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2024-03-28 19:53:16, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_037944               4653 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens WNT1 inducible signaling pathway protein 1 (WISP1),
            transcript variant 5, non-coding RNA.
ACCESSION   NR_037944
VERSION     NR_037944.1  GI:325910846
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4653)
  AUTHORS   Liu,J.F., Hou,S.M., Tsai,C.H., Huang,C.Y., Hsu,C.J. and Tang,C.H.
  TITLE     CCN4 induces vascular cell adhesion molecule-1 expression in human
            synovial fibroblasts and promotes monocyte adhesion
  JOURNAL   Biochim. Biophys. Acta 1833 (5), 966-975 (2013)
   PUBMED   23313051
  REMARK    GeneRIF: The CCN4-induced VCAM-1 expression promoted monocyte
            adhesion to human OASFs.
REFERENCE   2  (bases 1 to 4653)
  AUTHORS   Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A,
            Young R, Ho WK, Rasheed A, Frossard P, Sim X, Hassanali N, Radha V,
            Chidambaram M, Liju S, Rees SD, Ng DP, Wong TY, Yamauchi T, Hara K,
            Tanaka Y, Hirose H, McCarthy MI, Morris AP, Basit A, Barnett AH,
            Katulanda P, Matthews D, Mohan V, Wander GS, Singh JR, Mehra NK,
            Ralhan S, Kamboh MI, Mulvihill JJ, Maegawa H, Tobe K, Maeda S, Cho
            YS, Tai ES, Kelly MA, Chambers JC, Kooner JS, Kadowaki T, Deloukas
            P, Rader DJ, Danesh J and Sanghera DK.
  CONSRTM   DIAGRAM; MuTHER; AGEN
  TITLE     Genome-wide association study identifies a novel locus contributing
            to type 2 diabetes susceptibility in Sikhs of Punjabi origin from
            India
  JOURNAL   Diabetes 62 (5), 1746-1755 (2013)
   PUBMED   23300278
REFERENCE   3  (bases 1 to 4653)
  AUTHORS   Zemans,R.L., McClendon,J., Aschner,Y., Briones,N., Young,S.K.,
            Lau,L.F., Kahn,M. and Downey,G.P.
  TITLE     Role of beta-catenin-regulated CCN matricellular proteins in
            epithelial repair after inflammatory lung injury
  JOURNAL   Am. J. Physiol. Lung Cell Mol. Physiol. 304 (6), L415-L427 (2013)
   PUBMED   23316072
  REMARK    GeneRIF: Beta-catenin-dependent expression of WISP1 and Cyr61 is
            critical for epithelial repair.
REFERENCE   4  (bases 1 to 4653)
  AUTHORS   Hennemeier,I., Humpf,H.U., Gekle,M. and Schwerdt,G.
  TITLE     The food contaminant and nephrotoxin ochratoxin A enhances Wnt1
            inducible signaling protein 1 and tumor necrosis factor-alpha
            expression in human primary proximal tubule cells
  JOURNAL   Mol Nutr Food Res 56 (9), 1375-1384 (2012)
   PUBMED   22778029
  REMARK    GeneRIF: Prolonged exposure of kidney cells to ochratoxin A,
            expectable in human kidney due to a normal diet, leads to a marked
            ERK1/2-dependent upregulation of WISP1 gene expression, which,
            accompanied by increased ERK1/2- dependent TNF-alpha expression.
REFERENCE   5  (bases 1 to 4653)
  AUTHORS   Shao,H., Cai,L., Grichnik,J.M., Livingstone,A.S., Velazquez,O.C.
            and Liu,Z.J.
  TITLE     Activation of Notch1 signaling in stromal fibroblasts inhibits
            melanoma growth by upregulating WISP-1
  JOURNAL   Oncogene 30 (42), 4316-4326 (2011)
   PUBMED   21516124
  REMARK    GeneRIF: This study shows that constitutive activation of the
            Notch1 pathway confers fibroblasts with a suppressive phenotype to
            melanoma growth, partially through WISP-1.
