GGRNA | NR_047585.1

LOCUS       NR_047585               2942 bp    RNA     linear   PRI 17-JUL-2013
DEFINITION  Homo sapiens septin 10 (SEPT10), transcript variant 3, non-coding
            RNA.
ACCESSION   NR_047585
VERSION     NR_047585.1  GI:384871591
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Xu,M., Takanashi,M., Oikawa,K., Nishi,H., Isaka,K., Yoshimoto,T.,
            Ohyashiki,J. and Kuroda,M.
  TITLE     Identification of a novel role of Septin 10 in
            paclitaxel-resistance in cancers through a functional genomics
            screen
  JOURNAL   Cancer Sci. 103 (4), 821-827 (2012)
   PUBMED   22320903
  REMARK    GeneRIF: we found that paclitaxel-resistant tumors had decreased
            expression of SEPT10.
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Benedetti,D., Bomben,R., Dal-Bo,M., Marconi,D., Zucchetto,A.,
            Degan,M., Forconi,F., Del-Poeta,G., Gaidano,G. and Gattei,V.
  TITLE     Are surrogates of IGHV gene mutational status useful in B-cell
            chronic lymphocytic leukemia? The example of Septin-10
  JOURNAL   Leukemia 22 (1), 224-226 (2008)
   PUBMED   17657217
  REMARK    GeneRIF: Lack of SEPT10 transcript is associated with B-cell
            chronic lymphocytic leukemia
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
            Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
            McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
            Dunham,I., Hill,D.E. and Vidal,M.
  TITLE     hORFeome v3.1: a resource of human open reading frames representing
            over 10,000 human genes
  JOURNAL   Genomics 89 (3), 307-315 (2007)
   PUBMED   17207965
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Sui,L., Zhang,W., Liu,Q., Chen,T., Li,N., Wan,T., Yu,M. and Cao,X.
  TITLE     Cloning and functional characterization of human septin 10, a novel
            member of septin family cloned from dendritic cells
  JOURNAL   Biochem. Biophys. Res. Commun. 304 (2), 393-398 (2003)
   PUBMED   12711328
  REMARK    GeneRIF: Cloning and functional characterization of septin 10.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011753.6, AK295560.1 and
            AC140485.3.
            
            Summary: This gene encodes a member of the septin family of
            cytoskeletal proteins with GTPase activity. This protein localizes
            to the cytoplasm and nucleus and displays GTP-binding and GTPase
            activity. A pseudogene for this gene is located on chromosome 8.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (3) lacks two alternate internal
            exons compared to variant 1. This variant is represented as
            non-coding because the use of the 5'-most supported translational
            start codon, as used in variant 1, renders the transcript a
            candidate for nonsense-mediated mRNA decay (NMD).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC011753.6         69009-69299         c
            292-1670            AK295560.1         2-1380
            1671-2942           AC140485.3         45359-46630         c
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..2942
                     /gene="SEPT10"
                     /note="septin 10"
                     /db_xref="GeneID:151011"
                     /db_xref="HGNC:14349"
                     /db_xref="MIM:611737"
     misc_RNA        1..2942
                     /gene="SEPT10"
                     /product="septin 10, transcript variant 3"
                     /db_xref="GeneID:151011"
                     /db_xref="HGNC:14349"
                     /db_xref="MIM:611737"
     exon            1..409
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     variation       291
                     /gene="SEPT10"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:3829700"
     misc_feature    380..496
                     /gene="SEPT10"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_144710.3"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            410..478
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     exon            479..665
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     variation       631
                     /gene="SEPT10"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3829701"
     exon            666..827
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     exon            828..924
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     exon            925..1093
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     exon            1094..1226
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     exon            1227..1414
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     exon            1415..2942
                     /gene="SEPT10"
                     /inference="alignment:Splign:1.39.8"
     variation       1909
                     /gene="SEPT10"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3886070"
ORIGIN

