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2024-04-25 13:32:25, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_045204 3950 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 5,
non-coding RNA.
ACCESSION NR_045204
VERSION NR_045204.1 GI:349501062
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3950)
AUTHORS Cheng,Y.C., Lin,T.Y. and Shieh,S.Y.
TITLE Candidate tumor suppressor BTG3 maintains genomic stability by
promoting Lys63-linked ubiquitination and activation of the
checkpoint kinase CHK1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (15), 5993-5998 (2013)
PUBMED 23533280
REMARK GeneRIF: BTG3-dependent CHK1 ubiquitination contributes to its
chromatin localization and activation and a defect in this
regulation may increase genome instability and promote
tumorigenesis
REFERENCE 2 (bases 1 to 3950)
AUTHORS Wang,W.J., Wu,S.P., Liu,J.B., Shi,Y.S., Huang,X., Zhang,Q.B. and
Yao,K.T.
TITLE MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem
cell-like population of nasopharyngeal carcinoma cells
JOURNAL Cancer Res. 73 (3), 1219-1231 (2013)
PUBMED 23269272
REMARK GeneRIF: MYC regulation of CHK1 and CHK2 promotes radioresistance
in a stem cell-like population of nasopharyngeal carcinoma cells.
REFERENCE 3 (bases 1 to 3950)
AUTHORS Huh,J. and Piwnica-Worms,H.
TITLE CRL4(CDT2) targets CHK1 for PCNA-independent destruction
JOURNAL Mol. Cell. Biol. 33 (2), 213-226 (2013)
PUBMED 23109433
REMARK GeneRIF: CRL4 is a major regulator of CHK1 stability. CRL4CDT2
targets CHK1 for ubiquitination in the nucleoplasm, and for
PCNA-independent degradation. CHK1 is required for G2 arrest in
CDT2-depleted cells.
REFERENCE 4 (bases 1 to 3950)
AUTHORS Okita,N., Yoshimura,M., Watanabe,K., Minato,S., Kudo,Y., Higami,Y.
and Tanuma,S.
TITLE CHK1 cleavage in programmed cell death is intricately regulated by
both caspase and non-caspase family proteases
JOURNAL Biochim. Biophys. Acta 1830 (1), 2204-2213 (2013)
PUBMED 23085068
REMARK GeneRIF: CASP and non-CASP family proteases intricately regulate
cleavage for up-regulation of CHK1 kinase activity during PCD.
REFERENCE 5 (bases 1 to 3950)
AUTHORS Kumar,G., Breen,E.J. and Ranganathan,S.
TITLE Identification of ovarian cancer associated genes using an
integrated approach in a Boolean framework
JOURNAL BMC Syst Biol 7, 12 (2013)
PUBMED 23383610
REMARK GeneRIF: IRAK1, CHEK1 and BUB1 may play an important role in
ovarian cancer.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3950)
AUTHORS Ouyang,B., Li,W., Pan,H., Meadows,J., Hoffmann,I. and Dai,W.
TITLE The physical association and phosphorylation of Cdc25C protein
phosphatase by Prk
JOURNAL Oncogene 18 (44), 6029-6036 (1999)
PUBMED 10557092
REFERENCE 7 (bases 1 to 3950)
AUTHORS Giaccia,A.J. and Kastan,M.B.
TITLE The complexity of p53 modulation: emerging patterns from divergent
signals
JOURNAL Genes Dev. 12 (19), 2973-2983 (1998)
PUBMED 9765199
REMARK Review article
REFERENCE 8 (bases 1 to 3950)
AUTHORS Flaggs,G., Plug,A.W., Dunks,K.M., Mundt,K.E., Ford,J.C.,
Quiggle,M.R., Taylor,E.M., Westphal,C.H., Ashley,T., Hoekstra,M.F.
and Carr,A.M.
TITLE Atm-dependent interactions of a mammalian chk1 homolog with meiotic
chromosomes
JOURNAL Curr. Biol. 7 (12), 977-986 (1997)
PUBMED 9382850
REFERENCE 9 (bases 1 to 3950)
AUTHORS Peng,C.Y., Graves,P.R., Thoma,R.S., Wu,Z., Shaw,A.S. and
Piwnica-Worms,H.
