2024-03-29 00:27:22, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_046318 3705 bp RNA linear PRI 16-JUL-2013 DEFINITION Homo sapiens ectodermal-neural cortex 1 (with BTB domain) (ENC1), transcript variant 5, non-coding RNA. ACCESSION NR_046318 VERSION NR_046318.1 GI:375268725 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3705) AUTHORS Seng,S., Avraham,H.K., Birrane,G., Jiang,S., Li,H., Katz,G., Bass,C.E., Zagozdzon,R. and Avraham,S. TITLE NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors JOURNAL Oncogene 28 (3), 378-389 (2009) PUBMED 18981988 REMARK GeneRIF: NRP/B mutations impair Nrf2-dependent NQO1 induction in primary brain tumors. REFERENCE 2 (bases 1 to 3705) AUTHORS Wang,X.J. and Zhang,D.D. TITLE Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level JOURNAL PLoS ONE 4 (5), E5492 (2009) PUBMED 19424503 REMARK GeneRIF: ENC1 functions as a negative regulator of Nrf2 through suppressing Nrf2 protein translation. REFERENCE 3 (bases 1 to 3705) AUTHORS Seng,S., Avraham,H.K., Jiang,S., Yang,S., Sekine,M., Kimelman,N., Li,H. and Avraham,S. TITLE The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells JOURNAL Cancer Res. 67 (18), 8596-8604 (2007) PUBMED 17875699 REMARK GeneRIF: NRP/B enhances oxidative stress responses in breast cancer cells via the Nrf2 pathway, identifying a novel role of nuclear matrix protein(s) in oxidative stress responses. REFERENCE 4 (bases 1 to 3705) AUTHORS Fujita,M., Furukawa,Y., Tsunoda,T., Tanaka,T., Ogawa,M. and Nakamura,Y. TITLE Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the beta-catenin/T-cell factor complex, in colorectal carcinomas JOURNAL Cancer Res. 61 (21), 7722-7726 (2001) PUBMED 11691783 REFERENCE 5 (bases 1 to 3705) AUTHORS Kim,T.A., Ota,S., Jiang,S., Pasztor,L.M., White,R.A. and Avraham,S. TITLE Genomic organization, chromosomal localization and regulation of expression of the neuronal nuclear matrix protein NRP/B in human brain tumors JOURNAL Gene 255 (1), 105-116 (2000) PUBMED 10974570 REFERENCE 6 (bases 1 to 3705) AUTHORS Zhao,L., Gregoire,F. and Sul,H.S. TITLE Transient induction of ENC-1, a Kelch-related actin-binding protein, is required for adipocyte differentiation JOURNAL J. Biol. Chem. 275 (22), 16845-16850 (2000) PUBMED 10828068 REFERENCE 7 (bases 1 to 3705) AUTHORS Hernandez,M.C., Andres-Barquin,P.J., Kuo,W.L. and Israel,M.A. TITLE Assignment of the ectodermal-neural cortex 1 gene (ENC1) to human chromosome band 5q13 by in situ hybridization JOURNAL Cytogenet. Cell Genet. 87 (1-2), 89-90 (1999) PUBMED 10640818 REFERENCE 8 (bases 1 to 3705) AUTHORS Hernandez,M.C., Andres-Barquin,P.J., Holt,I. and Israel,M.A. TITLE Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors JOURNAL Exp. Cell Res. 242 (2), 470-477 (1998) PUBMED 9683534 REFERENCE 9 (bases 1 to 3705) AUTHORS Kim,T.A., Lim,J., Ota,S., Raja,S., Rogers,R., Rivnay,B., Avraham,H. and Avraham,S. TITLE NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation JOURNAL J. Cell Biol. 141 (3), 553-566 (1998) PUBMED 9566959 REFERENCE 10 (bases 1 to 3705) AUTHORS Polyak,K., Xia,Y., Zweier,J.L., Kinzler,K.W. and Vogelstein,B. TITLE A model for p53-induced apoptosis JOURNAL Nature 