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2024-03-29 13:55:44, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_028477               2132 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens RNA binding motif protein, X-linked (RBMX), transcript
            variant 4, non-coding RNA.
ACCESSION   NR_028477
VERSION     NR_028477.1  GI:258645156
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Matsunaga,S., Takata,H., Morimoto,A., Hayashihara,K., Higashi,T.,
            Akatsuchi,K., Mizusawa,E., Yamakawa,M., Ashida,M., Matsunaga,T.M.,
            Azuma,T., Uchiyama,S. and Fukui,K.
  TITLE     RBMX: a regulator for maintenance and centromeric protection of
            sister chromatid cohesion
  JOURNAL   Cell Rep 1 (4), 299-308 (2012)
   PUBMED   22832223
  REMARK    GeneRIF: RBMX is a cohesion regulator that maintains the proper
            cohesion of sister chromatids.
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Adamson,B., Smogorzewska,A., Sigoillot,F.D., King,R.W. and
            Elledge,S.J.
  TITLE     A genome-wide homologous recombination screen identifies the
            RNA-binding protein RBMX as a component of the DNA-damage response
  JOURNAL   Nat. Cell Biol. 14 (3), 318-328 (2012)
   PUBMED   22344029
  REMARK    GeneRIF: Data show that RBMX accumulated at DNA lesions through
            multiple domains in a poly(ADP-ribose) polymerase 1-dependent
            manner and promoted HR by facilitating proper BRCA2 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Shin,K.H., Kim,R.H., Yu,B., Kang,M.K., Elashoff,D., Christensen,R.,
            Pucar,A. and Park,N.H.
  TITLE     Expression and mutation analysis of heterogeneous nuclear
            ribonucleoprotein G in human oral cancer
  JOURNAL   Oral Oncol. 47 (11), 1011-1016 (2011)
   PUBMED   21840245
  REMARK    GeneRIF: studied the genetic and expression states of hnRNP G in
            normal, premalignant and malignant human oral tissues to further
            understand the relationship between the hnRNP G alterations and the
            development of human oral cancer
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J. Biol. Chem. 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   Shin,K.H., Kim,R.H., Kim,R.H., Kang,M.K. and Park,N.H.
  TITLE     hnRNP G elicits tumor-suppressive activity in part by upregulating
            the expression of Txnip
  JOURNAL   Biochem. Biophys. Res. Commun. 372 (4), 880-885 (2008)
   PUBMED   18541147
  REMARK    GeneRIF: These studies indicate that hnRNP G promotes the
            expression of Txnip and mediates its tumor-suppressive effect.
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Mazeyrat,S., Saut,N., Mattei,M.G. and Mitchell,M.J.
  TITLE     RBMY evolved on the Y chromosome from a ubiquitously transcribed
            X-Y identical gene
  JOURNAL   Nat. Genet. 22 (3), 224-226 (1999)
   PUBMED   10391207
REFERENCE   7  (bases 1 to 2132)
  AUTHORS   Delbridge,M.L., Lingenfelter,P.A., Disteche,C.M. and Graves,J.A.
  TITLE     The candidate spermatogenesis gene RBMY has a homologue on the
            human X chromosome
  JOURNAL   Nat. Genet. 22 (3), 223-224 (1999)
   PUBMED   10391206
REFERENCE   8  (bases 1 to 2132)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum. Mol. Genet. 8 (6), 959-969 (1999)
   PUBMED   10332027
REFERENCE   9  (bases 1 to 2132)
  AUTHORS   Soulard,M., Della Valle,V., Siomi,M.C., Pinol-Roma,S., Codogno,P.,
            Bauvy,C., Bellini,M., Lacroix,J.C., Monod,G., Dreyfuss,G. et al.
  TITLE     hnRNP G: sequence and characterization of a glycosylated
            RNA-binding protein
  JOURNAL   Nucleic Acids Res. 21 (18), 4210-4217 (1993)
   PUBMED   7692398
REFERENCE   10 (bases 1 to 2132)
  AUTHORS   Le Coniat,M., Soulard,M., Della Valle,V., Larsen,C.J. and Berger,R.
  TITLE     Localization of the human gene encoding heterogeneous nuclear RNA
            ribonucleoprotein G (hnRNP-G) to chromosome 6p12
  JOURNAL   Hum. Genet. 88 (5), 593-595 (1992)
   PUBMED   1551662
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM147410.1, DC337568.1,
            AK304573.1, AK096015.1 and BM993214.1.
            
            Summary: This gene belongs to the RBMY gene family which includes
            candidate Y chromosome spermatogenesis genes. This gene, an active
            X chromosome homolog of the Y chromosome RBMY gene, is widely
            expressed whereas the RBMY gene evolved a male-specific function in
            spermatogenesis. Pseudogenes of this gene, found on chromosomes 1,
            4, 9, 11, and 6, were likely derived by retrotransposition from the
            original gene. Alternatively spliced transcript variants encoding
            different isoforms have been identified. A snoRNA gene (SNORD61) is
            found in one of its introns. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (4) uses an alternate splice site
            in the 5' coding region, compared to variant 1. This variant is
            represented as non-coding due to the presence of an upstream ORF
            that is predicted to interfere with translation of the longest ORF;
            translation of the upstream ORF renders the transcript a candidate
            for nonsense-mediated mRNA decay (NMD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               BM147410.1         1-209
            210-606             DC337568.1         155-551
            607-1442            AK304573.1         552-1387
            1443-2098           AK096015.1         1314-1969
            2099-2132           BM993214.1         1-34                c
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..2132
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /note="RNA binding motif protein, X-linked"
                     /db_xref="GeneID:27316"
                     /db_xref="HGNC:9910"
                     /db_xref="MIM:300199"
     misc_RNA        1..2132
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /product="RNA binding motif protein, X-linked, transcript
                     variant 4"
                     /db_xref="GeneID:27316"
                     /db_xref="HGNC:9910"
                     /db_xref="MIM:300199"
     exon            1..184
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     exon            185..319
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       210
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2011584"
     misc_feature    211..324
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_002139.3"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            320..461
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     exon            462..633
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     exon            634..786
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       708
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11558422"
     exon            787..901
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       869
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1056264"
     exon            902..1027
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       997
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556431"
     exon            1028..1110
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       1053
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374604645"
     exon            1111..2117
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       1250
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:16978599"
     variation       1255
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35899675"
     variation       1311
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35085326"
     variation       1331
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34606958"
     variation       1514
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:15259"
     variation       1571
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230685"
     variation       1726
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:850"
     variation       1894
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:849"
     variation       2052
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:10147"
     polyA_signal    2079..2084
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
     polyA_site      2102
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
     polyA_site      2117
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
ORIGIN      


