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2024-03-29 17:45:13, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_028041               3643 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens glutamate receptor, metabotropic 8 (GRM8), transcript
            variant 3, non-coding RNA.
ACCESSION   NR_028041 NM_001127326
VERSION     NR_028041.1  GI:253970408
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3643)
  AUTHORS   Yanagawa,M., Yamashita,T. and Shichida,Y.
  TITLE     Glutamate acts as a partial inverse agonist to metabotropic
            glutamate receptor with a single amino acid mutation in the
            transmembrane domain
  JOURNAL   J. Biol. Chem. 288 (14), 9593-9601 (2013)
   PUBMED   23420844
  REMARK    GeneRIF: Glutamate acts as a partial inverse agonist to
            metabotropic glutamate receptor with a single amino acid mutation
            in the transmembrane domain
REFERENCE   2  (bases 1 to 3643)
  AUTHORS   Girotto,G., Pirastu,N., Sorice,R., Biino,G., Campbell,H.,
            d'Adamo,A.P., Hastie,N.D., Nutile,T., Polasek,O., Portas,L.,
            Rudan,I., Ulivi,S., Zemunik,T., Wright,A.F., Ciullo,M., Hayward,C.,
            Pirastu,M. and Gasparini,P.
  TITLE     Hearing function and thresholds: a genome-wide association study in
            European isolated populations identifies new loci and pathways
  JOURNAL   J. Med. Genet. 48 (6), 369-374 (2011)
   PUBMED   21493956
  REMARK    GeneRIF: Eight suggestive significant loci were detected with a
            series of genes expressed within the inner ear that underlie the
            auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
REFERENCE   3  (bases 1 to 3643)
  AUTHORS   Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
            Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
            Jr.
  TITLE     Genome-wide association scan of trait depression
  JOURNAL   Biol. Psychiatry 68 (9), 811-817 (2010)
   PUBMED   20800221
REFERENCE   4  (bases 1 to 3643)
  AUTHORS   Saus,E., Brunet,A., Armengol,L., Alonso,P., Crespo,J.M.,
            Fernandez-Aranda,F., Guitart,M., Martin-Santos,R., Menchon,J.M.,
            Navines,R., Soria,V., Torrens,M., Urretavizcaya,M., Valles,V.,
            Gratacos,M. and Estivill,X.
  TITLE     Comprehensive copy number variant (CNV) analysis of neuronal
            pathways genes in psychiatric disorders identifies rare variants
            within patients
  JOURNAL   J Psychiatr Res 44 (14), 971-978 (2010)
   PUBMED   20398908
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3643)
  AUTHORS   Fonseca,F., Gratacos,M., Escaramis,G., De Cid,R., Martin-Santos,R.,
            Fernandez-Espejo,E., Estivill,X. and Torrens,M.
  TITLE     Response to methadone maintenance treatment is associated with the
            MYOCD and GRM6 genes
  JOURNAL   Mol Diagn Ther 14 (3), 171-178 (2010)
   PUBMED   20560679
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 3643)
  AUTHORS   Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
            and Jane,D.E.
  TITLE     (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
            activates metabotropic glutamate receptors on primary afferent
            terminals in the neonatal rat spinal cord
  JOURNAL   Neuropharmacology 40 (3), 311-318 (2001)
   PUBMED   11166323
REFERENCE   7  (bases 1 to 3643)
  AUTHORS   Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
            and Mutel,V.
  TITLE     Cloning and functional expression of alternative spliced variants
            of the human metabotropic glutamate receptor 8
  JOURNAL   Brain Res. Mol. Brain Res. 67 (2), 201-210 (1999)
   PUBMED   10216218
REFERENCE   8  (bases 1 to 3643)
  AUTHORS   Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
            Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
  TITLE     Group III human metabotropic glutamate receptors 4, 7 and 8:
            molecular cloning, functional expression, and comparison of
            pharmacological properties in RGT cells
  JOURNAL   Brain Res. Mol. Brain Res. 53 (1-2), 88-97 (1998)
   PUBMED   9473604
REFERENCE   9  (bases 1 to 3643)
  AUTHORS   Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
  TITLE     The human metabotropic glutamate receptor 8 (GRM8) gene: a
            disproportionately large gene located at 7q31.3-q32.1
  JOURNAL   Genomics 44 (2), 232-236 (1997)
   PUBMED   9299241
REFERENCE   10 (bases 1 to 3643)
  AUTHORS   Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
            Tsui,L.C.
  TITLE     Localization of two metabotropic glutamate receptor genes, GRM3 and
            GRM8, to human chromosome 7q
  JOURNAL   Genomics 31 (2), 230-233 (1996)
   PUBMED   8824806
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315203.1, AJ236922.1,
            BC093725.1, BG202742.1 and BG211606.1.
            On Jul 15, 2009 this sequence version replaced gi:187960083.
            
            Summary: L-glutamate is the major excitatory neurotransmitter in
            the central nervous system and activates both ionotropic and
            metabotropic glutamate receptors. Glutamatergic neurotransmission
            is involved in most aspects of normal brain function and can be
            perturbed in many neuropathologic conditions. The metabotropic
            glutamate receptors are a family of G protein-coupled receptors,
            that have been divided into 3 groups on the basis of sequence
            homology, putative signal transduction mechanisms, and
            pharmacologic properties. Group I includes GRM1 and GRM5 and these
            receptors have been shown to activate phospholipase C. Group II
            includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
            and GRM8. Group II and III receptors are linked to the inhibition
            of the cyclic AMP cascade but differ in their agonist
            selectivities. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) contains an additional exon in
            the central coding region that results in a frameshift, compared to
            transcript variant 1. This variant is represented as non-coding
            because the use of the 5'-most supported translational start codon,
            as used in variant 1, renders the transcript a candidate for
            nonsense-mediated mRNA decay (NMD). This variant was designated as
            HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1668              AK315203.1         247-1914
            1669-2684           AJ236922.1         1373-2388
            2685-3137           BC093725.1         2329-2781
            3138-3626           BG202742.1         82-570
            3627-3643           BG211606.1         558-574
FEATURES             Location/Qualifiers
     source          1..3643
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.3-q32.1"
     gene            1..3643
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /note="glutamate receptor, metabotropic 8"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:4600"
                     /db_xref="MIM:601116"
     misc_RNA        1..3643
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /product="glutamate receptor, metabotropic 8, transcript
                     variant 3"
                     /db_xref="GeneID:2918"
                     /db_xref="HGNC:4600"
                     /db_xref="MIM:601116"
     exon            1..821
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       137
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:76817979"
     variation       219
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75009171"
     misc_feature    312..1817
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_000845.2"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     variation       340
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:769194"
     variation       373
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:769202"
     variation       668
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:769200"
     exon            822..1038
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            1039..1174
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1055
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1131702"
     variation       1075
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78266043"
     variation       1105..1106
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2234945"
     variation       1105
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17150343"
     exon            1175..1329
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            1330..1467
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1396
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78124913"
     variation       1414
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78947184"
     exon            1468..1668
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1486
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2234947"
     variation       1599
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75863532"
     exon            1669..1739
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            1740..1876
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       1846
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:769198"
     exon            1877..2812
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       2025
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2234948"
     variation       2404
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:77222071"
     variation       2539
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:769201"
     variation       2685
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1051433"
     exon            2813..3059
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     exon            3060..3630
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /inference="alignment:Splign:1.39.8"
     variation       3138
