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2024-04-26 01:45:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_045205 3711 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 6,
non-coding RNA.
ACCESSION NR_045205
VERSION NR_045205.1 GI:349501083
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3711)
AUTHORS Cheng,Y.C., Lin,T.Y. and Shieh,S.Y.
TITLE Candidate tumor suppressor BTG3 maintains genomic stability by
promoting Lys63-linked ubiquitination and activation of the
checkpoint kinase CHK1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (15), 5993-5998 (2013)
PUBMED 23533280
REMARK GeneRIF: BTG3-dependent CHK1 ubiquitination contributes to its
chromatin localization and activation and a defect in this
regulation may increase genome instability and promote
tumorigenesis
REFERENCE 2 (bases 1 to 3711)
AUTHORS Wang,W.J., Wu,S.P., Liu,J.B., Shi,Y.S., Huang,X., Zhang,Q.B. and
Yao,K.T.
TITLE MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem
cell-like population of nasopharyngeal carcinoma cells
JOURNAL Cancer Res. 73 (3), 1219-1231 (2013)
PUBMED 23269272
REMARK GeneRIF: MYC regulation of CHK1 and CHK2 promotes radioresistance
in a stem cell-like population of nasopharyngeal carcinoma cells.
REFERENCE 3 (bases 1 to 3711)
AUTHORS Huh,J. and Piwnica-Worms,H.
TITLE CRL4(CDT2) targets CHK1 for PCNA-independent destruction
JOURNAL Mol. Cell. Biol. 33 (2), 213-226 (2013)
PUBMED 23109433
REMARK GeneRIF: CRL4 is a major regulator of CHK1 stability. CRL4CDT2
targets CHK1 for ubiquitination in the nucleoplasm, and for
PCNA-independent degradation. CHK1 is required for G2 arrest in
CDT2-depleted cells.
REFERENCE 4 (bases 1 to 3711)
AUTHORS Okita,N., Yoshimura,M., Watanabe,K., Minato,S., Kudo,Y., Higami,Y.
and Tanuma,S.
TITLE CHK1 cleavage in programmed cell death is intricately regulated by
both caspase and non-caspase family proteases
JOURNAL Biochim. Biophys. Acta 1830 (1), 2204-2213 (2013)
PUBMED 23085068
REMARK GeneRIF: CASP and non-CASP family proteases intricately regulate
cleavage for up-regulation of CHK1 kinase activity during PCD.
REFERENCE 5 (bases 1 to 3711)
AUTHORS Kumar,G., Breen,E.J. and Ranganathan,S.
TITLE Identification of ovarian cancer associated genes using an
integrated approach in a Boolean framework
JOURNAL BMC Syst Biol 7, 12 (2013)
PUBMED 23383610
REMARK GeneRIF: IRAK1, CHEK1 and BUB1 may play an important role in
ovarian cancer.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3711)
AUTHORS Ouyang,B., Li,W., Pan,H., Meadows,J., Hoffmann,I. and Dai,W.
TITLE The physical association and phosphorylation of Cdc25C protein
phosphatase by Prk
JOURNAL Oncogene 18 (44), 6029-6036 (1999)
PUBMED 10557092
REFERENCE 7 (bases 1 to 3711)
AUTHORS Giaccia,A.J. and Kastan,M.B.
TITLE The complexity of p53 modulation: emerging patterns from divergent
signals
JOURNAL Genes Dev. 12 (19), 2973-2983 (1998)
PUBMED 9765199
REMARK Review article
REFERENCE 8 (bases 1 to 3711)
AUTHORS Flaggs,G., Plug,A.W., Dunks,K.M., Mundt,K.E., Ford,J.C.,
Quiggle,M.R., Taylor,E.M., Westphal,C.H., Ashley,T., Hoekstra,M.F.
and Carr,A.M.