TITLE Mitotic and G2 checkpoint control: regulation of 14-3-3 protein
binding by phosphorylation of Cdc25C on serine-216
JOURNAL Science 277 (5331), 1501-1505 (1997)
PUBMED 9278512
REFERENCE 10 (bases 1 to 3950)
AUTHORS Sanchez,Y., Wong,C., Thoma,R.S., Richman,R., Wu,Z.,
Piwnica-Worms,H. and Elledge,S.J.
TITLE Conservation of the Chk1 checkpoint pathway in mammals: linkage of
DNA damage to Cdk regulation through Cdc25
JOURNAL Science 277 (5331), 1497-1501 (1997)
PUBMED 9278511
REMARK GeneRIF: Biochemical studies suggest the functional interactions of
this protein with cell cycle regulators. Cdc25A, Cdc25B, and Cdc25C
can be phosphoryalted by this protein.
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX419129.2, AW149126.1,
CA868104.1, AK300082.1, DA567616.1, CA441277.1, BC004202.2,
BG191840.1, BM455102.1, BX506561.1, BX114781.1, AI750792.1 and
AA224205.1.
Summary: The protein encoded by this gene belongs to the Ser/Thr
protein kinase family. It is required for checkpoint mediated cell
cycle arrest in response to DNA damage or the presence of
unreplicated DNA. This protein acts to integrate signals from ATM
and ATR, two cell cycle proteins involved in DNA damage responses,
that also associate with chromatin in meiotic prophase I.
Phosphorylation of CDC25A protein phosphatase by this protein is
required for cells to delay cell cycle progression in response to
double-strand DNA breaks. Several alternatively spliced transcript
variants have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (5) lacks an exon in the 5' region
compared to variant 1, which reveals an out-of-frame upstream AUG,
translation from which results in a protein with a longer and
different N-terminus that has no other protein support. However,
the transcript is sufficiently abundant to represent as a RefSeq
record.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-85 BX419129.2 648-732 c
86-431 AW149126.1 82-427
432-744 CA868104.1 1-313 c
745-802 AK300082.1 155-212
803-803 DA567616.1 37-37
804-2083 AK300082.1 214-1493
2084-2084 CA441277.1 463-463 c
2085-2131 BC004202.2 1471-1517
2132-2518 BG191840.1 126-512
2519-2777 BM455102.1 369-627
2778-3049 BX506561.1 253-524
3050-3526 BX114781.1 281-757
3527-3919 AI750792.1 9-401 c
3920-3950 AA224205.1 1-31 c
FEATURES Location/Qualifiers
source 1..3950
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.2"
gene 1..3950
/gene="CHEK1"
/gene_synonym="CHK1"
/note="checkpoint kinase 1"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
misc_RNA 1..3950
/gene="CHEK1"
/gene_synonym="CHK1"
/product="checkpoint kinase 1, transcript variant 5"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
exon 1..877
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 14
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61612408"
variation 48
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61451117"
variation 157..159
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="aaa"
/db_xref="dbSNP:71715502"
variation 162..163
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="a"
/db_xref="dbSNP:34798120"
variation 179..180
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="g"
/db_xref="dbSNP:3216096"
variation 181..182
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="c"
/db_xref="dbSNP:28365794"
variation 181
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057733"
variation 181
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="cc"
/replace="t"
/db_xref="dbSNP:66498879"
variation 182
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2298482"
variation 205
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:192831922"
variation 234
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:558351"
variation 336
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:144289861"
variation 339
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:147779069"
variation 344
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:139443875"
variation 384
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112740384"
variation 465
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:184405894"
variation 491
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:555752"
variation 645
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:116191495"
variation 689
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73616024"
variation 707
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112362212"
variation 710
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:77183579"
variation 716
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:76045215"
exon 878..962
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 880
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371037025"
misc_feature 898..984
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_001274.5"
/note="primary ORF has stop codon >50 nucleotides from the
terminal splice site; nonsense-mediated decay (NMD)
candidate"
variation 907
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201459198"
variation 931
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200520758"
variation 936
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144523921"
exon 963..1027
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1027
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375305289"
exon 1028..1097
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1036
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368957964"
variation 1049
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112275638"
variation 1060
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114850047"
variation 1088
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371765740"
exon 1098..1286
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1105
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113468080"
variation 1139
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140276570"
variation 1140
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3731410"
variation 1151
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369248914"
variation 1171
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373714183"
variation 1197