ggtccttcagcctcgttcccgggcagtataaagtttgctgtctcctttgttcgccctcgttgcgcagtagtgctagcggcttcgcggttcggtcctcgcacccggcagccgccactggtgctgagctgctaggaagcccctatcgccgagctcgttggagcttgaacccattgtcacccctccgactcaccggcccaaaaaaaaaaaaacatggttgaagcagatcgcccaggaaagctcttcattggtgggcttaatacggaaacaaatgagaaagctcttgaagcagtatttggcaaatatggacgaatagtggaagggtaacactttatttttctgaaaactactttttagtactcttgatgaaagaccgtgaaaccaacaaatcaagaggatttgcttttgtcacctttgaaagcccagcagacgctaaggatgcagccagagacatgaatggaaagtcattagatggaaaagccatcaaggtggaacaagccaccaaaccatcatttgaaagtggtagacgtggaccgcctccacctccaagaagtagaggccctccaagaggtcttagaggtggaagaggaggaagtggaggaaccaggggacctccctcacggggaggacacatggatgacggtggatattccatgaattttaacatgagttcttccaggggaccactcccagtaaaaagaggaccaccaccaagaagtgggggtcctcctcctaagagatctgcaccttcaggaccagttcgcagtagcagtggaatgggaggaagagctcctgtatcacgtggaagagatagttatggaggtccacctcgaagggaaccgctgccctctcgtagagatgtttatttgtccccaagagatgatgggtattctactaaagacagctattcaagcagagattacccaagttctcgtgatactagagattatgcaccaccaccacgagattatacttaccgtgattatggtcattccagttcacgtgatgactatccatcaagaggatatagcgatagagatggatatggtcgtgatcgtgactattcagatcatccaagtggaggttcctacagagattcatatgagagttatggtaactcacgtagtgctccacctacacgagggcccccgccatcttatggtggaagcagtcgctatgatgattacagcagctcacgtgacggatatggtggaagtcgagacagttactcaagcagccgaagtgatctctactcaagtggtcgtgatcgggttggcagacaagaaagagggcttcccccttctatggaaagggggtaccctcctccacgtgattcctacagcagttcaagccgcggagcaccaagaggtggtggccgtggaggaagccgatctgatagagggggaggcagaagcagatactagaaacaaacaaaactttggaccaaaatcccagttcaaagaaacaaaaagtggaaactattctatcataactacccaaggactactaaaaggaaaaattgtgttactttttttaaattccctgttaagttcccctccataatttttatgttcttgtgaggaaaaaagtaaaacatgtttaattttatttgactttcgcattgcttttcaacaagcaaatgttaaatgtgttaagacttgtactagtgttgtaactttccaagtaaaagtatcccctaaaggccacttcctatctgatttttcccagcaaatgaggcaggcaattctaagatcttccacaaaacatctagccatctaaaatggagagatgaatcattctacctatacaaacaagctagctattagagggtggttggggtatgctactcataagatttcagggtgtcttccaactgaaatctcaatgttctcagtacgaaaaacctgaaatcacatgcctatgtaaggaaagtgctattcacccagtaaacccaaaaaagcaaatggataatgctggccattttgcctttctgacatttccttgggaatctgcaagaacctcccctttcccttcccccaataagaccatttaagtgtgtgttaaacaactacagaatactaaataaaaagtttggccaaaaccaaccatgaagctgcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:27316 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
            GeneID:27316 -> Molecular function: GO:0001047 [core promoter binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0003723 [RNA binding] evidence: NAS
            GeneID:27316 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:27316 -> Biological process: GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] evidence: IDA
            GeneID:27316 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: IC
            GeneID:27316 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: TAS
            GeneID:27316 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:27316 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IDA
            GeneID:27316 -> Biological process: GO:0008380 [RNA splicing] evidence: TAS
            GeneID:27316 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:27316 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:27316 -> Biological process: GO:0048025 [negative regulation of mRNA splicing, via spliceosome] evidence: ISS
            GeneID:27316 -> Biological process: GO:0048026 [positive regulation of mRNA splicing, via spliceosome] evidence: ISS
            GeneID:27316 -> Biological process: GO:0051260 [protein homooligomerization] evidence: ISS
            GeneID:27316 -> Biological process: GO:0071347 [cellular response to interleukin-1] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:27316 -> Cellular component: GO:0005719 [nuclear euchromatin] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0044530 [supraspliceosomal complex] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0071013 [catalytic step 2 spliceosome] evidence: IDA

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