TITLE Atm-dependent interactions of a mammalian chk1 homolog with meiotic
chromosomes
JOURNAL Curr. Biol. 7 (12), 977-986 (1997)
PUBMED 9382850
REFERENCE 9 (bases 1 to 3711)
AUTHORS Peng,C.Y., Graves,P.R., Thoma,R.S., Wu,Z., Shaw,A.S. and
Piwnica-Worms,H.
TITLE Mitotic and G2 checkpoint control: regulation of 14-3-3 protein
binding by phosphorylation of Cdc25C on serine-216
JOURNAL Science 277 (5331), 1501-1505 (1997)
PUBMED 9278512
REFERENCE 10 (bases 1 to 3711)
AUTHORS Sanchez,Y., Wong,C., Thoma,R.S., Richman,R., Wu,Z.,
Piwnica-Worms,H. and Elledge,S.J.
TITLE Conservation of the Chk1 checkpoint pathway in mammals: linkage of
DNA damage to Cdk regulation through Cdc25
JOURNAL Science 277 (5331), 1497-1501 (1997)
PUBMED 9278511
REMARK GeneRIF: Biochemical studies suggest the functional interactions of
this protein with cell cycle regulators. Cdc25A, Cdc25B, and Cdc25C
can be phosphoryalted by this protein.
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK292549.1, BG468734.1,
CA441277.1, BC004202.2, BG191840.1, BM455102.1, BX506561.1,
BX114781.1, AI750792.1 and AA224205.1.
Summary: The protein encoded by this gene belongs to the Ser/Thr
protein kinase family. It is required for checkpoint mediated cell
cycle arrest in response to DNA damage or the presence of
unreplicated DNA. This protein acts to integrate signals from ATM
and ATR, two cell cycle proteins involved in DNA damage responses,
that also associate with chromatin in meiotic prophase I.
Phosphorylation of CDC25A protein phosphatase by this protein is
required for cells to delay cell cycle progression in response to
double-strand DNA breaks. Several alternatively spliced transcript
variants have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (6) contains an alternate 5'
terminal exon compared to variant 1. It is represented as
non-coding due to the presence of an upstream ORF (with a strong
Kozak signal) that is predicted to interfere with the translation
of the longest ORF; translation of the upstream ORF renders this
transcript a candidate for nonsense-mediated mRNA decay (NMD).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-181 AK292549.1 1-181
182-182 BG468734.1 71-71
183-1844 AK292549.1 183-1844
1845-1845 CA441277.1 463-463 c
1846-1892 BC004202.2 1471-1517
1893-2279 BG191840.1 126-512
2280-2538 BM455102.1 369-627
2539-2810 BX506561.1 253-524
2811-3287 BX114781.1 281-757
3288-3680 AI750792.1 9-401 c
3681-3711 AA224205.1 1-31 c
FEATURES Location/Qualifiers
source 1..3711
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.2"
gene 1..3711
/gene="CHEK1"
/gene_synonym="CHK1"
/note="checkpoint kinase 1"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
misc_RNA 1..3711
/gene="CHEK1"
/gene_synonym="CHK1"
/product="checkpoint kinase 1, transcript variant 6"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
exon 1..414
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
misc_feature 96..266
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="COORDINATES: ab initio prediction:ORF Finder"
/note="long (>35aa) upstream ORF has strong Kozak
sequence; nonsense-mediated decay (NMD) candidate"
variation 155
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:3731394"
variation 238
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:201882373"
variation 276
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3731395"
variation 334
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:12574644"
exon 415..499
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 417
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371037025"
misc_feature 435..1865
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_001274.5"
/note="primary ORF"
variation 444
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201459198"
variation 468
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200520758"
variation 473
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144523921"
exon 500..723
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 550
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367942205"
variation 593
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372546907"
variation 596
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112291840"
variation 635
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148040708"
variation 639
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375481689"
variation 646
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141665265"
variation 674
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371045906"
exon 724..788
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 788
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375305289"
exon 789..858
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 797
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368957964"
variation 810
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112275638"
variation 821
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114850047"
variation 849
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371765740"
exon 859..1047
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 866
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113468080"
variation 900
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140276570"
variation 901
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3731410"
variation 912
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369248914"
variation 932
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373714183"
variation 958
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75583143"
variation 1019
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200960815"
variation 1040
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190137928"
variation 1041
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376741119"
exon 1048..1152
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1082
