Home |
Help |
Advanced search
2024-04-20 05:16:13, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_212554 2638 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens methyltransferase like 10 (METTL10), mRNA.
ACCESSION NM_212554
VERSION NM_212554.2 GI:58219055
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2638)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 2 (bases 1 to 2638)
AUTHORS Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
TITLE A scan of chromosome 10 identifies a novel locus showing strong
association with late-onset Alzheimer disease
JOURNAL Am. J. Hum. Genet. 78 (1), 78-88 (2006)
PUBMED 16385451
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC026167.1 and AL832292.1.
On Jan 26, 2005 this sequence version replaced gi:47086468.
##Evidence-Data-START##
Transcript exon combination :: BC026167.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-598 BC026167.1 6-603
599-1462 BC026167.1 605-1468
1463-2638 AL832292.1 1435-2610
FEATURES Location/Qualifiers
source 1..2638
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q26.13"
gene 1..2638
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/note="methyltransferase like 10"
/db_xref="GeneID:399818"
/db_xref="HGNC:33787"
/db_xref="HPRD:14216"
exon 1..147
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(27)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="c"
/db_xref="dbSNP:111980057"
variation complement(34)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:370424079"
CDS 38..913
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/codon_start=1
/product="methyltransferase-like protein 10"
/protein_id="NP_997719.2"
/db_xref="GI:58219056"
/db_xref="CCDS:CCDS31307.1"
/db_xref="GeneID:399818"
/db_xref="HGNC:33787"
/db_xref="HPRD:14216"
/translation="
MSSGADGGGGAAVAARSDKGSPGEDGFVPSALGTREHWDAVYERELQTFREYGDTGEIWFGEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLSGFHICIDKGTFDAISLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNWTKEELLNEFSEGWSTVAGFWLTAALTSWAQAIFSTSASRVGGTTGTHHHAWIIFVFLAETRFCHVVQAGLELLGSSDSPTWPPKVLGLYHARPSLAF
"
misc_feature 98..100
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q5JPI9.2); phosphorylation site"
misc_feature 215..712
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/note="Methyltransferase domain; Region: Methyltransf_23;
pfam13489"
/db_xref="CDD:205667"
misc_feature 284..607
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/note="S-adenosylmethionine-dependent methyltransferases
(SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
that use S-adenosyl-L-methionine (SAM or AdoMet) as a
substrate for methyltransfer, creating the product
S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases;
cd02440"
/db_xref="CDD:100107"
misc_feature order(293..313,362..367,440..448,521..523)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/note="S-adenosylmethionine binding site [chemical
binding]; other site"
/db_xref="CDD:100107"
variation complement(58)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:112471520"
variation complement(59)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144443222"
variation complement(93)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="t"
/db_xref="dbSNP:371368817"
variation complement(126)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201307810"
exon 148..213
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(156)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:146879084"
variation complement(185)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201104535"
variation complement(186)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:138061690"
variation complement(188)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149135673"
exon 214..328
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(227)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:112559169"
variation complement(234)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200604629"
variation complement(237)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:4347339"
variation complement(250)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="g"
/replace="t"
/db_xref="dbSNP:150002651"
variation complement(251)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="t"
/db_xref="dbSNP:201398946"
variation complement(300)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375556025"
variation complement(324)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369224597"
exon 329..436
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(329)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199727427"
variation complement(347)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372176056"
variation complement(398)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:139315006"
variation complement(401)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367926355"
variation complement(413)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375880079"
exon 437..653
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(457)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372365652"
variation complement(499)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="g"
/replace="t"
/db_xref="dbSNP:183204976"
variation complement(528)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201578844"
variation complement(557)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199658529"
variation complement(586)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:367744152"
variation complement(606)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:147182290"
variation complement(607)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:79266966"
variation complement(614)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:139714298"
exon 654..912
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(734)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:191386092"
