Home |
Help |
Advanced search
2024-04-17 06:48:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_026918 5504 bp RNA linear PRI 16-JUL-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 3
(PTPN3), transcript variant 7, non-coding RNA.
ACCESSION NR_026918
VERSION NR_026918.1 GI:223941893
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5504)
AUTHORS Hou,S., Suresh,P.S., Qi,X., Lepp,A., Mirza,S.P. and Chen,G.
TITLE p38gamma Mitogen-activated protein kinase signals through
phosphorylating its phosphatase PTPH1 in regulating ras protein
oncogenesis and stress response
JOURNAL J. Biol. Chem. 287 (33), 27895-27905 (2012)
PUBMED 22730326
REMARK GeneRIF: p38gamma Mitogen-activated protein kinase signals through
phosphorylating its phosphatase PTPH1 in regulating ras protein
oncogenesis and stress response.
REFERENCE 2 (bases 1 to 5504)
AUTHORS Jung,Y., Kim,P., Jung,Y., Keum,J., Kim,S.N., Choi,Y.S., Do,I.G.,
Lee,J., Choi,S.J., Kim,S., Lee,J.E., Kim,J., Lee,S. and Kim,J.
TITLE Discovery of ALK-PTPN3 gene fusion from human non-small cell lung
carcinoma cell line using next generation RNA sequencing
JOURNAL Genes Chromosomes Cancer 51 (6), 590-597 (2012)
PUBMED 22334442
REMARK GeneRIF: The fusion transcript of ALK and PTPN3 identified resulted
from translocation of a part of ALK gene into the third intron of
PTPN3. Analysis of the transcript sequence indicates that no
protein with any enzymatic activity is produced.
REFERENCE 3 (bases 1 to 5504)
AUTHORS Zhi,H.Y., Hou,S.W., Li,R.S., Basir,Z., Xiang,Q., Szabo,A. and
Chen,G.
TITLE PTPH1 cooperates with vitamin D receptor to stimulate breast cancer
growth through their mutual stabilization
JOURNAL Oncogene 30 (14), 1706-1715 (2011)
PUBMED 21119599
REMARK GeneRIF: PTPH1 stimulated breast cancer growth through regulating
vitamin D receptor expression. PTPH1 was overexpressed in primary
breast cancer and levels of its protein expression positively
correlated with clinical metastasis.
REFERENCE 4 (bases 1 to 5504)
AUTHORS Hou,S.W., Zhi,H.Y., Pohl,N., Loesch,M., Qi,X.M., Li,R.S., Basir,Z.
and Chen,G.
TITLE PTPH1 dephosphorylates and cooperates with p38gamma MAPK to
increase ras oncogenesis through PDZ-mediated interaction
JOURNAL Cancer Res. 70 (7), 2901-2910 (2010)
PUBMED 20332238
REMARK GeneRIF: PTPH1 plays a role in Ras-dependent malignant growth by a
mechanism depending on its p38gamma-binding activity. Ras increases
p38gamma and PTPH1 expression and there is a coupling of increased
p38gamma and PTPH1 protein expression in colon cancer.
REFERENCE 5 (bases 1 to 5504)
AUTHORS Barr,A.J., Ugochukwu,E., Lee,W.H., King,O.N., Filippakopoulos,P.,
Alfano,I., Savitsky,P., Burgess-Brown,N.A., Muller,S. and Knapp,S.
TITLE Large-scale structural analysis of the classical human protein
tyrosine phosphatome
JOURNAL Cell 136 (2), 352-363 (2009)
PUBMED 19167335
REFERENCE 6 (bases 1 to 5504)
AUTHORS Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and
Tonks,N.K.
TITLE Serine phosphorylation-dependent association of the band
4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta
protein
JOURNAL J. Biol. Chem. 272 (43), 27281-27287 (1997)
PUBMED 9341175
REFERENCE 7 (bases 1 to 5504)
AUTHORS Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and
Yachi,A.
TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase
PTPH1 mRNA in human hepatocellular carcinoma
JOURNAL J. Gastroenterol. 29 (6), 727-732 (1994)
PUBMED 7874267
REFERENCE 8 (bases 1 to 5504)
AUTHORS Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M.,
Ariyama,T., Inazawa,J., Imai,K. and Yachi,A.
TITLE Expression and chromosomal assignment of PTPH1 gene encoding a
cytosolic protein tyrosine phosphatase homologous to
cytoskeletal-associated proteins
JOURNAL Int. J. Cancer 55 (6), 947-951 (1993)
PUBMED 8253532
REFERENCE 9 (bases 1 to 5504)
AUTHORS Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M.,
Adachi,M., Imai,K. and Yachi,A.
