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2019-03-25 14:31:17, GGRNA : RefSeq release 60 (20130726)

LOCUS       NR_026571               4386 bp    RNA     linear   PRI 16-JUL-2013
DEFINITION  Homo sapiens NADPH oxidase 4 (NOX4), transcript variant 4,
            non-coding RNA.
ACCESSION   NR_026571
VERSION     NR_026571.1  GI:219842349
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4386)
  AUTHORS   Koziel,R., Pircher,H., Kratochwil,M., Lener,B., Hermann,M.,
            Dencher,N.A. and Jansen-Durr,P.
  TITLE     Mitochondrial respiratory chain complex I is inactivated by NADPH
            oxidase Nox4
  JOURNAL   Biochem. J. 452 (2), 231-239 (2013)
   PUBMED   23514110
  REMARK    GeneRIF: Nox4 specifically inhibits the activity of mitochondrial
            electron transport chain complex I, decreasing the concentration of
            complex I subunits and mitochondrial function by a new pathway.
REFERENCE   2  (bases 1 to 4386)
  AUTHORS   Matsushima,S., Kuroda,J., Ago,T., Zhai,P., Ikeda,Y., Oka,S.,
            Fong,G.H., Tian,R. and Sadoshima,J.
  TITLE     Broad suppression of NADPH oxidase activity exacerbates
            ischemia/reperfusion injury through inadvertent downregulation of
            hypoxia-inducible factor-1alpha and upregulation of peroxisome
            proliferator-activated receptor-alpha
  JOURNAL   Circ. Res. 112 (8), 1135-1149 (2013)
   PUBMED   23476056
  REMARK    GeneRIF: Nox4 protects the heart from ischemia/reperfusion injury
            by regulating hypoxia-inducible factor-1alpha and peroxisome
            proliferator-activated receptor-alpha.
REFERENCE   3  (bases 1 to 4386)
  AUTHORS   Anilkumar,N., Jose,G.S., Sawyer,I., Santos,C.X., Sand,C.,
            Brewer,A.C., Warren,D. and Shah,A.M.
  TITLE     A 28-kDa splice variant of NADPH oxidase-4 is nuclear-localized and
            involved in redox signaling in vascular cells
  JOURNAL   Arterioscler. Thromb. Vasc. Biol. 33 (4), E104-E112 (2013)
   PUBMED   23393389
  REMARK    GeneRIF: Nox4D is a nuclear-localized and functionally active
            splice variant of Nox4 that may have important pathophysiologic
            effects through modulation of nuclear signaling and DNA damage in
            vascular cells.
REFERENCE   4  (bases 1 to 4386)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 4386)
  AUTHORS   Chang,G., Chen,L., Lin,H.M., Lin,Y. and Maranchie,J.K.
  TITLE     Nox4 inhibition enhances the cytotoxicity of cisplatin in human
            renal cancer cells
  JOURNAL   J. Exp. Ther. Oncol. 10 (1), 9-18 (2012)
   PUBMED   22946340
  REMARK    GeneRIF: Nox4 contributes to renal cancer cells chemo-resistance
            through modulation of pro-apoptotic and anti-apoptotic signaling,
            suggesting that Nox4 inhibition might enhance the efficacy of
            conventional cytotoxic drugs against RCC.
REFERENCE   6  (bases 1 to 4386)
  AUTHORS   Bedard,K. and Krause,K.H.
  TITLE     The NOX family of ROS-generating NADPH oxidases: physiology and
            pathophysiology
  JOURNAL   Physiol. Rev. 87 (1), 245-313 (2007)
   PUBMED   17237347
  REMARK    Review article
REFERENCE   7  (bases 1 to 4386)
  AUTHORS   Brar,S.S., Kennedy,T.P., Sturrock,A.B., Huecksteadt,T.P.,
            Quinn,M.T., Whorton,A.R. and Hoidal,J.R.
  TITLE     An NAD(P)H oxidase regulates growth and transcription in melanoma
            cells
  JOURNAL   Am. J. Physiol., Cell Physiol. 282 (6), C1212-C1224 (2002)
   PUBMED   11997235
REFERENCE   8  (bases 1 to 4386)
  AUTHORS   Cheng,G., Cao,Z., Xu,X., van Meir,E.G. and Lambeth,J.D.