389 (6648), 300-305 (1997) PUBMED 9305847 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026405.5 and DA785554.1. Summary: This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]. Transcript Variant: This variant (5) is represented as non-coding because it lacks the coding exon found in variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-852 AC026405.5 99271-100122 c 853-1261 DA785554.1 157-565 1262-3705 AC026405.5 86104-88547 c FEATURES Location/Qualifiers source 1..3705 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="5" /map="5q13" gene 1..3705 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" /note="ectodermal-neural cortex 1 (with BTB domain)" /db_xref="GeneID:8507" /db_xref="HGNC:3345" /db_xref="MIM:605173" misc_RNA 1..3705 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" /product="ectodermal-neural cortex 1 (with BTB domain), transcript variant 5" /db_xref="GeneID:8507" /db_xref="HGNC:3345" /db_xref="MIM:605173" exon 1..1118 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" /inference="alignment:Splign:1.39.8" exon 1119..3705 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" /inference="alignment:Splign:1.39.8" variation 1645 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" /replace="c" /replace="t" /db_xref="dbSNP:11557038" variation 2952 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" /replace="c" /replace="t" /db_xref="dbSNP:1802334" polyA_signal 3676..3681 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" polyA_site 3702 /gene="ENC1" /gene_synonym="CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10" ORIGIN
agagtccagccgggggtgccgcacccactggggagtggggagggaggacacataggaaatgcctggggctggagtctctttggctctctgccagcaagaaacttaaacgtcctggcttgctcaacccgagtgtccctaaactgtccagacttttgcccgtccattgccactatctctccccactctgggtgtcctacccaaggcgctgtctatgcgtgcccagggcctgtcctgcggatacccagctcgccccttgcagccctttttagagcatctcgcgggctctggcatcaccaagcgcacagccccgggctgcgctcccctaaggtgggtccctcagatccggggctgtccattaaccaggctggcccaaagaggcgcagacactcgaacccgggaaaacttattttattctcggttcccggggttgcagctgccagcggctgagacagtgcgtccgctttgtctctctgcactccccgcagcccccctctcccgcttcctctcccgattaactcccccgacacgctcttctctagctcctctcctcctcccactccttctcctcctcttcctcctcctacaccacaggccgcgctaatgcgcttcctccctcccccggtgtcggtctctttgcatacgcgccccctcccctccccgccgcgccacttatagcggggcgcacggcggcggggcgcagactgctctggcagccggagaggaggcggtgcggcggtggcgctgcggagacccggtccagacgcctggcggccgccggcacacaaggcgctttctagctccctcccccgagcgcacagcccgcctccttccgcggcgcctgcagtggcaggcttgctctgccctaccgtgacgcgctccggagacgctctgcgggtcctggacaccgggtccgcggcgtggggacgacagacggaggcgaacgccatcggtagccggtccgcgagccatcgttcggggcgcagtcctctccccggctggccctcctttctccggggcattcgccaccgcttccctgggctgagacgaccggttcgtcgcctccttgcccgtgaccgtcgctagaactcagttgtgcgttgcggccagtcgccactgctctcactccatcactcgatgagataatatgagatttctacttcggagaggccaagtctaatgaagagaaaaaaaggaaaagaagttgcaagactcgaataaaatctgctgcaccttgtaaatgctctaactggacatgaaggaaaggggcgagggaggggggtgggatttttggtgcaagtagcacatggtttaaatatgaatgaacaaacctgtgatctagtccttgtcttgtaattgtggattaatgtcaatgttaatcagcccctcaaagggagagaaaagctggaccttttcccttgctgtaccatattcagcatttgatttccatgggccccaccatttatgtgtagaatttgaaatggttgtcacctctctctgaggacagagcttgaagcctccacaccagctgctgctggagattcaaagcccaactgtgggtccgagagggaagctggctgggctggctgaagaatgaagaccactggactctccgttaatctctaaggggtctgctccccaggaacgtttctgaacaatggggactttgttggtagccatttggtagatgttcttttctatttataagtgactttaaactttcccttggctgttaagaagtttgttatagatttagctatttattgttcgatgcctgcatgctgaaacaatgcctacagctgtcttcacatgtatggacgtgtgtgaatggttgtacgttttgcacattttgtggctgttgagatgtgctttgctgcacaaacatgaaaatttttgagttacaatttggagcataactggagggtgggttggggaggggtggatttttaaaatgtcaagacagggaaggatgacaaaatggaaatttaaatgacatcctagaggtagagaaaccgtggagatcgcttttctcagactcaccaacttttaatgggatttcatggggtttggttgtgctgatagggtaaggggaggctgctttctgcccttctccccactcccatctgatttacttaattcagtctcagctgctgaaatttggaaaggaccaaattgctttacagtttttttctttgtgtagtatcttgaaatcctggaaaattctatggaatagttctgtatatagggcacaagtaaaggcattgtccaaagtttatttatttatttattaccctaagaatgctttgccataaccacatttaatgggaaaaacggcagtatcacagatgtaaattaactcaccagatttactgggcctgaactcattctcttcttgctatatgatttagcaagttctagaaggtctccaagacaataattacattggcacaatgtatacttcagtgctcacccgtaggcaaatctctttttaaaaaactctttggtgcacaagtaacacatttggccacaaaacaccaaagaattgtaggcagtggcccctattgagaagttttccggtagagttggaaatcagttgtgaatacattctttgctagttggagtgcttgtttactaagcatgtgccgtcgtaggtattagtgctagtctcagataggtgcttcccctgaggtgcaggggaagaccaaagtttgcaactcgaactgctttcgtccatgtttctcacattgctgtattttagaaaataggggttaagactgataacaaccttttacattgtgactgtgtttgcattgtctaatgacagataaatccttaacatttctctccaccttagtactttagactaattgtgtttgtccgtccatgccatgaatgagtgggctgtagttgggcctaaataaatgagctgttggaagaaaagaatcacagtactttccagcagtcagtccctggttcctagatgtgttctaagcaatgcaaatgtctaattgtcccccagtgggcatagtcagtgtcgtttatattgtagcagttacagctctgtagtttatgatgcaaatctgccaagagagatgtatgtgtcactgcatggcttctgaaagcaggatgaattttctgcagctgtttcaaagttggggtctgttcttgaatcctctattaattactgtgtgtgagccagagggagctgtggtaagggttgggcccccagcctgtagggaactttctggactcccactctttgaatcgatataggcatttggtctcactacttgaccattctcaccctgtgaaacgtcccacactttgaagcaaatacaattcacagcacagtacacacaaaaaccttggcataagacagagaaggttcttcttattttgtgggctggttgctgtagaaacacataacaaagggcagccctccacttctggtataattgtgtagccccttttctttgggcttgacacctgtcttgaataagagtgattagagctgcataatgtccctctcttggctattgaccatgtggttcacgtacaaaactctgtataagttgaaggaaaatgttcatgttcatatgtacttgtttgctatgactacattttgaggttttgtaaaactgttatttttttttttttcacaatgtgaaactgaaggtcaataaattattagagattttctcttcatta
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:8507 -> Molecular function: GO:0003779 [actin binding] evidence: IEA GeneID:8507 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:8507 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS GeneID:8507 -> Biological process: GO:0007399 [nervous system development] evidence: TAS GeneID:8507 -> Biological process: GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] evidence: IDA GeneID:8507 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA GeneID:8507 -> Biological process: GO:0017148 [negative regulation of translation] evidence: IDA GeneID:8507 -> Cellular component: GO:0005634 [nucleus] evidence: TAS GeneID:8507 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:8507 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA GeneID:8507 -> Cellular component: GO:0016363 [nuclear matrix] evidence: IEA GeneID:8507 -> Cellular component: GO:0031463 [Cul3-RING ubiquitin ligase complex] evidence: IDA
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