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2024-03-29 14:37:52, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_037688               1855 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens actin, gamma 1 (ACTG1), transcript variant 3,
            non-coding RNA.
ACCESSION   NR_037688
VERSION     NR_037688.1  GI:316659410
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1855)
  AUTHORS   Baranwal,S., Naydenov,N.G., Harris,G., Dugina,V., Morgan,K.G.,
            Chaponnier,C. and Ivanov,A.I.
  TITLE     Nonredundant roles of cytoplasmic beta- and gamma-actin isoforms in
            regulation of epithelial apical junctions
  JOURNAL   Mol. Biol. Cell 23 (18), 3542-3553 (2012)
   PUBMED   22855531
  REMARK    GeneRIF: Data indicate beta-cytoplasmic (beta-CYA) and
            gamma-cytoplasmic (gamma-CYA) actins differential localization and
            dynamics at epithelial junctions.
REFERENCE   2  (bases 1 to 1855)
  AUTHORS   Xiang,Y., Zheng,K., Ju,H., Wang,S., Pei,Y., Ding,W., Chen,Z.,
            Wang,Q., Qiu,X., Zhong,M., Zeng,F., Ren,Z., Qian,C., Liu,G.,
            Kitazato,K. and Wang,Y.
  TITLE     Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells
            affect herpes simplex virus 1 infection and replication
  JOURNAL   J. Virol. 86 (16), 8440-8451 (2012)
   PUBMED   22623803
  REMARK    GeneRIF: These results showed the biphasic F-actin dynamics in
            herpes simplex virus 1 neuronal infection and confirmed the
            association of F-actin with the changes in the expression and
            activity of cofilin 1.
REFERENCE   3  (bases 1 to 1855)
  AUTHORS   Riviere,J.B., van Bon,B.W., Hoischen,A., Kholmanskikh,S.S.,
            O'Roak,B.J., Gilissen,C., Gijsen,S., Sullivan,C.T., Christian,S.L.,
            Abdul-Rahman,O.A., Atkin,J.F., Chassaing,N., Drouin-Garraud,V.,
            Fry,A.E., Fryns,J.P., Gripp,K.W., Kempers,M., Kleefstra,T.,
            Mancini,G.M., Nowaczyk,M.J., van Ravenswaaij-Arts,C.M.,
            Roscioli,T., Marble,M., Rosenfeld,J.A., Siu,V.M., de Vries,B.B.,
            Shendure,J., Verloes,A., Veltman,J.A., Brunner,H.G., Ross,M.E.,
            Pilz,D.T. and Dobyns,W.B.
  TITLE     De novo mutations in the actin genes ACTB and ACTG1 cause
            Baraitser-Winter syndrome
  JOURNAL   Nat. Genet. 44 (4), 440-444 (2012)
   PUBMED   22366783
  REMARK    GeneRIF: identified de novo missense changes in the cytoplasmic
            actin-encoding genes ACTB and ACTG1 in one and two probands,
            respectively; suggest that Baraitser-Winter syndrome is the
            predominant phenotype associated with mutation of these two genes
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1855)
  AUTHORS   Shum,M.S., Pasquier,E., Po'uha,S.T., O'Neill,G.M., Chaponnier,C.,
            Gunning,P.W. and Kavallaris,M.
  TITLE     gamma-Actin regulates cell migration and modulates the ROCK
            signaling pathway
  JOURNAL   FASEB J. 25 (12), 4423-4433 (2011)
   PUBMED   21908715
  REMARK    GeneRIF: knockdown of gamma-actin significantly reduced speed of
            motility and severely affected the cell's ability to explore, which
            was, in part, due to a loss of cell polarity
REFERENCE   5  (bases 1 to 1855)
  AUTHORS   Kiuchi,T., Nagai,T., Ohashi,K. and Mizuno,K.
  TITLE     Measurements of spatiotemporal changes in G-actin concentration
            reveal its effect on stimulus-induced actin assembly and
            lamellipodium extension
  JOURNAL   J. Cell Biol. 193 (2), 365-380 (2011)
   PUBMED   21502360
  REMARK    GeneRIF: Cytoplasmic G-actin concentration is a critical parameter
            for determining the extent of stimulus-induced G-actin assembly and
            cell extension.
REFERENCE   6  (bases 1 to 1855)
  AUTHORS   Rodriguez Del Castillo,A., Vitale,M.L. and Trifaro,J.M.
  TITLE     Ca2+ and pH determine the interaction of chromaffin cell scinderin
            with phosphatidylserine and phosphatidylinositol 4,5,-biphosphate
            and its cellular distribution during nicotinic-receptor stimulation
            and protein kinase C activation
  JOURNAL   J. Cell Biol. 119 (4), 797-810 (1992)
   PUBMED   1331119
REFERENCE   7  (bases 1 to 1855)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J. Infect. 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   8  (bases 1 to 1855)
  AUTHORS   Erba,H.P., Eddy,R., Shows,T., Kedes,L. and Gunning,P.