REFERENCE   6  (bases 1 to 4653)
  AUTHORS   Xie,D., Nakachi,K., Wang,H., Elashoff,R. and Koeffler,H.P.
  TITLE     Elevated levels of connective tissue growth factor, WISP-1, and
            CYR61 in primary breast cancers associated with more advanced
            features
  JOURNAL   Cancer Res. 61 (24), 8917-8923 (2001)
   PUBMED   11751417
  REMARK    GeneRIF: Elevated levels of connective tissue growth factor,
            WISP-1, and CYR61 in primary breast cancers associated with more
            advanced features.
REFERENCE   7  (bases 1 to 4653)
  AUTHORS   Desnoyers,L., Arnott,D. and Pennica,D.
  TITLE     WISP-1 binds to decorin and biglycan
  JOURNAL   J. Biol. Chem. 276 (50), 47599-47607 (2001)
   PUBMED   11598131
REFERENCE   8  (bases 1 to 4653)
  AUTHORS   Tanaka,S., Sugimachi,K., Saeki,H., Kinoshita,J., Ohga,T.,
            Shimada,M., Maehara,Y. and Sugimachi,K.
  TITLE     A novel variant of WISP1 lacking a Von Willebrand type C module
            overexpressed in scirrhous gastric carcinoma
  JOURNAL   Oncogene 20 (39), 5525-5532 (2001)
   PUBMED   11571650
REFERENCE   9  (bases 1 to 4653)
  AUTHORS   Xu,L., Corcoran,R.B., Welsh,J.W., Pennica,D. and Levine,A.J.
  TITLE     WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene
  JOURNAL   Genes Dev. 14 (5), 585-595 (2000)
   PUBMED   10716946
REFERENCE   10 (bases 1 to 4653)
  AUTHORS   Pennica,D., Swanson,T.A., Welsh,J.W., Roy,M.A., Lawrence,D.A.,
            Lee,J., Brush,J., Taneyhill,L.A., Deuel,B., Lew,M., Watanabe,C.,
            Cohen,R.L., Melhem,M.F., Finley,G.G., Quirke,P., Goddard,A.D.,
            Hillan,K.J., Gurney,A.L., Botstein,D. and Levine,A.J.
  TITLE     WISP genes are members of the connective tissue growth factor
            family that are up-regulated in wnt-1-transformed cells and
            aberrantly expressed in human colon tumors
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (25), 14717-14722 (1998)
   PUBMED   9843955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301508.1, AF192304.6 and
            AI347990.1.
            
            Summary: This gene encodes a member of the WNT1 inducible signaling
            pathway (WISP) protein subfamily, which belongs to the connective
            tissue growth factor (CTGF) family. WNT1 is a member of a family of
            cysteine-rich, glycosylated signaling proteins that mediate diverse
            developmental processes. The CTGF family members are characterized
            by four conserved cysteine-rich domains: insulin-like growth
            factor-binding domain, von Willebrand factor type C module,
            thrombospondin domain and C-terminal cystine knot-like domain. This
            gene may be downstream in the WNT1 signaling pathway that is
            relevant to malignant transformation. It is expressed at a high
            level in fibroblast cells, and overexpressed in colon tumors. The
            encoded protein binds to decorin and biglycan, two members of a
            family of small leucine-rich proteoglycans present in the
            extracellular matrix of connective tissue, and possibly prevents
            the inhibitory activity of decorin and biglycan in tumor cell
            proliferation. It also attenuates p53-mediated apoptosis in
            response to DNA damage through activation of the Akt kinase. It is
            83% identical to the mouse protein at the amino acid level.