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75583143"
variation 1258
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200960815"
variation 1279
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190137928"
variation 1280
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376741119"
exon 1287..1391
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1321
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377704459"
variation 1341
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:35817404"
variation 1351
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370350660"
exon 1392..1487
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1424
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201395400"
variation 1433
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553952"
variation 1445
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201385540"
exon 1488..1596
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1513
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:111852956"
variation 1550
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147323405"
variation 1585
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:182542971"
exon 1597..1774
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1607
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34097480"
variation 1618
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371546941"
variation 1651
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2847422"
variation 1673
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:139936669"
variation 1705
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375729370"
variation 1709
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199535573"
variation 1715
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374866866"
variation 1727
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149667923"
variation 1747
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111415405"
variation 1756
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200239581"
exon 1775..1906
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1780
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375980825"
variation 1783
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77764256"
variation 1810
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369650833"
variation 1825
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192063586"
variation 1843
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372751798"
variation 1861
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374032447"
variation 1881
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115991933"
variation 1882
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149857578"
variation 1890
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145794689"
exon 1907..2008
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1913
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148568641"
variation 1933
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141332865"
variation 1935
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370268372"
exon 2009..3931
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 2069
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146590504"
variation 2084
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:506504"
variation 2107
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373998065"
variation 2126
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:375887872"
variation 2165
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:9282658"
variation 2199
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148807246"
variation 2240
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373169887"
variation 2271
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:184393295"
variation 2430
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142447277"
variation 2476..2477
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:141464656"
variation 2477..2478
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:113628894"
variation 2477
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199723723"
variation 2478..2479
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:72531173"
variation 2479..2480
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:3731480"
variation 2480..2481
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:35167388"
variation 2480
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201914580"
polyA_signal 2508..2513
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2527
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:190098261"
polyA_site 2529
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2550
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181773130"
variation 2628
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184932784"
variation 2847
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113311223"
variation 2886
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189829306"
variation 2942
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151312608"
variation 3025
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140546391"
variation 3049
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144047942"
variation 3050
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:567889"
variation 3052
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368655022"
variation 3108
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="t"
/db_xref="dbSNP:34215005"
variation 3121
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146445217"
variation 3216
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370171293"
variation 3224
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140816182"
variation 3585
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623058"
variation 3599
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370678835"
variation 3663
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11220176"
variation 3794
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138368921"
variation 3854
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:180885007"
polyA_signal 3902..3907
/gene="CHEK1"
/gene_synonym="CHK1"
