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2019-03-23 04:08:03, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_028476               1925 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens RNA binding motif protein, X-linked (RBMX), transcript
            variant 3, non-coding RNA.
ACCESSION   NR_028476
VERSION     NR_028476.1  GI:258645155
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1925)
  AUTHORS   Matsunaga,S., Takata,H., Morimoto,A., Hayashihara,K., Higashi,T.,
            Akatsuchi,K., Mizusawa,E., Yamakawa,M., Ashida,M., Matsunaga,T.M.,
            Azuma,T., Uchiyama,S. and Fukui,K.
  TITLE     RBMX: a regulator for maintenance and centromeric protection of
            sister chromatid cohesion
  JOURNAL   Cell Rep 1 (4), 299-308 (2012)
   PUBMED   22832223
  REMARK    GeneRIF: RBMX is a cohesion regulator that maintains the proper
            cohesion of sister chromatids.
REFERENCE   2  (bases 1 to 1925)
  AUTHORS   Adamson,B., Smogorzewska,A., Sigoillot,F.D., King,R.W. and
            Elledge,S.J.
  TITLE     A genome-wide homologous recombination screen identifies the
            RNA-binding protein RBMX as a component of the DNA-damage response
  JOURNAL   Nat. Cell Biol. 14 (3), 318-328 (2012)
   PUBMED   22344029
  REMARK    GeneRIF: Data show that RBMX accumulated at DNA lesions through
            multiple domains in a poly(ADP-ribose) polymerase 1-dependent
            manner and promoted HR by facilitating proper BRCA2 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1925)
  AUTHORS   Shin,K.H., Kim,R.H., Yu,B., Kang,M.K., Elashoff,D., Christensen,R.,
            Pucar,A. and Park,N.H.
  TITLE     Expression and mutation analysis of heterogeneous nuclear
            ribonucleoprotein G in human oral cancer
  JOURNAL   Oral Oncol. 47 (11), 1011-1016 (2011)
   PUBMED   21840245
  REMARK    GeneRIF: studied the genetic and expression states of hnRNP G in
            normal, premalignant and malignant human oral tissues to further
            understand the relationship between the hnRNP G alterations and the
            development of human oral cancer
REFERENCE   4  (bases 1 to 1925)
  AUTHORS   Heinrich,B., Zhang,Z., Raitskin,O., Hiller,M., Benderska,N.,
            Hartmann,A.M., Bracco,L., Elliott,D., Ben-Ari,S., Soreq,H.,
            Sperling,J., Sperling,R. and Stamm,S.
  TITLE     Heterogeneous nuclear ribonucleoprotein G regulates splice site
            selection by binding to CC(A/C)-rich regions in pre-mRNA
  JOURNAL   J. Biol. Chem. 284 (21), 14303-14315 (2009)
   PUBMED   19282290
REFERENCE   5  (bases 1 to 1925)
  AUTHORS   Shin,K.H., Kim,R.H., Kim,R.H., Kang,M.K. and Park,N.H.
  TITLE     hnRNP G elicits tumor-suppressive activity in part by upregulating
            the expression of Txnip
  JOURNAL   Biochem. Biophys. Res. Commun. 372 (4), 880-885 (2008)
   PUBMED   18541147
  REMARK    GeneRIF: These studies indicate that hnRNP G promotes the
            expression of Txnip and mediates its tumor-suppressive effect.
REFERENCE   6  (bases 1 to 1925)
  AUTHORS   Mazeyrat,S., Saut,N., Mattei,M.G. and Mitchell,M.J.
  TITLE     RBMY evolved on the Y chromosome from a ubiquitously transcribed
            X-Y identical gene
  JOURNAL   Nat. Genet. 22 (3), 224-226 (1999)
   PUBMED   10391207
REFERENCE   7  (bases 1 to 1925)
  AUTHORS   Delbridge,M.L., Lingenfelter,P.A., Disteche,C.M. and Graves,J.A.
  TITLE     The candidate spermatogenesis gene RBMY has a homologue on the
            human X chromosome
  JOURNAL   Nat. Genet. 22 (3), 223-224 (1999)
   PUBMED   10391206
REFERENCE   8  (bases 1 to 1925)
  AUTHORS   Venables,J.P., Vernet,C., Chew,S.L., Elliott,D.J., Cowmeadow,R.B.,
            Wu,J., Cooke,H.J., Artzt,K. and Eperon,I.C.