  TITLE     Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4,
            and Nox5
  JOURNAL   Gene 269 (1-2), 131-140 (2001)
   PUBMED   11376945
REFERENCE   9  (bases 1 to 4386)
  AUTHORS   Shiose,A., Kuroda,J., Tsuruya,K., Hirai,M., Hirakata,H., Naito,S.,
            Hattori,M., Sakaki,Y. and Sumimoto,H.
  TITLE     A novel superoxide-producing NAD(P)H oxidase in kidney
  JOURNAL   J. Biol. Chem. 276 (2), 1417-1423 (2001)
   PUBMED   11032835
REFERENCE   10 (bases 1 to 4386)
  AUTHORS   Geiszt,M., Kopp,J.B., Varnai,P. and Leto,T.L.
  TITLE     Identification of renox, an NAD(P)H oxidase in kidney
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 97 (14), 8010-8014 (2000)
   PUBMED   10869423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002404.2, AJ704725.1,
            BU730205.1, AP001815.4 and AW207163.1.
            
            Summary: This gene encodes a member of the NOX-family of enzymes
            that functions as the catalytic subunit the NADPH oxidase complex.
            The encoded protein is localized to non-phagocytic cells where it
            acts as an oxygen sensor and catalyzes the reduction of molecular
            oxygen to various reactive oxygen species (ROS). The ROS generated
            by this protein have been implicated in numerous biological
            functions including signal transduction, cell differentiation and
            tumor cell growth. A pseudogene has been identified on the other
            arm of chromosome 11. Alternative splicing results in multiple
            transcript variants.[provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (4) uses an alternate splice site
            in an internal exon, compared to variant 1. This variant is
            represented as non-coding because the use of the 5'-most supported
            translational start codon, as used in variant 1, renders the
            transcript a candidate for nonsense-mediated mRNA decay (NMD).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AP002404.2         26180-26418         c
            240-1972            AJ704725.1         1-1733
            1973-2384           BU730205.1         16-427              c
            2385-3943           AP001815.4         17607-19165         c
            3944-4386           AW207163.1         1-443               c
FEATURES             Location/Qualifiers
     source          1..4386
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.2-q21"
     gene            1..4386
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /note="NADPH oxidase 4"
                     /db_xref="GeneID:50507"
                     /db_xref="HGNC:7891"
                     /db_xref="MIM:605261"
     misc_RNA        1..4386
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /product="NADPH oxidase 4, transcript variant 4"
                     /db_xref="GeneID:50507"
                     /db_xref="HGNC:7891"
                     /db_xref="MIM:605261"
     exon            1..296
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     variation       177
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2289124"
     variation       201
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2289125"
     misc_feature    240..404
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001143837.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            297..392
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            393..499
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            500..584
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     variation       546..547
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34078833"
     exon            585..682
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            683..710
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            711..783
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            784..864
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            865..1081
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1082..1246
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1247..1309
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1310..1370
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1371..1452
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1453..1572
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1573..1681
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1682..1750
