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2024-04-19 14:04:34, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_033519 3952 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens mannan-binding lectin serine peptidase 1 (C4/C2
activating component of Ra-reactive factor) (MASP1), transcript
variant 4, non-coding RNA.
ACCESSION NR_033519
VERSION NR_033519.1 GI:294997263
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3952)
AUTHORS Megyeri,M., Harmat,V., Major,B., Vegh,A., Balczer,J., Heja,D.,
Szilagyi,K., Datz,D., Pal,G., Zavodszky,P., Gal,P. and Dobo,J.
TITLE Quantitative characterization of the activation steps of
mannan-binding lectin (MBL)-associated serine proteases (MASPs)
points to the central role of MASP-1 in the initiation of the
complement lectin pathway
JOURNAL J. Biol. Chem. 288 (13), 8922-8934 (2013)
PUBMED 23386610
REMARK GeneRIF: autoactivation of MASP-1 is crucial for the activation of
MBL/ficolin.MASP complexes, and in the proenzymic phase zymogen
MASP-1 controls the process
REFERENCE 2 (bases 1 to 3952)
AUTHORS Sekine,H., Takahashi,M., Iwaki,D. and Fujita,T.
TITLE The role of MASP-1/3 in complement activation
JOURNAL Adv. Exp. Med. Biol. 735, 41-53 (2013)
PUBMED 23402018
REMARK GeneRIF: MASP-1 seems to be involved in activation of both the
lectin and alternative complement pathways--{review}
Review article
REFERENCE 3 (bases 1 to 3952)
AUTHORS Degn,S.E., Jensen,L., Hansen,A.G., Duman,D., Tekin,M.,
Jensenius,J.C. and Thiel,S.
TITLE Mannan-binding lectin-associated serine protease (MASP)-1 is
crucial for lectin pathway activation in human serum, whereas
neither MASP-1 nor MASP-3 is required for alternative pathway
function
JOURNAL J. Immunol. 189 (8), 3957-3969 (2012)
PUBMED 22966085
REMARK GeneRIF: A crucial role of MASP-1 is demonstrated in the activation
of MASP-2, as well as of MASP-3, based on a patient harboring a
nonsense mutation in the common part of the MASP1 gene.
REFERENCE 4 (bases 1 to 3952)
AUTHORS Skjoedt,M.O., Roversi,P., Hummelshoj,T., Palarasah,Y., Rosbjerg,A.,
Johnson,S., Lea,S.M. and Garred,P.
TITLE Crystal structure and functional characterization of the complement
regulator mannose-binding lectin (MBL)/ficolin-associated protein-1
(MAP-1)
JOURNAL J. Biol. Chem. 287 (39), 32913-32921 (2012)
PUBMED 22854970
REMARK GeneRIF: MAP-1 competes with all three MASPs for ligand binding and
is able to mediate a strong dose-dependent inhibitory effect on the
lectin pathway activation, as measured by levels of C3 and C9.
REFERENCE 5 (bases 1 to 3952)
AUTHORS Heja,D., Kocsis,A., Dobo,J., Szilagyi,K., Szasz,R., Zavodszky,P.,
Pal,G. and Gal,P.
TITLE Revised mechanism of complement lectin-pathway activation revealing
the role of serine protease MASP-1 as the exclusive activator of
MASP-2
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (26), 10498-10503 (2012)
PUBMED 22691502
REMARK GeneRIF: MASP-1 activates MASP-2 and, moreover, inhibition of
MASP-1 prevents autoactivation of MASP-2
REFERENCE 6 (bases 1 to 3952)
AUTHORS Endo,M., Ohi,H., Ohsawa,I., Fujita,T., Matsushita,M. and Fujita,T.
TITLE Glomerular deposition of mannose-binding lectin (MBL) indicates a
novel mechanism of complement activation in IgA nephropathy
JOURNAL Nephrol. Dial. Transplant. 13 (8), 1984-1990 (1998)
PUBMED 9719152
REFERENCE 7 (bases 1 to 3952)
AUTHORS Endo,Y., Sato,T., Matsushita,M. and Fujita,T.