  TITLE     T-STAR/ETOILE: a novel relative of SAM68 that interacts with an
            RNA-binding protein implicated in spermatogenesis
  JOURNAL   Hum. Mol. Genet. 8 (6), 959-969 (1999)
   PUBMED   10332027
REFERENCE   9  (bases 1 to 1925)
  AUTHORS   Soulard,M., Della Valle,V., Siomi,M.C., Pinol-Roma,S., Codogno,P.,
            Bauvy,C., Bellini,M., Lacroix,J.C., Monod,G., Dreyfuss,G. et al.
  TITLE     hnRNP G: sequence and characterization of a glycosylated
            RNA-binding protein
  JOURNAL   Nucleic Acids Res. 21 (18), 4210-4217 (1993)
   PUBMED   7692398
REFERENCE   10 (bases 1 to 1925)
  AUTHORS   Le Coniat,M., Soulard,M., Della Valle,V., Larsen,C.J. and Berger,R.
  TITLE     Localization of the human gene encoding heterogeneous nuclear RNA
            ribonucleoprotein G (hnRNP-G) to chromosome 6p12
  JOURNAL   Hum. Genet. 88 (5), 593-595 (1992)
   PUBMED   1551662
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM147410.1, AK091520.1,
            DA925805.1 and BM993214.1.
            
            Summary: This gene belongs to the RBMY gene family which includes
            candidate Y chromosome spermatogenesis genes. This gene, an active
            X chromosome homolog of the Y chromosome RBMY gene, is widely
            expressed whereas the RBMY gene evolved a male-specific function in
            spermatogenesis. Pseudogenes of this gene, found on chromosomes 1,
            4, 9, 11, and 6, were likely derived by retrotransposition from the
            original gene. Alternatively spliced transcript variants encoding
            different isoforms have been identified. A snoRNA gene (SNORD61) is
            found in one of its introns. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (3) lacks an alternate internal
            exons, compared to variant 1. This variant is represented as
            non-coding because the use of the 5'-most expected translational
            start codon, as used in variant 1, renders the transcript a
            candidate for nonsense-mediated mRNA decay (NMD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BM147410.1         1-55
            56-209              AK091520.1         1-154
            210-641             DA925805.1         155-586
            642-1907            AK091520.1         588-1853
            1908-1925           BM993214.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1925
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1925
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /note="RNA binding motif protein, X-linked"
                     /db_xref="GeneID:27316"
                     /db_xref="HGNC:9910"
                     /db_xref="MIM:300199"
     misc_RNA        1..1925
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /product="RNA binding motif protein, X-linked, transcript
                     variant 3"
                     /db_xref="GeneID:27316"
                     /db_xref="HGNC:9910"
                     /db_xref="MIM:300199"
     exon            1..184
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     exon            185..319
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       210
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2011584"
     misc_feature    211..447
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_002139.3"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            320..426
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     exon            427..579
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       501
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11558422"
     exon            580..694
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       662
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1056264"
     exon            695..820
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       790
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11556431"
     exon            821..903
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       846
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374604645"
     exon            904..1910
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /inference="alignment:Splign:1.39.8"
     variation       1043
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:16978599"
     variation       1048
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35899675"
     variation       1104
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35085326"
     variation       1124
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34606958"
     variation       1307
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:15259"