            Multiple alternatively spliced transcript variants have been
            identified. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (5) lacks internal two exons,
            resulting in an immature translation termination, as compared to
            variant 1. The transcript is a nonsense-mediated mRNA decay
            candidate.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1319              AK301508.1         1-1319
            1320-4373           AF192304.6         66484-69537
            4374-4653           AI347990.1         1-280               c
FEATURES             Location/Qualifiers
     source          1..4653
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..4653
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /note="WNT1 inducible signaling pathway protein 1"
                     /db_xref="GeneID:8840"
                     /db_xref="HGNC:12769"
                     /db_xref="MIM:603398"
     misc_RNA        1..4653
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /product="WNT1 inducible signaling pathway protein 1,
                     transcript variant 5"
                     /db_xref="GeneID:8840"
                     /db_xref="HGNC:12769"
                     /db_xref="MIM:603398"
     exon            1..175
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       22
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35244636"
     variation       55
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:116716037"
     variation       58
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113859079"
     variation       60
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201515187"
     variation       76
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370168550"
     variation       77
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373840690"
     misc_feature    107..217
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001204870.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     variation       128
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145302227"
     variation       130
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147864416"
     variation       134
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141541463"
     variation       135
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147047617"
     variation       140
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145240649"
     variation       144
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149172980"
     variation       155
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375956639"
     variation       174
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370536589"
     variation       175
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374241755"
     exon            176..369
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       178
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35513885"
     variation       179
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369847225"
     variation       192
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141179228"
     variation       198
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377427275"
     variation       236
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373574457"
     variation       247
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199564945"
     variation       255
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150744504"
     variation       256
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139602125"
     variation       284
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199672029"
     variation       291
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201767438"
     variation       292
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200522670"
     variation       315
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200030526"
     variation       319
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370235023"
     variation       335
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201197950"
     variation       343
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202087900"
     variation       360
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113292639"
     exon            370..4649
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /inference="alignment:Splign:1.39.8"
     variation       413
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370616029"
     variation       420
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35938742"
     variation       428
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374293123"
     variation       429
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34279368"
     variation       458
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368398252"
     variation       462
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150347257"
     variation       486
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3739261"
     variation       501
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369316693"
     variation       535
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200845163"
     variation       560
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371947572"
     variation       570
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34665171"
     variation       621
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:146812236"
     variation       663
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:140629356"
     variation       671