TITLE Exon structure of the gene encoding the human mannose-binding
protein-associated serine protease light chain: comparison with
complement C1r and C1s genes
JOURNAL Int. Immunol. 8 (9), 1355-1358 (1996)
PUBMED 8921412
REFERENCE 8 (bases 1 to 3952)
AUTHORS Takada,F., Seki,N., Matsuda,Y., Takayama,Y. and Kawakami,M.
TITLE Localization of the genes for the 100-kDa complement-activating
components of Ra-reactive factor (CRARF and Crarf) to human
3q27-q28 and mouse 16B2-B3
JOURNAL Genomics 25 (3), 757-759 (1995)
PUBMED 7759119
REFERENCE 9 (bases 1 to 3952)
AUTHORS Sato,T., Endo,Y., Matsushita,M. and Fujita,T.
TITLE Molecular characterization of a novel serine protease involved in
activation of the complement system by mannose-binding protein
JOURNAL Int. Immunol. 6 (4), 665-669 (1994)
PUBMED 8018603
REFERENCE 10 (bases 1 to 3952)
AUTHORS Takada,F., Takayama,Y., Hatsuse,H. and Kawakami,M.
TITLE A new member of the C1s family of complement proteins found in a
bactericidal factor, Ra-reactive factor, in human serum
JOURNAL Biochem. Biophys. Res. Commun. 196 (2), 1003-1009 (1993)
PUBMED 8240317
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC423174.1, AK304334.1,
AC007920.18, AF284421.1 and AI278088.1.
Summary: This gene encodes a serine protease that functions as a
component of the lectin pathway of complement activation. The
complement pathway plays an essential role in the innate and
adaptive immune response. The encoded protein is synthesized as a
zymogen and is activated when it complexes with the pathogen
recognition molecules of lectin pathway, the mannose-binding lectin
and the ficolins. This protein is not directly involved in
complement activation but may play a role as an amplifier of
complement activation by cleaving complement C2 or by activating
another complement serine protease, MASP-2. The encoded protein is
also able to cleave fibrinogen and factor XIII and may may be
involved in coagulation. A splice variant of this gene which lacks
the serine protease domain functions as an inhibitor of the
complement pathway. Alternate splicing results in multiple
transcript variants.[provided by RefSeq, Apr 2010].
Transcript Variant: This variant (4) has multiple differences,
compared to variant 1. This variant is represented as non-coding
because the use of the supported translational start codon, as used
in variant 1, renders the transcript a candidate for
nonsense-mediated mRNA decay (NMD).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-290 DC423174.1 1-290
291-1531 AK304334.1 1-1241
1532-1532 AC007920.18 125359-125359
1533-2590 AK304334.1 1243-2300
2591-3945 AF284421.1 2523-3877
3946-3952 AI278088.1 1-7 c
FEATURES Location/Qualifiers
source 1..3952
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q27-q28"
gene 1..3952
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/note="mannan-binding lectin serine peptidase 1 (C4/C2
activating component of Ra-reactive factor)"
/db_xref="GeneID:5648"
/db_xref="HGNC:6901"
/db_xref="MIM:600521"
misc_RNA 1..3952
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/product="mannan-binding lectin serine peptidase 1 (C4/C2
activating component of Ra-reactive factor), transcript
variant 4"
/db_xref="GeneID:5648"
/db_xref="HGNC:6901"
/db_xref="MIM:600521"
exon 1..395
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
variation 325
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="g"
/db_xref="dbSNP:72549255"
misc_feature 391..399
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_001879.5"
/note="primary ORF has stop codon >50 nucleotides from the
terminal splice site; nonsense-mediated decay (NMD)
candidate"
exon 396..573
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
exon 574..705
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
variation 575
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:72549252"
variation 624
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:200376787"
exon 706..902
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
variation 795
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:28945069"
variation 861