     variation       1364
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2230685"
     variation       1519
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:850"
     variation       1687
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:849"
     variation       1845
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:10147"
     polyA_signal    1872..1877
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
     polyA_site      1895
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
     polyA_site      1910
                     /gene="RBMX"
                     /gene_synonym="hnRNP-G; HNRNPG; HNRPG; RBMXP1; RBMXRT;
                     RNMX"
ORIGIN      


ggtccttcagcctcgttcccgggcagtataaagtttgctgtctcctttgttcgccctcgttgcgcagtagtgctagcggcttcgcggttcggtcctcgcacccggcagccgccactggtgctgagctgctaggaagcccctatcgccgagctcgttggagcttgaacccattgtcacccctccgactcaccggcccaaaaaaaaaaaaacatggttgaagcagatcgcccaggaaagctcttcattggtgggcttaatacggaaacaaatgagaaagctcttgaagcagtatttggcaaatatggacgaatagtggaagtactcttgatgaaagaccgtgaaaccaacaaatcaagaggatttgcttttgtcacctttgaaagcccagcagacgctaaggatgcagccagagacatgaatggaaagatgacggtggatattccatgaattttaacatgagttcttccaggggaccactcccagtaaaaagaggaccaccaccaagaagtgggggtcctcctcctaagagatctgcaccttcaggaccagttcgcagtagcagtggaatgggaggaagagctcctgtatcacgtggaagagatagttatggaggtccacctcgaagggaaccgctgccctctcgtagagatgtttatttgtccccaagagatgatgggtattctactaaagacagctattcaagcagagattacccaagttctcgtgatactagagattatgcaccaccaccacgagattatacttaccgtgattatggtcattccagttcacgtgatgactatccatcaagaggatatagcgatagagatggatatggtcgtgatcgtgactattcagatcatccaagtggaggttcctacagagattcatatgagagttatggtaactcacgtagtgctccacctacacgagggcccccgccatcttatggtggaagcagtcgctatgatgattacagcagctcacgtgacggatatggtggaagtcgagacagttactcaagcagccgaagtgatctctactcaagtggtcgtgatcgggttggcagacaagaaagagggcttcccccttctatggaaagggggtaccctcctccacgtgattcctacagcagttcaagccgcggagcaccaagaggtggtggccgtggaggaagccgatctgatagagggggaggcagaagcagatactagaaacaaacaaaactttggaccaaaatcccagttcaaagaaacaaaaagtggaaactattctatcataactacccaaggactactaaaaggaaaaattgtgttactttttttaaattccctgttaagttcccctccataatttttatgttcttgtgaggaaaaaagtaaaacatgtttaattttatttgactttcgcattgcttttcaacaagcaaatgttaaatgtgttaagacttgtactagtgttgtaactttccaagtaaaagtatcccctaaaggccacttcctatctgatttttcccagcaaatgaggcaggcaattctaagatcttccacaaaacatctagccatctaaaatggagagatgaatcattctacctatacaaacaagctagctattagagggtggttggggtatgctactcataagatttcagggtgtcttccaactgaaatctcaatgttctcagtacgaaaaacctgaaatcacatgcctatgtaaggaaagtgctattcacccagtaaacccaaaaaagcaaatggataatgctggccattttgcctttctgacatttccttgggaatctgcaagaacctcccctttcccttcccccaataagaccatttaagtgtgtgttaaacaactacagaatactaaataaaaagtttggccaaaaccaaccatgaagctgcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:27316 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
            GeneID:27316 -> Molecular function: GO:0001047 [core promoter binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0003723 [RNA binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0003723 [RNA binding] evidence: NAS
            GeneID:27316 -> Molecular function: GO:0003729 [mRNA binding] evidence: IDA
            GeneID:27316 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:27316 -> Biological process: GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] evidence: IDA
            GeneID:27316 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: IC
            GeneID:27316 -> Biological process: GO:0000398 [mRNA splicing, via spliceosome] evidence: TAS
            GeneID:27316 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:27316 -> Biological process: GO:0006509 [membrane protein ectodomain proteolysis] evidence: IDA
            GeneID:27316 -> Biological process: GO:0008380 [RNA splicing] evidence: TAS
            GeneID:27316 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:27316 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:27316 -> Biological process: GO:0048025 [negative regulation of mRNA splicing, via spliceosome] evidence: ISS
            GeneID:27316 -> Biological process: GO:0048026 [positive regulation of mRNA splicing, via spliceosome] evidence: ISS
            GeneID:27316 -> Biological process: GO:0051260 [protein homooligomerization] evidence: ISS
            GeneID:27316 -> Biological process: GO:0071347 [cellular response to interleukin-1] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:27316 -> Cellular component: GO:0005719 [nuclear euchromatin] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0044530 [supraspliceosomal complex] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
            GeneID:27316 -> Cellular component: GO:0071013 [catalytic step 2 spliceosome] evidence: IDA

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