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2024-03-28 21:14:12, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_049829                112 bp    RNA     linear   PRI 17-JUL-2013
DEFINITION  Homo sapiens microRNA 5197 (MIR5197), microRNA.
ACCESSION   NR_049829
VERSION     NR_049829.1  GI:388596756
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 112)
  AUTHORS   Schotte,D., Akbari Moqadam,F., Lange-Turenhout,E.A., Chen,C., van
            Ijcken,W.F., Pieters,R. and den Boer,M.L.
  TITLE     Discovery of new microRNAs by small RNAome deep sequencing in
            childhood acute lymphoblastic leukemia
  JOURNAL   Leukemia 25 (9), 1389-1399 (2011)
   PUBMED   21606961
  REMARK    Review article
REFERENCE   2  (bases 1 to 112)
  AUTHORS   Griffiths-Jones,S., Grocock,R.J., van Dongen,S., Bateman,A. and
            Enright,A.J.
  TITLE     miRBase: microRNA sequences, targets and gene nomenclature
  JOURNAL   Nucleic Acids Res. 34 (DATABASE ISSUE), D140-D144 (2006)
   PUBMED   16381832
COMMENT     PROVISIONAL REFSEQ: This record is based on preliminary annotation
            provided by NCBI staff in collaboration with miRBase. The reference
            sequence was derived from AC008696.6.
            
            Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs
            that are involved in post-transcriptional regulation of gene
            expression in multicellular organisms by affecting both the
            stability and translation of mRNAs. miRNAs are transcribed by RNA
            polymerase II as part of capped and polyadenylated primary
            transcripts (pri-miRNAs) that can be either protein-coding or
            non-coding. The primary transcript is cleaved by the Drosha
            ribonuclease III enzyme to produce an approximately 70-nt stem-loop
            precursor miRNA (pre-miRNA), which is further cleaved by the
            cytoplasmic Dicer ribonuclease to generate the mature miRNA and
            antisense miRNA star (miRNA*) products. The mature miRNA is
            incorporated into a RNA-induced silencing complex (RISC), which
            recognizes target mRNAs through imperfect base pairing with the
            miRNA and most commonly results in translational inhibition or
            destabilization of the target mRNA. The RefSeq represents the
            predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
            
            Sequence Note: This record represents a predicted microRNA
            stem-loop as defined by miRBase. Some sequence at the 5' and 3'
            ends may not be included in the intermediate precursor miRNA
            produced by Drosha cleavage.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC008696.6         125814-125925       c
FEATURES             Location/Qualifiers
     source          1..112
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5"
     gene            1..112
                     /gene="MIR5197"
                     /note="microRNA 5197"
                     /db_xref="GeneID:100846991"
                     /db_xref="HGNC:43450"
                     /db_xref="miRBase:MI0018176"
     precursor_RNA   1..112
                     /gene="MIR5197"
                     /product="microRNA 5197"
                     /db_xref="GeneID:100846991"
                     /db_xref="HGNC:43450"
                     /db_xref="miRBase:MI0018176"
     exon            1..112
                     /gene="MIR5197"
                     /inference="alignment:Splign:1.39.8"
     variation       6..7
                     /gene="MIR5197"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35579612"
     variation       9
                     /gene="MIR5197"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2042253"
     ncRNA           27..49
                     /gene="MIR5197"
                     /ncRNA_class="miRNA"
                     /product="hsa-miR-5197-5p"
                     /db_xref="miRBase:MIMAT0021130"
                     /db_xref="GeneID:100846991"
                     /db_xref="HGNC:43450"
                     /db_xref="miRBase:MI0018176"
     variation       45
                     /gene="MIR5197"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:372758014"
     ncRNA           64..86
                     /gene="MIR5197"
                     /ncRNA_class="miRNA"
                     /product="hsa-miR-5197-3p"
                     /db_xref="miRBase:MIMAT0021131"
                     /db_xref="GeneID:100846991"
                     /db_xref="HGNC:43450"
                     /db_xref="miRBase:MI0018176"
     variation       71
                     /gene="MIR5197"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:77549240"
ORIGIN      


tatgggattccacagacaatgagtatcaatggcacaaactcattcttgaatttttgccagttcaagaagagactgagtcatcgaatgctctaaatgtcacttcacctcatgt
//

Annotations:



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