GGRNA | NR_037874.1

LOCUS       NR_037874               2384 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens zinc fingers and homeoboxes 1 (ZHX1), transcript
            variant 4, non-coding RNA.
ACCESSION   NR_037874
VERSION     NR_037874.1  GI:323510650
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Bird,L.E., Ren,J., Nettleship,J.E., Folkers,G.E., Owens,R.J. and
            Stammers,D.K.
  TITLE     Novel structural features in two ZHX homeodomains derived from a
            systematic study of single and multiple domains
  JOURNAL   BMC Struct. Biol. 10, 13 (2010)
   PUBMED   20509910
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Wienk,H., Lammers,I., Hotze,A., Wu,J., Wechselberger,R.W.,
            Owens,R., Stammers,D.K., Stuart,D., Kaptein,R. and Folkers,G.E.
  TITLE     The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc
            finger structure with a C-terminal extension
  JOURNAL   Biochemistry 48 (21), 4431-4439 (2009)
   PUBMED   19348505
  REMARK    GeneRIF: structure of the tandem zinc-finger region of human ZHX1
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Kim,S.H., Park,J., Choi,M.C., Kim,H.P., Park,J.H., Jung,Y.,
            Lee,J.H., Oh,D.Y., Im,S.A., Bang,Y.J. and Kim,T.Y.
  TITLE     Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase
            (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression
  JOURNAL   Biochem. Biophys. Res. Commun. 355 (2), 318-323 (2007)
   PUBMED   17303076
  REMARK    GeneRIF: ZHX1 enhanced the transcriptional repression mediated by
            DNMT3B when DNMT3B is directly targeted to DNA. These results
            showed for the first the direct linkage between DNMT and
            zinc-fingers homeoboxes protein, leading to enhanced gene silencing
            by DNMT3B
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Ogata-Kawata,H., Yamada,K., Uesaka-Yoshino,M., Kagawa,N. and
            Miyamoto,K.
  TITLE     BS69, a corepressor interacting with ZHX1, is a bifunctional
            transcription factor
  JOURNAL   Front. Biosci. 12, 1911-1926 (2007)
   PUBMED   17127430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2384)
  AUTHORS   Liu,G., Clement,L.C., Kanwar,Y.S., Avila-Casado,C. and Chugh,S.S.
  TITLE     ZHX proteins regulate podocyte gene expression during the
            development of nephrotic syndrome
  JOURNAL   J. Biol. Chem. 281 (51), 39681-39692 (2006)
   PUBMED   17056598
  REMARK    GeneRIF: ZHX proteins 1, 2 and 3 are major transcriptional
            mediators of podocyte disease
            Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]
REFERENCE   6  (bases 1 to 2384)
  AUTHORS   Yamada,K., Kawata,H., Shou,Z., Hirano,S., Mizutani,T., Yazawa,T.,
            Sekiguchi,T., Yoshino,M., Kajitani,T. and Miyamoto,K.
  TITLE     Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting
            proteins: molecular cloning and characterization of a member of the
            ZHX family, ZHX3
  JOURNAL   Biochem. J. 373 (PT 1), 167-178 (2003)
   PUBMED   12659632
  REMARK    GeneRIF: a search of ZHX1-interacting proteins using a yeast
            two-hybrid system
REFERENCE   7  (bases 1 to 2384)
  AUTHORS   Yamada,K., Kawata,H., Matsuura,K., Shou,Z., Hirano,S., Mizutani,T.,
            Yazawa,T., Yoshino,M., Sekiguchi,T., Kajitani,T. and Miyamoto,K.
  TITLE     Functional analysis and the molecular dissection of zinc-fingers
            and homeoboxes 1 (ZHX1)
  JOURNAL   Biochem. Biophys. Res. Commun. 297 (2), 368-374 (2002)
   PUBMED   12237128
  REMARK    GeneRIF: This study characterized features of ZHX-1 involved in
            nuclear localization, dimerization, and transcriptional activity,
            and mapped these domains.
REFERENCE   8  (bases 1 to 2384)
  AUTHORS   Hirano,S., Yamada,K., Kawata,H., Shou,Z., Mizutani,T., Yazawa,T.,
            Kajitani,T., Sekiguchi,T., Yoshino,M., Shigematsu,Y., Mayumi,M. and
            Miyamoto,K.
  TITLE     Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear
            factor-YA-interacting nuclear protein, forms a homodimer
  JOURNAL   Gene 290 (1-2), 107-114 (2002)
   PUBMED   12062805
REFERENCE   9  (bases 1 to 2384)
  AUTHORS   Yamada,K., Osawa,H. and Granner,D.K.
  TITLE     Identification of proteins that interact with NF-YA
  JOURNAL   FEBS Lett. 460 (1), 41-45 (1999)
   PUBMED   10571058
REFERENCE   10 (bases 1 to 2384)
  AUTHORS   Yamada,K., Printz,R.L., Osawa,H. and Granner,D.K.
  TITLE     Human ZHX1: cloning, chromosomal location, and interaction with
            transcription factor NF-Y
  JOURNAL   Biochem. Biophys. Res. Commun. 261 (3), 614-621 (1999)
   PUBMED   10441475
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA238313.1, AK094451.1,
            CA776642.1, BC040481.1 and AK025236.1.
            