polyA_site 3931
/gene="CHEK1"
/gene_synonym="CHK1"
ORIGIN
cttttaaatttgcgttgtaagatttattttggctctccccgcctgttctttgcacattaaaaatgaaaaagtttgtagaactaagctaagcagatggtcttcctgcaaaaagaccgggctgaagtaaagcattgttttggagctggttcacagaaaaaaggcaaaactggttatcctgacttcaagctccaacataaactgctcgctttctccgggaaacttgccccgccacacacacttgactgcgtggccagttctttcgaagcctctcgctcccaacacggagttcctcccatttcttcacagtcggctctcagcagctgctgctggtttctcggctccagcaccacgagtaccgcactctgaggtttacaaagcactctgcttcaccgactgtgatcctcacagtcctgtccggtggcctcacgcaggtggcggtgcagcctttcaggcccagagcggccaggagcgaagcccgcagccccgcctggaagcgcagcgcggtcggtcgcgcgcccctgaggcttggaggcctgggcttcccccagcagcgctcgagcaccgcccagtcgagcctcacaccggatgccacttcatatttgggcccagagctcaattcgcgccgatgcggtccgccgtccttaaatctcttcagccaggatctctccccgactgcaaagcagccctgggcgggagcggcaacatctccacgtcacccttttggagccgccgacattcagaggggcaggacacgggaacgcgcgctgtcttgctttacggcgcgggtgcgcgagtttgcggcagcgtgacgccctcaagttttggcgggaaaagcgctgcatttggattcctgcagtggtgggcaaaggacagtccgccgaggtgctcggtggagtcatggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctatggagaagccagacataggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttatctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaaagggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgtgagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaagagaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgcaatgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgactggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagctctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaaaaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttcaggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttctctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaaccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaagggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttacttggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattctttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttgggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggagaaacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgacttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaagggaagctgattgatattgtgagcagccagaagatttggcttcctgccacatgatcggaccatcggctctggggaatcctggtgaatatagtgctgctatgttgacattattcttcctagagaagattatcctgtcctgcaaactgcaaatagtagttcctgaagtgttcacttccctgtttatccaaacatcttccaatttattttgtttgttcggcatacaaataatacctatatcttaattgtaagcaaaactttggggaaaggatgaatagaattcatttgattatttcttcatgtgtgtttagtatctgaatttgaaactcatctggtggaaaccaagtttcaggggacatgagttttccagcttttatacacacgtatctcatttttatcaaaacattttgtttaattcaaaaagtacatattccatgttgatttaattctaagatgaaccaataaagacataattcttgtgacttttggacagtagatttatcagtctgtgaagcgaagccagcttcaaaacatatccccaagatttgtacttatattttcaaaagggcctggccagttatataaacctgtttttgaattataatgattaattaaaattgcaagtaggtgttttttccagtgtagttagtaaaatacttgtattttacagtgttgcataaactctagtgcttaactaactttactctaaaaattactgttgaacatcttaaatatttttctatattttctactttcatagccatattttaaccttttcaacttactggtgaccaagcttttaggtgataaagaataaaagagggaagggaagagtaaggaagctataagaaaaatagatctgattctttgttcctttacctgttagacttacaaaaagtttgtttttctaataaaatttgtatcaactttggggcatattaggttgaggccttggctcctgcctgtagtcccagctacttaggaggctgagagaggaggatcgcgtgaacctggaagtttgaggctgtagtgagctatgattgcaccagtgcactccagcttggatgacagagtaagaccctacctctaataaaaatttttaaaattgtaaaacattataaaattaatcagttattttaatctgaagccaagaacatgtagaatgttatgattagagtttatcacatattaatgtatactggcaaattgtgttactggagtatacccataggaggaataaattcaaacctgttttatttatttgaacctatttacggtatgcttaagaattgaatcagtataaattctcaaatatgggagaaattttgttcttgagaattatctgagtcattaatatttttcaaaaacagctctcactgacttgaacctcttctgtaagctctaaccttttacctgctttacatttccacttgaatgtctagtaggcatctcttgaccaaaaacagcttttgattcctgttctccaacctgttcctctcctagttttctccatctcagaaatgttacttcctctgcaaagtctttccctgacttatctaaaataataacctcctctgtttgctgtgggaatttgtatagaatggtgggaaaatttcaagtttcatatttggattagctctgacatttatttatctgaacactggtaattgcctcagtaaagacactgataataagtaccttttagagttattttaatctttaatgctttaatgtgtaggaagagtatagtgtcctgttttgcacagaaaggcattctgtaaataataagttgccttaattttcctgtaatgttcattatattgttgtgggaaggtatttactcctattattaaaaataaaaatgtgtaaaatttactacctgaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1111 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:1111 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1111 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1111 -> Molecular function: GO:0035402 [histone kinase activity (H3-T11 specific)] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: IEA
GeneID:1111 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:1111 -> Biological process: GO:0006281 [DNA repair] evidence: IMP
GeneID:1111 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
GeneID:1111 -> Biological process: GO:0006975 [DNA damage induced protein phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0010569 [regulation of double-strand break repair via homologous recombination] evidence: IDA
GeneID:1111 -> Biological process: GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] evidence: ISS
GeneID:1111 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0033261 [regulation of S phase] evidence: IEA
GeneID:1111 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
GeneID:1111 -> Biological process: GO:0045839 [negative regulation of mitosis] evidence: IDA
GeneID:1111 -> Biological process: GO:0046602 [regulation of mitotic centrosome separation] evidence: IDA
GeneID:1111 -> Biological process: GO:0048096 [chromatin-mediated maintenance of transcription] evidence: ISS
GeneID:1111 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:1111 -> Biological process: GO:0071313 [cellular response to caffeine] evidence: IEA
GeneID:1111 -> Biological process: GO:0090399 [replicative senescence] evidence: NAS
GeneID:1111 -> Biological process: GO:2000615 [regulation of histone H3-K9 acetylation] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000781 [chromosome, telomeric region] evidence: IDA
GeneID:1111 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000794 [condensed nuclear chromosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1111 -> Cellular component: GO:0005657 [replication fork] evidence: IEA
GeneID:1111 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
by
@meso_cacase at
DBCLS
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