TITLE cDNA cloning of new protein tyrosine phosphatases in the human
colon
JOURNAL Tumour Biol. 13 (3), 180-186 (1992)
PUBMED 1626183
REFERENCE 10 (bases 1 to 5504)
AUTHORS Yang,Q. and Tonks,N.K.
TITLE Isolation of a cDNA clone encoding a human protein-tyrosine
phosphatase with homology to the cytoskeletal-associated proteins
band 4.1, ezrin, and talin
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991)
PUBMED 1648725
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK303608.1, BC033716.1,
DB173093.1, AK096975.1, AL359963.29 and BU624870.1.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This protein contains a C-terminal PTP
domain and an N-terminal domain homologous to the band 4.1
superfamily of cytoskeletal-associated proteins. P97, a cell cycle
regulator involved in a variety of membrane related functions, has
been shown to be a substrate of this PTP. This PTP was also found
to interact with, and be regulated by adaptor protein 14-3-3 beta.
Several alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Feb 2009].
Transcript Variant: This variant (7) contains an alternate 5'
terminal exon, compared to variant 1. This variant is represented
as non-coding due to the presence of an upstream ORF that is
predicted to interfere with translation of the longest ORF;
translation of the upstream ORF renders the transcript a candidate
for nonsense-mediated mRNA decay (NMD).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2093 AK303608.1 1-2093
2094-2944 BC033716.1 1350-2200
2945-3282 DB173093.1 253-590
3283-3766 AK096975.1 196-679
3767-3806 AL359963.29 93827-93866 c
3807-5481 AK096975.1 702-2376
5482-5504 BU624870.1 1-23 c
FEATURES Location/Qualifiers
source 1..5504
/organism="Homo sapiens"
/mol_type="transcribed RNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q31"
gene 1..5504
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/note="protein tyrosine phosphatase, non-receptor type 3"
/db_xref="GeneID:5774"
/db_xref="HGNC:9655"
/db_xref="MIM:176877"
misc_RNA 1..5504
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/product="protein tyrosine phosphatase, non-receptor type
3, transcript variant 7"
/db_xref="GeneID:5774"
/db_xref="HGNC:9655"
/db_xref="MIM:176877"
exon 1..195
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(120)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139265184"
exon 196..382
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(205)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199620488"
variation complement(206)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141809051"
variation complement(217)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:17803052"
variation complement(235)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:146992805"
variation complement(299)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141350094"
variation complement(300)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138707755"
variation complement(309)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375545706"
variation complement(328)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:147174947"
variation complement(337)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377369883"
variation complement(353)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373058480"
variation complement(370)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145875554"
exon 383..460
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(386)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372363344"
variation complement(388)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:368144041"
variation complement(408)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113237352"
variation complement(410)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:376855050"
variation complement(415)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371910658"
variation complement(417)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189241432"
misc_feature 435..503
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="COORDINATES: ab initio prediction:ORF Finder"
/note="upstream ORF that overlaps the primary ORF and has
strong Kozak sequence; nonsense-mediated decay (NMD)
candidate"
exon 461..517
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
misc_feature 479..1624
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="COORDINATES:
alignment:Blast2seq::RefSeq|NM_002829.3"
/note="primary ORF"
variation complement(488)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183458658"
variation complement(496)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149023035"
variation complement(497)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:372689393"
variation complement(498)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144915998"
exon 518..674
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(520)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150061689"
variation complement(523)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200410469"
variation complement(545)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140628740"
variation complement(576)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:181792746"
variation complement(580)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146841512"
variation complement(587)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:59324117"
variation complement(601)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140140279"
variation complement(615)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146077461"
variation complement(621)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201209769"
variation complement(639)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144304313"
variation complement(645)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199759803"
exon 675..835
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(680)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148505458"