cacttccggcctcgcgagggccgcaatcactgctccgcagttcccgcctgcattcctcgcgccgtcttcctggagtcccagctctccttcagcccgccccaacgctgacgctcagtcctcaggcgtcgagggtagctcctgtgaggggctcgcttggcgcaggcaaaacgctcagcgcgcaccacagggcgtccgccccaaccccgcccccggaggcctccagctcggccccgcccctgtcccttccccgtcgcggaggcagcctagcctcgcgccccgcccgttgcttctgccctccggccttcccgccgccgtcgccgggaccagccgctcggggccgggctgatacagccgcttcaccgtgcccctgcccgcgaccatggcctcctccgaggtggcgcggcacctgctctttcagtctcacatggcaacgaaaacaacttgtatgtcttcacaaggatcagatgatgaacagatactaccaaccaatagttgactacatagatgctcagtttgaggcctatctccaagaagaactgaagattaagcgttctctctttacctaccatgattctcgcatccatgtgtgtctctacttcatttcaccgacaggccactctctgaagacacttgatctcttaaccatgaagaaccttgacagcaaggtaaacattataccagtgattgccaaagcagatacggtttctaaaactgaattacagaagtttaagatcaagctcatgagtgaattggtcagcaatggcgtccagatataccagttcccaacggatgatgacactattgctaaggtcaacgctgcaatgaatggacagttgccgtttgctgttgtgggaagtatggatgaggtaaaagtcggaaacaagatggtcaaagctcgccagtacccttggggtgttgtacaagtggaaaatgaaaaccactgtgactttgtaaagctgcgggaaatgctcatttgtacaaatatggaggacctgcgagagcagacccataccaggcactatgagctttacaggcgctgcaaactggaggaaatgggctttacagatgtgggcccagaaaacaagccagtcagtgttcaagagacctatgaagccaaaagacatgagttccatggtgaacgtcagaggaaggaagaagaaatgaaacagatgtttgtgcagcgagtaaaggagaaagaagccatattgaaagaagctgagagagagctacaggccaaatttgagcaccttaagagacttcaccaagaagagagaatgaagcttgaagaaaagagaagacttttggaagaagaaataattgctttctctaaaaagaaagctacctccgagatatttcacagccagtcctttctggcaacaggcagcaacctgaggaaggacaaggaccgtaagaactccaattttttgtaaaacagaagttccagagcacagaaggtcatcatcacaagcaaactttattaaaaaaaaactagaagtgtgctttgattttgctgttatttgttttatcacttctatatttggtgaacagccacagttactgatatttatggaaaagtactttcaagtacaaggtcaatacataagccagagtgaatgatactacaagttgagcatctctaattcaaaaatctgaaatccagaagcttcaaaatctgaatctttttgagcactgacttgaccccacaagtggaaaattccccacccgacacctttgctttctgatggttcagtttaaacagattttgtttcttgcacaaaatttttgtataaattactttcaggctatatgtataaggtggatgtgaaacatgaattatgtaattagagtcgggtcccgttgtgtatatgcagatattccaaacctgaaatccaaaacacttctggtccctagcattttggataagggatactcagcttgtacctatatattcatatatattcactgttgttagaaatgtttaagttgctgttctgtgatgaatctaaatcttttctcttgctaccaagctattgtcactgcagtgcattataccaaagagcgaagtcagtgccactgaaaatacagaacccattaatatcgtggctatctgattacatttatattccaagatgaaccttttttatatatgctaaaaattttggggaatatgttttgggatgtattatggagctaaaactctaacctcttaatagttttatagaacttaaaaattttttatacaattacccaattggtgatatgatcttaagcttttgtgtcagattatttaatatgatgacttcatgctttattatgccttattatggctgacgtattactgtggtgaaacaaaatatctttaaaagttaaaacatccagatatataagctattttttcctaaggataaagtacctttgagcatgagtgtatcacagctttcattaggaaaacttttcattacatacttgtttaaactctgtcttccagggtaaaaataataaggttgaatcattttattaaaaatactttttaagaaaataactatgaacatctgaatattaaagatataaaaatgcacataattcatatttcaggtggtatttgcattcagtgccttactggtattctcagaacattttaatgatttctaacatttcttaacagtcatagatatatacattttcattttttgtacttgaatattctaaataaaactgacatttactcttgacaaataaaacatatatttactaaaatgtgtttaattttcctttctgaaaactctcattttaaaaacgttcatttaattatgtatttgaattattttggagatgaggtattttatgagtattttcagacaatgaaacttattagtctgtgtcagattctgagcaatcatagagtcatctaagttgtaaataaaaccttgcatagcacaatt

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