2024-04-25 03:31:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NR_026918 5504 bp RNA linear PRI 16-JUL-2013 DEFINITION Homo sapiens protein tyrosine phosphatase, non-receptor type 3 (PTPN3), transcript variant 7, non-coding RNA. ACCESSION NR_026918 VERSION NR_026918.1 GI:223941893 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5504) AUTHORS Hou,S., Suresh,P.S., Qi,X., Lepp,A., Mirza,S.P. and Chen,G. TITLE p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response JOURNAL J. Biol. Chem. 287 (33), 27895-27905 (2012) PUBMED 22730326 REMARK GeneRIF: p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. REFERENCE 2 (bases 1 to 5504) AUTHORS Jung,Y., Kim,P., Jung,Y., Keum,J., Kim,S.N., Choi,Y.S., Do,I.G., Lee,J., Choi,S.J., Kim,S., Lee,J.E., Kim,J., Lee,S. and Kim,J. TITLE Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing JOURNAL Genes Chromosomes Cancer 51 (6), 590-597 (2012) PUBMED 22334442 REMARK GeneRIF: The fusion transcript of ALK and PTPN3 identified resulted from translocation of a part of ALK gene into the third intron of PTPN3. Analysis of the transcript sequence indicates that no protein with any enzymatic activity is produced. REFERENCE 3 (bases 1 to 5504) AUTHORS Zhi,H.Y., Hou,S.W., Li,R.S., Basir,Z., Xiang,Q., Szabo,A. and Chen,G. TITLE PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization JOURNAL Oncogene 30 (14), 1706-1715 (2011) PUBMED 21119599 REMARK GeneRIF: PTPH1 stimulated breast cancer growth through regulating vitamin D receptor expression. PTPH1 was overexpressed in primary breast cancer and levels of its protein expression positively correlated with clinical metastasis. REFERENCE 4 (bases 1 to 5504) AUTHORS Hou,S.W., Zhi,H.Y., Pohl,N., Loesch,M., Qi,X.M., Li,R.S., Basir,Z. and Chen,G. TITLE PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction JOURNAL Cancer Res. 70 (7), 2901-2910 (2010) PUBMED 20332238 REMARK GeneRIF: PTPH1 plays a role in Ras-dependent malignant growth by a mechanism depending on its p38gamma-binding activity. Ras increases p38gamma and PTPH1 expression and there is a coupling of increased p38gamma and PTPH1 protein expression in colon cancer. REFERENCE 5 (bases 1 to 5504) AUTHORS Barr,A.J., Ugochukwu,E., Lee,W.H., King,O.N., Filippakopoulos,P., Alfano,I., Savitsky,P., Burgess-Brown,N.A., Muller,S. and Knapp,S. TITLE Large-scale structural analysis of the classical human protein tyrosine phosphatome JOURNAL Cell 136 (2), 352-363 (2009) PUBMED 19167335 REFERENCE 6 (bases 1 to 5504) AUTHORS Zhang,S.H., Kobayashi,R., Graves,P.R., Piwnica-Worms,H. and Tonks,N.K. TITLE Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein JOURNAL J. Biol. Chem. 272 (43), 27281-27287 (1997) PUBMED 9341175 REFERENCE 7 (bases 1 to 5504) AUTHORS Ikuta,S., Itoh,F., Hinoda,Y., Toyota,M., Makiguchi,Y., Imai,K. and Yachi,A. TITLE Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma JOURNAL J. Gastroenterol. 29 (6), 727-732 (1994) PUBMED 7874267 REFERENCE 8 (bases 1 to 5504) AUTHORS Itoh,F., Ikuta,S., Hinoda,Y., Arimura,Y., Ohe,M., Adachi,M., Ariyama,T., Inazawa,J., Imai,K. and Yachi,A. TITLE Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins JOURNAL Int. J. Cancer 55 (6), 947-951 (1993) PUBMED 8253532 REFERENCE 9 (bases 1 to 5504) AUTHORS Arimura,Y., Hinoda,Y., Itoh,F., Takekawa,M., Tsujisaki,M., Adachi,M., Imai,K. and Yachi,A. TITLE cDNA cloning of new protein tyrosine phosphatases in the human colon JOURNAL Tumour Biol. 13 (3), 180-186 (1992) PUBMED 1626183 REFERENCE 10 (bases 1 to 5504) AUTHORS Yang,Q. and Tonks,N.K. TITLE Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (14), 5949-5953 (1991) PUBMED 1648725 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK303608.1, BC033716.1, DB173093.1, AK096975.1, AL359963.29 and BU624870.1. Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]. Transcript Variant: This variant (7) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2093 AK303608.1 1-2093 2094-2944 BC033716.1 1350-2200 2945-3282 DB173093.1 253-590 3283-3766 AK096975.1 196-679 3767-3806 AL359963.29 93827-93866 c 3807-5481 AK096975.1 702-2376 5482-5504 BU624870.1 1-23 c FEATURES Location/Qualifiers source 1..5504 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="9" /map="9q31" gene 1..5504 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /note="protein tyrosine phosphatase, non-receptor type 3" /db_xref="GeneID:5774" /db_xref="HGNC:9655" /db_xref="MIM:176877" misc_RNA 1..5504 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /product="protein tyrosine phosphatase, non-receptor type 3, transcript variant 7" /db_xref="GeneID:5774" /db_xref="HGNC:9655" /db_xref="MIM:176877" exon 1..195 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(120) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:139265184" exon 196..382 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(205) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:199620488" variation complement(206) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:141809051" variation complement(217) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:17803052" variation complement(235) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:146992805" variation complement(299) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:141350094" variation