320215"
     exon            1549..1749
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1572
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375699839"
     variation       1582
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374206318"
     variation       1584
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9895749"
     variation       1649
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139842854"
     variation       1659
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200535885"
     variation       1702
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139431164"
     variation       1713
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368213609"
     exon            1750..1877
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1821
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372345142"
     variation       1830
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150057313"
     variation       1845
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145368701"
     variation       1853
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200034399"
     exon            1878..2000
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       1910
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372134223"
     variation       1952
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376056941"
     variation       1953
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140944543"
     variation       1978
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371774794"
     variation       1979
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376006877"
     variation       1989
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149924362"
     variation       1992
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7209610"
     exon            2001..2110
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2010
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201169182"
     variation       2022
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147905984"
     variation       2033
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200851525"
     variation       2038
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144179290"
     variation       2041
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373122324"
     variation       2110
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:142047019"
     exon            2111..2311
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2116
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200464103"
     variation       2124
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201657571"
     variation       2125
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376791823"
     variation       2173
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199572430"
     variation       2210
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373654877"
     variation       2233
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376635428"
     variation       2247
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370583951"
     variation       2288
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151034607"
     variation       2289
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140412541"
     variation       2295
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150381644"
     variation       2297
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138093156"
     exon            2312..2433
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2366
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376019829"
     exon            2434..2582
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2435
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144567782"
     variation       2460
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368003711"
     variation       2467
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142568223"
     variation       2474
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182760245"
     variation       2486
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144724584"
     variation       2535
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138625739"
     variation       2536
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141626132"
     variation       2550
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144460161"
     variation       2576
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368262323"
     variation       2577
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372082761"
     exon            2583..2725
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2589
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148396663"
     variation       2651
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149882032"
     variation       2662
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375390149"
     variation       2668
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150697158"
     variation       2679
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140982768"
     variation       2694
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147930073"
     variation       2697
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79757327"
     variation       2697
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144931466"
     exon            2726..2884
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2729
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370227023"
     variation       2735
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200519240"
     variation       2738
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150006059"
     variation       2739
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145231603"
     variation       2747
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17852530"
     variation       2748
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149142028"
     variation       2753
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374611444"
     variation       2769
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371753550"
     variation       2791
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143215236"
     variation       2817
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146517457"