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:712723"
     polyA_signal    3408..3413
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_site      3428
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_signal    3551..3556
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_site      3577
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_signal    3606..3611
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
     polyA_site      3630
                     /gene="GRM8"
                     /gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
ORIGIN      


gaataattctgctacaaggctgatttcaaggacatgaattgttgacctcatcccaacatcagaacctcagatgttctaatttttgcaccattccaggcaagttgatcttataaggaaataaaattgaaccttaggggtctgatggaaattcactgtgacattcaaatcaagaaaacttgctaatgcccacagagccttttccccatgggccctgatggtagcctccagaaggtgcagcctcaggtggtgccctttcttctgtggcaagaataaactttgggtcttggattgcaataccacctgtggagaaaatggtatgcgagggaaagcgatcagcctcttgcccttgtttcttcctcttgaccgccaagttctactggatcctcacaatgatgcaaagaactcacagccaggagtatgcccattccatacgggtggatggggacattattttggggggtctcttccctgtccacgcaaagggagagagaggggtgccttgtggggagctgaagaaggaaaaggggattcacagactggaggccatgctttatgcaattgaccagattaacaaggaccctgatctcctttccaacatcactctgggtgtccgcatcctcgacacgtgctctagggacacctatgctttggagcagtctctaacattcgtgcaggcattaatagagaaagatgcttcggatgtgaagtgtgctaatggagatccacccattttcaccaagcccgacaagatttctggcgtcataggtgctgcagcaagctccgtgtccatcatggttgctaacattttaagactttttaagatacctcaaatcagctatgcatccacagccccagagctaagtgataacaccaggtatgactttttctctcgagtggttccgcctgactcctaccaagcccaagccatggtggacatcgtgacagcactgggatggaattatgtttcgacactggcttctgaggggaactatggtgagagcggtgtggaggccttcacccagatctcgagggagattggtggtgtttgcattgctcagtcacagaaaatcccacgtgaaccaagacctggagaatttgaaaaaattatcaaacgcctgctagaaacacctaatgctcgagcagtgattatgtttgccaatgaggatgacatcaggaggatattggaagcagcaaaaaaactaaaccaaagtgggcattttctctggattggctcagatagttggggatccaaaatagcacctgtctatcagcaagaggagattgcagaaggggctgtgacaattttgcccaaacgagcatcaattgatggatttgatcgatactttagaagccgaactcttgccaataatcgaagaaatgtgtggtttgcagaattctgggaggagaattttggctgcaagttaggatcacatgggaaaaggaacagtcatataaagaaatgcacagggctggagcgaattgctcgggattcatcttatgaacaggaaggaaaggtccaatttgtaattgatgctgtatattccatggcttacgccctgcacaatatgcacaaagatctctgccctggatacattggcctttgtccacgaatgagtaccattgatgggaaagagctacttggttatattcgggctgtaaattttaatggttgccgaagagggatccagatgtctctaccctggccaactctttttactccttcattttccagtagttgggcagtgctggcactcctgtcacttttaatgaaaacggagatgctcctggacgttatgatatcttccagtatcaaataaccaacaaaagcacagagtacaaagtcatcggccactggaccaatcagcttcatctaaaagtggaagacatgcagtgggctcatagagaacatactcacccggcgtctgtctgcagcctgccgtgtaagccaggggagaggaagaaaacggtgaaaggggtcccttgctgctggcactgtgaacgctgtgaaggttacaactaccaggtggatgagctgtcctgtgaactttgccctctggatcagagacccaacatgaaccgcacaggctgccagcttatccccatcatcaaattggagtggcattctccctgggctgtggtgcctgtgtttgttgcaatattgggaatcatcgccaccacctttgtgatcgtgacctttgtccgctataatgacacacctatcgtgagggcttcaggacgcgaacttagttacgtgctcctaacggggatttttctctgttattcaatcacgtttttaatgattgcagcaccagatacaatcatatgctccttccgacgggtcttcctaggacttggcatgtgtttcagctatgcagcccttctgaccaaaacaaaccgtatccaccgaatatttgagcaggggaagaaatctgtcacagcgcccaagttcattagtccagcatctcagctggtgatcaccttcagcctcatctccgtccagctccttggagtgtttgtctggtttgttgtggatcccccccacatcatcattgactatggagagcagcggacactagatccagagaaggccaggggagtgctcaagtgtgacatttctgatctctcactcatttgttcacttggatacagtatcctcttgatggtcacttgtactgtttatgccattaaaacgagaggtgtcccagagactttcaatgaagccaaacctattggatttaccatgtataccacctgcatcatttggttagctttcatccccatcttttttggtacagcccagtcagcagaaaagatgtacatccagacaacaacacttactgtctccatgagtttaagtgcttcagtatctctgggcatgctctatatgcccaaggtttatattataatttttcatccagaacagaatgttcaaaaacgcaagaggagcttcaaggctgtggtgacagctgccaccatgcaaagcaaactgatccaaaaaggaaatgacagaccaaatggcgaggtgaaaagtgaactctgtgagagtcttgaaaccaacacttcctctaccaagacaacatatatcagttacagcaatcattcaatctgaaacagggaaatggcacaatctgaagagatgtggtatatgatcttaaatgatgaacatgagaccgcaaaaattcactcctggagatctccgtagactacaatcaatcaaatcaatagtcagtcttgtaaggaacaaaaattagccatgagccaaaagtatcaataaacggggagtgaagaaacccgttttatacaataaaaccaatgagtgtcaagctaaagtattgcttattcatgagcagttaaaacaaatcacaaaaggaaaactaatgttagctcgtgaaaaaaaatgctgttgaaataaataatgtctgatgttattcttgtatttttctgtgattgtgagaactcccgttcctgtcccacattgtttaacttgtataagacaatgagtctgtttcttgtaatggctgaccagattgaagccctgggttgtgctaaaaataaatgcaatgattgatgcatgcaattttttatacaaataatttatttctaataataaaggaatgttttgcaaatgttaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2918 -> Molecular function: GO:0001642 [group III metabotropic glutamate receptor activity] evidence: IEA
            GeneID:2918 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS
            GeneID:2918 -> Molecular function: GO:0008066 [glutamate receptor activity] evidence: TAS
            GeneID:2918 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
            GeneID:2918 -> Biological process: GO:0007601 [visual perception] evidence: TAS
            GeneID:2918 -> Biological process: GO:0007608 [sensory perception of smell] evidence: IEA
            GeneID:2918 -> Biological process: GO:0030818 [negative regulation of cAMP biosynthetic process] evidence: IDA
            GeneID:2918 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:2918 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS

by @meso_cacase at DBCLS
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