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:192420341"
     variation       691
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200836970"
     variation       696
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374163879"
     variation       814
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138013484"
     variation       924
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57390041"
     variation       1038
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:142394577"
     variation       1120
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113549310"
     variation       1145
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184580529"
     variation       1262
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:190313906"
     variation       1310
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142461254"
     variation       1413
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929969"
     variation       1639
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12164193"
     variation       1648
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145960909"
     variation       1654
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:73362554"
     variation       1723
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:182003497"
     variation       1802
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:4265166"
     variation       1853
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929970"
     variation       1922
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374010309"
     variation       1927
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4577938"
     variation       2018
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:377032724"
     variation       2132
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146162433"
     variation       2187
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185849289"
     variation       2483
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188945068"
     variation       2492
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181057409"
     variation       2495
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148796937"
     variation       2716
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117072299"
     variation       2749
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977549"
     variation       3052
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73362557"
     variation       3054
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76779268"
     variation       3088
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:2929971"
     variation       3095
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373530385"
     variation       3119
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142427022"
     variation       3171
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2929972"
     variation       3224
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2929973"
     variation       3248
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151300566"
     variation       3396
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:16904856"
     variation       3427..3428
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:36017627"
     variation       3483
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370468302"
     variation       3525
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977550"
     variation       3640
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9649971"
     variation       3642
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186406622"
     variation       3672
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16904857"
     variation       3761
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191533905"
     variation       3795
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200715437"
     variation       3823
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145461011"
     variation       3964
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:16904858"
     variation       4072
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114925013"
     variation       4082
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:16904859"
     variation       4138
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:73711826"
     variation       4140..4141
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35647766"
     variation       4145
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16904860"
     variation       4158..4161
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="ctga"
                     /db_xref="dbSNP:372155216"
     variation       4160..4163
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace=""
                     /replace="gact"
                     /db_xref="dbSNP:367926394"
     variation       4184
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:182511484"
     variation       4201
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186242527"
     variation       4247
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:74818902"
     variation       4266
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2977551"
     variation       4378
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147688784"
     variation       4390
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191950359"
     variation       4555
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77866098"
     polyA_signal    4627..4632
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
     polyA_site      4649
                     /gene="WISP1"
                     /gene_synonym="CCN4; WISP1c; WISP1i; WISP1tc"
ORIGIN      


atatctggtgctcctgatgggccggccagtctgggcccagctcccccgagaggtggtcggatcctctgggctgctcggtcgatgcctgtgccactgacgtccaggcatgaggtggttcctgccctggacgctggcagcagtgacagcagcagccgccagcaccgtcctggccacgatgctgtgggtgaggtggaggcatggcacaggaactgcatagcctacacaagcccctggagcccttgctccaccagctgcggcctgggggtctccactcggatctccaatgttaacgcccagtgctggcctgagcaagagagccgcctctgcaacttgcggccatgcgatgtggacatccatacactcattaaggcagggaagaagtgtctggctgtgtaccagccagaggcatccatgaacttcacacttgcgggctgcatcagcacacgctcctatcaacccaagtactgtggagtttgcatggacaataggtgctgcatcccctacaagtctaagactatcgacgtgtccttccagtgtcctgatgggcttggcttctcccgccaggtcctatggattaatgcctgcttctgtaacctgagctgtaggaatcccaatgacatctttgctgacttggaatcctaccctgacttctcagaaattgccaactaggcaggcacaaatcttgggtcttggggactaacccaatgcctgtgaagcagtcagcccttatggccaataacttttcaccaatgagccttagttaccctgatctggacccttggcctccatttctgtctctaaccattcaaatgacgcctgatggtgctgctcaggcccatgctatgagttttctccttgatatcattcagcatctactctaaagaaaaatgcctgtctctagctgttctggactacacccaagcctgatccagcctttccaagtcactagaagtcctgctggatcttgcctaaatcccaagaaatggaatcaggtagacttttaatatcactaatttcttctttagatgccaaaccacaagactctttgggtccattcagatgaatagatggaatttggaacaatagaataatctattatttggagcctgccaagaggtactgtaatgggtaattctgacgtcagcgcaccaaaactatcctgattccaaatatgtatgcacctcaaggtcatcaaacatttgccaagtgagttgaatagttgcttaattttgatttttaatggaaagttgtatccattaacctgggcattgttgaggttaagtttctcttcacccctacactgtgaagggtacagattaggtttgtcccagtcagaaataaaatttgataaacattcctgttgatgggaaaagcccccagttaatactccagagacagggaaaggtcagcccgtttcagaaggaccaattgactctcacactgaatcagctgctgactggcagggctttgggcagttggccaggctcttccttgaatcttctcccttgtcctgcttggggttcataggaattggtaaggcctctggactggcctgtctggcccctgagagtggtgccctggaacactcctctactcttacagagccttgagagacccagctgcagaccatgccagacccactgaaatgaccaagacaggttcaggtaggggtgtgggtcaaaccaagaagtgggtgcccttggtagcagcctggggtgacctctagagctggaggctgtgggactccaggggcccccgtgttcaggacacatctattgcagagactcatttcacagcctttcgttctgctgaccaaatggccagttttctggtaggaagatggaggtttaccggttgtttagaaacagaaatagacttaataaaggtttaaagctgaagaggttgaagctaaaaggaaaaggttgttgttaatgaatatcaggctattatttattgtattaggaaaatataatatttactgttagaattcttttatttagggccttttctgtgccagacattgctctcagtgctttgcatgtattagctcactgaatcttcacgacaatgttgagaagttcccattattatttctgttcttacaaatgtgaaacggaagctcatagaggtgagaaaactcaaccagagtcacccagttggtgactgggaaagttaggattcagatcgaaattggactgtctttataacccatattttccccctgtttttagagcttccaaatgtgtcagaataggaaaacattgcaataaatggcttgattttttaatgtcatttttccctcttatagtctttctagctccttttcaaaagacgagaatatctgattttctgataatttaggtgcttaagcatccaaaatacatgggacacacaaaaatccaggaatcccctgtagcttattccctctttcccatcggaaccagctctcatcacacatttaaaagatgattctgtttacccaatgctgcatattgaatgttgtgtagttattcacagggaattctgtgcagtgtgcagagagattcctaaacgggaaaaggactgggaatacatcctccttactgtgacctccccaaaacctagtccagtgcaaggtatacagtggtgctcattaaatacttgatgaatacaggaagctgtgcatgtgttcctacttttattcgaagctctcttcttccaaagctacatgaaaatagaattttaacagtcaaaattttatattaagtgccttagcaaaagagacatttaatatttcaaagaaatgcatatgtatgtatacatatatttgtgtatgcgtatgcaagaattcttgtataaagagaattcactccatgaatgatctcttctgtaagtcagtgtgaatcatgttagattttctgagagtgaaaacacctgccatctacaaattacaaggctggataacagctcactccatttgaaattcagtggaaacccaagagctaggttcttactgaatttgcatctcaatttgggaaactgaacttagctttcaaagatcataggaagtctggttggagaaactagggattattctggcaatgggtgcaggaaggtggtcagaataacccagtcgccattggttttgagaaacggaactatcttatgcagagcccggagggcaagtctcagacccatgggttgaagccatggagaaggaaatttggatccaatgtaatgaagcgctttctaagtcagaatttccctgcaatggtgtggcctgattcaataaaaattaagaataataaatataatggaaaaaaatctccactgattgagtgtttacttggtgccaagcactatgctaagttgttcattattttatttaattgttacagcaattttgagtatgcatctttcactattttataagtggaaaagagaagtgcccccaaaaagttagagctcaaacagcagcttattctaccagcccctgctcttgcggaggcctctggaaaagacctgaatgacacctattggagaattacatctacaaggggcttcaaacagaccaaatagatcatcacctctgtggtcccttgttaactatatgttctgagacaaaggaaagctaccctaagggttagttaacctttgctgaggaaatttacattcatacttagagtgaattactcaggtgtgcttaggtgtgcaaaagggaaggagacctgaattcaccaagttaaatcttgctaaaccttatcataagcattttttgagcgcttagcatacaccaagccttgtggaaggtgctttcctgccatatctcatttaatcctcacagcaaacctatagaatatggcattatcatctgagtctcacagaagtttagtcgtgtactcaaggtcttaccagctagtgaacagcagaccaagactggaaacccaggatagtctgatacctgagccatctcttcttgtgctacgcctagttattctgtcccccaaatcaaaaggcatgacctttataagaggcgctttactgacaatagctgcaattttaactttgaaaatgattcagaattatcaaagatagtagattcgaatgacatgattgtctataatctcgctagccttgtactgtgtgtgcatagcaattacagggaagtaatctagctcctgactattatgttgaactatgtcgctgctttttacaaacttgtcttgatccaaagcagtcacaatgataaccctgcatatctgggaatcataagtcaactatgtatccctgtgtgtgtatatatatgtatgtatgtatctattttcaaactgtgatttaatatttaaatattcctactgccatttttgtgactgaaaaactacacatgaggaaacgtcttagaattttccaatagaggaaaaataacacttgggcaatctgtcatgtttcacaacagttctcatttttctcatgatttgtgtagcgtggaatgtgtttgctcaatgtgaagggttttcattgctcaatttctctgtgtaagtcttttccttaaggtaataaaccatcagcaaagtcacatactggagttggtggcttttcttgtacaggcagttgttatgagacaatgatggagcattgagcatgttcaataaatgtgcagatggtggaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8840 -> Molecular function: GO:0005520 [insulin-like growth factor binding] evidence: IEA
            GeneID:8840 -> Biological process: GO:0001558 [regulation of cell growth] evidence: IEA
            GeneID:8840 -> Biological process: GO:0007155 [cell adhesion] evidence: IEA
            GeneID:8840 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:8840 -> Biological process: GO:0007267 [cell-cell signaling] evidence: TAS
            GeneID:8840 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
            GeneID:8840 -> Cellular component: GO:0005615 [extracellular space] evidence: NAS
            GeneID:8840 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
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