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377704459"
variation 1102
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:35817404"
variation 1112
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370350660"
exon 1153..1248
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1185
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201395400"
variation 1194
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553952"
variation 1206
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201385540"
exon 1249..1357
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1274
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:111852956"
variation 1311
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147323405"
variation 1346
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:182542971"
exon 1358..1535
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1368
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34097480"
variation 1379
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371546941"
variation 1412
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2847422"
variation 1434
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:139936669"
variation 1466
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375729370"
variation 1470
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199535573"
variation 1476
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374866866"
variation 1488
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149667923"
variation 1508
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111415405"
variation 1517
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200239581"
exon 1536..1667
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1541
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375980825"
variation 1544
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77764256"
variation 1571
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369650833"
variation 1586
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192063586"
variation 1604
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372751798"
variation 1622
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374032447"
variation 1642
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115991933"
variation 1643
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149857578"
variation 1651
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145794689"
exon 1668..1769
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1674
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148568641"
variation 1694
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141332865"
variation 1696
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370268372"
exon 1770..3692
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1830
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146590504"
variation 1845
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:506504"
variation 1868
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373998065"
variation 1887
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:375887872"
variation 1926
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:9282658"
variation 1960
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148807246"
variation 2001
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373169887"
variation 2032
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:184393295"
variation 2191
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142447277"
variation 2237..2238
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:141464656"
variation 2238..2239
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:113628894"
variation 2238
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199723723"
variation 2239..2240
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:72531173"
variation 2240..2241
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:3731480"
variation 2241..2242
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:35167388"
variation 2241
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201914580"
polyA_signal 2269..2274
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2288
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:190098261"
polyA_site 2290
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2311
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181773130"
variation 2389
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184932784"
variation 2608
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113311223"
variation 2647
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189829306"
variation 2703
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151312608"
variation 2786
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140546391"
variation 2810
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144047942"
variation 2811
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:567889"
variation 2813
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368655022"
variation 2869
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="t"
/db_xref="dbSNP:34215005"
variation 2882
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146445217"
variation 2977
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370171293"
variation 2985
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140816182"
variation 3346
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623058"
variation 3360
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370678835"
variation 3424
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11220176"
variation 3555
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138368921"
variation 3615
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:180885007"
polyA_signal 3663..3668
/gene="CHEK1"
/gene_synonym="CHK1"
polyA_site 3692
/gene="CHEK1"