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1751..1851
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     exon            1852..4375
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    2361..2366
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
     polyA_site      2384
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
     variation       2804..2805
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /replace=""
                     /replace="ac"
                     /db_xref="dbSNP:67347334"
     variation       3236..3237
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34486773"
     variation       3336..3337
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35013442"
     polyA_signal    4356..4361
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
     polyA_site      4375
                     /gene="NOX4"
                     /gene_synonym="KOX; KOX-1; RENOX"
ORIGIN      


tgagtgggcagagctgacccggtgcgggtgggagtcagggcgcccggaaaacccggctctgggtagcagaccccgcccgggctggctcggcgccgggccttcgggcttccactcagtctttgaccctcggtcctcgctcagcggcccggcaggccgcacaactgtaaccgctgccccggccgccgcccgctccttctcggtccggcgggcacagagcgcagcgcggcggggccggcggcatggctgtgtcctggaggagctggctcgccaacgaaggggttaaacacctctgcctgttcatctggctctccatgaatgtcctgcttttctggaaaaccttcttgctgtataaccaagggccagagtatcactacctccaccagatgttgggggattgtgtctaagcagagcctcagcatctgttcttaacctcaactgcagccttatccttttacccatgtgccgaacactcttggcttacctccgaggatcacagaaggttccaagcaggagaaccaggagattgttggataaaagcagaacattccatattacctgtggtgttactatctgtattttctcaggcgtgcatgtggctgcccatctggtgaatgccctcaacttctcagtgaattacagtgaagactttgttgaactgaatgcagcaagataccgagatgaggatcctagaaaacttctcttcacaactgttcctggcctgacaggggtctgcatggtggtggtgctattcctcatgatcacagcctctacatatgcaataagagtttctaactatgatatcttctggtatactcataacctcttctttgtcttctacatgctgctgacgttgcatgtttcaggagggctgctgaagtatcaaactaatttagatacccaccctcccggctgcatcagtcttaaccgaaccagctctcagaatatttccttaccagagtatttctcagaacattttcatgaacctttccctgaaggattttcaaaaccggcagagtttacccagcacaaatttgtgaagatttgtatggaagagcccagattccaagctaattttccacagacttggctttggatttctggacctttgtgcctgtactgtgccgaaagactttacaggtatatccggagcaataagccagtcaccatcatttcggtcataagtcatccctcagatgtcatggaaatccgaatggtcaaagaaaattttaaagcaagacctggtcagtatattactctacattgtcccagtgtatctgcattagaaaatcatccatttaccctcacaatgtgtccaactgaaaccaaagcaacatttggggttcatcttaaaatagtaggagactggacagaacgatttcgagatttactactgcctccatctagtcaagactccgaaattctgcccttcattcaatctagaaattatcccaagctgtatattgatggtccttttggaagtccatttgaggaatcactgaactatgaggtcagcctctgcgtggctggaggcattggagtaactccatttgcatcaatactcaacaccctgttggatgactggaaaccatacaagcttagaagactatactttatttgggtatgcagagatatccagtccttccgttggtttgcagatttactctgtatgttgcataacaagttttggcaagagaacagacctgactatgtcaacatccagctgtacctcagtcaaacagatgggatacagaagataattggagaaaaatatcatgcactgaattcaagactgtttataggacgtcctcggtggaaacttttgtttgatgaaatagcaaaatataacagaggaaaaacagttggtgttttctgttgtggacccaattcactatccaagactcttcataaactgagtaaccagaacaactcatatgggacaagatttgaatacaataaagagtctttcagctgaaaacttttgccatgaagcaggactctaaagaaggaatgagtgcaatttctaagactttgaaactcagcggaatcaatcagctgtgttatgccaaagaatagtaaggttttcttatttatgattatttaaaatggaaatgtgagaatgtggcaagatgaccgtcacattacatgtttaatctggaaaccaaagagaccctgaagaatatttgatgtgatgattcacttttcagttctcaaattaaaagaaaactgttagatgcacactgttgattttcatggtggattcaagaactccctagtgaggagctgaacttgctcaatctaaggctgattgtcgtgttcctctttaaattgtttttggttgaacaaatgcaagattgaacaaaattaaaaattcattgaagctgaaattccattttctgtgttgtgtataaacagagtagctttaatttgcaagcactccaggcaaatatattagatgtttgaaaacacagcacaagactctgtattgatacgggtactttgtgtcaatatctaatcgtctccactacttatgctaatacctctatttgatatctgaagactatatgctaactgaaccttcctcaaatgttgttatagtatctatttttatatatttttttctttttattcctctctctagggaaatatgccttcccttagcatgcattagacataatgatttaataggtccctttcatcttcatttaaatctatcactattgcatggtaatgaaaatattcctactataaattataaagggatatatatatatggatatatatatgtatatacacatatatatatacacacacacacacatatatatatatatatatatatatacacatatactaataacttttcccttttttcagcatttttgtctctattattattattgtttttttcccaggtagggtttgtcttaggctgtagcctctaaggatagttagttaatttgcactttgagaccaaaggacatcatgtgtgtcagtagggactgaatataagatttatctcctttgccacacattggtttatgatggagacattgaaagtctagtcatattcctgaacagtaaaacctgtattttaccttttaagtaagaggaaatatgatattcttattcaaacttaagtttagaatccagaatattactgtcgcactttttggtatcctgagtttccatagggaactattgggtttaaagtcaccgttggaactacactgtgtgatcttataaacttatgttccctggctatcatattcttggctcagaacaatatttcccattactatcttaagaattaaggcattcatggctcacgcctgtaatcccggcactttgggaggccaaggcaggtggatcacgaggtcagagttcaagaccagcctgaccaagttggtgaaaccccatcgctactaaaaatacaaatattaggcgggtgtggtggcgggtgcctataatcccaactactcgggagactgaggcaaagaatcgcttgaacccggtgggcggaggttgcagtgagccaagattgcaccactgcactccagcctgggtgacagagcaagattccatctcaaaaaaaaaaaaaaaaaaaaaaaaaaagaattaaagcattcatacagtttagtgattttgtttagtagtcggctatcaattgctatcaaatataacactgctgaaatcagcagtgtgacttaccttgccattgttaaaatgttacataaaacataacatgatagatgctaaggcctttttttgctataattcaccaatagcaatcaagcatgctaacccatactgaatgatatttacttgtagatatttcttcctttccttgaaattctcctttctatggaaagaagatgaacccaaaaaagtgataggaaatgtggaatgctcatgcagatttagctctgaaggcatatttaataactagtatgtcttgacaacagtctttagattaaaaagaattttcatggaaacatttaacagaaagaactagtaaaaagacactttgagttagtccaggcttaatgtgcaatactgactctatactgatcataatttatttatgcgatcatattaatagacctaatttcattaaaacaggtagaagatttttcaaaagaaagatgatgtttcaaagctggtctgccattctagatgagcctccttgcttatttaagttccagtaggtgttcaaatgttaaatgttaaacataggtcatctttgcttctgcagggcttcatcttgcatgtttaagagaactttgttttattttgagggattatttctctggggatcattcttataatacaagccttaaatcactaattttagtagcaataaatgttaaaattgaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:50507 -> Molecular function: GO:0000166 [nucleotide binding] evidence: TAS
            GeneID:50507 -> Molecular function: GO:0009055 [electron carrier activity] evidence: TAS
            GeneID:50507 -> Molecular function: GO:0016174 [NAD(P)H oxidase activity] evidence: TAS
            GeneID:50507 -> Molecular function: GO:0016175 [superoxide-generating NADPH oxidase activity] evidence: IEA
            GeneID:50507 -> Molecular function: GO:0019826 [oxygen sensor activity] evidence: TAS
            GeneID:50507 -> Molecular function: GO:0020037 [heme binding] evidence: TAS
            GeneID:50507 -> Molecular function: GO:0050660 [flavin adenine dinucleotide binding] evidence: TAS
            GeneID:50507 -> Molecular function: GO:0072341 [modified amino acid binding] evidence: IDA
            GeneID:50507 -> Biological process: GO:0000902 [cell morphogenesis] evidence: ISS
            GeneID:50507 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
            GeneID:50507 -> Biological process: GO:0006954 [inflammatory response] evidence: TAS
            GeneID:50507 -> Biological process: GO:0007569 [cell aging] evidence: ISS
            GeneID:50507 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: ISS
            GeneID:50507 -> Biological process: GO:0014911 [positive regulation of smooth muscle cell migration] evidence: IEA
            GeneID:50507 -> Biological process: GO:0035051 [cardiocyte differentiation] evidence: IEA
            GeneID:50507 -> Biological process: GO:0042554 [superoxide anion generation] evidence: ISS
            GeneID:50507 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:50507 -> Biological process: GO:0043406 [positive regulation of MAP kinase activity] evidence: IEA
            GeneID:50507 -> Biological process: GO:0045453 [bone resorption] evidence: IEA
            GeneID:50507 -> Biological process: GO:0050667 [homocysteine metabolic process] evidence: IDA
            GeneID:50507 -> Biological process: GO:0051496 [positive regulation of stress fiber assembly] evidence: IEA
            GeneID:50507 -> Biological process: GO:0051897 [positive regulation of protein kinase B signaling cascade] evidence: IEA
            GeneID:50507 -> Biological process: GO:0055114 [oxidation-reduction process] evidence: IDA
            GeneID:50507 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: IEA
            GeneID:50507 -> Biological process: GO:0071320 [cellular response to cAMP] evidence: IEA
            GeneID:50507 -> Biological process: GO:0071333 [cellular response to glucose stimulus] evidence: IEA
            GeneID:50507 -> Biological process: GO:0071480 [cellular response to gamma radiation] evidence: IEA
            GeneID:50507 -> Biological process: GO:0071560 [cellular response to transforming growth factor beta stimulus] evidence: IEA
            GeneID:50507 -> Biological process: GO:0072593 [reactive oxygen species metabolic process] evidence: IDA
            GeneID:50507 -> Biological process: GO:2000379 [positive regulation of reactive oxygen species metabolic process] evidence: IEA
            GeneID:50507 -> Biological process: GO:2000573 [positive regulation of DNA biosynthetic process] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0016021 [integral to membrane] evidence: TAS
            GeneID:50507 -> Cellular component: GO:0016324 [apical plasma membrane] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0043020 [NADPH oxidase complex] evidence: IEA
            GeneID:50507 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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