complement(300) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:138707755" variation complement(309) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:375545706" variation complement(328) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:147174947" variation complement(337) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:377369883" variation complement(353) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:373058480" variation complement(370) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:145875554" exon 383..460 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(386) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:372363344" variation complement(388) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="t" /db_xref="dbSNP:368144041" variation complement(408) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:113237352" variation complement(410) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:376855050" variation complement(415) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:371910658" variation complement(417) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:189241432" misc_feature 435..503 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="COORDINATES: ab initio prediction:ORF Finder" /note="upstream ORF that overlaps the primary ORF and has strong Kozak sequence; nonsense-mediated decay (NMD) candidate" exon 461..517 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" misc_feature 479..1624 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="COORDINATES: alignment:Blast2seq::RefSeq|NM_002829.3" /note="primary ORF" variation complement(488) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:183458658" variation complement(496) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:149023035" variation complement(497) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:372689393" variation complement(498) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:144915998" exon 518..674 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(520) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:150061689" variation complement(523) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:200410469" variation complement(545) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:140628740" variation complement(576) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:181792746" variation complement(580) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:146841512" variation complement(587) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:59324117" variation complement(601) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:140140279" variation complement(615) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:146077461" variation complement(621) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:201209769" variation complement(639) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:144304313" variation complement(645) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:199759803" exon 675..835 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(680) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:148505458" variation complement(682) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:374405230" variation complement(697) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:7859962" variation complement(718) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:34302609" variation complement(742) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:150353247" variation complement(754) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:371992176" exon 836..926 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(838) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:147437194" variation complement(857) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:371372947" variation complement(909) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="t" /db_xref="dbSNP:377718578" exon 927..988 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(947) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:76416062" variation complement(982) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:138839766" variation complement(987) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:145864054" exon 989..1135 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(1027) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:140802922" variation complement(1045) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:147976452" variation complement(1047) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:189256306" variation complement(1050) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:143462283" variation complement(1091) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:199692080" variation complement(1114) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:148827369" exon 1136..1264 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(1150) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:146869100" variation complement(1163) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:375763821" variation complement(1168) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:2304742" variation complement(1169) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:10116806" variation complement(1183) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:373493427" variation