            Summary: The members of the zinc fingers and homeoboxes gene family
            are nuclear homodimeric transcriptional repressors that interact
            with the A subunit of nuclear factor-Y (NF-YA) and contain two
            C2H2-type zinc fingers and five homeobox DNA-binding domains. This
            gene encodes member 1 of this gene family. In addition to forming
            homodimers, this protein heterodimerizes with members 2 and 3 of
            the zinc fingers and homeoboxes family. Alternative splicing
            results in multiple transcript variants. Read-through transcription
            also exists between this gene and the downstream chromosome 8 open
            reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (4) lacks an internal coding exon,
            compared to variant 1. This variant is represented as non-coding
            because it lacks the entire coding region, as found in variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               DA238313.1         1-219
            220-963             AK094451.1         1-744
            964-1417            CA776642.1         141-594
            1418-2338           BC040481.1         3994-4914
            2339-2384           AK025236.1         2584-2629
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..2384
                     /gene="ZHX1"
                     /note="zinc fingers and homeoboxes 1"
                     /db_xref="GeneID:11244"
                     /db_xref="HGNC:12871"
                     /db_xref="MIM:604764"
     misc_RNA        1..2384
                     /gene="ZHX1"
                     /product="zinc fingers and homeoboxes 1, transcript
                     variant 4"
                     /db_xref="GeneID:11244"
                     /db_xref="HGNC:12871"
                     /db_xref="MIM:604764"
     exon            1..366
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     exon            367..480
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     exon            481..2351
                     /gene="ZHX1"
                     /inference="alignment:Splign:1.39.8"
     variation       963..964
                     /gene="ZHX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1966863"
     polyA_signal    2034..2039
                     /gene="ZHX1"
     variation       2055
                     /gene="ZHX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1869248"
     polyA_site      2058
                     /gene="ZHX1"
     polyA_signal    2321..2326
                     /gene="ZHX1"
     polyA_site      2351
                     /gene="ZHX1"
ORIGIN

gacgcgcgcgcgggagggccccgccttggccggctctctcccttccccctccgcccccggacggccgctggggcgcgcgcctctcctcgcacccccaccctgagtccccacactccgcggggccaccgagctgctgaggcccctttgcgggcccgccgagcggttccgggtttagggttcacaggtcagagttgactccctgaaaagtgcagccggtttgaaatgcaagatggcggcggcgtggcgctgagaggcgcggcggcccctgcaggtagtggcgcgagccggctccgcgaccagcgggcccggagactctgggctgcgggtgggaactggagcgcagagtccgcggccggcacgggaaaggagaagacagactgctgctttggacctgttggtaatgatggcctgagctaaacatctaactagaagggatacccttccatttcaaagaacagaatgctaaggaagctgtggcaactgcctaaaacgttgaaggagaatcaattcttcaactcaagatgtctgatttactgtgaatttgcccaatctttgatgacattgaaaacgttttggggcatacacactcaaaaagcaggatccaatacccaaaagaaatggaacttaatgttgtgccaaagttaaactactgcagttggtggaagttctgcaatgtaaatagaacactaattaaaaaacaacttgtaaaaatgcaatttaaattttaatacagtacatttttcttctaatatgatggagacattctgaatcttagactttctgagggggtttaatgaccactagagcttgtcctcatattcagtccagtttaatactgtatgtctagtaagatgggctatatattgcctctattctttgagatgtgattaagcttagaactttgaccaaaaattttacagtaaaaattgttagaaatgggtaaaaaaaaaaaaaaaaaaaaaaccctgatttattactatgtcttatttatcagaccctgcactaagattaaaagttgtgcatgggcttatacaatttcaaatgtaaaaacagcctatttatatatgttgaaacaataagattttatggtttcactggcccttaataattggatccttcattaaacacatccatgaataccactgtttctactgttacttgttccattagaagctgatttgctttttattaaactgcaggaaattaattctgaagaaggaaaagaaactgacatggtaatttggatagggtgaagctttgaaataaatactgcaccaaaaatgtgaaaaagaatcacgtagtaaatgtatacttagtgttttcttacaatcgtggaaatcagaaatgtttatacaggtgtcagatcagaatttttaagagttatctttcagtgaaattttataacagtttcagtgaatagagaaaaaattctgaactgatcataatgagttaaaagttagcttttcacttatgaatcatgggagtgttaactgttaactcttgccgtatcaggagactgaaagttcatactaatttacaaactttgtaaagactggtgctgttcattcatattgggaagaaccctttcttttgtgaccataggaccatttttcaaaatgcgctttcttcgtagaagaaatgttcagtttaattagctttggattttaacatgtttttctgaatgaccagatgtaggcttagccagtttattttctctaatttaatggataataaatattaagctcttggttaaatgtttttcagccattgaaaatgttatgaaaaagccttgaatatgcatgctgctttcatttttataaactttttattttttaactatagctttattagtaattccaaaatgctgcaatgtagctgatttcctcactcagacagctggctttgtgggtggcttttttcatactactgttaacttttttaaaaaagaagcaatgtaaagaccgtaatgcactaagctttttttttttcttttacacgtttaaaaacttcttaaagcactctgtaatataatgattaaattgctcccttttataaacattgctaatgtggtctgagttttgtttgacaataattttaatgttctcaaaatttgaaatgtcaagtattagaaatgaagcctttgaatatagttgtttcccttgcaatatgttaactctgtgtagctgtatataactattaatttccctcatctcttttataggcctgataaaactcttctctgacgtttgctagcttttaaatatatttatttgacagagcaaaagaaccctcttctggttgattgtgaccttgaatacaaaataaaagtagtgattagtagtttacagtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//

Annotations: