2024-03-28 17:34:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_046072 2484 bp RNA linear PRI 16-JUL-2013 DEFINITION Homo sapiens NK3 homeobox 1 (NKX3-1), transcript variant 3, non-coding RNA. ACCESSION NR_046072 VERSION NR_046072.1 GI:373432629 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2484) AUTHORS Rao,V., Guan,B., Mutton,L.N. and Bieberich,C.J. TITLE Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1 JOURNAL J. Biol. Chem. 287 (43), 36331-36340 (2012) PUBMED 22910912 REMARK GeneRIF: Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1. REFERENCE 2 (bases 1 to 2484) AUTHORS Anderson,P.D., McKissic,S.A., Logan,M., Roh,M., Franco,O.E., Wang,J., Doubinskaia,I., van der Meer,R., Hayward,S.W., Eischen,C.M., Eltoum,I.E. and Abdulkadir,S.A. TITLE Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis JOURNAL J. Clin. Invest. 122 (5), 1907-1919 (2012) PUBMED 22484818 REMARK GeneRIF: NKX3.1 and MYC coregulate prostate tumorigenesis by converging on, and crossregulating, a common set of target genes. REFERENCE 3 (bases 1 to 2484) AUTHORS Hui,J., Wang,J.Y., Shi,X.H., Zhang,Y.G., Liu,M., Wang,X., Wang,N.N., Chen,X., Liang,S.Y., Wei,D., Zhao,F., Zhang,Y.H. and Yang,Z. TITLE [Association of prostate cancer with PDLIM5, SLC22A3 and NKX3-1 in Chinese men] JOURNAL Zhonghua Nan Ke Xue 18 (5), 404-411 (2012) PUBMED 22741436 REMARK GeneRIF: PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. REFERENCE 4 (bases 1 to 2484) AUTHORS Nagel,S., Ehrentraut,S., Tomasch,J., Lienenklaus,S., Schneider,B., Geffers,R., Meyer,C., Kaufmann,M., Drexler,H.G. and MacLeod,R.A. TITLE Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL) JOURNAL PLoS ONE 7 (7), E40747 (2012) PUBMED 22848398 REMARK GeneRIF: Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL). REFERENCE 5 (bases 1 to 2484) AUTHORS Korkmaz,K.S., Korkmaz,C.G., Ragnhildstveit,E., Kizildag,S., Pretlow,T.G. and Saatcioglu,F. TITLE Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens JOURNAL Gene 260 (1-2), 25-36 (2000) PUBMED 11137288 REFERENCE 6 (bases 1 to 2484) AUTHORS Carson,J.A., Fillmore,R.A., Schwartz,R.J. and Zimmer,W.E. TITLE The smooth muscle gamma-actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor JOURNAL J. Biol. Chem. 275 (50), 39061-39072 (2000) PUBMED 10993896 REFERENCE 7 (bases 1 to 2484) AUTHORS Choi,C.Y., Kim,Y.H., Kwon,H.J. and Kim,Y. TITLE The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription JOURNAL J. Biol. Chem. 274 (47), 33194-33197 (1999) PUBMED 10559189 REFERENCE 8 (bases 1 to 2484) AUTHORS Prescott,J.L., Blok,L. and Tindall,D.J. TITLE Isolation and androgen regulation of the human homeobox cDNA, NKX3.1 JOURNAL Prostate 35 (1), 71-80 (1998) PUBMED 9537602 REFERENCE 9 (bases 1 to 2484) AUTHORS Voeller,H.J., Augustus,M., Madike,V., Bova,G.S., Carter,K.C. and Gelmann,E.P. TITLE Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers JOURNAL Cancer Res. 57 (20), 4455-4459 (1997) PUBMED 9377551 REMARK Erratum:[Cancer Res 1997 Dec 15;57(24):5613] REFERENCE 10 (bases 1 to 2484) AUTHORS He,W.W., Sciavolino,P.J., Wing,J., Augustus,M., Hudson,P., Meissner,P.S., Curtis,R.T., Shell,B.K., Bostwick,D.G., Tindall,D.J., Gelmann,E.P., Abate-Shen,C. and Carter,K.C. TITLE A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer JOURNAL Genomics 43 (1), 69-77 (1997) PUBMED 9226374 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC111574.1, AC051642.5 and BF511129.1. Summary: This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]. Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-140 BC111574.1 1-140 141-2104 AC051642.5 692-2655 2105-2484 BF511129.1 1-380 c FEATURES Location/Qualifiers source 1..2484 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="8" /map="8p21.2" gene 1..2484 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /note="NK3 homeobox 1" /db_xref="GeneID:4824" /db_xref="HGNC:7838" /db_xref="MIM:602041" misc_RNA 1..2484 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /product="NK3 homeobox 1, transcript variant 3" /db_xref="GeneID:4824" /db_xref="HGNC:7838" /db_xref="MIM:602041" exon 1..18 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /inference="alignment:Splign:1.39.8" exon 19..2468 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /inference="alignment:Splign:1.39.8" variation 141 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /replace="c" /replace="t" /db_xref="dbSNP:1567669" misc_feature 243..449 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /inference="COORDINATES: ab initio prediction:ORF Finder" /note="predicted ORF does not meet quality criteria for protein coding locus with longer protein data" variation 2113 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" /replace="" /replace="a" /replace="aaa" /replace="aaaaaa" /db_xref="dbSNP:3060139" polyA_signal 2439..2444 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" polyA_site 2468 /gene="NKX3-1" /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A" ORIGIN