variation complement(682)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374405230"
variation complement(697)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:7859962"
variation complement(718)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:34302609"
variation complement(742)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:150353247"
variation complement(754)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371992176"
exon 836..926
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(838)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147437194"
variation complement(857)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371372947"
variation complement(909)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:377718578"
exon 927..988
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(947)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:76416062"
variation complement(982)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138839766"
variation complement(987)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145864054"
exon 989..1135
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(1027)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140802922"
variation complement(1045)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:147976452"
variation complement(1047)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189256306"
variation complement(1050)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143462283"
variation complement(1091)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199692080"
variation complement(1114)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148827369"
exon 1136..1264
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(1150)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146869100"
variation complement(1163)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:375763821"
variation complement(1168)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2304742"
variation complement(1169)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:10116806"
variation complement(1183)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373493427"
variation complement(1186)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146618446"
variation complement(1202)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:150008661"
variation complement(1226)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370019146"
variation complement(1256)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:139321235"
exon 1265..1410
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(1303)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150855452"
variation complement(1306)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146486489"
variation complement(1331)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371886206"
variation complement(1333)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367766327"
variation complement(1339)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140717531"
variation complement(1358)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:375434242"
variation complement(1383)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374209870"
variation complement(1387)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371197800"
variation complement(1388)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147420952"
variation complement(1393)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142937669"
variation complement(1394)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138828543"
variation complement(1405)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368814204"
exon 1411..1546
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(1425)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372894176"
variation complement(1452)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370374314"
variation complement(1514)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201209437"
variation complement(1526)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201640227"
variation complement(1530)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200077324"
variation complement(1537)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:147200776"
exon 1547..5486
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/inference="alignment:Splign:1.39.8"
variation complement(1563)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149479153"
variation complement(1573)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:137963642"
variation complement(1603)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370012185"
variation complement(1612)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200403602"
variation complement(1614)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150328766"
variation complement(1628)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200494712"
variation complement(1631)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377490884"
variation complement(1639)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374288172"
variation complement(1666)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138931600"
variation complement(1702)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371464957"
variation complement(1822)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150282450"
variation complement(1852)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:180926631"
variation complement(1887)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189242626"
variation complement(1962)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140930516"
variation complement(1993)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:185827185"
variation complement(2119)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:151038868"
variation complement(2172)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:114131793"
variation complement(2281)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="t"
/db_xref="dbSNP:115197904"
variation complement(2304)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:143684539"
variation complement(2409)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:41278397"
variation complement(2416)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140622120"
variation complement(2436)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146826909"
variation complement(2574)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144086616"
variation complement(2590)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139353948"
variation complement(2608)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145615584"
variation complement(2676)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149748563"
variation complement(2777)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374631187"
variation complement(2826)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139439518"
variation complement(3286)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:181698971"
variation complement(3311)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190049858"
variation complement(3316)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112728642"
variation complement(3433)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185204780"
variation complement(3441)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111938473"
variation complement(3443)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374737737"
variation complement(3474)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:79977262"
variation complement(3721)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:191660985"
variation complement(3722..3741)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="tgtgtgtgtgtgtgtgtgtg"
/db_xref="dbSNP:55719272"
variation complement(3727)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="tgtgtg"
/replace="tgtgtgtgtg"
/db_xref="dbSNP:56934484"
variation complement(3772..3773)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="tgtgtg"
/db_xref="dbSNP:35223249"
variation complement(3774..3775)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="gtgtgt"
/db_xref="dbSNP:10627956"
variation complement(3775..3784)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="gtgtgtgtgt"
/db_xref="dbSNP:72205265"
variation complement(3777..3784)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="gtgtgtgt"
/db_xref="dbSNP:368150329"
variation complement(3783..3784)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="gt"
/db_xref="dbSNP:72107370"
variation complement(3867)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:116604074"
variation complement(3976)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188762071"
variation complement(4146)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:183693786"
variation complement(4179)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:78043549"
variation complement(4181)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:191559276"
variation complement(4209..4210)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="ca"
/db_xref="dbSNP:201032332"
variation complement(4311)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368512455"
variation complement(4444)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139540788"
variation complement(4456)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="t"
/db_xref="dbSNP:36043083"
variation complement(4589)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188734291"
variation complement(4595)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:73525119"
variation complement(4691)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:113826491"
variation complement(4756)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:143204263"
variation complement(4810)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:75255713"
variation complement(4822)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:76421318"
variation complement(4825)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="g"
/replace="t"
/db_xref="dbSNP:34740968"
variation complement(4894)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111487162"
variation complement(4990..4991)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="g"
/db_xref="dbSNP:34907594"
variation complement(4997)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149641144"
variation complement(4998)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115259973"
variation complement(5008..5009)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace=""
/replace="t"
/db_xref="dbSNP:35111984"
variation complement(5071)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184231955"
variation complement(5109)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="g"
/db_xref="dbSNP:193101927"
variation complement(5148)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138126149"
variation complement(5201)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:188503580"
variation complement(5231)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145645925"
variation complement(5253)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11537746"
variation complement(5254)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183499796"
variation complement(5283)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189997655"
variation complement(5291)
/gene="PTPN3"
/gene_synonym="PTP-H1; PTPH1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61744961"
ORIGIN