variation complement(885)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="c"
/db_xref="dbSNP:139012328"
exon 913..2579
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/inference="alignment:Splign:1.39.8"
variation complement(921)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367893747"
variation complement(940)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375199533"
variation complement(950)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:189706561"
variation complement(951)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377640360"
variation complement(962)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:187331217"
variation complement(964)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:141231302"
variation complement(981)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377063279"
variation complement(1087)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:182332370"
variation complement(1182)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372939008"
STS 1325..1523
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/standard_name="D10S1451"
/db_xref="UniSTS:54860"
variation complement(1417)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:191651591"
variation complement(1437)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="g"
/replace="t"
/db_xref="dbSNP:200602002"
variation complement(1479)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:114614765"
variation complement(1602)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="c"
/db_xref="dbSNP:186857458"
variation complement(1611)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:78521377"
variation complement(1612)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:181292300"
variation complement(1638)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="t"
/db_xref="dbSNP:370770252"
variation complement(1654)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="t"
/db_xref="dbSNP:188521297"
variation complement(1700)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:77830073"
variation complement(1761)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375068743"
variation complement(1933)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374446725"
variation complement(1959)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:369755346"
variation complement(2152)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="g"
/db_xref="dbSNP:184154030"
variation complement(2185)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="c"
/db_xref="dbSNP:180966453"
variation complement(2211)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="t"
/db_xref="dbSNP:147813057"
variation complement(2233)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:28693410"
variation complement(2328)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="t"
/db_xref="dbSNP:41314424"
variation complement(2437)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:77776466"
variation complement(2440)
/gene="METTL10"
/gene_synonym="C10orf138; Em:AC068896.3"
/replace="c"
/replace="g"
/db_xref="dbSNP:4962697"
ORIGIN
atggcggccccaacggccgtccaggacgtggagcgaaatgagctcgggcgctgacggcggcggtggcgctgcggtggcggcgcggtcggacaagggcagtcccggggaggacggtttcgtcccgtcggcgctggggacccgcgagcattgggatgctgtctatgagagagaactgcaaactttccgagaatatggagatacaggtgaaatctggtttggagaagagagtatgaatcgactaataaggtggatgcagaaacacaagattccactggatgcttcagtgcttgatattggaactggaaatggtgttttcctggttgaacttgcaaaatttggtttctctaatattactggaattgattactctccttctgcaattcagctttctggaagtattatagaaaaagaaggtttatctaacattaagttaaaggtagaagactttttgaatctctccacacagctgtctggatttcatatttgtattgacaaagggacttttgatgccataagccttaatcctgacaatgcaattgagaagaggaagcaatatgtgaaatctctctccagggtgttgaaagtaaaaggcttttttctaataacgtcatgtaattggaccaaggaagagttgctaaatgaattcagtgaaggttggagtacagtggcaggattttggctcactgcagccttgacttcctgggctcaagcgatcttttccacttcagcctcccgagtaggtggaactacaggcacacatcatcatgcctggataatttttgtatttttagcagagacgaggttttgccatgttgtccaggctggtctggaactcctgggctcaagtgattctcccacctggcctcccaaagtgctgggattataccatgccaggccctcgttggcattttagatttgaacttctcgaagagctaccaacacccaagttcagctttggaggcagatctggaaacagtgtagcagcattggttttccaaaaaatgtgagactttttcttggacgaattcaggtagctacacagaatctacacagcaaagttaacctgacacagaaaatccttgtgcaaataaatgcttagtaagtacacaggatgcacatgttgaatagagtatactggattggtgaaagaaaataataataatgagcatctaagtggttgggttttagagatcaatcaagaataattttaattttcttttgtatttgaaatgtaaatagttttcttttcgattaaaaaaatttcctataactgctaaacagttaaaaactttaaagtagtaaatgagtttatagaaagcatgtattcttgatttttgtgccttggtaaagttgataactatttatgaatatttgaccaaattattccagcatcagaataataagcaaaataactttgttagtgttttgttagactgtttatgaaatataacaagaaatactattttgtgttggatggcggttatttttaaacttaattaatacctgtgaaaaggcctcttacctttatgtatataattaaacaaaatcagagaaatgtatcagttgctcaagttatcaagcctgcattttgcagctatggtcttctacacactgtaagggtagtagaaggaaagagaactaaggaatgttattatttgctagcgctatgttaagttgtcttattaagtaattgagtcctttcaatgtcttcttgaggtatgtattgcttgttcttgtttctacgtataaggaaaatgaagctgagagaagtgaagtcacttttatgaggttcaacagtacaggatggagccaggatttttatctgggtctgtctgactttaaaacacatactcttctcctagcatattctgcctcacaggtgcttagtctttgcctttgtagcatttacagtacagctggagacccatgatgattacatataaagttcagttagaaaagatgggtagttactttattagtgttcatctgtggagtatcagaatagcagtcagccaactctgtctcatatcatccttcattacttttccccatctccctactcaaagacttgcctctattaagaattttgtcattcttctgtgaaagggtagtgtaagttatataagccctcagcgatacatgcacaaagatgttctagttaggggctaatttggcaagagaaacagtttattaatgtttttgaaaagataagtcatattcatacttaataccattttgtatttgtggtaatattttaatattggagctaaatacaaatttttgcataattttttgatgattttcagctttgtgggcctattgggttacataagtgactttttgtttggcaaatgttactcctgtattgagtaagtctaacattacgtcccttttctttttggggaggggtagccagaggagtgagtttttcatttagatgaacattgatcaaccattaagacaagatagttgaagacatgtatgtggactgtcaacaaaaataacattttttgaaaagcttttattttcaacatgtaaaaagtgagaaattacttcaaaatatatgcaatttaaattttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:399818 -> Molecular function: GO:0008168 [methyltransferase activity] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_997719 -> EC 2.1.1.-
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.