  TITLE     Structure, chromosome location, and expression of the human
            gamma-actin gene: differential evolution, location, and expression
            of the cytoskeletal beta- and gamma-actin genes
  JOURNAL   Mol. Cell. Biol. 8 (4), 1775-1789 (1988)
   PUBMED   2837653
REFERENCE   9  (bases 1 to 1855)
  AUTHORS   Vandekerckhove,J., Schering,B., Barmann,M. and Aktories,K.
  TITLE     Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in
            arginine 177
  JOURNAL   J. Biol. Chem. 263 (2), 696-700 (1988)
   PUBMED   3335520
REFERENCE   10 (bases 1 to 1855)
  AUTHORS   Chou,C.C., Davis,R.C., Fuller,M.L., Slovin,J.P., Wong,A.,
            Wright,J., Kania,S., Shaked,R., Gatti,R.A. and Salser,W.A.
  TITLE     Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and
            amino acid substitutions that may be cancer related
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (9), 2575-2579 (1987)
   PUBMED   3472224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB455954.1, AC139149.6 and
            BC063495.1.
            
            Summary: Actins are highly conserved proteins that are involved in
            various types of cell motility, and maintenance of the
            cytoskeleton. In vertebrates, three main groups of actin isoforms,
            alpha, beta and gamma have been identified. The alpha actins are
            found in muscle tissues and are a major constituent of the
            contractile apparatus. The beta and gamma actins co-exist in most
            cell types as components of the cytoskeleton, and as mediators of
            internal cell motility. Actin, gamma 1, encoded by this gene, is a
            cytoplasmic actin found in non-muscle cells. Mutations in this gene
            are associated with DFNA20/26, a subtype of autosomal dominant
            non-syndromic sensorineural progressive hearing loss. Alternative
            splicing results in multiple transcript variants.[provided by
            RefSeq, Jan 2011].
            
            Transcript Variant: This variant (3) includes an alternate splice
            site in the 3' UTR, compared to variant 1, which makes the
            transcript a candidate for nonsense-mediated mRNA decay (NMD).
            Transcripts subjected to NMD are degraded prior to protein
            translation. The transcript is sufficiently abundant to represent
            as a RefSeq record though a predicted protein is not represented.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                DB455954.1         9-83
            76-133              AC139149.6         18631-18688
            134-262             AC139149.6         19062-19190
            263-502             AC139149.6         19280-19519
            503-941             AC139149.6         19796-20234
            942-1123            AC139149.6         20314-20495
            1124-1478           AC139149.6         20589-20943
            1479-1795           AC139149.6         21093-21409
            1796-1855           BC063495.1         1797-1856
FEATURES             Location/Qualifiers
     source          1..1855
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25"
     gene            1..1855
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /note="actin, gamma 1"
                     /db_xref="GeneID:71"
                     /db_xref="HGNC:144"
                     /db_xref="MIM:102560"
     misc_RNA        1..1855
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /product="actin, gamma 1, transcript variant 3"
                     /db_xref="GeneID:71"
                     /db_xref="HGNC:144"
                     /db_xref="MIM:102560"
     exon            1..133
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       85
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7503278"
     variation       101
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139403"
     variation       109..110
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549207"
     variation       113..114
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549240"
     variation       117..118
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549198"
     exon            134..262
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    140..1267
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001199954.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     variation       144
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549194"
     variation       181
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549195"
     variation       185
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549241"
     variation       217
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549228"
     variation       220
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549230"
     variation       226
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549232"
     variation       227
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549243"
     variation       234
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549231"
     variation       238
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549238"
     variation       244
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549193"
     variation       252
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549244"
     variation       258
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549236"
     variation       259
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549174"
     exon            263..502
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       265
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549197"
     variation       280
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549215"
     variation       281
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549214"
     variation       300
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549216"
     variation       315
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11549199"
     variation       316
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549220"
     variation       328
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549245"
     variation       338
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549224"
     variation       341
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11549233"
     variation       360
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549185"
     variation       409
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549209"
     variation       437
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549188"
     variation       439
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549239"
     variation       443
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11549229"
     variation       444
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549172"
     variation       462
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549181"
     variation       474
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549176"
     exon            503..941
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       517
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549201"
     variation       532
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11150794"