complement(1186) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:146618446" variation complement(1202) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="t" /db_xref="dbSNP:150008661" variation complement(1226) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:370019146" variation complement(1256) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:139321235" exon 1265..1410 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(1303) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:150855452" variation complement(1306) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:146486489" variation complement(1331) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:371886206" variation complement(1333) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:367766327" variation complement(1339) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:140717531" variation complement(1358) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="t" /db_xref="dbSNP:375434242" variation complement(1383) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:374209870" variation complement(1387) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:371197800" variation complement(1388) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:147420952" variation complement(1393) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:142937669" variation complement(1394) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:138828543" variation complement(1405) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:368814204" exon 1411..1546 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(1425) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:372894176" variation complement(1452) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:370374314" variation complement(1514) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:201209437" variation complement(1526) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:201640227" variation complement(1530) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:200077324" variation complement(1537) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:147200776" exon 1547..5486 /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /inference="alignment:Splign:1.39.8" variation complement(1563) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:149479153" variation complement(1573) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:137963642" variation complement(1603) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:370012185" variation complement(1612) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:200403602" variation complement(1614) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:150328766" variation complement(1628) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:200494712" variation complement(1631) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:377490884" variation complement(1639) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:374288172" variation complement(1666) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:138931600" variation complement(1702) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:371464957" variation complement(1822) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:150282450" variation complement(1852) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:180926631" variation complement(1887) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:189242626" variation complement(1962) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:140930516" variation complement(1993) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:185827185" variation complement(2119) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:151038868" variation complement(2172) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:114131793" variation complement(2281) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="t" /db_xref="dbSNP:115197904" variation complement(2304) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:143684539" variation complement(2409) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:41278397" variation complement(2416) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:140622120" variation complement(2436) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:146826909" variation complement(2574) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:144086616" variation complement(2590) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:139353948" variation complement(2608) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:145615584" variation complement(2676) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:149748563" variation complement(2777) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:374631187" variation complement(2826) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:139439518" variation complement(3286) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:181698971" variation complement(3311) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:190049858" variation complement(3316) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:112728642" variation complement(3433) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:185204780" variation complement(3441) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:111938473" variation complement(3443) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:374737737" variation