     variation       2831
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117585894"
     variation       2847
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144820718"
     exon            2885..3156
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       2903
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368827263"
     variation       2933
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372149006"
     variation       2936
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138657360"
     variation       2945
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369517876"
     variation       2952
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78640521"
     variation       2962
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150329747"
     variation       2971
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:137965030"
     variation       3000
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372209815"
     variation       3011
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200658685"
     variation       3023..3026
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace=""
                     /replace="tctc"
                     /db_xref="dbSNP:377314029"
     variation       3098
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139177136"
     variation       3107
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149546887"
     variation       3124
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376804860"
     variation       3125
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147138981"
     exon            3157..3213
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       3204
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372890959"
     variation       3205
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375352795"
     exon            3214..3484
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /inference="alignment:Splign:1.39.8"
     variation       3221
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1318979"
     variation       3221
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147994056"
     variation       3231
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77817142"
     variation       3312
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373632534"
     variation       3327
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1024657"
     variation       3327
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117160613"
     variation       3454
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2014354"
     variation       3454
                     /gene="FBXW10"
                     /gene_synonym="Fbw10; HREP; SM25H2; SM2SH2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:28690836"
ORIGIN      


acggtaaagccatgtttccaaggaggtctgtacaaaaagccagacttctgctggcagttactgagagagataggctttccatccatggcagccatttacttttgctctgggagacgtttgtaatagaaaaggcacaactggggtatttattcattccccccgttcctctagtgtttggtggcgttgccgttgcaagtgcgcagggctaaaatggactggttatcttaggatcatggaaaacctggaatcaaggctcaagaatgccccctattttcgttgtgagaagggaaccgattccatccctctatgccggaagtgtgagacgtgtgtcttagcctggaagatcttctctaccaaagagtggttctgcaggatcaatgacatatcacagaggaggtttctagttggcattctgaagcagttaaatagcttatatttgttacactatttccaaaatatccttcagaccacacagggaaaggatttcatctataacaggtcccggatcaacctcagcaagaaagaggggaaagttgtgaagtcctccttgaaccaaatgttggataaaacagtagaacagaagatgaaagagatcttgtactggtttgcgaacagcacccagtggaccaaggcgaattatactctcttactgctgcagatgtgcaaccccaaattactgctcactgctgccaatgtgatcagagtcctgtttctgagagaggagaacaatatctcaggtaaacaaggccacaggcagagactagagggcccccgaagaccagaaggcaaggcttcagaaatctgtaaggaactgcagttgtagacaacataggtagacagagattgcacagaactcagcataggttttttgaactgacaccttgtcctgacacccgatcctgtttaccaaaggagaaatgactgagtgtaacttccttcttgaaaatgatcaatgcaggaggaagtacacaacttttaactcacaagcatttatcatggatttctgcatctcataggcccagaaatggctggtccctgcccctgaccccttaatgctggtgtcgttcctgctttagggattggactgagctcgagagggttgtaaaggggaagcttttgtttttctcttcagctgccctgcacagaaaccagaccaagaagtcaaaacttagggctttttttttttttttcattcactctaccatgctccttgcttatccatgaaatgaaaccttaaagtagagtttctccaaggctggagatagcttaagggccaaataagtctagggtggtagttctccagctgtggcttgtatcaggatctccagcaggacctgttaaaacaagctcctcccccagaacttcggactcagcaggtctgagggctcaatcaagacatcacagatgtgtgtttttcccctgagaaagaccacagctccaagtctgcgacctcacaagtctattggacagccaaaactcagcacacatcccttcctttgtccaaagccccagaaaatgaacacttgcttggggcagcatctaaccctgaggaaccatggaggaattcactccggtgtatatccgaaatgaataggctgttttctggaaaaggagacataaccaagccagggtacgatccctgcaatctattggttgacctggatgacatcagagacctgtcttctgggttcagcaaataccgagacttcatccgttacctgcccatccacctctccaagtacattctaagaatgctggatagacacaccctgaacaagtgcgcctctgtgagccagcactgggccgccatggctcaacaggtcaagatggacttgtcagcgcacggcttcattcagaaccagattaccttcttgcaggggtcctacacaagaggaattgatcctaattatgccaataaggtttctatcccagttcctaaaatggtagatgacgggaagagcatgcgtgtgaaacatccgaagtggaagctgagaacgaagaatgagtacaacctgtggactgcataccagaacgaggaaacgcagcaggtcctgatagaggagagaaatgttttctgtgggacctacaatgttcgcattctctctgacacgtgggatcaaaaccgagtcatccactattccgggggagatctgatagctgtgtcatctaatcgaaagatccatcttctggacatcatacaagtgaaagcgatacccgttgaattccgaggccatgctgggagtgtccgggccctcttcctgtgtgaggaggaaaactttctcctaagcgggagctatgacctaagtatcagatactgggatctgaaaagtggggtttgcacacgaatcttcggtggtcaccaggggactatcacttgcatggacttgtgtaagaacaggctcgtatctggaggaagagattgccaggtaaaagtatgggatgtagacacagggaagtgcctgaagacgtttagacacaaagaccccatcttggccaccaggatcaatgatacctacattgtgagcagctgtgagcgagggctggtgaaagtgtggcacattgccatggcccagttggtaaagactctcagtggccatgagggagccgtgaaatgcctgttctttgaccagtggcatctcctctcaggaagtactgatggcctggtcatggcctggagcatggtggggaagtacgagcgctgcctgatggccttcaagcatcccaaggaggtgctcgacgtgtcccttctcttcctccgggtcatcagcgcctgtgcagatggcaagatccgaatttacaatttcctcaacgggaactgtatgaaggtgttaaaagccaatggcagaggtgatcctgtgctgtccttctttattcagggcaacaggatggtggtcaacacagagagcaatgttctcatgttccagtttgagcacataaagtggcagtatgccgtggaaaaaacgaaacaaaagaagaataaggagaaagaggaggaaaaagaagaaaatagtctcatggaaattctctctaagtgtaatattcaggttcacagcccaagagagtctgtatccagtaaacaaactgtgatccaagagctcctaccaggcaaacctcccaagtcccgagtactcctgaagccggccaagttctcttcagcagtgttaatagaggaacttcaaagtcaaggaaagtcaaaatcaccccgaagagatgagtgaacactgagttcgtgctgttgaccgtgaaggaggagaaggagcaccaggaagccaagatgaaggaatatcaggccagggagtccactggagtggttgatccaggaaaagtcagcaaagctgcatggatcaggaagatcaaaggcctgcctattgataatttcacgaagcaagggaaaacagcggcccctgaacttggacaaaatgtatttatctaaaccagccttgggaaattacaatgttttacaataaacagaaagccaagcggaaaaaaaaaaa
//

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