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="g"
/db_xref="dbSNP:3203210"
variation 889
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="g"
/db_xref="dbSNP:28945071"
exon 903..1050
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
exon 1051..1169
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
exon 1170..1248
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
exon 1249..1386
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
variation 1283
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:34207306"
exon 1387..1461
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
variation 1435
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="g"
/db_xref="dbSNP:28945068"
exon 1462..3947
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/inference="alignment:Splign:1.39.8"
variation 1532
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:710452"
variation 1544
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="g"
/db_xref="dbSNP:35384947"
variation 1842
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="g"
/db_xref="dbSNP:72549155"
variation 1885
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="g"
/replace="t"
/db_xref="dbSNP:72549154"
variation 2009
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="g"
/db_xref="dbSNP:850312"
variation 2036
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="t"
/db_xref="dbSNP:710458"
variation 2054
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:710457"
variation 2078
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:710456"
variation 2591
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="g"
/db_xref="dbSNP:850313"
variation 2668
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:72549263"
variation 2903
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="g"
/db_xref="dbSNP:72549262"
variation 2912
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:72549261"
variation 2979
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:72549260"
variation 3229
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:1109452"
variation 3248
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="g"
/db_xref="dbSNP:72549168"
variation 3319
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="g"
/replace="t"
/db_xref="dbSNP:1317971"
variation 3442
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="g"
/db_xref="dbSNP:72549167"
variation 3533
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="t"
/db_xref="dbSNP:72549166"
variation 3595
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="t"
/db_xref="dbSNP:72549175"
variation 3790
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="t"
/db_xref="dbSNP:72549174"
variation 3846
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="c"
/replace="g"
/db_xref="dbSNP:72549173"
variation 3869
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
/replace="a"
/replace="c"
/db_xref="dbSNP:2679547"
polyA_signal 3923..3928
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
polyA_site 3947
/gene="MASP1"
/gene_synonym="3MC1; CRARF; CRARF1; MAP1; MAp44; MASP;
MASP3; PRSS5; RaRF"
ORIGIN
acacacagagtgatacaaatacctgcttgagcccctcagttattttctctcaagggctgaagtcagccacacaggataaaggagggaagggaaggagcagatcttttcggtaggaagacagattttgttgtcaggttcctgggagtgcaagagcaagtcaaaggagagagagaggagagaggaaaagccagagggagagagggggagaggggatctgttgcaggcaggggaaggcgtgacctgaatggagaatgccagccaattccagagacacacagggacctcagaacaaagataaggcatcacggacaccacaccgggcacgagctcacaggcaagtcaagctgggaggaccaaggccgggcagccgggagcacccaaggcaggaaaatgaggtagaaactgaggaccaggtgctggcaaccttctgtggcagggagaccacagacacagagcagactcccggccaggaggtggtcctctcccctggctccttcatgtccatcactttccggtcagatttctccaatgaggagcgtttcacaggctttgatgcccactacatggctgtggatgtggacgagtgcaaggagagggaggacgaggagctgtcctgtgaccactactgccacaactacattggcggctactactgctcctgccgcttcggctacatcctccacacagacaacaggacctgccgagtggagtgcagtgacaacctcttcactcaaaggactggggtgatcaccagccctgacttcccaaacccttaccccaagagctctgaatgcctgtataccatcgagctggaggagggtttcatggtcaacctgcagtttgaggacatatttgacattgaggaccatcctgaggtgccctgcccctatgactacatcaagatcaaagttggtccaaaagttttggggcctttctgtggagagaaagccccagaacccatcagcacccagagccacagtgtcctgatcctgttccatagtgacaactcgggagagaaccggggctggaggctctcatacagggctgcaggaaatgagtgcccagagctacagcctcctgtccatgggaaaatcgagccctcccaagccaagtatttcttcaaagaccaagtgctcgtcagctgtgacacaggctacaaagtgctgaaggataatgtggagatggacacattccagattgagtgtctgaaggatgggacgtggagtaacaagattcccacctgtaaaattgtagactgtagagccccaggagagctggaacacgggctgatcaccttctctacaaggaacaacctcaccacatacaagtctgagatcaaatactcctgtcaggagccctattacaagatgctcaacaataacacaggtatatatacctgttctgcccaaggagtctggatgaataaagtattggggagaagcctacccacctgccttccagagtgtggtcagccctcccgctccctgccaagcctggtcaagaggatcattgggggccgaaatgctgagcctggcctcttcccgtggcaggccctgatagtggtggaggacacttcgagagtgccaaatgacaagtggtttgggagtggggccctgctctctgcgtcctggatcctcacagcagctcatgtgctgcgctcccagcgtagagacaccacggtgataccagtctccaaggagcatgtcaccgtctacctgggcttgcatgatgtgcgagacaaatcgggggcagtcaacagctcagctgcccgagtggtgctccacccagacttcaacatccaaaactacaaccacgatatagctctggtgcagctgcaggagcctgtgcccctgggaccccacgttatgcctgtctgcctgccaaggcttgagcctgaaggcccggccccccacatgctgggcctggtggccggctggggcatctccaatcccaatgtgacagtggatgagatcatcagcagtggcacacggaccttgtcagatgtcctgcagtatgtcaagttacccgtggtgcctcacgctgagtgcaaaactagctatgagtcccgctcgggcaattacagcgtcacggagaacatgttctgtgctggctactacgagggcggcaaagacacgtgccttggagatagcggtggggcctttgtcatctttgatgacttgagccagcgctgggtggtgcaaggcctggtgtcctgggggggacctgaagaatgcggcagcaagcaggtctatggagtctacacaaaggtctccaattacgtggactgggtgtgggagcagatgggcttaccacaaagtgttgtggagccccaggtggaacggtgagctgacttacttcctcggggcctgcctcccctgagcgaagctacaccgcacttccgacagcacactccacattacttatcagaccatatggaatggaacacactgacctagcggtggcttctcctaccgagacagcccccaggaccctgagaggcagagtgtggtatagggaaaaggctccaggcaggagacctgtgttcctgagcttgtccaagtctctttccctgtctgggcctcactctaccgagtaatacaatgcaggagctcaaccaaggcctctgtgccaatcccagcactcctttccaggccatgcttcttaccccagtggcctttattcactcctgaccacttatcaaacccatcggtcctactgttggtataactgagcttggacctgactattagaaaatggtttctaacattgaactgaatgccgcatctgtatattttcctgctctgccttctgggactagccttggcctaatccttcctctaggagaagagcattcaggttttgggagatggctcatagccaagcccctctctcttagtgtgatcccttggagcaccttcatgcctggggtttctctcccaaaagcttcttgcagtctaagccttatcccttatgttccccattaaaggaatttcaaaagacatggagaaagttgggaaggtttgtgctgactgctgggagcagaatagccgtgggaggcccaccaagcccttaaattcccattgtcaactcagaacacatttgggcccatatgccaccctggaacaccagctgacaccatgggcgtccacacctgctgctccagacaagcacaaagcaatctttcagccttgaaatgtattatctgaaaggctacctgaagcccaggcccgaatatggggacttagtcgattacctggaaaaagaaaagacccacactgtgtcctgctgtgcttttgggcaggaaaatggaagaaagagtggggtgggcacattagaagtcacccaaatcctgccaggctgcctggcatccctggggcatgagctgggcggagaatccaccccgcaggatgttcagagggacccactccttcatttttcagagtcaaaggaatcagaggctcacccatggcaggcagtgaaaagagccaggagtcctgggttctagtccctgctctgcccccaactggctgtataacctttgaaaaatcattttctttgtctgagtctctggttctccgtcagcaacaggctggcataaggtcccctgcaggttccttctagctggagcactcagagcttccctgactgctagcagcctctctggccctcacagggctgattgttctccttctccctggagctctctctcctgaaaatctccatcagagcaaggcagccagagaagcccctgagagggaatgattgggaagtgtccactttctcaaccggctcatcaaacacactcctttgtctatgaatggcacatgtaaatgatgttatattttgtatcttttatatcatatgcttcaccattctgtaaagggcctctgcattgttgctcccatcaggggtctcaagtggaaataaaccctcgtggataaccaacaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5648 -> Molecular function: GO:0004252 [serine-type endopeptidase activity] evidence: IDA
GeneID:5648 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IDA
GeneID:5648 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5648 -> Molecular function: GO:0008233 [peptidase activity] evidence: IDA
GeneID:5648 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
GeneID:5648 -> Molecular function: GO:0048306 [calcium-dependent protein binding] evidence: IPI
GeneID:5648 -> Biological process: GO:0001867 [complement activation, lectin pathway] evidence: IMP
GeneID:5648 -> Biological process: GO:0001867 [complement activation, lectin pathway] evidence: TAS
GeneID:5648 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:5648 -> Biological process: GO:0006956 [complement activation] evidence: TAS
GeneID:5648 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:5648 -> Biological process: GO:0045916 [negative regulation of complement activation] evidence: IDA
GeneID:5648 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS
GeneID:5648 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
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