/gene_synonym="CHK1"
ORIGIN
aagaaccccaaggaagagtcccagcccttcctttcgcctctgggggcagtttggccccgccccggcctttgggacgggtggggctgtggatggggatgggaattggaattgagcaattgggaggaggcgctgccgcaggcgttttctgccccataccgctccctatatcctcttcctctcttccccagacccccacctctccctcctccttccccagtcgttcgccggaaagcatttgtctcccacctcttcataacaacaattaatttcctctggggcctgaggagggcagaatttcaaccttcggtgtgcttgggagtggcgattgtgatttacacgacaaaatggtcaggtttagaatagttgttcgtggttgaaagacttggataaatgtggatgagatagaaggggaagccgaggtgctcggtggagtcatggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctatggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgtagatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaaatgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaatatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacataggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttatctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaaagggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgtgagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaagagaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgcaatgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgactggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagctctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaaaaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttcaggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttctctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaaccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaagggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttacttggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattctttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttgggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggagaaacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgacttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaagggaagctgattgatattgtgagcagccagaagatttggcttcctgccacatgatcggaccatcggctctggggaatcctggtgaatatagtgctgctatgttgacattattcttcctagagaagattatcctgtcctgcaaactgcaaatagtagttcctgaagtgttcacttccctgtttatccaaacatcttccaatttattttgtttgttcggcatacaaataatacctatatcttaattgtaagcaaaactttggggaaaggatgaatagaattcatttgattatttcttcatgtgtgtttagtatctgaatttgaaactcatctggtggaaaccaagtttcaggggacatgagttttccagcttttatacacacgtatctcatttttatcaaaacattttgtttaattcaaaaagtacatattccatgttgatttaattctaagatgaaccaataaagacataattcttgtgacttttggacagtagatttatcagtctgtgaagcgaagccagcttcaaaacatatccccaagatttgtacttatattttcaaaagggcctggccagttatataaacctgtttttgaattataatgattaattaaaattgcaagtaggtgttttttccagtgtagttagtaaaatacttgtattttacagtgttgcataaactctagtgcttaactaactttactctaaaaattactgttgaacatcttaaatatttttctatattttctactttcatagccatattttaaccttttcaacttactggtgaccaagcttttaggtgataaagaataaaagagggaagggaagagtaaggaagctataagaaaaatagatctgattctttgttcctttacctgttagacttacaaaaagtttgtttttctaataaaatttgtatcaactttggggcatattaggttgaggccttggctcctgcctgtagtcccagctacttaggaggctgagagaggaggatcgcgtgaacctggaagtttgaggctgtagtgagctatgattgcaccagtgcactccagcttggatgacagagtaagaccctacctctaataaaaatttttaaaattgtaaaacattataaaattaatcagttattttaatctgaagccaagaacatgtagaatgttatgattagagtttatcacatattaatgtatactggcaaattgtgttactggagtatacccataggaggaataaattcaaacctgttttatttatttgaacctatttacggtatgcttaagaattgaatcagtataaattctcaaatatgggagaaattttgttcttgagaattatctgagtcattaatatttttcaaaaacagctctcactgacttgaacctcttctgtaagctctaaccttttacctgctttacatttccacttgaatgtctagtaggcatctcttgaccaaaaacagcttttgattcctgttctccaacctgttcctctcctagttttctccatctcagaaatgttacttcctctgcaaagtctttccctgacttatctaaaataataacctcctctgtttgctgtgggaatttgtatagaatggtgggaaaatttcaagtttcatatttggattagctctgacatttatttatctgaacactggtaattgcctcagtaaagacactgataataagtaccttttagagttattttaatctttaatgctttaatgtgtaggaagagtatagtgtcctgttttgcacagaaaggcattctgtaaataataagttgccttaattttcctgtaatgttcattatattgttgtgggaaggtatttactcctattattaaaaataaaaatgtgtaaaatttactacctgaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1111 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:1111 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1111 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1111 -> Molecular function: GO:0035402 [histone kinase activity (H3-T11 specific)] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: IEA
GeneID:1111 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:1111 -> Biological process: GO:0006281 [DNA repair] evidence: IMP
GeneID:1111 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
GeneID:1111 -> Biological process: GO:0006975 [DNA damage induced protein phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0010569 [regulation of double-strand break repair via homologous recombination] evidence: IDA
GeneID:1111 -> Biological process: GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] evidence: ISS
GeneID:1111 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0033261 [regulation of S phase] evidence: IEA
GeneID:1111 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
GeneID:1111 -> Biological process: GO:0045839 [negative regulation of mitosis] evidence: IDA
GeneID:1111 -> Biological process: GO:0046602 [regulation of mitotic centrosome separation] evidence: IDA
GeneID:1111 -> Biological process: GO:0048096 [chromatin-mediated maintenance of transcription] evidence: ISS
GeneID:1111 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:1111 -> Biological process: GO:0071313 [cellular response to caffeine] evidence: IEA
GeneID:1111 -> Biological process: GO:0090399 [replicative senescence] evidence: NAS
GeneID:1111 -> Biological process: GO:2000615 [regulation of histone H3-K9 acetylation] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000781 [chromosome, telomeric region] evidence: IDA
GeneID:1111 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000794 [condensed nuclear chromosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1111 -> Cellular component: GO:0005657 [replication fork] evidence: IEA
GeneID:1111 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
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