     variation       538
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230158"
     variation       552
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549180"
     variation       562
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549226"
     variation       569
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549196"
     variation       588
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549175"
     variation       595
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549208"
     variation       604
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549227"
     variation       610
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549222"
     variation       618
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549206"
     variation       652..653
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549192"
     variation       654
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549177"
     variation       750
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549225"
     variation       755..756
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549212"
     variation       799
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549205"
     variation       829
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11549213"
     variation       840
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549179"
     variation       853
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549173"
     variation       861..862
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549235"
     variation       868
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230159"
     variation       875
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549178"
     variation       891
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549202"
     variation       912
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549191"
     exon            942..1123
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       1015
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549211"
     variation       1038
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549204"
     variation       1057
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139405"
     variation       1069
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1135989"
     variation       1093
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3211110"
     variation       1108
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549187"
     exon            1124..1478
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       1130
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11549200"
     variation       1153
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139807"
     variation       1165
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139406"
     variation       1179
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549186"
     variation       1267
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11549223"
     exon            1479..1837
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /inference="alignment:Splign:1.39.8"
     variation       1488
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139408"
     variation       1513
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549221"
     variation       1600
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1140383"
     variation       1643
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139409"
     variation       1644
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1139410"
     variation       1673
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11549203"
     variation       1718
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:7502276"
     variation       1735
                     /gene="ACTG1"
                     /gene_synonym="ACT; ACTG; BRWS2; DFNA20; DFNA26"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1139414"
ORIGIN      


gcgcgccgccgggccgcgcgggcgcgccgcttccgcttaaataacggcgggggaggccgcggtcggtctcagtcgccgctgccagctctcgcactctgttcttccgccgctccgccgtcgcgtttctctgccggtcgcaatggaagaagagatcgccgcgctggtcattgacaatggctccggcatgtgcaaagctggttttgctggggacgacgctccccgagccgtgtttccttccatcgtcgggcgccccagacaccagggcgtcatggtgggcatgggccagaaggactcctacgtgggcgacgaggcccagagcaagcgtggcatcctgaccctgaagtaccccattgagcatggcatcgtcaccaactgggacgacatggagaagatctggcaccacaccttctacaacgagctgcgcgtggccccggaggagcacccagtgctgctgaccgaggcccccctgaaccccaaggccaacagagagaagatgactcagattatgtttgagaccttcaacaccccggccatgtacgtggccatccaggccgtgctgtccctctacgcctctgggcgcaccactggcattgtcatggactctggagacggggtcacccacacggtgcccatctacgagggctacgccctcccccacgccatcctgcgtctggacctggctggccgggacctgaccgactacctcatgaagatcctcactgagcgaggctacagcttcaccaccacggccgagcgggaaatcgtgcgcgacatcaaggagaagctgtgctacgtcgccctggacttcgagcaggagatggccaccgccgcatcctcctcttctctggagaagagctacgagctgcccgatggccaggtcatcaccattggcaatgagcggttccggtgtccggaggcgctgttccagccttccttcctgggtatggaatcttgcggcatccacgagaccaccttcaactccatcatgaagtgtgacgtggacatccgcaaagacctgtacgccaacacggtgctgtcgggcggcaccaccatgtacccgggcattgccgacaggatgcagaaggagatcaccgccctggcgcccagcaccatgaagatcaagatcatcgcacccccagagcgcaagtactcggtgtggatcggtggctccatcctggcctcactgtccaccttccagcagatgtggattagcaagcaggagtacgacgagtcgggcccctccatcgtccaccgcaaatgcttctaaacggactcagcagatgcgtagcatttgctgcatgggttaattgagaatagaaatttgcccctggcaaatgcacacacctcatgctagcctcacgaaactggaataagccttcgaaaagaaattgtccttgaagcttgtatctgatatcagcactggattgtagaacttgttgctgattttgaccttgtattgaagttaactgttccccttgggtattaacgtgtcagggctgagtgttctgggatttctctagaggctggcaagaaccagttgttttgtcttgcgggtctgtcagggttggaaagtccaagccgtaggacccagtttcctttcttagctgatgtctttggccagaacaccgtgggctgttacttgctttgagttggaagcggtttgcatttacgcctgtaaatgtattcattcttaatttatgtaaggttttttttgtacgcaattctcgattctttgaagagatgacaacaaattttggttttctactgttatgtgagaacattaggccccagcaacacgtcattgtgtaaggaaaaataaaagtgctgccgtaaccaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:71 -> Molecular function: GO:0005200 [structural constituent of cytoskeleton] evidence: IC
            GeneID:71 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:71 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:71 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:71 -> Biological process: GO:0006928 [cellular component movement] evidence: TAS
            GeneID:71 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
            GeneID:71 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS
            GeneID:71 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:71 -> Biological process: GO:0034332 [adherens junction organization] evidence: TAS
            GeneID:71 -> Biological process: GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] evidence: TAS
            GeneID:71 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:71 -> Biological process: GO:0045214 [sarcomere organization] evidence: IEA
            GeneID:71 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:71 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:71 -> Cellular component: GO:0005856 [cytoskeleton] evidence: TAS
            GeneID:71 -> Cellular component: GO:0030016 [myofibril] evidence: IEA
            GeneID:71 -> Cellular component: GO:0031941 [filamentous actin] evidence: IEA
            GeneID:71 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA

by @meso_cacase at DBCLS
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