gggtgcattcaggccaaggtcagggagcaagaggtgtgcacaccaaagctattggagatttgcgtggaaatctcagattcttcactggtgagacaatgaaacaacagagacagtgaaagttttaatacctaagtcattcctccagtgcatactgtaggtcattttttttgcttctggctacctgtttgaaggggagagagggaaaatcaagtggtattttccagcactttgtatgattttggatgagttgtacacccaaggattctgttctgcaactccatcctcctgtgtcactgaatatcaactctgaaagagcaaacctaacaggagaaaggacaaccaggatgaggatgtcaccaactgaattaaacttaagtccagaagcctcctgttggccttggaatatggccaaggctctctctgtccctgtaaaagagaggggcaaatagagagtctccaagagaacgccctcatgctcagcacatatttgcatgggagggggagatgggtgggaggagatgaaaatatcagcttttcttattcctttttattccttttaaaatggtatgccaacttaagtatttacagggtggcccaaatagaacaagatgcactcgctgtgattttaagacaagctgtataaacagaactccactgcaagagggggggccgggccaggagaatctccgcttgtccaagacaggggcctaaggagggtctccacactgctgctaggggctgttgcatttttttattagtagaaagtggaaaggcctcttctcaacttttttcccttgggctggagaatttagaatcagaagtttcctggagttttcaggctatcatatatactgtatcctgaaaggcaacataattcttccttccctccttttaaaattttgtgttcctttttgcagcaattactcactaaagggcttcattttagtccagatttttagtctggctgcacctaacttatgcctcgcttatttagcccgagatctggtctttttttttttttttttttttttttttccgtctccccaaagctttatctgtcttgactttttaaaaaagtttgggggcagattctgaattggctaaaagacatgcatttttaaaactagcaactcttatttctttcctttaaaaatacatagcattaaatcccaaatcctatttaaagacctgacagcttgagaaggtcactactgcatttataggaccttctggtggttctgctgttacgtttgaagtctgacaatccttgagaatctttgcatgcagaggaggtaagaggtattggattttcacagaggaagaacacagcgcagaatgaagggccaggcttactgagctgtccagtggagggctcatgggtgggacatggaaaagaaggcagcctaggccctggggagcccagtccactgagcaagcaagggactgagtgagccttttgcaggaaaaggctaagaaaaaggaaaaccattctaaaacacaacaagaaactgtccaaatgctttgggaactgtgtttattgcctataatgggtccccaaaatgggtaacctagacttcagagagaatgagcagagagcaaaggagaaatctggctgtccttccattttcattctgttatctcaggtgagctggtagaggggagacattagaaaaaaatgaaacaacaaaacaattactaatgaggtacgctgaggcctgggagtctcttgactccactacttaattccgtttagtgagaaacctttcaattttcttttattagaagggccagcttactgttggtggcaaaattgccaacataagttaatagaaagttggccaatttcaccccattttctgtggtttgggctccacattgcaatgttcaatgccacgtgctgctgacaccgaccggagtactagccagcacaaaaggcagggtagcctgaattgctttctgctctttacatttcttttaaaataagcatttagtgctcagtccctactgagtactctttctctcccctcctctgaatttaattctttcaacttgcaatttgcaaggattacacatttcactgtgatgtatattgtgttgcaaaaaaaaaaaaaaagtgtctttgtttaaaattacttggtttgtgaatccatcttgctttttccccattggaactagtcattaacccatctctgaactggtagaaaaacatctgaagagctagtctatcagcatctgacaggtgaattggatggttctcagaaccatttcacccagacagcctgtttctatcctgtttaataaattagtttgggttctctacatgcataacaaaccctgctccaatctgtcacataaaagtctgtgacttgaagtttagtcagcacccccaccaaactttatttttctatgtgttttttgcaacatatgagtgttttgaaaataaagtacccatgtctttattagatttaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:4824 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IDA GeneID:4824 -> Molecular function: GO:0000983 [RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity] evidence: IEA GeneID:4824 -> Molecular function: GO:0000988 [protein binding transcription factor activity] evidence: IDA GeneID:4824 -> Molecular function: GO:0001047 [core promoter binding] evidence: IDA GeneID:4824 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA GeneID:4824 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS GeneID:4824 -> Molecular function: GO:0004882 [androgen receptor activity] evidence: IDA GeneID:4824 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:4824 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI GeneID:4824 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: IDA GeneID:4824 -> Molecular function: GO:0030284 [estrogen receptor activity] evidence: IDA GeneID:4824 -> Molecular function: GO:0030295 [protein kinase activator activity] evidence: IDA GeneID:4824 -> Molecular function: GO:0030331 [estrogen receptor binding] evidence: IDA GeneID:4824 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IPI GeneID:4824 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA GeneID:4824 -> Molecular function: GO:0043621 [protein self-association] evidence: IDA GeneID:4824 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA GeneID:4824 -> Molecular function: GO:0097162 [MADS box domain binding] evidence: IEA GeneID:4824 -> Biological process: GO:0001656 [metanephros development] evidence: IEA GeneID:4824 -> Biological process: GO:0001756 [somitogenesis] evidence: IEA GeneID:4824 -> Biological process: GO:0001934 [positive regulation of protein phosphorylation] evidence: IDA GeneID:4824 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS GeneID:4824 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA GeneID:4824 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS GeneID:4824 -> Biological process: GO:0007431 [salivary gland development] evidence: ISS GeneID:4824 -> Biological process: GO:0007507 [heart development] evidence: IEA GeneID:4824 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP GeneID:4824 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA GeneID:4824 -> Biological process: GO:0008584 [male gonad development] evidence: IEA GeneID:4824 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IDA GeneID:4824 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IMP GeneID:4824 -> Biological process: GO:0010629 [negative regulation of gene expression] evidence: IDA GeneID:4824 -> Biological process: GO:0010942 [positive regulation of cell death] evidence: IDA GeneID:4824 -> Biological process: GO:0014068 [positive regulation of phosphatidylinositol 3-kinase cascade] evidence: IDA GeneID:4824 -> Biological process: GO:0030521 [androgen receptor signaling pathway] evidence: IDA GeneID:4824 -> Biological process: GO:0033574 [response to testosterone stimulus] evidence: ISS GeneID:4824 -> Biological process: GO:0035690 [cellular response to drug] evidence: IEP GeneID:4824 -> Biological process: GO:0035907 [dorsal aorta development] evidence: IEA GeneID:4824 -> Biological process: GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IDA GeneID:4824 -> Biological process: GO:0043491 [protein kinase B signaling cascade] evidence: IMP GeneID:4824 -> Biological process: GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway] evidence: ISS GeneID:4824 -> Biological process: GO:0045860 [positive regulation of protein kinase activity] evidence: IDA GeneID:4824 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA GeneID:4824 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IMP GeneID:4824 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IMP GeneID:4824 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: ISS GeneID:4824 -> Biological process: GO:0045930 [negative regulation of mitotic cell cycle] evidence: IDA GeneID:4824 -> Biological process: GO:0045931 [positive regulation of mitotic cell cycle] evidence: IMP GeneID:4824 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA GeneID:4824 -> Biological process: GO:0048754 [branching morphogenesis of an epithelial tube] evidence: ISS GeneID:4824 -> Biological process: GO:0050680 [negative regulation of epithelial cell proliferation] evidence: ISS GeneID:4824 -> Biological process: GO:0051781 [positive regulation of cell division] evidence: IMP GeneID:4824 -> Biological process: GO:0060037 [pharyngeal system development] evidence: IEA GeneID:4824 -> Biological process: GO:0060442 [branching involved in prostate gland morphogenesis] evidence: ISS GeneID:4824 -> Biological process: GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis] evidence: ISS GeneID:4824 -> Biological process: GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] evidence: ISS GeneID:4824 -> Biological process: GO:0071347 [cellular response to interleukin-1] evidence: IEP GeneID:4824 -> Biological process: GO:0071356 [cellular response to tumor necrosis factor] evidence: IEP GeneID:4824 -> Biological process: GO:0071383 [cellular response to steroid hormone stimulus] evidence: IDA GeneID:4824 -> Biological process: GO:0071456 [cellular response to hypoxia] evidence: IDA GeneID:4824 -> Biological process: GO:0071850 [mitotic cell cycle arrest] evidence: IDA GeneID:4824 -> Biological process: GO:0071899 [negative regulation of estrogen receptor binding] evidence: IDA GeneID:4824 -> Biological process: GO:2000836 [positive regulation of androgen secretion] evidence: IDA GeneID:4824 -> Biological process: GO:2001022 [positive regulation of response to DNA damage stimulus] evidence: IDA GeneID:4824 -> Biological process: GO:2001235 [positive regulation of apoptotic signaling pathway] evidence: IDA GeneID:4824 -> Biological process: GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] evidence: IDA GeneID:4824 -> Cellular component: GO:0005622 [intracellular] evidence: IDA GeneID:4824 -> Cellular component: GO:0005634 [nucleus] evidence: IC GeneID:4824 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:4824 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
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