aggtgcactgacaatagacatgtcagggggtcaagttagtgactgtgctctgcaagtgggatgaacagccagaaaagcagcccccaccacctctgttaggtgggagacctcttcctgccggtgggaagccactttgtgctgggtcttcagaggaggctggccctcctgagggtctgggaacccccattgctccaggagtttatccgagaacaatccggcacaaagctacctgacccagaagtcatccagttctgtgtctccatcttcaaatgctccaggctcctgctcacctgacggcgttgatcagcagctcttagatgacttccacagggtgaccaaagggggctccaccgaggacgccagccagtactactgtgacaagaatgataatggtgacagctacttagtcttgatccgtatcacaccagatgaagatggaaaatttggatttaatcttaagggaggagtggatcaaaagatgcctcttgtggtatcaaggataaacccagagtcacctgcggacacctgcattcctaagctgaacgaaggggatcaaatcgtgttaatcaatggccgggacatctcagaacacacgcatgaccaagtggtgatgttcatcaaagccagccgggagtcccactcacgggagctggccctggtgatcaggaggagagctgtccgctcatttgctgacttcaagtctgaagatgaactgaaccagcttttccccgaagccattttccccatgtgtccggagggtggggacactttggagggatccatggcacagctaaagaagggcctcgaaagcgggacggtgctgatccagtttgagcaactctacagaaaaaagccaggtttggccatcacgtttgcaaagctgcctcaaaatttggacaaaaaccgatataaagatgtgctgccttatgacaccacccgggtattattgcagggaaatgaagattatattaatgcaagttacgtgaacatggaaattcctgctgctaaccttgtgaacaagtacatcgccactcaggggcccctgccgcatacctgtgcacagttttggcaggttgtctgggatcagaagttgtcactcattgtcatgttgacgactctcacagaacgagggcggaccaaatgtcaccagtactggccagatccccccgacgtcatgaaccacggcggctttcacatccagtgtcagtcagaggactgcaccatcgcctatgtgtcccgagaaatgctggtcacaaacacccagaccggggaagaacacacagtgacacatctccagtacgtcgcatggcctgaccacggtgtgcccgatgactcctccgactttctggaatttgtaaactatgtgaggtctctgagagtggacagcgagcccgtcctagttcactgcagtgctggaataggtcgaaccggtgtgttggtcactatggaaacagccatgtgcctaactgagaggaacctgcccatttacccactggatattgtccgaaaaatgcgagaccagcgcgccatgatggtgcagacatcaagccagtacaagtttgtgtgtgaagcgattcttcgtgtgtatgaagaaggtttagtccaaatgctggatcctagttaagacaactgtgaaaaagttcattcctctttcccaagggcatcctccttgaaagaggaggacagacctctctggaagcagcaagaggaaccagtagctgtgggaaaggaatgggcacctctgaacccaggcactttaaacttctatagaaaagatatcgtgtacataggaactggtgtagataagcatgcaattatggcatcatttaggcctgtatttctatggaaagatacaaaaaggatctcagtttggggcctgtcctaatgccttcttccctaacatcaccacacacacccctgtcggcatcctggagcaattgagaccggacacccacagagctgttgtcctcccagcaacaagatggtgtggttatcttgggtcatttggatgttttgtttgtttctgtgtgtcagactgtaagggctgagctttctgtgcttctaggtggagctggaacaattcagattcacccgccctgatgctaaggaaaccctgacgtatgtactagatggcagggcactgggggtcaggctgaaggctgagcaacacctctctgccctccctccctttgtcccatctcccagcgacttccaatattcatgtttctgagaattgtgtccctcttcaggttccctcttggtgcctaacctggattagtaatgtgcattcaggtgaattttcagctgaggctctgagaactggtactctcagtgtgttctggtcatcttgtggcttagttgtagaagcaggtgtgtctcttgcctctgcttgcctcctactgcacactcagcacccaggactggaatcaccgactactgaatctcctacatgtattgctgctacttcaagctcctccacttgaaaccttatgattttcccaaggggagatgggacagtgtcatctaaatattccgaatgtttggccttctgagaaaagagcttctagtaattgaaccatgggaaacccagcttctggagggttggccgtggggctgtgtacatgtgtgtgcccaggggtgagtgtttctcaggattcctaacgattcaaattaccgttgagtatatataaagaatgagtctctgtatggaagaacaaatgtgtgcattcacccccagtcacaatggtctccattgcatttcaaaggagaggatcagactatctgaatataaacacaatctgatgttaatttattctaagaacaccatcattttgattgtcctaaagaattctgcctttgtgaataccgtgttaaatttttttaaatttgtgacaggattgtagcaaattattatttaaggaaaataaattgtgtaaacatttaatgtggtatttttgaacagcggtttttatgtactcagaagaggaagtaaagccaggttcttaatggtatttatagaaaagatgttttcatattataatgcacataaatgaagccattttgatattcagcaaattcggtgccaattgaatagtttgctggtagcaagacggatgaagacctatatgggagattctttatctctagagctagcatatttacttgcatactttgtttcttttccacatggatattttactgctaaatggcagaggtgggagggagatgtcacacagtaccataaccccatattgaaaacaagaaaccaccagaaagtttgcagctaaggggcaggggattcagttcctacgcccactcagcactaactacttgcgggcctggttgcttagaagctctacctctctttcattatctgtaaaatagaaacaatacttaggactttagttggaacatgaggattgaataagatcacgctattcatgtgactttttatcggctagaacagcaacagacactgctgtgggtgagttacttagaaaagtttagttatcagtgattagcccaaaaacacatcagtcaaaaatagaatccactggatttttgtctctctttttagagacagggtctcactgtcgcccaggctggagtacagtggcatgatcattgttcactgcagcctcaaattcctgggctcaagcaatcctcgcacctcagcctcctgagtagccgggactataggcacatgccacctcacctggcttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtagagacaggatcttgatgtgttgcctaggctggtctcaaactcctggcctcaagtgatcttcccacctcagcctccaaaactgttgggattataggcgtgagccactgtgcccagcctaactgggtttttatgagaggaaaatagaaaatgctcttctagaagagagagaacaagagcacaaaataatctggactcacaaaaattcagcaagctccaagaaagggggatggagggaacgctggcaaaaatttaaatgccattaggatatttagcaagttattactgtttggtaaaaatgcatcatcaccctgtgtgcaaaatgcttgcaaagtagtctaaatgtctttggagatgggtgttttactgcttttttccaaaaacaaattgtttattatggttgcagaaatgcagccattacggtcacataaatttctaaaaagcctaccaaaggttgcaagcagtcttctgccactgggcaggccagcagttcagacccagcgaggttgccaggaacaaatccaggaaatactgggaagaacaagacaagagaattacctaaaagagcaaacaattcaagtaaatcctgtagctattaccacttaaaatccgtagctcaagattcctgtttcaccaccttatacacttaagcaattatacttaagcctttttttagtcctaagtgaagaactacatcagaatcaggataagtattttgcctgggaaatttggctgcatatgaatggagaagacatttacatcctatgttctggcactttctgaaagatctaattaaacatgttgatgtgccaatttaatcaagatgagagatccctgctggtgtcaccctctagaacctgcacttggtgttttgactttccagaagaaaaaaatgcaactttggttagggggcagtggttggatcacacagttgtctttcgtttcctaccacagtaattcatatttaaatatgcttttagattagtgtggatactattgctgctgtgttgctacctgacctttttctggggggggtacctcagaaatgagcatttgagggcaagcgaaaaagccctcttcatcctccagaggcaacaaagaggcagcagaaatggggaaagattgtgagaggcagggcttgggtctagacctggacttaggcaagatatgttgccctcaaccctgagttttcttatatgtaaaaagggaaggttgggctggactagatgaggtcaagatttgccattctgggaggctgatattccagagaatcaaaattaatcctaaaccaaagctttatggctgctacagagacatgtcacatttctgagacttgtcaccaagagtttgtccctcagactttggcgctgttgaatgcaaagacaaggatggccaccttctggttcttgcctgttgtcctcagctgagagcagtctcggtaaaggtggcaaagattctgtgacctcagaccggggaccaaatgcttgggagtctgatggccgggctgggccaccattctcatagctctcattctgtttggagcaaccaaaggatttgtgtgaagttatttggaaaaggaccttaactgagcagtaatcttttttctgtatatttggaatgtttttcattctgacctgttctgtcagtgattctactgaaaaacaatttaatcaatataaaaatgttcaagctatgcaacactgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5774 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IPI
GeneID:5774 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IDA
GeneID:5774 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5774 -> Molecular function: GO:0008092 [cytoskeletal protein binding] evidence: IEA
GeneID:5774 -> Molecular function: GO:0051117 [ATPase binding] evidence: IPI
GeneID:5774 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA
GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: IDA
GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: TAS
GeneID:5774 -> Biological process: GO:0045930 [negative regulation of mitotic cell cycle] evidence: IDA
GeneID:5774 -> Biological process: GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] evidence: IMP
GeneID:5774 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5774 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
GeneID:5774 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.