complement(3474) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:79977262" variation complement(3721) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:191660985" variation complement(3722..3741) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="tgtgtgtgtgtgtgtgtgtg" /db_xref="dbSNP:55719272" variation complement(3727) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="tgtgtg" /replace="tgtgtgtgtg" /db_xref="dbSNP:56934484" variation complement(3772..3773) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="tgtgtg" /db_xref="dbSNP:35223249" variation complement(3774..3775) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="gtgtgt" /db_xref="dbSNP:10627956" variation complement(3775..3784) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:72205265" variation complement(3777..3784) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:368150329" variation complement(3783..3784) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="gt" /db_xref="dbSNP:72107370" variation complement(3867) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:116604074" variation complement(3976) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:188762071" variation complement(4146) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:183693786" variation complement(4179) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:78043549" variation complement(4181) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:191559276" variation complement(4209..4210) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="ca" /db_xref="dbSNP:201032332" variation complement(4311) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:368512455" variation complement(4444) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:139540788" variation complement(4456) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="t" /db_xref="dbSNP:36043083" variation complement(4589) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:188734291" variation complement(4595) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:73525119" variation complement(4691) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:113826491" variation complement(4756) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:143204263" variation complement(4810) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:75255713" variation complement(4822) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:76421318" variation complement(4825) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="g" /replace="t" /db_xref="dbSNP:34740968" variation complement(4894) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:111487162" variation complement(4990..4991) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="g" /db_xref="dbSNP:34907594" variation complement(4997) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:149641144" variation complement(4998) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:115259973" variation complement(5008..5009) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="" /replace="t" /db_xref="dbSNP:35111984" variation complement(5071) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:184231955" variation complement(5109) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="g" /db_xref="dbSNP:193101927" variation complement(5148) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:138126149" variation complement(5201) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:188503580" variation complement(5231) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="c" /db_xref="dbSNP:145645925" variation complement(5253) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:11537746" variation complement(5254) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:183499796" variation complement(5283) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="c" /replace="t" /db_xref="dbSNP:189997655" variation complement(5291) /gene="PTPN3" /gene_synonym="PTP-H1; PTPH1" /replace="a" /replace="g" /db_xref="dbSNP:61744961" ORIGIN
aggtgcactgacaatagacatgtcagggggtcaagttagtgactgtgctctgcaagtgggatgaacagccagaaaagcagcccccaccacctctgttaggtgggagacctcttcctgccggtgggaagccactttgtgctgggtcttcagaggaggctggccctcctgagggtctgggaacccccattgctccaggagtttatccgagaacaatccggcacaaagctacctgacccagaagtcatccagttctgtgtctccatcttcaaatgctccaggctcctgctcacctgacggcgttgatcagcagctcttagatgacttccacagggtgaccaaagggggctccaccgaggacgccagccagtactactgtgacaagaatgataatggtgacagctacttagtcttgatccgtatcacaccagatgaagatggaaaatttggatttaatcttaagggaggagtggatcaaaagatgcctcttgtggtatcaaggataaacccagagtcacctgcggacacctgcattcctaagctgaacgaaggggatcaaatcgtgttaatcaatggccgggacatctcagaacacacgcatgaccaagtggtgatgttcatcaaagccagccgggagtcccactcacgggagctggccctggtgatcaggaggagagctgtccgctcatttgctgacttcaagtctgaagatgaactgaaccagcttttccccgaagccattttccccatgtgtccggagggtggggacactttggagggatccatggcacagctaaagaagggcctcgaaagcgggacggtgctgatccagtttgagcaactctacagaaaaaagccaggtttggccatcacgtttgcaaagctgcctcaaaatttggacaaaaaccgatataaagatgtgctgccttatgacaccacccgggtattattgcagggaaatgaagattatattaatgcaagttacgtgaacatggaaattcctgctgctaaccttgtgaacaagtacatcgccactcaggggcccctgccgcatacctgtgcacagttttggcaggttgtctgggatcagaagttgtcactcattgtcatgttgacgactctcacagaacgagggcggaccaaatgtcaccagtactggccagatccccccgacgtcatgaaccacggcggctttcacatccagtgtcagtcagaggactgcaccatcgcctatgtgtcccgagaaatgctggtcacaaacacccagaccggggaagaacacacagtgacacatctccagtacgtcgcatggcctgaccacggtgtgcccgatgactcctccgactttctggaatttgtaaactatgtgaggtctctgagagtggacagcgagcccgtcctagttcactgcagtgctggaataggtcgaaccggtgtgttggtcactatggaaacagccatgtgcctaactgagaggaacctgcccatttacccactggatattgtccgaaaaatgcgagaccagcgcgccatgatggtgcagacatcaagccagtacaagtttgtgtgtgaagcgattcttcgtgtgtatgaagaaggtttagtccaaatgctggatcctagttaagacaactgtgaaaaagttcattcctctttcccaagggcatcctccttgaaagaggaggacagacctctctggaagcagcaagaggaaccagtagctgtgggaaaggaatgggcacctctgaacccaggcactttaaacttctatagaaaagatatcgtgtacataggaactggtgtagataagcatgcaattatggcatcatttaggcctgtatttctatggaaagatacaaaaaggatctcagtttggggcctgtcctaatgccttcttccctaacatcaccacacacacccctgtcggcatcctggagcaattgagaccggacacccacagagctgttgtcctcccagcaacaagatggtgtggttatcttgggtcatttggatgttttgtttgtttctgtgtgtcagactgtaagggctgagctttctgtgcttctaggtggagctggaacaattcagattcacccgccctgatgctaaggaaaccctgacgtatgtactagatggcagggcactgggggtcaggctgaaggctgagcaacacctctctgccctccctccctttgtcccatctcccagcgacttccaatattcatgtttctgagaattgtgtccctcttcaggttccctcttggtgcctaacctggattagtaatgtgcattcaggtgaattttcagctgaggctctgagaactggtactctcagtgtgttctggtcatcttgtggcttagttgtagaagcaggtgtgtctcttgcctctgcttgcctcctactgcacactcagcacccaggactggaatcaccgactactgaatctcctacatgtattgctgctacttcaagctcctccacttgaaaccttatgattttcccaaggggagatgggacagtgtcatctaaatattccgaatgtttggccttctgagaaaagagcttctagtaattgaaccatgggaaacccagcttctggagggttggccgtggggctgtgtacatgtgtgtgcccaggggtgagtgtttctcaggattcctaacgattcaaattaccgttgagtatatataaagaatgagtctctgtatggaagaacaaatgtgtgcattcacccccagtcacaatggtctccattgcatttcaaaggagaggatcagactatctgaatataaacacaatctgatgttaatttattctaagaacaccatcattttgattgtcctaaagaattctgcctttgtgaataccgtgttaaatttttttaaatttgtgacaggattgtagcaaattattatttaaggaaaataaattgtgtaaacatttaatgtggtatttttgaacagcggtttttatgtactcagaagaggaagtaaagccaggttcttaatggtatttatagaaaagatgttttcatattataatgcacataaatgaagccattttgatattcagcaaattcggtgccaattgaatagtttgctggtagcaagacggatgaagacctatatgggagattctttatctctagagctagcatatttacttgcatactttgtttcttttccacatggatattttactgctaaatggcagaggtgggagggagatgtcacacagtaccataaccccatattgaaaacaagaaaccaccagaaagtttgcagctaaggggcaggggattcagttcctacgcccactcagcactaactacttgcgggcctggttgcttagaagctctacctctctttcattatctgtaaaatagaaacaatacttaggactttagttggaacatgaggattgaataagatcacgctattcatgtgactttttatcggctagaacagcaacagacactgctgtgggtgagttacttagaaaagtttagttatcagtgattagcccaaaaacacatcagtcaaaaatagaatccactggatttttgtctctctttttagagacagggtctcactgtcgcccaggctggagtacagtggcatgatcattgttcactgcagcctcaaattcctgggctcaagcaatcctcgcacctcagcctcctgagtagccgggactataggcacatgccacctcacctggcttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtagagacaggatcttgatgtgttgcctaggctggtctcaaactcctggcctcaagtgatcttcccacctcagcctccaaaactgttgggattataggcgtgagccactgtgcccagcctaactgggtttttatgagaggaaaatagaaaatgctcttctagaagagagagaacaagagcacaaaataatctggactcacaaaaattcagcaagctccaagaaagggggatggagggaacgctggcaaaaatttaaatgccattaggatatttagcaagttattactgtttggtaaaaatgcatcatcaccctgtgtgcaaaatgcttgcaaagtagtctaaatgtctttggagatgggtgttttactgcttttttccaaaaacaaattgtttattatggttgcagaaatgcagccattacggtcacataaatttctaaaaagcctaccaaaggttgcaagcagtcttctgccactgggcaggccagcagttcagacccagcgaggttgccaggaacaaatccaggaaatactgggaagaacaagacaagagaattacctaaaagagcaaacaattcaagtaaatcctgtagctattaccacttaaaatccgtagctcaagattcctgtttcaccaccttatacacttaagcaattatacttaagcctttttttagtcctaagtgaagaactacatcagaatcaggataagtattttgcctgggaaatttggctgcatatgaatggagaagacatttacatcctatgttctggcactttctgaaagatctaattaaacatgttgatgtgccaatttaatcaagatgagagatccctgctggtgtcaccctctagaacctgcacttggtgttttgactttccagaagaaaaaaatgcaactttggttagggggcagtggttggatcacacagttgtctttcgtttcctaccacagtaattcatatttaaatatgcttttagattagtgtggatactattgctgctgtgttgctacctgacctttttctggggggggtacctcagaaatgagcatttgagggcaagcgaaaaagccctcttcatcctccagaggcaacaaagaggcagcagaaatggggaaagattgtgagaggcagggcttgggtctagacctggacttaggcaagatatgttgccctcaaccctgagttttcttatatgtaaaaagggaaggttgggctggactagatgaggtcaagatttgccattctgggaggctgatattccagagaatcaaaattaatcctaaaccaaagctttatggctgctacagagacatgtcacatttctgagacttgtcaccaagagtttgtccctcagactttggcgctgttgaatgcaaagacaaggatggccaccttctggttcttgcctgttgtcctcagctgagagcagtctcggtaaaggtggcaaagattctgtgacctcagaccggggaccaaatgcttgggagtctgatggccgggctgggccaccattctcatagctctcattctgtttggagcaaccaaaggatttgtgtgaagttatttggaaaaggaccttaactgagcagtaatcttttttctgtatatttggaatgtttttcattctgacctgttctgtcagtgattctactgaaaaacaatttaatcaatataaaaatgttcaagctatgcaacactgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5774 -> Molecular function: GO:0001784 [phosphotyrosine binding] evidence: IPI GeneID:5774 -> Molecular function: GO:0004725 [protein tyrosine phosphatase activity] evidence: IDA GeneID:5774 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5774 -> Molecular function: GO:0008092 [cytoskeletal protein binding] evidence: IEA GeneID:5774 -> Molecular function: GO:0051117 [ATPase binding] evidence: IPI GeneID:5774 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: IDA GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: IDA GeneID:5774 -> Biological process: GO:0035335 [peptidyl-tyrosine dephosphorylation] evidence: TAS GeneID:5774 -> Biological process: GO:0045930 [negative regulation of mitotic cell cycle] evidence: IDA GeneID:5774 -> Biological process: GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] evidence: IMP GeneID:5774 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:5774 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA GeneID:5774 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: IDA
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